| MeSH term | MeSH ID | Detail |
|---|---|---|
| Melanoma | D008545 | 69 associated lipids |
Total
1
Isopentenyl pyrophosphate
Isopentenyl pyrophosphate is a lipid of Prenol Lipids (PR) class. Isopentenyl pyrophosphate is associated with abnormalities such as Tuberculosis, NAVAJO NEUROHEPATOPATHY and Cryptosporidiosis. The involved functions are known as Signal, Anabolism, T-Cell Activation, T-Cell Proliferation and isoprenoid biosynthetic process. Isopentenyl pyrophosphate often locates in Protoplasm, Host Cell, soluble, Plastids and Cell surface. The associated genes with Isopentenyl pyrophosphate are oxytocin, 1-desamino-(O-Et-Tyr)(2)-, HLA-E gene, RAP1A gene, Gene Family and Orthologous Gene. The related lipids are Steroids, Sterols and isopentenol.
Cross Reference
Introduction
To understand associated biological information of Isopentenyl pyrophosphate, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Isopentenyl pyrophosphate?
Isopentenyl pyrophosphate is suspected in Tuberculosis, NAVAJO NEUROHEPATOPATHY, Cryptosporidiosis and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Isopentenyl pyrophosphate
PubChem Associated disorders and diseases
What pathways are associated with Isopentenyl pyrophosphate
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Isopentenyl pyrophosphate through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Isopentenyl pyrophosphate?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Isopentenyl pyrophosphate?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Isopentenyl pyrophosphate?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Isopentenyl pyrophosphate?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Isopentenyl pyrophosphate?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with Isopentenyl pyrophosphate
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Testa CA and Johnson LJ | A whole-cell phenotypic screening platform for identifying methylerythritol phosphate pathway-selective inhibitors as novel antibacterial agents. | 2012 | Antimicrob. Agents Chemother. | pmid:22777049 |
| Barta ML et al. | Structural basis for nucleotide binding and reaction catalysis in mevalonate diphosphate decarboxylase. | 2012 | Biochemistry | pmid:22734632 |
| Suzuki N et al. | Construction and analysis of EST libraries of the trans-polyisoprene producing plant, Eucommia ulmoides Oliver. | 2012 | Planta | pmid:22729820 |
| pmid:22722993 | ||||
| Lamsen EN and Atsumi S | Recent progress in synthetic biology for microbial production of C3-C10 alcohols. | 2012 | Front Microbiol | pmid:22701113 |
| Zhang YL and Li ZX | Functional analysis and molecular docking identify two active short-chain prenyltransferases in the green peach aphid, Myzus persicae. | 2012 | Arch. Insect Biochem. Physiol. | pmid:22696503 |
| Raina M et al. | Association of a multi-synthetase complex with translating ribosomes in the archaeon Thermococcus kodakarensis. | 2012 | FEBS Lett. | pmid:22683511 |
| Mbaya B et al. | Isoprenoid metabolism in Plasmodium falciparum during the intraerythrocytic phase of malaria. | 1990 | Biochem. Biophys. Res. Commun. | pmid:2268347 |
| Van Laar TA et al. | Effect of levels of acetate on the mevalonate pathway of Borrelia burgdorferi. | 2012 | PLoS ONE | pmid:22675445 |
| Ma YG et al. | Activation of BK(Ca) channels in zoledronic acid-induced apoptosis of MDA-MB-231 breast cancer cells. | 2012 | PLoS ONE | pmid:22655048 |
