Isopentenyl pyrophosphate

Isopentenyl pyrophosphate is a lipid of Prenol Lipids (PR) class. Isopentenyl pyrophosphate is associated with abnormalities such as Tuberculosis, NAVAJO NEUROHEPATOPATHY and Cryptosporidiosis. The involved functions are known as Signal, Anabolism, T-Cell Activation, T-Cell Proliferation and isoprenoid biosynthetic process. Isopentenyl pyrophosphate often locates in Protoplasm, Host Cell, soluble, Plastids and Cell surface. The associated genes with Isopentenyl pyrophosphate are oxytocin, 1-desamino-(O-Et-Tyr)(2)-, HLA-E gene, RAP1A gene, Gene Family and Orthologous Gene. The related lipids are Steroids, Sterols and isopentenol.

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Introduction

To understand associated biological information of Isopentenyl pyrophosphate, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Isopentenyl pyrophosphate?

Isopentenyl pyrophosphate is suspected in Tuberculosis, NAVAJO NEUROHEPATOPATHY, Cryptosporidiosis and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Isopentenyl pyrophosphate

MeSH term MeSH ID Detail
Melanoma D008545 69 associated lipids
Total 1

PubChem Associated disorders and diseases

What pathways are associated with Isopentenyl pyrophosphate

Lipid pathways are not clear in current pathway databases. We organized associated pathways with Isopentenyl pyrophosphate through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
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PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Isopentenyl pyrophosphate?

Related references are published most in these journals:

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What functions are associated with Isopentenyl pyrophosphate?


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Function Cross reference Weighted score Related literatures

What lipids are associated with Isopentenyl pyrophosphate?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Isopentenyl pyrophosphate?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Isopentenyl pyrophosphate?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Isopentenyl pyrophosphate

