Valeric acid is a lipid of Fatty Acyls (FA) class. Valeric acid is associated with abnormalities such as Papillon-Lefevre Disease, Obesity, Diabetes Mellitus, Non-Insulin-Dependent and Dehydration. The involved functions are known as Process, Odorant, Stimulus, Irritation and Phenomenon. Valeric acid often locates in Receptive field, soluble, Extracellular, Entire gastrointestinal tract and Body tissue. The associated genes with Valeric acid are Orthologous Gene, Fusion Gene and AS gene. The related lipids are Valerates, butyrate, Propionate, Caproates and Palmitates.
To understand associated biological information of Valeric acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Valeric acid is suspected in Obesity, Papillon-Lefevre Disease, Diabetes Mellitus, Non-Insulin-Dependent, Dehydration and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with Valeric acid
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Stomach Ulcer | D013276 | 75 associated lipids |
| Dermatitis, Contact | D003877 | 59 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
| Glioma | D005910 | 112 associated lipids |
| Peripheral Nervous System Diseases | D010523 | 33 associated lipids |
| Arthritis, Infectious | D001170 | 8 associated lipids |
| Anemia, Sickle Cell | D000755 | 34 associated lipids |
| Psoriasis | D011565 | 47 associated lipids |
| Reye Syndrome | D012202 | 14 associated lipids |
| Uterine Hemorrhage | D014592 | 6 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
|---|
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
| Gene | Cross reference | Weighted score | Related literatures |
|---|
There are no associated biomedical information in the current reference collection.
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Zhao G et al. | Rapid determination of short-chain fatty acids in colonic contents and faeces of humans and rats by acidified water-extraction and direct-injection gas chromatography. | 2006 | Biomed. Chromatogr. | pmid:16206138 |
| Andrews FM et al. | In vitro effects of hydrochloric acid and various concentrations of acetic, propionic, butyric, or valeric acids on bioelectric properties of equine gastric squamous mucosa. | 2006 | Am. J. Vet. Res. | pmid:17078749 |
| Clifford S et al. | Monte carlo simulation of carboxylic acid phase equilibria. | 2006 | J Phys Chem B | pmid:17064162 |
| Hu ZH and Yu HQ | Anaerobic digestion of cattail by rumen cultures. | 2006 | Waste Manag | pmid:16198552 |
| Hidalgo-Fernández P et al. | Avidin and streptavidin ligands based on the glycoluril bicyclic system. | 2006 | Org. Biomol. Chem. | pmid:16886084 |
| Zagar E et al. | Sequence distribution in microbial poly(3-hydroxybutyrate-co-3-hydroxyvalerate) co-polyesters determined by NMR and MS. | 2006 | Biomacromolecules | pmid:16827589 |
| Pederson EN et al. | Bacterial synthesis of PHA block copolymers. | 2006 | Biomacromolecules | pmid:16768413 |
| Shilling JE et al. | Uptake of small oxygenated organic molecules onto ammonium nitrate under upper tropospheric conditions. | 2006 | J Phys Chem A | pmid:16722684 |
| Saha SP et al. | Incorporation of polyethylene glycol in polyhydroxyalkanoic acids accumulated by Azotobacter chroococcum MAL-201. | 2006 | J. Ind. Microbiol. Biotechnol. | pmid:16550437 |
| Iadevaia S and Mantzaris NV | Genetic network driven control of PHBV copolymer composition. | 2006 | J. Biotechnol. | pmid:16219380 |
| Chanprateep S and Kulpreecha S | Production and characterization of biodegradable terpolymer poly(3-hydroxybutyrate-co-3-hydroxyvalerate-co-4-hydroxybutyrate) by Alcaligenes sp. A-04. | 2006 | J. Biosci. Bioeng. | pmid:16503291 |
| Larreta J et al. | Experimental design to optimise the analysis of organic volatile compounds in cow slurry by headspace solid-phase microextraction-gas chromatography-mass spectrometry. | 2006 | J Chromatogr A | pmid:17049541 |
| Jacob TJ and Wang L | A new method for measuring reaction times for odour detection at iso-intensity: Comparison between an unpleasant and pleasant odour. | 2006 | Physiol. Behav. | pmid:16469339 |