| Xu W et al. | A closer look at the spectroscopic properties of possible reaction intermediates in wild-type and mutant (E)-4-hydroxy-3-methylbut-2-enyl diphosphate reductase. | 2012 | Biochemistry | pmid:22646150 |
| Wurtzel ET et al. | Maize provitamin a carotenoids, current resources, and future metabolic engineering challenges. | 2012 | Front Plant Sci | pmid:22645578 |
| Yokoi T et al. | Archaeal phospholipid biosynthetic pathway reconstructed in Escherichia coli. | 2012 | Archaea | pmid:22645416 |
| Sawai S and Saito K | Triterpenoid biosynthesis and engineering in plants. | 2011 | Front Plant Sci | pmid:22639586 |
| pmid:22638903 | ||||
| pmid:22623313 | ||||
| pmid:22623294 | ||||
| Kumar M et al. | Cholesterol-lowering probiotics as potential biotherapeutics for metabolic diseases. | 2012 | Exp Diabetes Res | pmid:22611376 |
| Liu D et al. | The genome of Ganoderma lucidum provides insights into triterpenes biosynthesis and wood degradation [corrected]. | 2012 | PLoS ONE | pmid:22567134 |
| Tidten-Luksch N et al. | IspE inhibitors identified by a combination of in silico and in vitro high-throughput screening. | 2012 | PLoS ONE | pmid:22563402 |
| Förster F et al. | Transcriptome analysis in tardigrade species reveals specific molecular pathways for stress adaptations. | 2012 | Bioinform Biol Insights | pmid:22563243 |
| Fatima T et al. | Fatty acid composition of developing sea buckthorn (Hippophae rhamnoides L.) berry and the transcriptome of the mature seed. | 2012 | PLoS ONE | pmid:22558083 |
| Yang J et al. | Enhancing production of bio-isoprene using hybrid MVA pathway and isoprene synthase in E. coli. | 2012 | PLoS ONE | pmid:22558074 |
| Wan L et al. | De novo transcriptomic analysis of an oleaginous microalga: pathway description and gene discovery for production of next-generation biofuels. | 2012 | PLoS ONE | pmid:22536352 |
| Mabanglo MF et al. | Mutagenesis of isopentenyl phosphate kinase to enhance geranyl phosphate kinase activity. | 2012 | ACS Chem. Biol. | pmid:22533411 |
| Nakatani H et al. | Substrate-induced change in the quaternary structure of type 2 isopentenyl diphosphate isomerase from Sulfolobus shibatae. | 2012 | J. Bacteriol. | pmid:22505674 |
| Berthelot K et al. | Isopentenyl diphosphate isomerase: A checkpoint to isoprenoid biosynthesis. | 2012 | Biochimie | pmid:22503704 |
| Teng KH and Liang PH | Undecaprenyl diphosphate synthase, a cis-prenyltransferase synthesizing lipid carrier for bacterial cell wall biosynthesis. | 2012 | Mol. Membr. Biol. | pmid:22471620 |
| Jonnalagadda V et al. | Isopentenyl diphosphate isomerase catalyzed reactions in D2O: product release limits the rate of this sluggish enzyme-catalyzed reaction. | 2012 | J. Am. Chem. Soc. | pmid:22471428 |
| Bendersky A et al. | Cellular interactions of synovial fluid γδ T cells in juvenile idiopathic arthritis. | 2012 | J. Immunol. | pmid:22450805 |
| Kuzuyama T and Seto H | Two distinct pathways for essential metabolic precursors for isoprenoid biosynthesis. | 2012 | Proc. Jpn. Acad., Ser. B, Phys. Biol. Sci. | pmid:22450534 |
| Lei A et al. | Expression of fatty acid synthesis genes and fatty acid accumulation in haematococcus pluvialis under different stressors. | 2012 | Biotechnol Biofuels | pmid:22448811 |
| Mohanta TK et al. | Ginkgo biloba responds to herbivory by activating early signaling and direct defenses. | 2012 | PLoS ONE | pmid:22448229 |
