Isopentenyl pyrophosphate

Isopentenyl pyrophosphate is a lipid of Prenol Lipids (PR) class. Isopentenyl pyrophosphate is associated with abnormalities such as Tuberculosis, NAVAJO NEUROHEPATOPATHY and Cryptosporidiosis. The involved functions are known as Signal, Anabolism, T-Cell Activation, T-Cell Proliferation and isoprenoid biosynthetic process. Isopentenyl pyrophosphate often locates in Protoplasm, Host Cell, soluble, Plastids and Cell surface. The associated genes with Isopentenyl pyrophosphate are oxytocin, 1-desamino-(O-Et-Tyr)(2)-, HLA-E gene, RAP1A gene, Gene Family and Orthologous Gene. The related lipids are Steroids, Sterols and isopentenol.

Cross Reference

Introduction

To understand associated biological information of Isopentenyl pyrophosphate, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Isopentenyl pyrophosphate?

Isopentenyl pyrophosphate is suspected in Tuberculosis, NAVAJO NEUROHEPATOPATHY, Cryptosporidiosis and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Isopentenyl pyrophosphate

MeSH term MeSH ID Detail
Melanoma D008545 69 associated lipids
Total 1

PubChem Associated disorders and diseases

What pathways are associated with Isopentenyl pyrophosphate

Lipid pathways are not clear in current pathway databases. We organized associated pathways with Isopentenyl pyrophosphate through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
Loading... please refresh the page if content is not showing up.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Isopentenyl pyrophosphate?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with Isopentenyl pyrophosphate?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Isopentenyl pyrophosphate?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with Isopentenyl pyrophosphate?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Isopentenyl pyrophosphate?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Isopentenyl pyrophosphate

