Valeric acid is a lipid of Fatty Acyls (FA) class. Valeric acid is associated with abnormalities such as Papillon-Lefevre Disease, Obesity, Diabetes Mellitus, Non-Insulin-Dependent and Dehydration. The involved functions are known as Process, Odorant, Stimulus, Irritation and Phenomenon. Valeric acid often locates in Receptive field, soluble, Extracellular, Entire gastrointestinal tract and Body tissue. The associated genes with Valeric acid are Orthologous Gene, Fusion Gene and AS gene. The related lipids are Valerates, butyrate, Propionate, Caproates and Palmitates.
To understand associated biological information of Valeric acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Valeric acid is suspected in Obesity, Papillon-Lefevre Disease, Diabetes Mellitus, Non-Insulin-Dependent, Dehydration and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with Valeric acid
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Stomach Ulcer | D013276 | 75 associated lipids |
| Dermatitis, Contact | D003877 | 59 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
| Glioma | D005910 | 112 associated lipids |
| Peripheral Nervous System Diseases | D010523 | 33 associated lipids |
| Arthritis, Infectious | D001170 | 8 associated lipids |
| Anemia, Sickle Cell | D000755 | 34 associated lipids |
| Psoriasis | D011565 | 47 associated lipids |
| Reye Syndrome | D012202 | 14 associated lipids |
| Uterine Hemorrhage | D014592 | 6 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
|---|
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
| Gene | Cross reference | Weighted score | Related literatures |
|---|
There are no associated biomedical information in the current reference collection.
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Reddy SR et al. | Reliable GC Method for Related Substances in Divalproex Sodium Drug. | 2017 | J Chromatogr Sci | pmid:29048489 |
| Neirinck B et al. | Influence of short chain organic acids and bases on the wetting properties and surface energy of submicrometer ceramic powders. | 2010 | J Colloid Interface Sci | pmid:20553808 |
| Elefsiniotis P and Li W | Biodegradation behavior of agricultural pesticides in anaerobic batch reactors. | 2008 | J Environ Sci Health B | pmid:18246509 |
| Pacifico A et al. | A new formulation of an occlusive dressing containing betamethasone valerate 0.1% in the treatment of mild to moderate psoriasis. | 2006 | J Eur Acad Dermatol Venereol | pmid:16441622 |
| Laskov I et al. | Successful pregnancy following transfer of frozen-thawed embryos in a patient with pseudomyxoma peritonei who underwent peritonectomy and bilateral oophorectomy. | 2012 | J Gynecol Oncol | pmid:22523631 |
| Reimer RA et al. | Faecal short chain fatty acids in healthy subjects participating in a randomised controlled trial examining a soluble highly viscous polysaccharide versus control. | 2012 | J Hum Nutr Diet | pmid:22320902 |
| Kamath MS et al. | Blastocyst cryopreservation using solid surface vitrification: A preliminary study. | 2011 | J Hum Reprod Sci | pmid:22346077 |
| DEICHMANN WB et al. | Observations on the effects of gamma-valero-lactone upon experimental animals. | 1945 | J Ind Hyg Toxicol | pmid:21007121 |
| Shishatskaya EI and Volova TG | A comparative investigation of biodegradable polyhydroxyalkanoate films as matrices for in vitro cell cultures. | 2004 | J Mater Sci Mater Med | pmid:15477744 |
| Kim SH et al. | HemoHIM improves ovarian morphology and decreases expression of nerve growth factor in rats with steroid-induced polycystic ovaries. | 2009 | J Med Food | pmid:20041792 |
| Embleton JK and Tighe BJ | Polymers for biodegradable medical devices XI. Microencapsulation studies: characterization of hydrocortisone-loaded poly-hydroxybutyrate-hydroxyvalerate microspheres. | 2002 Nov-Dec | J Microencapsul | pmid:12569022 |
| Maiti P and Yadav PJ | Biodegradable nanocomposites of poly(hydroxybutyrate-co-hydroxyvalerate): the effect of nanoparticles. | 2008 | J Nanosci Nanotechnol | pmid:18572587 |