| Song AA et al. | Functional expression of an orchid fragrance gene in Lactococcus lactis. | 2012 | Int J Mol Sci | pmid:22408409 |
| Lin YS et al. | Design and synthesis of active site inhibitors of the human farnesyl pyrophosphate synthase: apoptosis and inhibition of ERK phosphorylation in multiple myeloma cells. | 2012 | J. Med. Chem. | pmid:22390415 |
| Luo H et al. | Analysis of the transcriptome of Panax notoginseng root uncovers putative triterpene saponin-biosynthetic genes and genetic markers. | 2011 | BMC Genomics | pmid:22369100 |
| Hussain MS et al. | Current approaches toward production of secondary plant metabolites. | 2012 | J Pharm Bioallied Sci | pmid:22368394 |
| Mosqueda J et al. | Current advances in detection and treatment of babesiosis. | 2012 | Curr. Med. Chem. | pmid:22360483 |
| Quinzii CM et al. | Effects of inhibiting CoQ10 biosynthesis with 4-nitrobenzoate in human fibroblasts. | 2012 | PLoS ONE | pmid:22359546 |
| Umeda T et al. | Molecular basis of fosmidomycin's action on the human malaria parasite Plasmodium falciparum. | 2011 | Sci Rep | pmid:22355528 |
| Radakovits R et al. | Draft genome sequence and genetic transformation of the oleaginous alga Nannochloropis gaditana. | 2012 | Nat Commun | pmid:22353717 |
| Al-Bazi MM et al. | Reduced coenzyme Q(10) in female smokers and its association with lipid profile in a young healthy adult population. | 2011 | Arch Med Sci | pmid:22328876 |
| Leblond JD et al. | Sterol composition and biosynthetic genes of the recently discovered photosynthetic alveolate, Chromera velia (chromerida), a close relative of apicomplexans. | 2012 May-Jun | J. Eukaryot. Microbiol. | pmid:22313428 |
| Ma Y et al. | Genome-wide identification and characterization of novel genes involved in terpenoid biosynthesis in Salvia miltiorrhiza. | 2012 | J. Exp. Bot. | pmid:22291132 |
| pmid:22281742 | ||||
| Wen W and Yu R | Artemisinin biosynthesis and its regulatory enzymes: Progress and perspective. | 2011 | Pharmacogn Rev | pmid:22279377 |
| Aros D et al. | Volatile emissions of scented Alstroemeria genotypes are dominated by terpenes, and a myrcene synthase gene is highly expressed in scented Alstroemeria flowers. | 2012 | J. Exp. Bot. | pmid:22268153 |
| Nagel R et al. | Nonradioactive assay for detecting isoprenyl diphosphate synthase activity in crude plant extracts using liquid chromatography coupled with tandem mass spectrometry. | 2012 | Anal. Biochem. | pmid:22266300 |
| Angaman DM et al. | Precursor uptake assays and metabolic analyses in isolated tomato fruit chromoplasts. | 2012 | Plant Methods | pmid:22243738 |
| Post J et al. | Laticifer-specific cis-prenyltransferase silencing affects the rubber, triterpene, and inulin content of Taraxacum brevicorniculatum. | 2012 | Plant Physiol. | pmid:22238421 |
| Holte D et al. | An approach to mimicking the sesquiterpene cyclase phase by nickel-promoted diene/alkyne cooligomerization. | 2012 | J. Org. Chem. | pmid:22229741 |
| Baikar S and Malpathak N | Secondary metabolites as DNA topoisomerase inhibitors: A new era towards designing of anticancer drugs. | 2010 | Pharmacogn Rev | pmid:22228937 |
| Odom AR | Five questions about non-mevalonate isoprenoid biosynthesis. | 2011 | PLoS Pathog. | pmid:22216001 |
| Vivas Y et al. | Early peroxisome proliferator-activated receptor gamma regulated genes involved in expansion of pancreatic beta cell mass. | 2011 | BMC Med Genomics | pmid:22208362 |
