Valeric acid is a lipid of Fatty Acyls (FA) class. Valeric acid is associated with abnormalities such as Papillon-Lefevre Disease, Obesity, Diabetes Mellitus, Non-Insulin-Dependent and Dehydration. The involved functions are known as Process, Odorant, Stimulus, Irritation and Phenomenon. Valeric acid often locates in Receptive field, soluble, Extracellular, Entire gastrointestinal tract and Body tissue. The associated genes with Valeric acid are Orthologous Gene, Fusion Gene and AS gene. The related lipids are Valerates, butyrate, Propionate, Caproates and Palmitates.
To understand associated biological information of Valeric acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Valeric acid is suspected in Obesity, Papillon-Lefevre Disease, Diabetes Mellitus, Non-Insulin-Dependent, Dehydration and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with Valeric acid
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Stomach Ulcer | D013276 | 75 associated lipids |
| Dermatitis, Contact | D003877 | 59 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
| Glioma | D005910 | 112 associated lipids |
| Peripheral Nervous System Diseases | D010523 | 33 associated lipids |
| Arthritis, Infectious | D001170 | 8 associated lipids |
| Anemia, Sickle Cell | D000755 | 34 associated lipids |
| Psoriasis | D011565 | 47 associated lipids |
| Reye Syndrome | D012202 | 14 associated lipids |
| Uterine Hemorrhage | D014592 | 6 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
|---|
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
| Gene | Cross reference | Weighted score | Related literatures |
|---|
There are no associated biomedical information in the current reference collection.
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Kapp VJ et al. | [Studies on the Pharmacology of 6alpha,9-difluoro-11beta-hydroxy-16alpha-methyl-21-valeryloxy-1,4-pregnadiene-3,20-dione (diflucortolon valerate) (author's transl)]. | 1976 | Arzneimittelforschung | pmid:188428 |
| Täuber VU | [Percutaneous absorption of diflucortolone valerate in guinea pigs and man (author's transl)]. | 1976 | Arzneimittelforschung | pmid:1036943 |
| Täuber VU et al. | [Comparative studies in man on the percutaneous absorption of diflucortolone valerate, betamethasone-17-valerate, beclomethasone dipropionate and fluocinolone acetonide]. | 1976 | Arzneimittelforschung | pmid:1036945 |
| Saunders MJ et al. | High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors. | 2010 | Assay Drug Dev Technol | pmid:20035615 |
| Paassilta M et al. | Insulin-like growth factor binding protein-1 (IGFBP-1) and IGF-I during oral and transdermal estrogen replacement therapy: relation to lipoprotein(a) levels. | 2000 | Atherosclerosis | pmid:10704627 |
| Koivu TA et al. | The relation of oxidized LDL autoantibodies and long-term hormone replacement therapy to ultrasonographically assessed atherosclerotic plaque quantity and severity in postmenopausal women. | 2001 | Atherosclerosis | pmid:11472749 |
| Saunders DM et al. | The effect of oestradiol valerate therapy on coagulation factors and lipid and oestrogen levels in oöphorectomised women. | 1978 | Aust N Z J Obstet Gynaecol | pmid:283783 |
| Ishihara K et al. | Identification of urinary biomarkers useful for distinguishing a difference in mechanism of toxicity in rat model of cholestasis. | 2009 | Basic Clin. Pharmacol. Toxicol. | pmid:19486331 |
| Binsl TW et al. | Measuring non-steady-state metabolic fluxes in starch-converting faecal microbiota in vitro. | 2010 | Benef Microbes | pmid:21831778 |
| Wächtershäuser A et al. | PPAR-gamma is selectively upregulated in Caco-2 cells by butyrate. | 2000 | Biochem. Biophys. Res. Commun. | pmid:10833422 |
| Palmeira CM et al. | Induction of the mitochondrial permeability transition in vitro by short-chain carboxylic acids. | 2000 | Biochem. Biophys. Res. Commun. | pmid:10833431 |
| Nilsson NE et al. | Identification of a free fatty acid receptor, FFA2R, expressed on leukocytes and activated by short-chain fatty acids. | 2003 | Biochem. Biophys. Res. Commun. | pmid:12684041 |
| Holland PC and Sherratt HS | Biochemical effects of the hypoglycaemic compound pent-4-enoic acid and related non-hypoglycaemic fatty acids. Effects of the free acids and their carnitine esters on coenzyme A-dependent oxidations in rat liver mitochondria. | 1973 | Biochem. J. | pmid:4772622 |
| Chen S and Engel PC | Protection of glutamate dehydrogenase by nicotinamide-adenine dinucleotide against reversible inactivation by pyridoxal 5'-phosphate as a sensitive indicator of conformational change induced by substrates and substrate analogues. | 1974 | Biochem. J. | pmid:4376949 |
| GERSON T et al. | The role of n-valeric acid in the synthesis of the higher saturated straight-chain acids containing an odd number of carbon atoms in bovine milk fat. | 1960 | Biochem. J. | pmid:13827621 |
| VERBEKE R et al. | Incorporation of DL-[1-14C]leucine and [1-14C]liso valeric acid into milk constituents by the perfused cow's udder. | 1959 | Biochem. J. | pmid:13855213 |
| BROUWER E and NIJKAMP HJ | Occurrence of two valeric acids (beta-methylbutyric acid and alpha-methylbutyric acid) in the hair grease of the dog. | 1953 | Biochem. J. | pmid:13105653 |
| ANNISON EF and PENNINGTON RJ | The metabolism of n-valeric acid and some branched chain acids by sheep tissues in vitro. | 1952 | Biochem. J. | pmid:13018194 |
| Brown NA et al. | Chain length dependency of fatty acid and carbamate binding to serum albumin. | 1982 | Biochem. Pharmacol. | pmid:7159478 |
| Ni X and Cole RD | Effects of various salts and pH on the stability of the nucleosome in chromatin fragments. | 1994 | Biochemistry | pmid:8049228 |