Dimethylallyl pyrophosphate

Dimethylallyl pyrophosphate is a lipid of Prenol Lipids (PR) class. Dimethylallyl pyrophosphate is associated with abnormalities such as Consumption-archaic term for TB and Wiskott-Aldrich Syndrome. The involved functions are known as Anabolism, Biochemical Pathway, Oxidation, Process and Chelating Activity [MoA]. Dimethylallyl pyrophosphate often locates in Chloroplasts, Plastids, chloroplast stroma, Cytosol and Cell membrane. The associated genes with Dimethylallyl pyrophosphate are IRF6 wt Allele and ADRBK1 gene. The related lipids are Sterols.

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Introduction

To understand associated biological information of Dimethylallyl pyrophosphate, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Dimethylallyl pyrophosphate?

Dimethylallyl pyrophosphate is suspected in and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Dimethylallyl pyrophosphate

MeSH term MeSH ID Detail
Melanoma D008545 69 associated lipids
Total 1

PubChem Associated disorders and diseases

What pathways are associated with Dimethylallyl pyrophosphate

Lipid pathways are not clear in current pathway databases. We organized associated pathways with Dimethylallyl pyrophosphate through full-text articles, including metabolic pathways or pathways of biological mechanisms.

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PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Dimethylallyl pyrophosphate?

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What functions are associated with Dimethylallyl pyrophosphate?


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What lipids are associated with Dimethylallyl pyrophosphate?

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What genes are associated with Dimethylallyl pyrophosphate?

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Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Dimethylallyl pyrophosphate?

There are no associated biomedical information in the current reference collection.

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All references with Dimethylallyl pyrophosphate