| Rauthan M and Pilon M | The mevalonate pathway in C. elegans. | 2011 | Lipids Health Dis | pmid:22204706 |
| Wang L et al. | Genome characterization of the oleaginous fungus Mortierella alpina. | 2011 | PLoS ONE | pmid:22174787 |
| pmid:22166808 | ||||
| Green SA et al. | Identification, functional characterization, and regulation of the enzyme responsible for floral (E)-nerolidol biosynthesis in kiwifruit (Actinidia chinensis). | 2012 | J. Exp. Bot. | pmid:22162874 |
| Chow KS et al. | Metabolic routes affecting rubber biosynthesis in Hevea brasiliensis latex. | 2012 | J. Exp. Bot. | pmid:22162870 |
| Pan J et al. | ATP synthase ecto-α-subunit: a novel therapeutic target for breast cancer. | 2011 | J Transl Med | pmid:22152132 |
| Barrero RA et al. | De novo assembly of Euphorbia fischeriana root transcriptome identifies prostratin pathway related genes. | 2011 | BMC Genomics | pmid:22151917 |
| Mabanglo MF et al. | The Streptomyces-produced antibiotic fosfomycin is a promiscuous substrate for archaeal isopentenyl phosphate kinase. | 2012 | Biochemistry | pmid:22148590 |
| Sivy TL et al. | Evidence of isoprenoid precursor toxicity in Bacillus subtilis. | 2011 | Biosci. Biotechnol. Biochem. | pmid:22146731 |
| Hu C et al. | Antigen-presenting effects of effector memory Vγ9Vδ2 T cells in rheumatoid arthritis. | 2012 | Cell. Mol. Immunol. | pmid:22139198 |
| Span I et al. | Crystal structures of mutant IspH proteins reveal a rotation of the substrate's hydroxymethyl group during catalysis. | 2012 | J. Mol. Biol. | pmid:22137895 |
| Schneiders FL et al. | Activated iNKT cells promote Vγ9Vδ2-T cell anti-tumor effector functions through the production of TNF-α. | 2012 | Clin. Immunol. | pmid:22122798 |
| Dozier JK and Distefano MD | An enzyme-coupled continuous fluorescence assay for farnesyl diphosphate synthases. | 2012 | Anal. Biochem. | pmid:22085443 |
| Clastre M et al. | Subcellular evidence for the involvement of peroxisomes in plant isoprenoid biosynthesis. | 2011 | Plant Signal Behav | pmid:22080790 |
| Tijerino A et al. | Overexpression of the Trichoderma brevicompactum tri5 gene: effect on the expression of the trichodermin biosynthetic genes and on tomato seedlings. | 2011 | Toxins (Basel) | pmid:22069764 |
| Yadav VR et al. | Targeting inflammatory pathways by triterpenoids for prevention and treatment of cancer. | 2010 | Toxins (Basel) | pmid:22069560 |
| Chang PK et al. | Cyclopiazonic acid biosynthesis of Aspergillus flavus and Aspergillus oryzae. | 2009 | Toxins (Basel) | pmid:22069533 |
| Caballero MC et al. | Characterization of acyl carrier protein and LytB in Babesia bovis apicoplast. | 2012 | Mol. Biochem. Parasitol. | pmid:22057350 |
| Sui C et al. | Transcriptome analysis of Bupleurum chinense focusing on genes involved in the biosynthesis of saikosaponins. | 2011 | BMC Genomics | pmid:22047182 |
| Heaps NA and Poulter CD | Type-2 isopentenyl diphosphate isomerase: evidence for a stepwise mechanism. | 2011 | J. Am. Chem. Soc. | pmid:22047048 |
| Schafer WR et al. | Enzymatic coupling of cholesterol intermediates to a mating pheromone precursor and to the ras protein. | 1990 | Science | pmid:2204115 |
| Elmore ZC et al. | Sumo-dependent substrate targeting of the SUMO protease Ulp1. | 2011 | BMC Biol. | pmid:22034919 |
| Poonia B and Pauza CD | Gamma delta T cells from HIV+ donors can be expanded in vitro by zoledronate/interleukin-2 to become cytotoxic effectors for antibody-dependent cellular cytotoxicity. | 2012 | Cytotherapy | pmid:22029653 |