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Authors Title Published Journal PubMed Link
Charon L et al. Deuterium-labelled isotopomers of 2-C-methyl-D-erythritol as tools for the elucidation of the 2-C-methyl-D-erythritol 4-phosphate pathway for isoprenoid biosynthesis. 2000 Biochem. J. pmid:10698701
Disch A et al. Distribution of the mevalonate and glyceraldehyde phosphate/pyruvate pathways for isoprenoid biosynthesis in unicellular algae and the cyanobacterium Synechocystis PCC 6714. 1998 Biochem. J. pmid:9657979
Tonhosolo R et al. Identification, molecular cloning and functional characterization of an octaprenyl pyrophosphate synthase in intra-erythrocytic stages of Plasmodium falciparum. 2005 Biochem. J. pmid:15984931
Zhou D and White RH Early steps of isoprenoid biosynthesis in Escherichia coli. 1991 Biochem. J. pmid:1996960
Ding VD et al. Purification and characterization of recombinant human farnesyl diphosphate synthase expressed in Escherichia coli. 1991 Biochem. J. pmid:2018485
Nave JF et al. Mechanism of the inhibition of cholesterol biosynthesis by 6-fluoromevalonate. 1985 Biochem. J. pmid:2986604
Hirooka K et al. Cloning and kinetic characterization of Arabidopsis thaliana solanesyl diphosphate synthase. 2003 Biochem. J. pmid:12437513
Skilleter DN and Kekwick RG The enzymes forming isopentenyl pyrophosphate from 5-phosphomevalonate (mevalonate 5-phosphate) in the latex of Hevea brasiliensis. 1971 Biochem. J. pmid:4333851
Disch A et al. Mevalonate-derived isopentenyl diphosphate is the biosynthetic precursor of ubiquinone prenyl side chain in tobacco BY-2 cells. 1998 Biochem. J. pmid:9531505
Hoeffler JF et al. Isoprenoid biosynthesis in higher plants and in Escherichia coli: on the branching in the methylerythritol phosphate pathway and the independent biosynthesis of isopentenyl diphosphate and dimethylallyl diphosphate. 2002 Biochem. J. pmid:12010124
Sillero MA et al. Synthesis of ATP derivatives of compounds of the mevalonate pathway (isopentenyl di- and triphosphate; geranyl di- and triphosphate, farnesyl di- and triphosphate, and dimethylallyl diphosphate) catalyzed by T4 RNA ligase, T4 DNA ligase and other ligases Potential relationship with the effect of bisphosphonates on osteoclasts. 2009 Biochem. Pharmacol. pmid:19414000
Räikkönen J et al. Mevalonate pathway intermediates downregulate zoledronic acid-induced isopentenyl pyrophosphate and ATP analog formation in human breast cancer cells. 2010 Biochem. Pharmacol. pmid:19819230
Rohdich F et al. Isoprenoid biosynthetic pathways as anti-infective drug targets. 2005 Biochem. Soc. Trans. pmid:16042599
Lichtenthaler HK Non-mevalonate isoprenoid biosynthesis: enzymes, genes and inhibitors. 2000 Biochem. Soc. Trans. pmid:11171208
Mabanglo MF et al. The Streptomyces-produced antibiotic fosfomycin is a promiscuous substrate for archaeal isopentenyl phosphate kinase. 2012 Biochemistry pmid:22148590
Sharma NK et al. Type II isopentenyl diphosphate isomerase: probing the mechanism with alkyne/allene diphosphate substrate analogues. 2010 Biochemistry pmid:20560533
Xu W et al. A closer look at the spectroscopic properties of possible reaction intermediates in wild-type and mutant (E)-4-hydroxy-3-methylbut-2-enyl diphosphate reductase. 2012 Biochemistry pmid:22646150
Pan JJ et al. Effect of site-directed mutagenesis of the conserved aspartate and glutamate on E. coli undecaprenyl pyrophosphate synthase catalysis. 2000 Biochemistry pmid:11076526
Stanley Fernandez SM et al. Farnesyl diphosphate synthase. Altering the catalytic site to select for geranyl diphosphate activity. 2000 Biochemistry pmid:11112517
Kloer DP et al. Structure and reaction geometry of geranylgeranyl diphosphate synthase from Sinapis alba. 2006 Biochemistry pmid:17176041
Pan JJ et al. Product distribution and pre-steady-state kinetic analysis of Escherichia coli undecaprenyl pyrophosphate synthase reaction. 2000 Biochemistry pmid:10978182
de Ruyck J et al. Crystal structure of type 2 isopentenyl diphosphate isomerase from Thermus thermophilus in complex with inorganic pyrophosphate. 2008 Biochemistry pmid:18693754
Koyama T et al. Intersubunit location of the active site of farnesyl diphosphate synthase: reconstruction of active enzymes by hybrid-type heteromeric dimers of site-directed mutants. 2000 Biochemistry pmid:10631008
