MeSH term | MeSH ID | Detail |
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Melanoma | D008545 | 69 associated lipids |
Isopentenyl pyrophosphate is a lipid of Prenol Lipids (PR) class. Isopentenyl pyrophosphate is associated with abnormalities such as Tuberculosis, NAVAJO NEUROHEPATOPATHY and Cryptosporidiosis. The involved functions are known as Signal, Anabolism, T-Cell Activation, T-Cell Proliferation and isoprenoid biosynthetic process. Isopentenyl pyrophosphate often locates in Protoplasm, Host Cell, soluble, Plastids and Cell surface. The associated genes with Isopentenyl pyrophosphate are oxytocin, 1-desamino-(O-Et-Tyr)(2)-, HLA-E gene, RAP1A gene, Gene Family and Orthologous Gene. The related lipids are Steroids, Sterols and isopentenol.
To understand associated biological information of Isopentenyl pyrophosphate, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Isopentenyl pyrophosphate is suspected in Tuberculosis, NAVAJO NEUROHEPATOPATHY, Cryptosporidiosis and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Isopentenyl pyrophosphate
MeSH term | MeSH ID | Detail |
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Melanoma | D008545 | 69 associated lipids |
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Isopentenyl pyrophosphate through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Vavassori S et al. | Butyrophilin 3A1 binds phosphorylated antigens and stimulates human γδ T cells. | 2013 | Nat. Immunol. | pmid:23872678 |
Bessoff K et al. | Drug repurposing screen reveals FDA-approved inhibitors of human HMG-CoA reductase and isoprenoid synthesis that block Cryptosporidium parvum growth. | 2013 | Antimicrob. Agents Chemother. | pmid:23380723 |
Idrees AS et al. | Comparison of γδ T cell responses and farnesyl diphosphate synthase inhibition in tumor cells pretreated with zoledronic acid. | 2013 | Cancer Sci. | pmid:23387443 |
Banerjee A et al. | Feedback inhibition of deoxy-D-xylulose-5-phosphate synthase regulates the methylerythritol 4-phosphate pathway. | 2013 | J. Biol. Chem. | pmid:23612965 |
Liu YL et al. | Taxodione and arenarone inhibit farnesyl diphosphate synthase by binding to the isopentenyl diphosphate site. | 2014 | Proc. Natl. Acad. Sci. U.S.A. | pmid:24927548 |
Xi Y et al. | [Amplification efficency and optimization of culture conditions of γδ T cells in peripheral blood by different phosphate compounds]. | 2014 | Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi | pmid:25108442 |
Bowman JD et al. | Antiapicoplast and gametocytocidal screening to identify the mechanisms of action of compounds within the malaria box. | 2014 | Antimicrob. Agents Chemother. | pmid:24247137 |
Mannen K et al. | Coordinated transcriptional regulation of isopentenyl diphosphate biosynthetic pathway enzymes in plastids by phytochrome-interacting factor 5. | 2014 | Biochem. Biophys. Res. Commun. | pmid:24342623 |
Bentinger M et al. | Effects of various squalene epoxides on coenzyme Q and cholesterol synthesis. | 2014 | Biochim. Biophys. Acta | pmid:24747199 |
Banerjee A and Sharkey TD | Methylerythritol 4-phosphate (MEP) pathway metabolic regulation. | 2014 | Nat Prod Rep | pmid:24921065 |