Download all related citations
Per page 10 20 50 100 | Total 1004
Authors Title Published Journal PubMed Link
Leaver MJ et al. Functional genomics reveals increases in cholesterol biosynthetic genes and highly unsaturated fatty acid biosynthesis after dietary substitution of fish oil with vegetable oils in Atlantic salmon (Salmo salar). 2008 BMC Genomics pmid:18577222
Wang Y et al. The effect of 24S-hydroxycholesterol on cholesterol homeostasis in neurons: quantitative changes to the cortical neuron proteome. 2008 J. Proteome Res. pmid:18303831
Srivastava A et al. Structural analysis of farnesyl pyrophosphate synthase from parasitic protozoa, a potential chemotherapeutic target. 2008 Infect Disord Drug Targets pmid:18473904
Jackson NM and Kocarek TA Suppression of CYP2B induction by alendronate-mediated farnesyl diphosphate synthase inhibition in primary cultured rat hepatocytes. 2008 Drug Metab. Dispos. pmid:18617600
Wang W et al. The structural basis of chain length control in Rv1086. 2008 J. Mol. Biol. pmid:18597781
Cummings JS et al. Impacts of HIV infection on Vgamma2Vdelta2 T cell phenotype and function: a mechanism for reduced tumor immunity in AIDS. 2008 J. Leukoc. Biol. pmid:18495780
Sgraja T et al. Characterization of Aquifex aeolicus 4-diphosphocytidyl-2C-methyl-d-erythritol kinase - ligand recognition in a template for antimicrobial drug discovery. 2008 FEBS J. pmid:18422643
Martín JF et al. Conversion of beta-carotene into astaxanthin: Two separate enzymes or a bifunctional hydroxylase-ketolase protein? 2008 Microb. Cell Fact. pmid:18289382
Kuo CJ et al. Structure-based inhibitors exhibit differential activities against Helicobacter pylori and Escherichia coli undecaprenyl pyrophosphate synthases. 2008 J. Biomed. Biotechnol. pmid:18382620
Spencer CT et al. Only a subset of phosphoantigen-responsive gamma9delta2 T cells mediate protective tuberculosis immunity. 2008 J. Immunol. pmid:18802050
Sarikonda G et al. Photoaffinity antigens for human gammadelta T cells. 2008 J. Immunol. pmid:19017963
Skorupinska-Tudek K et al. Contribution of the mevalonate and methylerythritol phosphate pathways to the biosynthesis of dolichols in plants. 2008 J. Biol. Chem. pmid:18502754
Vandermoten S et al. Characterization of a novel aphid prenyltransferase displaying dual geranyl/farnesyl diphosphate synthase activity. 2008 FEBS Lett. pmid:18466770
Phillips MA et al. The Arabidopsis thaliana type I Isopentenyl Diphosphate Isomerases are targeted to multiple subcellular compartments and have overlapping functions in isoprenoid biosynthesis. 2008 Plant Cell pmid:18319397
Dupont FM Metabolic pathways of the wheat (Triticum aestivum) endosperm amyloplast revealed by proteomics. 2008 BMC Plant Biol. pmid:18419817
de Ruyck J and Wouters J Structure-based drug design targeting biosynthesis of isoprenoids: a crystallographic state of the art of the involved enzymes. 2008 Curr. Protein Pept. Sci. pmid:18393884
Opitz S et al. Increased terpenoid accumulation in cotton (Gossypium hirsutum) foliage is a general wound response. 2008 J. Chem. Ecol. pmid:18386096
Yoon SH et al. Increased beta-carotene production in recombinant Escherichia coli harboring an engineered isoprenoid precursor pathway with mevalonate addition. 2007 May-Jun Biotechnol. Prog. pmid:17500531
Quinzii CM et al. Human coenzyme Q10 deficiency. 2007 Apr-May Neurochem. Res. pmid:17094036
Bock O et al. Common musculoskeletal adverse effects of oral treatment with once weekly alendronate and risedronate in patients with osteoporosis and ways for their prevention. 2007 Apr-Jun J Musculoskelet Neuronal Interact pmid:17627083
Moe M et al. Gene expression profiles in testis of pigs with extreme high and low levels of androstenone. 2007 BMC Genomics pmid:17988377
Yoon SH et al. Engineering the lycopene synthetic pathway in E. coli by comparison of the carotenoid genes of Pantoea agglomerans and Pantoea ananatis. 2007 Appl. Microbiol. Biotechnol. pmid:17115209
Das A et al. An update on microbial carotenoid production: application of recent metabolic engineering tools. 2007 Appl. Microbiol. Biotechnol. pmid:17912511
Walsh CT Revealing coupling patterns in isoprenoid alkylation biocatalysis. 2007 ACS Chem. Biol. pmid:17518430