| Janoria KG et al. | Biotin uptake by rabbit corneal epithelial cells: role of sodium-dependent multivitamin transporter (SMVT). | 2006 | Curr. Eye Res. | pmid:17038304 |
| Johnson BN et al. | A comparison of methods for sniff measurement concurrent with olfactory tasks in humans. | 2006 | Chem. Senses | pmid:16914503 |
| Saunders MJ et al. | Microsphere-based protease assays and screening application for lethal factor and factor Xa. | 2006 | Cytometry A | pmid:16604538 |
| Ahvenjärvi S et al. | Effects of replacing grass silage with barley silage in dairy cow diets. | 2006 | J. Dairy Sci. | pmid:16606738 |
| Resende Júnior JC et al. | Comparison of techniques to determine the clearance of ruminal volatile fatty acids. | 2006 | J. Dairy Sci. | pmid:16840627 |
| Kobayashi D and Sakata T | Influence of temperature on short-chain fatty acid production by pig cecal bacteria in vitro. | 2006 | J. Nutr. Sci. Vitaminol. | pmid:16637232 |
| Brennan RA et al. | Chitin and corncobs as electron donor sources for the reductive dechlorination of tetrachloroethene. | 2006 | Water Res. | pmid:16725176 |
| Manni L et al. | Effect of anti-NGF on ovarian expression of alpha1- and beta2-adrenoceptors, TrkA, p75NTR, and tyrosine hydroxylase in rats with steroid-induced polycystic ovaries. | 2006 | Am. J. Physiol. Regul. Integr. Comp. Physiol. | pmid:16195501 |
| Mu Y et al. | The role of pH in the fermentative H2 production from an acidogenic granule-based reactor. | 2006 | Chemosphere | pmid:16466779 |
| Lundström E et al. | Digitized assessment of mammographic breast density in patients who received low-dose intrauterine levonorgestrel in continuous combination with oral estradiol valerate: a pilot study. | 2006 | Fertil. Steril. | pmid:16580385 |
| Fatemi HM et al. | Addition of estradiol to progesterone for luteal supplementation in patients stimulated with GnRH antagonist/rFSH for IVF: a randomized controlled trial. | 2006 | Hum. Reprod. | pmid:16857887 |
| Nishikawa S and Kondo M | Kinetic study for the inclusion complex of carboxylic acids with cyclodextrin by the ultrasonic relaxation method. | 2006 | J Phys Chem B | pmid:17181269 |
| Perroud B et al. | Pathway analysis of kidney cancer using proteomics and metabolic profiling. | 2006 | Mol. Cancer | pmid:17123452 |
| Genazzani AR et al. | Beneficial effect of tibolone on mood, cognition, well-being, and sexuality in menopausal women. | 2006 | Neuropsychiatr Dis Treat | pmid:19412477 |
| Kendall MM et al. | Butyrate- and propionate-degrading syntrophs from permanently cold marine sediments in Skan Bay, Alaska, and description of Algorimarina butyrica gen. nov., sp. nov. | 2006 | FEMS Microbiol. Lett. | pmid:16907746 |
| Jiracek J et al. | S-alkylated homocysteine derivatives: new inhibitors of human betaine-homocysteine S-methyltransferase. | 2006 | J. Med. Chem. | pmid:16789755 |
| Zhao L and Brinton RD | Select estrogens within the complex formulation of conjugated equine estrogens (Premarin) are protective against neurodegenerative insults: implications for a composition of estrogen therapy to promote neuronal function and prevent Alzheimer's disease. | 2006 | BMC Neurosci | pmid:16533397 |
| Orzechowska GE et al. | Photochemical sources of organic acids. 2. Formation of C5-C9 carboxylic acids from alkene ozonolysis under dry and humid conditions. | 2005 | J Phys Chem A | pmid:16839061 |
| Momekov G et al. | Comparative assessment of the cytotoxic effects of carboxylato-bridged dinuclear platinum (II) complexes against human tumor cell lines. | 2005 | Neoplasma | pmid:16284691 |
| Zhang J et al. | Zeolite-fiber integrated optical chemical sensors for detection of dissolved organics in water. | 2005 | Langmuir | pmid:16142937 |
| Taylor CC and Allen MS | Corn grain endosperm type and brown midrib 3 corn silage: ruminal fermentation and N partitioning in lactating cows. | 2005 | J. Dairy Sci. | pmid:15778312 |
| Yildiz MF et al. | Effects of raloxifene, hormone therapy, and soy isoflavone on serum high-sensitive C-reactive protein in postmenopausal women. | 2005 | Int J Gynaecol Obstet | pmid:15970291 |