| Park M et al. | Determination of XLR-11 and its metabolites in hair by liquid chromatography-tandem mass spectrometry. | 2015 | J Pharm Biomed Anal | pmid:26070160 |
| Chan JC et al. | A novel LCMSMS method for quantitative measurement of short-chain fatty acids in human stool derivatized with C- and C-labelled aniline. | 2017 | J Pharm Biomed Anal | pmid:28178633 |
| Smith RV et al. | GLC determination of indoprofen in plasma. | 1977 | J Pharm Sci | pmid:299889 |
| Abdel-Monem MM and Mikhail EA | Inhibitors of polyamine biosynthesis VI: 2,5-Diamino-2-(cyanomethyl) pentanoic acid, a potential irreversible inhibitor of ornithine decarboxylase. | 1978 | J Pharm Sci | pmid:671262 |
| Kubota K and Maibach HI | In vitro percutaneous permeation of betamethasone and betamethasone 17-valerate. | 1993 | J Pharm Sci | pmid:8254489 |
| Siddiqui O et al. | Percutaneous absorption of steroids: relative contributions of epidermal penetration and dermal clearance. | 1989 | J Pharmacokinet Biopharm | pmid:2614679 |
| Burden DK et al. | HCl uptake through films of pentanoic acid and pentanoic acid/hexanol mixtures at the surface of sulfuric acid. | 2009 | J Phys Chem A | pmid:19924886 |
| Orzechowska GE et al. | Photochemical sources of organic acids. 2. Formation of C5-C9 carboxylic acids from alkene ozonolysis under dry and humid conditions. | 2005 | J Phys Chem A | pmid:16839061 |
| Shilling JE et al. | Uptake of small oxygenated organic molecules onto ammonium nitrate under upper tropospheric conditions. | 2006 | J Phys Chem A | pmid:16722684 |
| MartÃnez Casado FJ et al. | A novel rotator glass in lead(II) pentanoate: calorimetric and spectroscopic study. | 2008 | J Phys Chem B | pmid:19367908 |
| Clifford S et al. | Monte carlo simulation of carboxylic acid phase equilibria. | 2006 | J Phys Chem B | pmid:17064162 |
| MartÃnez Casado FJ et al. | Structural and thermodynamic study on short metal alkanoates: lithium propanoate and pentanoate. | 2009 | J Phys Chem B | pmid:19736960 |
| Li J et al. | Rate enhancement of an interfacial biochemical reaction through localization of substrate and enzyme by an adaptor domain. | 2010 | J Phys Chem B | pmid:21047083 |
| Nishikawa S and Kondo M | Kinetic study for the inclusion complex of carboxylic acids with cyclodextrin by the ultrasonic relaxation method. | 2006 | J Phys Chem B | pmid:17181269 |
| MartÃnez Casado FJ et al. | Thermal and structural study of the crystal phases and mesophases in the lithium and thallium(i) propanoates and pentanoates binary systems: formation of mixed salts and stabilization of the ionic liquid crystal phase. | 2010 | J Phys Chem B | pmid:20684631 |
| Du XL et al. | 6-Oxy-(acetyl ethylenediamine) fluorescein, a novel fluorescent derivatization reagent for carboxylic acids and its application in HPLC. | 2008 | J Sep Sci | pmid:18381692 |
| Tomoda K et al. | Cigarette smoke decreases organic acids levels and population of bifidobacterium in the caecum of rats. | 2011 | J Toxicol Sci | pmid:21628954 |
| Shimo T et al. | [Irritation test of dexamethasone valerate (DV-17) and other steroid ointments in rabbits. Skin and eye primary irritation tests, and skin cumulative irritation test]. | 1982 | J Toxicol Sci | pmid:7154133 |
| Shimo T et al. | [Comparative toxicity test of dexamethasone valerate (DV-17) and other steroid ointments in rats]. | 1982 | J Toxicol Sci | pmid:7154134 |
| Takagaki A and Nanjo F | Catabolism of (+)-catechin and (-)-epicatechin by rat intestinal microbiota. | 2013 | J. Agric. Food Chem. | pmid:23621128 |
| Rico CM et al. | Effect of cerium oxide nanoparticles on the quality of rice ( Oryza sativa L.) grains. | 2013 | J. Agric. Food Chem. | pmid:24188281 |
| Karagül-Yüceer Y et al. | Volatile flavor components of stored nonfat dry milk. | 2002 | J. Agric. Food Chem. | pmid:11782199 |
| Gutierrez-Bañuelos H et al. | Effects of nitroethane and monensin on ruminal fluid fermentation characteristics and nitrocompound-metabolizing bacterial populations. | 2008 | J. Agric. Food Chem. | pmid:18491914 |