Amslinger S et al. Stimulation of Vgamma9/Vdelta2 T-lymphocyte proliferation by the isoprenoid precursor, (E)-1-hydroxy-2-methyl-but-2-enyl 4-diphosphate. 2007 Immunobiology pmid:17270709
Christianson DW Chemistry. Roots of biosynthetic diversity. 2007 Science pmid:17412944
Matsumura Y et al. The carboxyl-terminal region of the geranylgeranyl diphosphate synthase is indispensable for the stabilization of the region involved in substrate binding and catalysis. 2007 J. Biochem. pmid:17846065
Omoigui S The Interleukin-6 inflammation pathway from cholesterol to aging--role of statins, bisphosphonates and plant polyphenols in aging and age-related diseases. 2007 Immun Ageing pmid:17374166
Nagaki M et al. Substrate specificities of wild and mutated farnesyl diphosphate synthases from Bacillus stearothermophilus with artificial substrates. 2007 Biosci. Biotechnol. Biochem. pmid:17617711
Mi J et al. Age-related subproteomic analysis of mouse liver and kidney peroxisomes. 2007 Proteome Sci pmid:18042274
Hoshino T and Eguchi T Functional analysis of type 1 isopentenyl diphosphate isomerase from Halobacterium sp. NRC-1. 2007 Biosci. Biotechnol. Biochem. pmid:17928693
Anisimova M et al. Phylogenomic analysis of natural selection pressure in Streptococcus genomes. 2007 BMC Evol. Biol. pmid:17760998
Sangar V et al. Quantitative sequence-function relationships in proteins based on gene ontology. 2007 BMC Bioinformatics pmid:17686158
Lodato P et al. Expression of the carotenoid biosynthesis genes in Xanthophyllomyces dendrorhous. 2007 Biol. Res. pmid:17657357
Huang J and Gogarten JP Did an ancient chlamydial endosymbiosis facilitate the establishment of primary plastids? 2007 Genome Biol. pmid:17547748
Murphy DJ and Brown JR Identification of gene targets against dormant phase Mycobacterium tuberculosis infections. 2007 BMC Infect. Dis. pmid:17655757
Na-Bangchang K et al. Pharmacokinetics and pharmacodynamics of fosmidomycin monotherapy and combination therapy with clindamycin in the treatment of multidrug resistant falciparum malaria. 2007 Malar. J. pmid:17531088
Clizbe DB et al. IDI2, a second isopentenyl diphosphate isomerase in mammals. 2007 J. Biol. Chem. pmid:17202134
Bulashevska S et al. New insights into the genetic regulation of Plasmodium falciparum obtained by Bayesian modeling. 2007 Gene Regul Syst Bio pmid:19936084
Lopes AA et al. Biosynthetic origins of the isoprene units of gaudichaudianic acid in Piper gaudichaudianum (Piperaceae). 2007 Phytochemistry pmid:17574633
Kulaber A et al. Pro-inflammatory cellular immune response in Behçet's disease. 2007 Rheumatol. Int. pmid:17549482
Sgraja T et al. Structure, substrate recognition and reactivity of Leishmania major mevalonate kinase. 2007 BMC Struct. Biol. pmid:17397541
Wang YD et al. Salicylic acid-induced taxol production and isopentenyl pyrophosphate biosynthesis in suspension cultures of Taxus chinensis var. mairei. 2007 Cell Biol. Int. pmid:17521928
Puan KJ et al. Preferential recognition of a microbial metabolite by human Vgamma2Vdelta2 T cells. 2007 Int. Immunol. pmid:17446209
Henriksson LM et al. Structures of Mycobacterium tuberculosis 1-deoxy-D-xylulose-5-phosphate reductoisomerase provide new insights into catalysis. 2007 J. Biol. Chem. pmid:17491006
Rothman SC et al. Kinetic and spectroscopic characterization of type II isopentenyl diphosphate isomerase from Thermus thermophilus: evidence for formation of substrate-induced flavin species. 2007 Biochemistry pmid:17428035
Julsing MK et al. Functional analysis of genes involved in the biosynthesis of isoprene in Bacillus subtilis. 2007 Appl. Microbiol. Biotechnol. pmid:17458547
Glickman JF and Schmid A Farnesyl pyrophosphate synthase: real-time kinetics and inhibition by nitrogen-containing bisphosphonates in a scintillation assay. 2007 Assay Drug Dev Technol pmid:17477829
Saito K et al. Short-chain prenyl diphosphate synthase that condenses isopentenyl diphosphate with dimethylallyl diphosphate in ispA null Escherichia coli strain lacking farnesyl diphosphate synthase. 2007 J. Biosci. Bioeng. pmid:17630132
Klein-Marcuschamer D et al. Engineering microbial cell factories for biosynthesis of isoprenoid molecules: beyond lycopene. 2007 Trends Biotechnol. pmid:17681626
Mönkkönen H et al. Zoledronic acid-induced IPP/ApppI production in vivo. 2007 Life Sci. pmid:17850825