| Carter LP et al. | Comparison of the behavioral effects of gamma-hydroxybutyric acid (GHB) and its 4-methyl-substituted analog, gamma-hydroxyvaleric acid (GHV). | 2005 | Drug Alcohol Depend | pmid:15769562 |
| Van Nevel CJ et al. | Incorporation of galactomannans in the diet of newly weaned piglets: effect on bacteriological and some morphological characteristics of the small intestine. | 2005 | Arch Anim Nutr | pmid:16080306 |
| Kristensen NB and Harmon DL | Effects of adding valerate, caproate, and heptanoate to ruminal buffers on splanchnic metabolism in steers under washed-rumen conditions. | 2005 | J. Anim. Sci. | pmid:16024710 |
| Abuknesha RA and Luk C | Paraquat enzyme-immunoassays in biological samples: assessment of the effects of hapten-protein bridge structures on assay sensitivity. | 2005 | Analyst | pmid:15912246 |
| Manni L et al. | Effect of electro-acupuncture on ovarian expression of alpha (1)- and beta (2)-adrenoceptors, and p75 neurotrophin receptors in rats with steroid-induced polycystic ovaries. | 2005 | Reprod. Biol. Endocrinol. | pmid:15941472 |
| Manni L et al. | Effect of exercise on ovarian morphology and expression of nerve growth factor and alpha(1)- and beta(2)-adrenergic receptors in rats with steroid-induced polycystic ovaries. | 2005 | J. Neuroendocrinol. | pmid:16280032 |
| Sakurazawa T and Ohkusa T | Cytotoxicity of organic acids produced by anaerobic intestinal bacteria on cultured epithelial cells. | 2005 | J. Gastroenterol. | pmid:16007394 |
| Miller SJ et al. | Short-chain fatty acids modulate gene expression for vascular endothelial cell adhesion molecules. | 2005 | Nutrition | pmid:15925300 |
| Dionisi D et al. | Olive oil mill effluents as a feedstock for production of biodegradable polymers. | 2005 | Water Res. | pmid:15913705 |
| Kasukabe T et al. | Effects of combined treatment with rapamycin and cotylenin A, a novel differentiation-inducing agent, on human breast carcinoma MCF-7 cells and xenografts. | 2005 | Breast Cancer Res. | pmid:16457690 |
| Bourel-Bonnet L et al. | Solid-phase total synthesis of kahalalide A and related analogues. | 2005 | J. Med. Chem. | pmid:15743176 |
| Park MO et al. | Production of alternatives to fuel oil from organic waste by the alkane-producing bacterium, Vibrio furnissii M1. | 2005 | J. Appl. Microbiol. | pmid:15659187 |
| Alias Z and Tan IK | Isolation of palm oil-utilising, polyhydroxyalkanoate (PHA)-producing bacteria by an enrichment technique. | 2005 | Bioresour. Technol. | pmid:15734309 |
| Yun SI and Ohta Y | Removal of volatile fatty acids with immobilized Rhodococcus sp. B261. | 2005 | Bioresour. Technol. | pmid:15364078 |
| Chi FH et al. | Quick determination of malodor-causing fatty acids in manure by capillary electrophoresis. | 2005 | Chemosphere | pmid:16018897 |
| Steinhaus M and Schieberle P | Characterization of odorants causing an atypical aroma in white pepper powder (Piper nigrum L.) based on quantitative measurements and orthonasal breakthrough thresholds. | 2005 | J. Agric. Food Chem. | pmid:16028994 |
| Bourriaud C et al. | Lactate is mainly fermented to butyrate by human intestinal microfloras but inter-individual variation is evident. | 2005 | J. Appl. Microbiol. | pmid:15960680 |
| Zagar E and Krzan A | SEC-MALS characterization of microbial polyhydroxyalkanoates. | 2004 Mar-Apr | Biomacromolecules | pmid:15003030 |
| Shang L et al. | Sequential feeding of glucose and valerate in a fed-batch culture of Ralstonia eutropha for production of poly(hydroxybutyrate-co-hydroxyvalerate) with high 3-hydroxyvalerate fraction. | 2004 Jan-Feb | Biotechnol. Prog. | pmid:14763836 |
| Wallace RJ et al. | Metabolic properties of Eubacterium pyruvativorans, a ruminal 'hyper-ammonia-producing' anaerobe with metabolic properties analogous to those of Clostridium kluyveri. | 2004 | Microbiology (Reading, Engl.) | pmid:15347751 |
| Rossi S et al. | Antimicrobial efficacy of a new antibiotic-loaded poly(hydroxybutyric-co-hydroxyvaleric acid) controlled release system. | 2004 | J. Antimicrob. Chemother. | pmid:15537698 |
| Giavaresi G et al. | Natural and synthetic polyesters for musculoskeletal tissue repair: experimental in vitro and in vivo evaluations. | 2004 | Int J Artif Organs | pmid:15521220 |