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Authors Title Published Journal PubMed Link
Whitaker JW et al. The transferome of metabolic genes explored: analysis of the horizontal transfer of enzyme encoding genes in unicellular eukaryotes. 2009 Genome Biol. pmid:19368726
Trapp SC and Croteau RB Genomic organization of plant terpene synthases and molecular evolutionary implications. 2001 Genetics pmid:11404343
Hümbelin M et al. Genetics of isoprenoid biosynthesis in Paracoccus zeaxanthinifaciens. 2002 Gene pmid:12384294
Lamsen EN and Atsumi S Recent progress in synthetic biology for microbial production of C3-C10 alcohols. 2012 Front Microbiol pmid:22701113
Mann FM et al. Rv0989c encodes a novel (E)-geranyl diphosphate synthase facilitating decaprenyl diphosphate biosynthesis in Mycobacterium tuberculosis. 2011 FEBS Lett. pmid:21237161
Wolff M et al. Isoprenoid biosynthesis via the methylerythritol phosphate pathway: the (E)-4-hydroxy-3-methylbut-2-enyl diphosphate reductase (LytB/IspH) from Escherichia coli is a [4Fe-4S] protein. 2003 FEBS Lett. pmid:12706830
Tritsch D et al. Plant isoprenoid biosynthesis via the MEP pathway: in vivo IPP/DMAPP ratio produced by (E)-4-hydroxy-3-methylbut-2-enyl diphosphate reductase in tobacco BY-2 cell cultures. 2010 FEBS Lett. pmid:19903472
Vitali A et al. Chalcone dimethylallyltransferase from Morus nigra cell cultures. Substrate specificity studies. 2004 FEBS Lett. pmid:14741337
Chu HM et al. Binding and catalysis of Humulus lupulus adenylate isopentenyltransferase for the synthesis of isopentenylated diadenosine polyphosphates. 2010 FEBS Lett. pmid:20807533
Vandermoten S et al. Characterization of a novel aphid prenyltransferase displaying dual geranyl/farnesyl diphosphate synthase activity. 2008 FEBS Lett. pmid:18466770
Altincicek B et al. LytB protein catalyzes the terminal step of the 2-C-methyl-D-erythritol-4-phosphate pathway of isoprenoid biosynthesis. 2002 FEBS Lett. pmid:12482608
Miller B et al. A Synechococcus leopoliensis SAUG 1402-1 operon harboring the 1-deoxyxylulose 5-phosphate synthase gene and two additional open reading frames is functionally involved in the dimethylallyl diphosphate synthesis. 1999 FEBS Lett. pmid:10556522
Rodríguez-Concepción M et al. Genetic evidence of branching in the isoprenoid pathway for the production of isopentenyl diphosphate and dimethylallyl diphosphate in Escherichia coli. 2000 FEBS Lett. pmid:10818234
Ershov Y et al. Isopentenyl diphosphate isomerase deficiency in Synechocystis sp. strain PCC6803. 2000 FEBS Lett. pmid:10818236
Hirooka K et al. The role of histidine-114 of Ssulfolobus acidocaldarius geranylgeranyl diphosphate synthase in chain-length determination. 2000 FEBS Lett. pmid:10984617
Miller B et al. Functional involvement of a deoxy-D-xylulose 5-phosphate reductoisomerase gene harboring locus of Synechococcus leopoliensis in isoprenoid biosynthesis. 2000 FEBS Lett. pmid:11007968
Heider SA et al. IdsA is the major geranylgeranyl pyrophosphate synthase involved in carotenogenesis in Corynebacterium glutamicum. 2014 FEBS J. pmid:25181035
Kabelitz D Human γδ T lymphocytes for immunotherapeutic strategies against cancer. 2010 F1000 Med Rep pmid:20948839
Yamashita S et al. Type 2 isopentenyl diphosphate isomerase from a thermoacidophilic archaeon Sulfolobus shibatae. 2004 Eur. J. Biochem. pmid:15009187
Laupitz R et al. Biochemical characterization of Bacillus subtilis type II isopentenyl diphosphate isomerase, and phylogenetic distribution of isoprenoid biosynthesis pathways. 2004 Eur. J. Biochem. pmid:15206931
Hemmi H et al. An alternative mechanism of product chain-length determination in type III geranylgeranyl diphosphate synthase. 2003 Eur. J. Biochem. pmid:12752438
Liang PH et al. Structure, mechanism and function of prenyltransferases. 2002 Eur. J. Biochem. pmid:12135472
Hirooka K et al. Mechanism of product chain length determination for heptaprenyl diphosphate synthase from Bacillus stearothermophilus. 2000 Eur. J. Biochem. pmid:10880976
Tachibana A et al. Novel prenyltransferase gene encoding farnesylgeranyl diphosphate synthase from a hyperthermophilic archaeon, Aeropyrum pernix. Molecularevolution with alteration in product specificity. 2000 Eur. J. Biochem. pmid:10632701
Wiley JD et al. Isoprenoid precursor biosynthesis is the essential metabolic role of the apicoplast during gametocytogenesis in Plasmodium falciparum. 2015 Eukaryotic Cell pmid:25446055
Durbecq V et al. Crystal structure of isopentenyl diphosphate:dimethylallyl diphosphate isomerase. 2001 EMBO J. pmid:11285217
de Ruyck J and Wouters J Structure-based drug design targeting biosynthesis of isoprenoids: a crystallographic state of the art of the involved enzymes. 2008 Curr. Protein Pept. Sci. pmid:18393884
Docampo R and Moreno SN The acidocalcisome as a target for chemotherapeutic agents in protozoan parasites. 2008 Curr. Pharm. Des. pmid:18473837
Hunter WN Isoprenoid precursor biosynthesis offers potential targets for drug discovery against diseases caused by apicomplexan parasites. 2011 Curr Top Med Chem pmid:21619509
Chang WC et al. Current development in isoprenoid precursor biosynthesis and regulation. 2013 Curr Opin Chem Biol pmid:23891475
Ganjewala D et al. An account of cloned genes of Methyl-erythritol-4-phosphate pathway of isoprenoid biosynthesis in plants. 2009 Curr Issues Mol Biol pmid:19193963
Brück TB and Kerr RG Purification and kinetic properties of elisabethatriene synthase from the coral Pseudopterogorgia elisabethae. 2006 Comp. Biochem. Physiol. B, Biochem. Mol. Biol. pmid:16423548
Meraviglia S et al. γδ T cells cross-link innate and adaptive immunity in Mycobacterium tuberculosis infection. 2011 Clin. Dev. Immunol. pmid:21253470
Yin WB et al. CdpNPT, an N-prenyltransferase from Aspergillus fumigatus: overproduction, purification and biochemical characterisation. 2007 Chembiochem pmid:17525915
Brandt W et al. A proposed mechanism for the reductive ring opening of the cyclodiphosphate MEcPP, a crucial transformation in the new DXP/MEP pathway to isoprenoids based on modeling studies and feeding experiments. 2004 Chembiochem pmid:14997523
Neundorf I et al. Evidence for the combined participation of a C10 and a C15 precursor in the biosynthesis of moenocinol, the lipid part of the moenomycin antibiotics. 2003 Chembiochem pmid:14613112
Nes WD Biosynthesis of cholesterol and other sterols. 2011 Chem. Rev. pmid:21902244
Arens J et al. Exploration of biosynthetic access to the shared precursor of the fusicoccane diterpenoid family. 2013 Chem. Commun. (Camb.) pmid:23295536
Narayanasamy P et al. Synthesis of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate and kinetic studies of Mycobacterium tuberculosis IspF. 2010 Chem. Biol. pmid:20189102
Laupitz R et al. Stereochemical studies on the making and unmaking of isopentenyl diphosphate in different biological systems. 2004 Chem. Biodivers. pmid:17191914
Vandermoten S et al. New insights into short-chain prenyltransferases: structural features, evolutionary history and potential for selective inhibition. 2009 Cell. Mol. Life Sci. pmid:19633972
Fowler DW et al. Mycobacteria activate γδ T-cell anti-tumour responses via cytokines from type 1 myeloid dendritic cells: a mechanism of action for cancer immunotherapy. 2012 Cancer Immunol. Immunother. pmid:22002242
Bang S et al. Nociceptive and pro-inflammatory effects of dimethylallyl pyrophosphate via TRPV4 activation. 2012 Br. J. Pharmacol. pmid:22300296
Roelofs AJ et al. Peripheral blood monocytes are responsible for gammadelta T cell activation induced by zoledronic acid through accumulation of IPP/DMAPP. 2009 Br. J. Haematol. pmid:19016713
Riebeling C et al. The bisphosphonate pamidronate induces apoptosis in human melanoma cells in vitro. 2002 Br. J. Cancer pmid:12177810
Boghigian BA et al. Utilizing elementary mode analysis, pathway thermodynamics, and a genetic algorithm for metabolic flux determination and optimal metabolic network design. 2010 BMC Syst Biol pmid:20416071
Meier S et al. A transcriptional analysis of carotenoid, chlorophyll and plastidial isoprenoid biosynthesis genes during development and osmotic stress responses in Arabidopsis thaliana. 2011 BMC Syst Biol pmid:21595952
Sgraja T et al. Structure, substrate recognition and reactivity of Leishmania major mevalonate kinase. 2007 BMC Struct. Biol. pmid:17397541
Buetow L et al. The structure of Mycobacteria 2C-methyl-D-erythritol-2,4-cyclodiphosphate synthase, an essential enzyme, provides a platform for drug discovery. 2007 BMC Struct. Biol. pmid:17956607
Andrews M et al. The CaaX specificities of Arabidopsis protein prenyltransferases explain era1 and ggb phenotypes. 2010 BMC Plant Biol. pmid:20565889