Grimplet J et al. Tissue-specific mRNA expression profiling in grape berry tissues. 2007 BMC Genomics pmid:17584945
Towler MJ and Weathers PJ Evidence of artemisinin production from IPP stemming from both the mevalonate and the nonmevalonate pathways. 2007 Plant Cell Rep. pmid:17710406
Withers ST et al. Identification of isopentenol biosynthetic genes from Bacillus subtilis by a screening method based on isoprenoid precursor toxicity. 2007 Appl. Environ. Microbiol. pmid:17693564
Wilcox CB et al. Coordinate up-regulation of TMEM97 and cholesterol biosynthesis genes in normal ovarian surface epithelial cells treated with progesterone: implications for pathogenesis of ovarian cancer. 2007 BMC Cancer pmid:18070364
Velasco R et al. A high quality draft consensus sequence of the genome of a heterozygous grapevine variety. 2007 PLoS ONE pmid:18094749
Buetow L et al. The structure of Mycobacteria 2C-methyl-D-erythritol-2,4-cyclodiphosphate synthase, an essential enzyme, provides a platform for drug discovery. 2007 BMC Struct. Biol. pmid:17956607
Cassera MB et al. Effect of fosmidomycin on metabolic and transcript profiles of the methylerythritol phosphate pathway in Plasmodium falciparum. 2007 Mem. Inst. Oswaldo Cruz pmid:17568945
Schirra F et al. Androgen influence on cholesterogenic enzyme mRNA levels in the mouse meibomian gland. 2007 Curr. Eye Res. pmid:17514523
Hebbeler AM et al. Individual Vgamma2-Jgamma1.2+ T cells respond to both isopentenyl pyrophosphate and Daudi cell stimulation: generating tumor effectors with low molecular weight phosphoantigens. 2007 Cancer Immunol. Immunother. pmid:17131122
Byres E et al. Crystal structures of Trypanosoma brucei and Staphylococcus aureus mevalonate diphosphate decarboxylase inform on the determinants of specificity and reactivity. 2007 J. Mol. Biol. pmid:17583736
Kinjoh T et al. Control of juvenile hormone biosynthesis in Bombyx mori: cloning of the enzymes in the mevalonate pathway and assessment of their developmental expression in the corpora allata. 2007 Insect Biochem. Mol. Biol. pmid:17628279
Scott KM et al. The genome of deep-sea vent chemolithoautotroph Thiomicrospira crunogena XCL-2. 2006 PLoS Biol. pmid:17105352
Kloer DP et al. Structure and reaction geometry of geranylgeranyl diphosphate synthase from Sinapis alba. 2006 Biochemistry pmid:17176041
Gibon Y et al. Integration of metabolite with transcript and enzyme activity profiling during diurnal cycles in Arabidopsis rosettes. 2006 Genome Biol. pmid:16916443
Thulasiram HV and Poulter CD Farnesyl diphosphate synthase: the art of compromise between substrate selectivity and stereoselectivity. 2006 J. Am. Chem. Soc. pmid:17147392
Forster AC and Church GM Towards synthesis of a minimal cell. 2006 Mol. Syst. Biol. pmid:16924266
Depasquale I and Wheatley DN Action of Lovastatin (Mevinolin) on an in vitro model of angiogenesis and its co-culture with malignant melanoma cell lines. 2006 Cancer Cell Int. pmid:16573823
Chang TH et al. Crystal structure of type-III geranylgeranyl pyrophosphate synthase from Saccharomyces cerevisiae and the mechanism of product chain length determination. 2006 J. Biol. Chem. pmid:16554305
Kharel Y et al. Manipulation of prenyl chain length determination mechanism of cis-prenyltransferases. 2006 FEBS J. pmid:16420487
Goffinet M et al. Zoledronic acid treatment impairs protein geranyl-geranylation for biological effects in prostatic cells. 2006 BMC Cancer pmid:16539721
Houde M et al. Wheat EST resources for functional genomics of abiotic stress. 2006 BMC Genomics pmid:16772040
Chemler JA et al. Biosynthesis of isoprenoids, polyunsaturated fatty acids and flavonoids in Saccharomyces cerevisiae. 2006 Microb. Cell Fact. pmid:16719921
Kim SJ et al. Amplification of 1-deoxy-D-xyluose 5-phosphate (DXP) synthase level increases coenzyme Q10 production in recombinant Escherichia coli. 2006 Appl. Microbiol. Biotechnol. pmid:16532312
Workalemahu G et al. Expression of metalloproteinase-7 (matrilysin) in human blood and bronchoalveolar gamma/delta T-lymphocytes. Selective upregulation by the soluble non-peptidic mycobacterial phosphoantigen (isopentenyl pyrophosphate). 2006 J. Cell. Physiol. pmid:16250011