| Karagül-Yüceer Y et al. | Aroma-active components of nonfat dry milk. | 2001 | J. Agric. Food Chem. | pmid:11409991 |
| Trabue S et al. | Ruminal fermentation of propylene glycol and glycerol. | 2007 | J. Agric. Food Chem. | pmid:17655323 |
| Akdeniz N et al. | Air sampling and analysis method for volatile organic compounds (VOCs) related to field-scale mortality composting operations. | 2009 | J. Agric. Food Chem. | pmid:19514732 |
| Schneider IC et al. | Fermentation of cottonseed and other feedstuffs in cattle rumen fluid. | 2002 | J. Agric. Food Chem. | pmid:11929282 |
| Steinhaus M and Schieberle P | Characterization of odorants causing an atypical aroma in white pepper powder (Piper nigrum L.) based on quantitative measurements and orthonasal breakthrough thresholds. | 2005 | J. Agric. Food Chem. | pmid:16028994 |
| CORSE J et al. | Alpha-Amino-beta-mercapto-n-valeric acid hydrochloride. | 1948 | J. Am. Chem. Soc. | pmid:18918849 |
| Khenkin AM and Neumann R | Oxidative C-C bond cleavage of primary alcohols and vicinal diols catalyzed by H5PV2Mo10O40 by an electron transfer and oxygen transfer reaction mechanism. | 2008 | J. Am. Chem. Soc. | pmid:18841966 |
| Rishel MJ et al. | Conformationally constrained analogues of bleomycin A5. | 2003 | J. Am. Chem. Soc. | pmid:12926941 |
| Dangel BD et al. | Selective functionalization of amino acids in water: a synthetic method via catalytic C-H bond activation. | 2001 | J. Am. Chem. Soc. | pmid:11506585 |
| Kristensen NB and Harmon DL | Effects of adding valerate, caproate, and heptanoate to ruminal buffers on splanchnic metabolism in steers under washed-rumen conditions. | 2005 | J. Anim. Sci. | pmid:16024710 |
| Arrizon A et al. | Feeding value of dried shredded sugarbeets as a partial replacement for steam-flaked corn in finishing diets for feedlot cattle. | 2012 | J. Anim. Sci. | pmid:22648752 |
| Nery J et al. | Influence of dietary protein content and source on colonic fermentative activity in dogs differing in body size and digestive tolerance. | 2012 | J. Anim. Sci. | pmid:22328724 |
| Kerr KR et al. | Apparent total tract energy and macronutrient digestibility and fecal fermentative end-product concentrations of domestic cats fed extruded, raw beef-based, and cooked beef-based diets. | 2012 | J. Anim. Sci. | pmid:22003235 |
| Baisden LA et al. | n-Valeric acid in stomachs and on unwashed hair of swine. | 1972 | J. Anim. Sci. | pmid:5039919 |
| Barry KA et al. | Adaptation of healthy adult cats to select dietary fibers in vivo affects gas and short-chain fatty acid production from fiber fermentation in vitro. | 2011 | J. Anim. Sci. | pmid:21531846 |
| Kanakupt K et al. | Effects of short-chain fructooligosaccharides and galactooligosaccharides, individually and in combination, on nutrient digestibility, fecal fermentative metabolite concentrations, and large bowel microbial ecology of healthy adults cats. | 2011 | J. Anim. Sci. | pmid:21216981 |
| Barry KA et al. | Dietary cellulose, fructooligosaccharides, and pectin modify fecal protein catabolites and microbial populations in adult cats. | 2010 | J. Anim. Sci. | pmid:20495116 |
| May ML et al. | Effects of dry-rolled or steam-flaked corn finishing diets with or without twenty-five percent dried distillers grains on ruminal fermentation and apparent total tract digestion. | 2009 | J. Anim. Sci. | pmid:19648506 |
| Goiri I et al. | Use of chitosans to modulate ruminal fermentation of a 50:50 forage-to-concentrate diet in sheep. | 2010 | J. Anim. Sci. | pmid:19854994 |
| Barry KA et al. | Low-level fructan supplementation of dogs enhances nutrient digestion and modifies stool metabolite concentrations, but does not alter fecal microbiota populations. | 2009 | J. Anim. Sci. | pmid:19574565 |
| Gozho GN et al. | Effects of type of canola protein supplement on ruminal fermentation and nutrient flow to the duodenum in beef heifers. | 2009 | J. Anim. Sci. | pmid:19542502 |