| Larsen L et al. | Expression and localization of microRNAs in perinatal rat pancreas: role of miR-21 in regulation of cholesterol metabolism. | 2011 | PLoS ONE | pmid:22022489 |
| Wang H et al. | Indirect stimulation of human Vγ2Vδ2 T cells through alterations in isoprenoid metabolism. | 2011 | J. Immunol. | pmid:22013129 |
| Modi ND and Lentzsch S | Bisphosphonates as antimyeloma drugs. | 2012 | Leukemia | pmid:22005788 |
| Rogers TL and Holen I | Tumour macrophages as potential targets of bisphosphonates. | 2011 | J Transl Med | pmid:22005011 |
| Schmidt A et al. | Induction of isoprenyl diphosphate synthases, plant hormones and defense signalling genes correlates with traumatic resin duct formation in Norway spruce (Picea abies). | 2011 | Plant Mol. Biol. | pmid:22002747 |
| Fowler DW et al. | Mycobacteria activate γδ T-cell anti-tumour responses via cytokines from type 1 myeloid dendritic cells: a mechanism of action for cancer immunotherapy. | 2012 | Cancer Immunol. Immunother. | pmid:22002242 |
| Targett-Adams P et al. | Lipid metabolism and HCV infection. | 2010 | Viruses | pmid:21994676 |
| Fu X et al. | Plastid structure and carotenogenic gene expression in red- and white-fleshed loquat (Eriobotrya japonica) fruits. | 2012 | J. Exp. Bot. | pmid:21994170 |
| Teng KH and Liang PH | Structures, mechanisms and inhibitors of undecaprenyl diphosphate synthase: a cis-prenyltransferase for bacterial peptidoglycan biosynthesis. | 2012 | Bioorg. Chem. | pmid:21993493 |
| Richardson PG et al. | The Medical Research Council Myeloma IX trial: the impact on treatment paradigms. | 2012 | Eur. J. Haematol. | pmid:21991938 |
| Xiao Y et al. | Study of IspH, a key enzyme in the methylerythritol phosphate pathway using fluoro-substituted substrate analogues. | 2011 | Org. Lett. | pmid:21981393 |
| Srivastava NK and Srivastava AK | Influence of Some Heavy Metals on Growth, Alkaloid Content and Composition in Catharanthus roseus L. | 2010 | Indian J Pharm Sci | pmid:21969751 |
| Peralta-Yahya PP et al. | Identification and microbial production of a terpene-based advanced biofuel. | 2011 | Nat Commun | pmid:21952217 |
| Zheng Q et al. | Diverse arrangement of photosynthetic gene clusters in aerobic anoxygenic phototrophic bacteria. | 2011 | PLoS ONE | pmid:21949847 |
| Kondo M et al. | Expansion of human peripheral blood γδ T cells using zoledronate. | 2011 | J Vis Exp | pmid:21931292 |
| Bergman P et al. | Studies on the antibacterial effects of statins--in vitro and in vivo. | 2011 | PLoS ONE | pmid:21912631 |
| Yeh E and DeRisi JL | Chemical rescue of malaria parasites lacking an apicoplast defines organelle function in blood-stage Plasmodium falciparum. | 2011 | PLoS Biol. | pmid:21912516 |
| Nair SC and Striepen B | What do human parasites do with a chloroplast anyway? | 2011 | PLoS Biol. | pmid:21912515 |
| Nes WD | Biosynthesis of cholesterol and other sterols. | 2011 | Chem. Rev. | pmid:21902244 |
| Thabet I et al. | The subcellular localization of periwinkle farnesyl diphosphate synthase provides insight into the role of peroxisome in isoprenoid biosynthesis. | 2011 | J. Plant Physiol. | pmid:21872968 |
| Battilana J et al. | Functional effect of grapevine 1-deoxy-D-xylulose 5-phosphate synthase substitution K284N on Muscat flavour formation. | 2011 | J. Exp. Bot. | pmid:21868399 |
| pmid:21866161 | ||||
| pmid:21850432 |