Zahiri HS et al. Coenzyme Q10 production in recombinant Escherichia coli strains engineered with a heterologous decaprenyl diphosphate synthase gene and foreign mevalonate pathway. 2006 Metab. Eng. pmid:16815062
Caccamo N et al. Sex-specific phenotypical and functional differences in peripheral human Vgamma9/Vdelta2 T cells. 2006 J. Leukoc. Biol. pmid:16461739
Scholte AA and Vederas JC Incorporation of deuterium-labelled analogs of isopentenyl diphosphate for the elucidation of the stereochemistry of rubber biosynthesis. 2006 Org. Biomol. Chem. pmid:16467948
Fischbach MA and Walsh CT Biochemistry. Directing biosynthesis. 2006 Science pmid:17068249
Theivagt AE et al. Characterization of an HMG-CoA reductase from Listeria monocytogenes that exhibits dual coenzyme specificity. 2006 Biochemistry pmid:17128979
Zahiri HS et al. Biochemical characterization of the decaprenyl diphosphate synthase of Rhodobacter sphaeroides for coenzyme Q10 production. 2006 Appl. Microbiol. Biotechnol. pmid:16896603
Muñoz-Bertomeu J et al. Up-regulation of 1-deoxy-D-xylulose-5-phosphate synthase enhances production of essential oils in transgenic spike lavender. 2006 Plant Physiol. pmid:16980564
Herzig C et al. Bovine T cell receptor gamma variable and constant genes: combinatorial usage by circulating gammadelta T cells. 2006 Immunogenetics pmid:16541255
Cervantes-Cervantes M et al. Maize cDNAs expressed in endosperm encode functional farnesyl diphosphate synthase with geranylgeranyl diphosphate synthase activity. 2006 Plant Physiol. pmid:16581875
Yoon SH et al. Enhanced lycopene production in Escherichia coli engineered to synthesize isopentenyl diphosphate and dimethylallyl diphosphate from mevalonate. 2006 Biotechnol. Bioeng. pmid:16547999
Maurice T et al. Neuro(active)steroids actions at the neuromodulatory sigma1 (sigma1) receptor: biochemical and physiological evidences, consequences in neuroprotection. 2006 Pharmacol. Biochem. Behav. pmid:16945406
Grochowski LL et al. Methanocaldococcus jannaschii uses a modified mevalonate pathway for biosynthesis of isopentenyl diphosphate. 2006 J. Bacteriol. pmid:16621811
Kavanagh KL et al. The crystal structure of human geranylgeranyl pyrophosphate synthase reveals a novel hexameric arrangement and inhibitory product binding. 2006 J. Biol. Chem. pmid:16698791
Hsiao YY et al. Comparison of transcripts in Phalaenopsis bellina and Phalaenopsis equestris (Orchidaceae) flowers to deduce monoterpene biosynthesis pathway. 2006 BMC Plant Biol. pmid:16836766
Thompson K et al. Alkylamines cause Vgamma9Vdelta2 T-cell activation and proliferation by inhibiting the mevalonate pathway. 2006 Blood pmid:16179378
Vadali RV et al. Enhanced lycopene productivity by manipulation of carbon flow to isopentenyl diphosphate in Escherichia coli. 2005 Sep-Oct Biotechnol. Prog. pmid:16209562
da Costa BM et al. Regulation of rubber biosynthetic rate and molecular weight in Hevea brasiliensis by metal cofactor. 2005 Jan-Feb Biomacromolecules pmid:15638531
Re F et al. Skewed representation of functionally distinct populations of Vgamma9Vdelta2 T lymphocytes in aging. 2005 Jan-Feb Exp. Gerontol. pmid:15664733
Ku B et al. Preparation, characterization, and optimization of an in vitro C30 carotenoid pathway. 2005 Appl. Environ. Microbiol. pmid:16269684
Park YC et al. Batch and fed-batch production of coenzyme Q10 in recombinant Escherichia coli containing the decaprenyl diphosphate synthase gene from Gluconobacter suboxydans. 2005 Appl. Microbiol. Biotechnol. pmid:15459799
Seker T et al. Analysis of acyl CoA ester intermediates of the mevalonate pathway in Saccharomyces cerevisiae. 2005 Appl. Microbiol. Biotechnol. pmid:15448940
Chen AP et al. Substrate and product specificities of cis-type undecaprenyl pyrophosphate synthase. 2005 Biochem. J. pmid:15447632
Dudareva N et al. The nonmevalonate pathway supports both monoterpene and sesquiterpene formation in snapdragon flowers. 2005 Proc. Natl. Acad. Sci. U.S.A. pmid:15630092
Conti L et al. Reciprocal activating interaction between dendritic cells and pamidronate-stimulated gammadelta T cells: role of CD86 and inflammatory cytokines. 2005 J. Immunol. pmid:15611247
Kao CL et al. Stereochemical analysis of isopentenyl diphosphate isomerase type II from Staphylococcus aureus using chemically synthesized (S)- and (R)-[2-2H]isopentenyl diphosphates. 2005 Org. Lett. pmid:16321020