Valeric acid is a lipid of Fatty Acyls (FA) class. Valeric acid is associated with abnormalities such as Papillon-Lefevre Disease, Obesity, Diabetes Mellitus, Non-Insulin-Dependent and Dehydration. The involved functions are known as Process, Odorant, Stimulus, Irritation and Phenomenon. Valeric acid often locates in Receptive field, soluble, Extracellular, Entire gastrointestinal tract and Body tissue. The associated genes with Valeric acid are Orthologous Gene, Fusion Gene and AS gene. The related lipids are Valerates, butyrate, Propionate, Caproates and Palmitates.
To understand associated biological information of Valeric acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Valeric acid is suspected in Obesity, Papillon-Lefevre Disease, Diabetes Mellitus, Non-Insulin-Dependent, Dehydration and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with Valeric acid
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Stomach Ulcer | D013276 | 75 associated lipids |
| Dermatitis, Contact | D003877 | 59 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
| Glioma | D005910 | 112 associated lipids |
| Peripheral Nervous System Diseases | D010523 | 33 associated lipids |
| Arthritis, Infectious | D001170 | 8 associated lipids |
| Anemia, Sickle Cell | D000755 | 34 associated lipids |
| Psoriasis | D011565 | 47 associated lipids |
| Reye Syndrome | D012202 | 14 associated lipids |
| Uterine Hemorrhage | D014592 | 6 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
|---|
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
| Gene | Cross reference | Weighted score | Related literatures |
|---|
There are no associated biomedical information in the current reference collection.
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Kristensen NB and Harmon DL | Effects of adding valerate, caproate, and heptanoate to ruminal buffers on splanchnic metabolism in steers under washed-rumen conditions. | 2005 | J. Anim. Sci. | pmid:16024710 |
| Arrizon A et al. | Feeding value of dried shredded sugarbeets as a partial replacement for steam-flaked corn in finishing diets for feedlot cattle. | 2012 | J. Anim. Sci. | pmid:22648752 |
| Nery J et al. | Influence of dietary protein content and source on colonic fermentative activity in dogs differing in body size and digestive tolerance. | 2012 | J. Anim. Sci. | pmid:22328724 |
| Kerr KR et al. | Apparent total tract energy and macronutrient digestibility and fecal fermentative end-product concentrations of domestic cats fed extruded, raw beef-based, and cooked beef-based diets. | 2012 | J. Anim. Sci. | pmid:22003235 |
| Baisden LA et al. | n-Valeric acid in stomachs and on unwashed hair of swine. | 1972 | J. Anim. Sci. | pmid:5039919 |
| Barry KA et al. | Adaptation of healthy adult cats to select dietary fibers in vivo affects gas and short-chain fatty acid production from fiber fermentation in vitro. | 2011 | J. Anim. Sci. | pmid:21531846 |
| Kanakupt K et al. | Effects of short-chain fructooligosaccharides and galactooligosaccharides, individually and in combination, on nutrient digestibility, fecal fermentative metabolite concentrations, and large bowel microbial ecology of healthy adults cats. | 2011 | J. Anim. Sci. | pmid:21216981 |
| Barry KA et al. | Dietary cellulose, fructooligosaccharides, and pectin modify fecal protein catabolites and microbial populations in adult cats. | 2010 | J. Anim. Sci. | pmid:20495116 |
| May ML et al. | Effects of dry-rolled or steam-flaked corn finishing diets with or without twenty-five percent dried distillers grains on ruminal fermentation and apparent total tract digestion. | 2009 | J. Anim. Sci. | pmid:19648506 |