| Song R et al. | Effects of feeding diets containing bacitracin methylene disalicylate to heat-stressed finishing pigs. | 2011 | J. Anim. Sci. | pmid:21297060 |
| Varel VH et al. | Odorant production and persistence of Escherichia coli in manure slurries from cattle fed zero, twenty, forty, or sixty percent wet distillers grains with solubles. | 2008 | J. Anim. Sci. | pmid:18676716 |
| Robles V et al. | Effects of feeding frequency on intake, ruminal fermentation, and feeding behavior in heifers fed high-concentrate diets. | 2007 | J. Anim. Sci. | pmid:17609471 |
| Kim SC et al. | Effects of dietary n-6:n-3 fatty acid ratio on feed intake, digestibility, and fatty acid profiles of the ruminal contents, liver, and muscle of growing lambs. | 2007 | J. Anim. Sci. | pmid:17121972 |
| Cardozo PW et al. | Effects of natural plant extracts on ruminal protein degradation and fermentation profiles in continuous culture. | 2004 | J. Anim. Sci. | pmid:15542469 |
| Manzanilla EG et al. | Effect of plant extracts and formic acid on the intestinal equilibrium of early-weaned pigs. | 2004 | J. Anim. Sci. | pmid:15542467 |
| Kristensen NB and Harmon DL | Effect of increasing ruminal butyrate absorption on splanchnic metabolism of volatile fatty acids absorbed from the washed reticulorumen of steers. | 2004 | J. Anim. Sci. | pmid:15537776 |
| Kristensen NB and Harmon DL | Splanchnic metabolism of volatile fatty acids absorbed from the washed reticulorumen of steers. | 2004 | J. Anim. Sci. | pmid:15309950 |
| Akay V et al. | NutriDense and waxy corn hybrids: effects on site and extent of disappearance of nutrients in sheep. | 2002 | J. Anim. Sci. | pmid:12019623 |
| Kristensen NB | Rumen microbial sequestration of [2-(13)C]acetate in cattle. | 2001 | J. Anim. Sci. | pmid:11583438 |
| Bandyk CA et al. | Effect of ruminal vs postruminal administration of degradable protein on utilization of low-quality forage by beef steers. | 2001 | J. Anim. Sci. | pmid:11204704 |
| Rossi S et al. | Antimicrobial efficacy of a new antibiotic-loaded poly(hydroxybutyric-co-hydroxyvaleric acid) controlled release system. | 2004 | J. Antimicrob. Chemother. | pmid:15537698 |
| Chee JY et al. | Expression of Aeromonas caviae polyhydroxyalkanoate synthase gene in Burkholderia sp. USM (JCM15050) enables the biosynthesis of SCL-MCL PHA from palm oil products. | 2012 | J. Appl. Microbiol. | pmid:22054430 |
| Park MO et al. | Production of alternatives to fuel oil from organic waste by the alkane-producing bacterium, Vibrio furnissii M1. | 2005 | J. Appl. Microbiol. | pmid:15659187 |
| Bourriaud C et al. | Lactate is mainly fermented to butyrate by human intestinal microfloras but inter-individual variation is evident. | 2005 | J. Appl. Microbiol. | pmid:15960680 |
| Ruman J et al. | Severe hypertriglyceridemia and pancreatitis following hormone replacement prior to cryothaw transfer. | 2002 | J. Assist. Reprod. Genet. | pmid:11958513 |
| SampaÃo MA and Geber S | Births after transfer of zona-free blastocysts in oocyte donation cycles. | 2001 | J. Assist. Reprod. Genet. | pmid:11411431 |
| OTTKE RC et al. | Isotopic acetate and isovalerate in the synthesis of ergosterol by Neurospora. | 1951 | J. Biol. Chem. | pmid:14832256 |
| SIEGEL I and LORBER V | Conversion of C14, C13, labeled n-valerate to rat liver glycogen. | 1951 | J. Biol. Chem. | pmid:14832274 |
| MEISTER A | Studies on d- and tau-alpha-keto-beta-methylvaleric acids. | 1951 | J. Biol. Chem. | pmid:14841174 |
| COON MJ | The metabolic fate of the isopropyl group of leucine. | 1950 | J. Biol. Chem. | pmid:14794691 |
| Schmidt J et al. | Selective orthosteric free fatty acid receptor 2 (FFA2) agonists: identification of the structural and chemical requirements for selective activation of FFA2 versus FFA3. | 2011 | J. Biol. Chem. | pmid:21220428 |
| ZABIN I and BLOCH K | The formation of ketone bodies from isovaleric acid. | 1950 | J. Biol. Chem. | pmid:15436482 |
| ZABIN I and BLOCH K | The utilization of isovaleric acid for the synthesis of cholesterol. | 1950 | J. Biol. Chem. | pmid:15436483 |