Lafitte D et al. DNA gyrase interaction with coumarin-based inhibitors: the role of the hydroxybenzoate isopentenyl moiety and the 5'-methyl group of the noviose. 2002 Biochemistry pmid:12044152
Lee LV et al. Biophysical investigation of the mode of inhibition of tetramic acids, the allosteric inhibitors of undecaprenyl pyrophosphate synthase. 2010 Biochemistry pmid:20476728
Ito M et al. Stereochemical analysis of prenyltransferase reactions leading to (Z)- and (E)-polyprenyl chains. 1987 Biochemistry pmid:3117106
Reardon JE and Abeles RH Inhibition of cholesterol biosynthesis by fluorinated mevalonate analogues. 1987 Biochemistry pmid:3663621
Muehlbacher M and Poulter CD Isopentenyl-diphosphate isomerase: inactivation of the enzyme with active-site-directed irreversible inhibitors and transition-state analogues. 1988 Biochemistry pmid:3207678
Chang SY et al. Identification of the active conformation and the importance of length of the flexible loop 72-83 in regulating the conformational change of undecaprenyl pyrophosphate synthase. 2003 Biochemistry pmid:14661956
Reardon JE and Abeles RH Mechanism of action of isopentenyl pyrophosphate isomerase: evidence for a carbonium ion intermediate. 1986 Biochemistry pmid:3022798
Poulter CD and Rilling HC Prenyltransferase: the mechanism of the reaction. 1976 Biochemistry pmid:175829
Reed BC and Rilling HC Substrate Binding of avian liver prenyltransferase. 1976 Biochemistry pmid:182217
Nishino T and Rudney H Effects of detergents on the properties of 4-hydroxybenzoate. Polyprenyl transferase and the specificity of the polyprenyl pyrophosphate synthetic system in mitochondria. 1977 Biochemistry pmid:836803
Poulter CD and Satterwhite DM Mechanism of the prenyl-transfer reaction. Studies with (E)- and (Z)-3-trifluoromethyl-2-buten-1-yl pyrophosphate. 1977 Biochemistry pmid:562673
Chen M and Poulter CD Characterization of thermophilic archaeal isopentenyl phosphate kinases. 2010 Biochemistry pmid:19928876
Reed BC and Rilling HC Crystallization and partial characterization of prenyltransferase from avian liver. 1975 Biochemistry pmid:1109590
Brems DN and Rilling HC Photoaffinity labeling of the catalytic site of prenyltransferase. 1979 Biochemistry pmid:84684
Rothman SC et al. Kinetic and spectroscopic characterization of type II isopentenyl diphosphate isomerase from Thermus thermophilus: evidence for formation of substrate-induced flavin species. 2007 Biochemistry pmid:17428035
Laskovics FM and Poulter CD Prenyltransferase; determination of the binding mechanism and individual kinetic constants for farnesylpyrophosphate synthetase by rapid quench and isotope partitioning experiments. 1981 Biochemistry pmid:7013805
Thibodeaux CJ et al. Evidence for the involvement of acid/base chemistry in the reaction catalyzed by the type II isopentenyl diphosphate/dimethylallyl diphosphate isomerase from Staphylococcus aureus. 2008 Biochemistry pmid:18229948
Theivagt AE et al. Characterization of an HMG-CoA reductase from Listeria monocytogenes that exhibits dual coenzyme specificity. 2006 Biochemistry pmid:17128979
Barta ML et al. Structural basis for nucleotide binding and reaction catalysis in mevalonate diphosphate decarboxylase. 2012 Biochemistry pmid:22734632
Zhang YW et al. Chain length determination of prenyltransferases: both heteromeric subunits of medium-chain (E)-prenyl diphosphate synthase are involved in the product chain length determination. 2000 Biochemistry pmid:11027152
Ladygin VG Biosynthesis of carotenoids in plastids of plants. 2000 Biochemistry Mosc. pmid:11092953
Paseshnichenko VA A new alternative non-mevalonate pathway for isoprenoid biosynthesis in eubacteria and plants. 1998 Biochemistry Mosc. pmid:9526105
Bentinger M et al. Effects of various squalene epoxides on coenzyme Q and cholesterol synthesis. 2014 Biochim. Biophys. Acta pmid:24747199
Sagami H et al. The biosynthesis of dehydrodolichyl phosphates by rat liver microsomes. 1989 Biochim. Biophys. Acta pmid:2930770
Lee CS and O'Sullivan WJ Improved procedures for the synthesis of phosphomevalonate and for the assay and purification of pig liver phosphomevalonate kinase. 1985 Biochim. Biophys. Acta pmid:2983770
Block MA et al. Site of synthesis of geranylgeraniol derivatives in intact spinach chloroplasts. 1980 Biochim. Biophys. Acta pmid:6249390
Hutson KG and Threlfall DR Synthesis of plastoquinone-9 and phytylplastoquinone from homogentisate in lettuce chloroplasts. 1980 Biochim. Biophys. Acta pmid:7002223