| Barry KA et al. | Low-level fructan supplementation of dogs enhances nutrient digestion and modifies stool metabolite concentrations, but does not alter fecal microbiota populations. | 2009 | J. Anim. Sci. | pmid:19574565 |
| Gozho GN et al. | Effects of type of canola protein supplement on ruminal fermentation and nutrient flow to the duodenum in beef heifers. | 2009 | J. Anim. Sci. | pmid:19542502 |
| Song R et al. | Effects of feeding diets containing bacitracin methylene disalicylate to heat-stressed finishing pigs. | 2011 | J. Anim. Sci. | pmid:21297060 |
| Robles V et al. | Effects of feeding frequency on intake, ruminal fermentation, and feeding behavior in heifers fed high-concentrate diets. | 2007 | J. Anim. Sci. | pmid:17609471 |
| Kim SC et al. | Effects of dietary n-6:n-3 fatty acid ratio on feed intake, digestibility, and fatty acid profiles of the ruminal contents, liver, and muscle of growing lambs. | 2007 | J. Anim. Sci. | pmid:17121972 |
| Akay V et al. | NutriDense and waxy corn hybrids: effects on site and extent of disappearance of nutrients in sheep. | 2002 | J. Anim. Sci. | pmid:12019623 |
| Kristensen NB | Rumen microbial sequestration of [2-(13)C]acetate in cattle. | 2001 | J. Anim. Sci. | pmid:11583438 |
| Bandyk CA et al. | Effect of ruminal vs postruminal administration of degradable protein on utilization of low-quality forage by beef steers. | 2001 | J. Anim. Sci. | pmid:11204704 |
| Rossi S et al. | Antimicrobial efficacy of a new antibiotic-loaded poly(hydroxybutyric-co-hydroxyvaleric acid) controlled release system. | 2004 | J. Antimicrob. Chemother. | pmid:15537698 |
| Chee JY et al. | Expression of Aeromonas caviae polyhydroxyalkanoate synthase gene in Burkholderia sp. USM (JCM15050) enables the biosynthesis of SCL-MCL PHA from palm oil products. | 2012 | J. Appl. Microbiol. | pmid:22054430 |
| Park MO et al. | Production of alternatives to fuel oil from organic waste by the alkane-producing bacterium, Vibrio furnissii M1. | 2005 | J. Appl. Microbiol. | pmid:15659187 |
| Bourriaud C et al. | Lactate is mainly fermented to butyrate by human intestinal microfloras but inter-individual variation is evident. | 2005 | J. Appl. Microbiol. | pmid:15960680 |
| Ruman J et al. | Severe hypertriglyceridemia and pancreatitis following hormone replacement prior to cryothaw transfer. | 2002 | J. Assist. Reprod. Genet. | pmid:11958513 |
| SampaÃo MA and Geber S | Births after transfer of zona-free blastocysts in oocyte donation cycles. | 2001 | J. Assist. Reprod. Genet. | pmid:11411431 |
| OTTKE RC et al. | Isotopic acetate and isovalerate in the synthesis of ergosterol by Neurospora. | 1951 | J. Biol. Chem. | pmid:14832256 |
| SIEGEL I and LORBER V | Conversion of C14, C13, labeled n-valerate to rat liver glycogen. | 1951 | J. Biol. Chem. | pmid:14832274 |
| MEISTER A | Studies on d- and tau-alpha-keto-beta-methylvaleric acids. | 1951 | J. Biol. Chem. | pmid:14841174 |
| COON MJ | The metabolic fate of the isopropyl group of leucine. | 1950 | J. Biol. Chem. | pmid:14794691 |
| Schmidt J et al. | Selective orthosteric free fatty acid receptor 2 (FFA2) agonists: identification of the structural and chemical requirements for selective activation of FFA2 versus FFA3. | 2011 | J. Biol. Chem. | pmid:21220428 |
| ZABIN I and BLOCH K | The formation of ketone bodies from isovaleric acid. | 1950 | J. Biol. Chem. | pmid:15436482 |
| ZABIN I and BLOCH K | The utilization of isovaleric acid for the synthesis of cholesterol. | 1950 | J. Biol. Chem. | pmid:15436483 |
| STADTMAN ER et al. | Tracer experiments on the mechanism of synthesis of valeric and caproic acids by Clostridium kluyveri. | 1949 | J. Biol. Chem. | pmid:18116989 |