| STADTMAN ER et al. | Tracer experiments on the mechanism of synthesis of valeric and caproic acids by Clostridium kluyveri. | 1949 | J. Biol. Chem. | pmid:18116989 |
| Massillon D et al. | Regulation of glucose-6-phosphatase gene expression in cultured hepatocytes and H4IIE cells by short-chain fatty acids: role of hepatic nuclear factor-4alpha. | 2003 | J. Biol. Chem. | pmid:12915406 |
| Ikeda Y et al. | Mechanism of action of short-chain, medium-chain, and long-chain acyl-CoA dehydrogenases. Direct evidence for carbanion formation as an intermediate step using enzyme-catalyzed C-2 proton/deuteron exchange in the absence of C-3 exchange. | 1985 | J. Biol. Chem. | pmid:3968064 |
| BUEDING E | Formation of tiglic and n-valeric acids by bacteria-free Ascaris lumbricoides. | 1953 | J. Biol. Chem. | pmid:13061475 |
| BERLINGUET L and GAUDRY R | Enzymatic resolution of DL-alpha amino-epsilon hydroxy-n caproic acid and DL-alpha amino-delta hydroxy-n-valeric acid. | 1952 | J. Biol. Chem. | pmid:12999793 |
| Brown AJ et al. | The Orphan G protein-coupled receptors GPR41 and GPR43 are activated by propionate and other short chain carboxylic acids. | 2003 | J. Biol. Chem. | pmid:12496283 |
| Ortiz-Caro J et al. | Modulation of thyroid hormone nuclear receptors by short-chain fatty acids in glial C6 cells. Role of histone acetylation. | 1986 | J. Biol. Chem. | pmid:3771518 |
| Gadda G et al. | Identification of a cysteine residue in the active site of nitroalkane oxidase by modification with N-ethylmaleimide. | 2000 | J. Biol. Chem. | pmid:10913134 |
| Park SO and Park BS | Bifidogenic effect of grain larvae extract on serum lipid, glucose and intestinal microflora in rats. | 2015 | J. Biosci. | pmid:26333397 |
| Chanprateep S and Kulpreecha S | Production and characterization of biodegradable terpolymer poly(3-hydroxybutyrate-co-3-hydroxyvalerate-co-4-hydroxybutyrate) by Alcaligenes sp. A-04. | 2006 | J. Biosci. Bioeng. | pmid:16503291 |
| Liu C et al. | Pentanoic acid, a novel protein synthesis stimulant for Chinese Hamster Ovary (CHO) cells. | 2001 | J. Biosci. Bioeng. | pmid:16232949 |
| Cho K et al. | Utilization of swine wastewater as a feedstock for the production of polyhydroxyalkanoates by Azotobacter vinelandii UWD. | 2001 | J. Biosci. Bioeng. | pmid:16232963 |
| Karlsson A et al. | Impact of trace element addition on degradation efficiency of volatile fatty acids, oleic acid and phenyl acetate and on microbial populations in a biogas digester. | 2012 | J. Biosci. Bioeng. | pmid:22683024 |
| Moita R and Lemos PC | Biopolymers production from mixed cultures and pyrolysis by-products. | 2012 | J. Biotechnol. | pmid:21983233 |
| Albuquerque MG et al. | Mixed culture polyhydroxyalkanoate (PHA) production from volatile fatty acid (VFA)-rich streams: effect of substrate composition and feeding regime on PHA productivity, composition and properties. | 2011 | J. Biotechnol. | pmid:21034785 |
| Saha SP et al. | Studies on intracellular degradation of polyhydroxyalkanoic acid-polyethylene glycol copolymer accumulated by Azotobacter chroococcum MAL-201. | 2007 | J. Biotechnol. | pmid:17543409 |
| Iadevaia S and Mantzaris NV | Genetic network driven control of PHBV copolymer composition. | 2006 | J. Biotechnol. | pmid:16219380 |
| Pozo C et al. | Effects of culture conditions on the production of polyhydroxyalkanoates by Azotobacter chroococcum H23 in media containing a high concentration of alpechÃn (wastewater from olive oil mills) as primary carbon source. | 2002 | J. Biotechnol. | pmid:12067519 |
| Lemos PC et al. | Synthesis of polyhydroxyalkanoates from different short-chain fatty acids by mixed cultures submitted to aerobic dynamic feeding. | 2006 | J. Biotechnol. | pmid:16253370 |
| Bengtsson S et al. | Production of polyhydroxyalkanoates from fermented sugar cane molasses by a mixed culture enriched in glycogen accumulating organisms. | 2010 | J. Biotechnol. | pmid:19958801 |