| Seki M et al. | A practical synthesis of (+)-biotin from L-cysteine. | 2004 | Chemistry | pmid:15515067 |
| Pederson EN and Srienc F | Mass spectrometry feedback control for synthesis of polyhydroxyalkanoate granule microstructures in Ralstonia eutropha. | 2004 | Macromol Biosci | pmid:15468214 |
| Shishatskaya EI and Volova TG | A comparative investigation of biodegradable polyhydroxyalkanoate films as matrices for in vitro cell cultures. | 2004 | J Mater Sci Mater Med | pmid:15477744 |
| Simons CT et al. | Mustard oil has differential effects on the response of trigeminal caudalis neurons to heat and acidity. | 2004 | Pain | pmid:15275753 |
| Yu HQ et al. | Thermodynamic analysis of product formation in mesophilic acidogenesis of lactose. | 2004 | Biotechnol. Bioeng. | pmid:15334408 |
| Dionisi D et al. | Biodegradable polymers from organic acids by using activated sludge enriched by aerobic periodic feeding. | 2004 | Biotechnol. Bioeng. | pmid:14966798 |
| Vihma V et al. | Postmenopausal estrogen therapy and serum estradiol fatty acid esters in women with and without previous intrahepatic cholestasis of pregnancy. | 2004 | Ann. Med. | pmid:15478314 |
| Dafopoulos K et al. | Changes in pituitary sensitivity to GnRH in estrogen-treated post-menopausal women: evidence that gonadotrophin surge attenuating factor plays a physiological role. | 2004 | Hum. Reprod. | pmid:15229199 |
| Xiong Y et al. | Short-chain fatty acids stimulate leptin production in adipocytes through the G protein-coupled receptor GPR41. | 2004 | Proc. Natl. Acad. Sci. U.S.A. | pmid:14722361 |
| Ishigaki T et al. | The degradability of biodegradable plastics in aerobic and anaerobic waste landfill model reactors. | 2004 | Chemosphere | pmid:14575734 |
| Kim JD and Kang KH | Isolation of Lactobacillus sakei strain KJ-2008 and its removal of characteristic malodorous gases under anaerobic culture conditions. | 2004 | Biosci. Biotechnol. Biochem. | pmid:15618611 |
| Cardozo PW et al. | Effects of natural plant extracts on ruminal protein degradation and fermentation profiles in continuous culture. | 2004 | J. Anim. Sci. | pmid:15542469 |
| Manzanilla EG et al. | Effect of plant extracts and formic acid on the intestinal equilibrium of early-weaned pigs. | 2004 | J. Anim. Sci. | pmid:15542467 |
| Kristensen NB and Harmon DL | Effect of increasing ruminal butyrate absorption on splanchnic metabolism of volatile fatty acids absorbed from the washed reticulorumen of steers. | 2004 | J. Anim. Sci. | pmid:15537776 |
| Kristensen NB and Harmon DL | Splanchnic metabolism of volatile fatty acids absorbed from the washed reticulorumen of steers. | 2004 | J. Anim. Sci. | pmid:15309950 |
| Huuskonen J et al. | Regulation of microglial inflammatory response by sodium butyrate and short-chain fatty acids. | 2004 | Br. J. Pharmacol. | pmid:14744800 |
| Choi GG et al. | Production of poly(3-hydroxybutyrate-co-3-hydroxyvalerate) with high molar fractions of 3-hydroxyvalerate by a threonine-overproducing mutant of Alcaligenes sp. SH-69. | 2003 | Biotechnol. Lett. | pmid:12882163 |
| Wallace RJ et al. | Eubacterium pyruvativorans sp. nov., a novel non-saccharolytic anaerobe from the rumen that ferments pyruvate and amino acids, forms caproate and utilizes acetate and propionate. | 2003 | Int. J. Syst. Evol. Microbiol. | pmid:12892112 |
| Bernard JK et al. | Ruminal fermentation and bacterial protein synthesis of whole cottonseed coated with combinations of gelatinized corn starch and urea. | 2003 | J. Dairy Sci. | pmid:14672196 |
| Tsukahara T et al. | Stimulation of butyrate production in the large intestine of weaning piglets by dietary fructooligosaccharides and its influence on the histological variables of the large intestinal mucosa. | 2003 | J. Nutr. Sci. Vitaminol. | pmid:14974732 |
| Voelker JA and Allen MS | Pelleted beet pulp substituted for high-moisture corn: 3. Effects on ruminal fermentation, pH, and microbial protein efficiency in lactating dairy cows. | 2003 | J. Dairy Sci. | pmid:14672186 |
