| MeSH term | MeSH ID | Detail |
|---|---|---|
| Melanoma | D008545 | 69 associated lipids |
Total
1
Isopentenyl pyrophosphate
Isopentenyl pyrophosphate is a lipid of Prenol Lipids (PR) class. Isopentenyl pyrophosphate is associated with abnormalities such as Tuberculosis, NAVAJO NEUROHEPATOPATHY and Cryptosporidiosis. The involved functions are known as Signal, Anabolism, T-Cell Activation, T-Cell Proliferation and isoprenoid biosynthetic process. Isopentenyl pyrophosphate often locates in Protoplasm, Host Cell, soluble, Plastids and Cell surface. The associated genes with Isopentenyl pyrophosphate are oxytocin, 1-desamino-(O-Et-Tyr)(2)-, HLA-E gene, RAP1A gene, Gene Family and Orthologous Gene. The related lipids are Steroids, Sterols and isopentenol.
Cross Reference
Introduction
To understand associated biological information of Isopentenyl pyrophosphate, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Isopentenyl pyrophosphate?
Isopentenyl pyrophosphate is suspected in Tuberculosis, NAVAJO NEUROHEPATOPATHY, Cryptosporidiosis and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Isopentenyl pyrophosphate
PubChem Associated disorders and diseases
What pathways are associated with Isopentenyl pyrophosphate
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Isopentenyl pyrophosphate through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Isopentenyl pyrophosphate?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with Isopentenyl pyrophosphate?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Isopentenyl pyrophosphate?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Isopentenyl pyrophosphate?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Isopentenyl pyrophosphate?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with Isopentenyl pyrophosphate
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Sillero MA et al. | Synthesis of ATP derivatives of compounds of the mevalonate pathway (isopentenyl di- and triphosphate; geranyl di- and triphosphate, farnesyl di- and triphosphate, and dimethylallyl diphosphate) catalyzed by T4 RNA ligase, T4 DNA ligase and other ligases Potential relationship with the effect of bisphosphonates on osteoclasts. | 2009 | Biochem. Pharmacol. | pmid:19414000 |
| Räikkönen J et al. | Mevalonate pathway intermediates downregulate zoledronic acid-induced isopentenyl pyrophosphate and ATP analog formation in human breast cancer cells. | 2010 | Biochem. Pharmacol. | pmid:19819230 |
| Rohdich F et al. | Isoprenoid biosynthetic pathways as anti-infective drug targets. | 2005 | Biochem. Soc. Trans. | pmid:16042599 |
| Lichtenthaler HK | Non-mevalonate isoprenoid biosynthesis: enzymes, genes and inhibitors. | 2000 | Biochem. Soc. Trans. | pmid:11171208 |
| Mabanglo MF et al. | The Streptomyces-produced antibiotic fosfomycin is a promiscuous substrate for archaeal isopentenyl phosphate kinase. | 2012 | Biochemistry | pmid:22148590 |
| Sharma NK et al. | Type II isopentenyl diphosphate isomerase: probing the mechanism with alkyne/allene diphosphate substrate analogues. | 2010 | Biochemistry | pmid:20560533 |
| Pan JJ et al. | Effect of site-directed mutagenesis of the conserved aspartate and glutamate on E. coli undecaprenyl pyrophosphate synthase catalysis. | 2000 | Biochemistry | pmid:11076526 |
| Stanley Fernandez SM et al. | Farnesyl diphosphate synthase. Altering the catalytic site to select for geranyl diphosphate activity. | 2000 | Biochemistry | pmid:11112517 |
| Lafitte D et al. | DNA gyrase interaction with coumarin-based inhibitors: the role of the hydroxybenzoate isopentenyl moiety and the 5'-methyl group of the noviose. | 2002 | Biochemistry | pmid:12044152 |
| Lee LV et al. | Biophysical investigation of the mode of inhibition of tetramic acids, the allosteric inhibitors of undecaprenyl pyrophosphate synthase. | 2010 | Biochemistry | pmid:20476728 |
| Ito M et al. | Stereochemical analysis of prenyltransferase reactions leading to (Z)- and (E)-polyprenyl chains. | 1987 | Biochemistry | pmid:3117106 |
| Reardon JE and Abeles RH | Inhibition of cholesterol biosynthesis by fluorinated mevalonate analogues. | 1987 | Biochemistry | pmid:3663621 |
| Muehlbacher M and Poulter CD | Isopentenyl-diphosphate isomerase: inactivation of the enzyme with active-site-directed irreversible inhibitors and transition-state analogues. | 1988 | Biochemistry | pmid:3207678 |
| Nishino T and Rudney H | Effects of detergents on the properties of 4-hydroxybenzoate. Polyprenyl transferase and the specificity of the polyprenyl pyrophosphate synthetic system in mitochondria. | 1977 | Biochemistry | pmid:836803 |
| Poulter CD and Satterwhite DM | Mechanism of the prenyl-transfer reaction. Studies with (E)- and (Z)-3-trifluoromethyl-2-buten-1-yl pyrophosphate. | 1977 | Biochemistry | pmid:562673 |
| Chen M and Poulter CD | Characterization of thermophilic archaeal isopentenyl phosphate kinases. | 2010 | Biochemistry | pmid:19928876 |
| Reed BC and Rilling HC | Crystallization and partial characterization of prenyltransferase from avian liver. | 1975 | Biochemistry | pmid:1109590 |
| Brems DN and Rilling HC | Photoaffinity labeling of the catalytic site of prenyltransferase. | 1979 | Biochemistry | pmid:84684 |
| Laskovics FM and Poulter CD | Prenyltransferase; determination of the binding mechanism and individual kinetic constants for farnesylpyrophosphate synthetase by rapid quench and isotope partitioning experiments. | 1981 | Biochemistry | pmid:7013805 |
| Thibodeaux CJ et al. | Evidence for the involvement of acid/base chemistry in the reaction catalyzed by the type II isopentenyl diphosphate/dimethylallyl diphosphate isomerase from Staphylococcus aureus. | 2008 | Biochemistry | pmid:18229948 |