| Massillon D et al. | Regulation of glucose-6-phosphatase gene expression in cultured hepatocytes and H4IIE cells by short-chain fatty acids: role of hepatic nuclear factor-4alpha. | 2003 | J. Biol. Chem. | pmid:12915406 |
| Ikeda Y et al. | Mechanism of action of short-chain, medium-chain, and long-chain acyl-CoA dehydrogenases. Direct evidence for carbanion formation as an intermediate step using enzyme-catalyzed C-2 proton/deuteron exchange in the absence of C-3 exchange. | 1985 | J. Biol. Chem. | pmid:3968064 |
| BUEDING E | Formation of tiglic and n-valeric acids by bacteria-free Ascaris lumbricoides. | 1953 | J. Biol. Chem. | pmid:13061475 |
| BERLINGUET L and GAUDRY R | Enzymatic resolution of DL-alpha amino-epsilon hydroxy-n caproic acid and DL-alpha amino-delta hydroxy-n-valeric acid. | 1952 | J. Biol. Chem. | pmid:12999793 |
| Brown AJ et al. | The Orphan G protein-coupled receptors GPR41 and GPR43 are activated by propionate and other short chain carboxylic acids. | 2003 | J. Biol. Chem. | pmid:12496283 |
| Ortiz-Caro J et al. | Modulation of thyroid hormone nuclear receptors by short-chain fatty acids in glial C6 cells. Role of histone acetylation. | 1986 | J. Biol. Chem. | pmid:3771518 |
| Gadda G et al. | Identification of a cysteine residue in the active site of nitroalkane oxidase by modification with N-ethylmaleimide. | 2000 | J. Biol. Chem. | pmid:10913134 |
| Park SO and Park BS | Bifidogenic effect of grain larvae extract on serum lipid, glucose and intestinal microflora in rats. | 2015 | J. Biosci. | pmid:26333397 |
| Chanprateep S and Kulpreecha S | Production and characterization of biodegradable terpolymer poly(3-hydroxybutyrate-co-3-hydroxyvalerate-co-4-hydroxybutyrate) by Alcaligenes sp. A-04. | 2006 | J. Biosci. Bioeng. | pmid:16503291 |
| Liu C et al. | Pentanoic acid, a novel protein synthesis stimulant for Chinese Hamster Ovary (CHO) cells. | 2001 | J. Biosci. Bioeng. | pmid:16232949 |
| Cho K et al. | Utilization of swine wastewater as a feedstock for the production of polyhydroxyalkanoates by Azotobacter vinelandii UWD. | 2001 | J. Biosci. Bioeng. | pmid:16232963 |
| Karlsson A et al. | Impact of trace element addition on degradation efficiency of volatile fatty acids, oleic acid and phenyl acetate and on microbial populations in a biogas digester. | 2012 | J. Biosci. Bioeng. | pmid:22683024 |
| Moita R and Lemos PC | Biopolymers production from mixed cultures and pyrolysis by-products. | 2012 | J. Biotechnol. | pmid:21983233 |
| Saha SP et al. | Studies on intracellular degradation of polyhydroxyalkanoic acid-polyethylene glycol copolymer accumulated by Azotobacter chroococcum MAL-201. | 2007 | J. Biotechnol. | pmid:17543409 |
| Iadevaia S and Mantzaris NV | Genetic network driven control of PHBV copolymer composition. | 2006 | J. Biotechnol. | pmid:16219380 |
| Fang HH and Yu H | Mesophilic acidification of gelatinaceous wastewater. | 2002 | J. Biotechnol. | pmid:11738717 |
| Pozo C et al. | Effects of culture conditions on the production of polyhydroxyalkanoates by Azotobacter chroococcum H23 in media containing a high concentration of alpechÃn (wastewater from olive oil mills) as primary carbon source. | 2002 | J. Biotechnol. | pmid:12067519 |
| Lemos PC et al. | Synthesis of polyhydroxyalkanoates from different short-chain fatty acids by mixed cultures submitted to aerobic dynamic feeding. | 2006 | J. Biotechnol. | pmid:16253370 |
| Bengtsson S et al. | Production of polyhydroxyalkanoates from fermented sugar cane molasses by a mixed culture enriched in glycogen accumulating organisms. | 2010 | J. Biotechnol. | pmid:19958801 |