| Simons CT et al. | Mecamylamine reduces nicotine cross-desensitization of trigeminal caudalis neuronal responses to oral chemical irritation. | 2003 | Brain Res. | pmid:14575899 |
| Donzello MP et al. | Synthesis, X-ray crystal structure, UV/visible linear and nonlinear (optical limiting) spectral properties of symmetrical and unsymmetrical porphyrazines with annulated 1,2,5-thiadiazole and 1,4-diamyloxybenzene moieties. | 2003 | Chemistry | pmid:12953187 |
| Mancuso G et al. | Efficacy of betamethasone valerate foam formulation in comparison with betamethasone dipropionate lotion in the treatment of mild-to-moderate alopecia areata: a multicenter, prospective, randomized, controlled, investigator-blinded trial. | 2003 | Int. J. Dermatol. | pmid:12839615 |
| Simons CT et al. | Lack of quinine-evoked activity in rat trigeminal subnucleus caudalis. | 2003 | Chem. Senses | pmid:12714448 |
| Schroeder JW | Optimizing the level of wet corn gluten feed in the diet of lactating dairy cows. | 2003 | J. Dairy Sci. | pmid:12703621 |
| Sudo S et al. | Activation of neurons in trigeminal caudalis by noxious oral acidic or salt stimuli is not reduced by amiloride. | 2003 | Brain Res. | pmid:12676384 |
| Massillon D et al. | Regulation of glucose-6-phosphatase gene expression in cultured hepatocytes and H4IIE cells by short-chain fatty acids: role of hepatic nuclear factor-4alpha. | 2003 | J. Biol. Chem. | pmid:12915406 |
| Song R et al. | Synthesis and cytotoxicity of new platinum(IV) complexes of mixed carboxylates. | 2003 | J. Inorg. Biochem. | pmid:12888269 |
| Lakshman K and Shamala TR | Enhanced biosynthesis of polyhydroxyalkanoates in a mutant strain of Rhizobium meliloti. | 2003 | Biotechnol. Lett. | pmid:12882285 |
| Batstone DJ et al. | Kinetics of thermophilic, anaerobic oxidation of straight and branched chain butyrate and valerate. | 2003 | Biotechnol. Bioeng. | pmid:12966576 |
| Pind PF et al. | Dynamics of the anaerobic process: effects of volatile fatty acids. | 2003 | Biotechnol. Bioeng. | pmid:12701145 |
| Rishel MJ et al. | Conformationally constrained analogues of bleomycin A5. | 2003 | J. Am. Chem. Soc. | pmid:12926941 |
| Sutton JD et al. | Effect of method of application of a fibrolytic enzyme product on digestive processes and milk production in Holstein-Friesian cows. | 2003 | J. Dairy Sci. | pmid:12647961 |
| Nadeau JA et al. | Effects of hydrochloric, valeric, and other volatile fatty acids on pathogenesis of ulcers in the nonglandular portion of the stomach of horses. | 2003 | Am. J. Vet. Res. | pmid:12693529 |
| Jacob TJ et al. | Psychophysical evaluation of responses to pleasant and mal-odour stimulation in human subjects; adaptation, dose response and gender differences. | 2003 | Int J Psychophysiol | pmid:12694902 |
| Vuotto ML et al. | Improvement of (+)-catechin inhibitory activity on human PMN respiratory burst by (+)-3-O-propionyl and (-)-3-O-valeryl substitution. | 2003 | J. Pharm. Pharmacol. | pmid:12724048 |
| Nilsson NE et al. | Identification of a free fatty acid receptor, FFA2R, expressed on leukocytes and activated by short-chain fatty acids. | 2003 | Biochem. Biophys. Res. Commun. | pmid:12684041 |
| Anderer P et al. | Effects of hormone replacement therapy on perceptual and cognitive event-related potentials in menopausal insomnia. | 2003 | Psychoneuroendocrinology | pmid:12573306 |
| Brown AJ et al. | The Orphan G protein-coupled receptors GPR41 and GPR43 are activated by propionate and other short chain carboxylic acids. | 2003 | J. Biol. Chem. | pmid:12496283 |
| Embleton JK and Tighe BJ | Polymers for biodegradable medical devices XI. Microencapsulation studies: characterization of hydrocortisone-loaded poly-hydroxybutyrate-hydroxyvalerate microspheres. | 2002 Nov-Dec | J Microencapsul | pmid:12569022 |
| Sanjuán A et al. | Cyproterone acetate could counteract the benefits of estradiol valerate in oophorectomized cholesterol-fed rabbits. | 2002 Jul-Aug | Menopause | pmid:12082364 |
| Cherry N et al. | Oestrogen therapy for prevention of reinfarction in postmenopausal women: a randomised placebo controlled trial. | 2002 Dec 21-28 | Lancet | pmid:12504395 |