Isopentenyl pyrophosphate

Isopentenyl pyrophosphate is a lipid of Prenol Lipids (PR) class. Isopentenyl pyrophosphate is associated with abnormalities such as Tuberculosis, NAVAJO NEUROHEPATOPATHY and Cryptosporidiosis. The involved functions are known as Signal, Anabolism, T-Cell Activation, T-Cell Proliferation and isoprenoid biosynthetic process. Isopentenyl pyrophosphate often locates in Protoplasm, Host Cell, soluble, Plastids and Cell surface. The associated genes with Isopentenyl pyrophosphate are oxytocin, 1-desamino-(O-Et-Tyr)(2)-, HLA-E gene, RAP1A gene, Gene Family and Orthologous Gene. The related lipids are Steroids, Sterols and isopentenol.

Cross Reference

Introduction

To understand associated biological information of Isopentenyl pyrophosphate, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Isopentenyl pyrophosphate?

Isopentenyl pyrophosphate is suspected in Tuberculosis, NAVAJO NEUROHEPATOPATHY, Cryptosporidiosis and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Isopentenyl pyrophosphate

MeSH term MeSH ID Detail
Melanoma D008545 69 associated lipids
Total 1

PubChem Associated disorders and diseases

What pathways are associated with Isopentenyl pyrophosphate

Lipid pathways are not clear in current pathway databases. We organized associated pathways with Isopentenyl pyrophosphate through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
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PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Isopentenyl pyrophosphate?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Isopentenyl pyrophosphate?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Isopentenyl pyrophosphate?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Isopentenyl pyrophosphate?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Isopentenyl pyrophosphate?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Isopentenyl pyrophosphate

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Authors Title Published Journal PubMed Link
Quinzii CM et al. Effects of inhibiting CoQ10 biosynthesis with 4-nitrobenzoate in human fibroblasts. 2012 PLoS ONE pmid:22359546
Baumeister S et al. Fosmidomycin uptake into Plasmodium and Babesia-infected erythrocytes is facilitated by parasite-induced new permeability pathways. 2011 PLoS ONE pmid:21573242
Rubio-Aliaga I et al. Dll1 haploinsufficiency in adult mice leads to a complex phenotype affecting metabolic and immunological processes. 2009 PLoS ONE pmid:19562077
Banerjee A et al. Engineering of Recombinant Poplar Deoxy-D-Xylulose-5-Phosphate Synthase (PtDXS) by Site-Directed Mutagenesis Improves Its Activity. 2016 PLoS ONE pmid:27548482
Odom AR Five questions about non-mevalonate isoprenoid biosynthesis. 2011 PLoS Pathog. pmid:22216001
Yao S et al. Differentiation, distribution and gammadelta T cell-driven regulation of IL-22-producing T cells in tuberculosis. 2010 PLoS Pathog. pmid:20195465
Gold MC et al. Human innate Mycobacterium tuberculosis-reactive alphabetaTCR+ thymocytes. 2008 PLoS Pathog. pmid:18282101
Diamond DL et al. Temporal proteome and lipidome profiles reveal hepatitis C virus-associated reprogramming of hepatocellular metabolism and bioenergetics. 2010 PLoS Pathog. pmid:20062526
Davey MS et al. Human neutrophil clearance of bacterial pathogens triggers anti-microbial γδ T cell responses in early infection. 2011 PLoS Pathog. pmid:21589907
Eberl M et al. A rapid crosstalk of human gammadelta T cells and monocytes drives the acute inflammation in bacterial infections. 2009 PLoS Pathog. pmid:19229322
Goto T et al. Various Terpenoids Derived from Herbal and Dietary Plants Function as PPAR Modulators and Regulate Carbohydrate and Lipid Metabolism. 2010 PPAR Res pmid:20613991
Kuzuyama T and Seto H Two distinct pathways for essential metabolic precursors for isoprenoid biosynthesis. 2012 Proc. Jpn. Acad., Ser. B, Phys. Biol. Sci. pmid:22450534
Laule O et al. Crosstalk between cytosolic and plastidial pathways of isoprenoid biosynthesis in Arabidopsis thaliana. 2003 Proc. Natl. Acad. Sci. U.S.A. pmid:12748386
Lange BM and Croteau R Isopentenyl diphosphate biosynthesis via a mevalonate-independent pathway: isopentenyl monophosphate kinase catalyzes the terminal enzymatic step. 1999 Proc. Natl. Acad. Sci. U.S.A. pmid:10570138
Lange BM et al. Isoprenoid biosynthesis: the evolution of two ancient and distinct pathways across genomes. 2000 Proc. Natl. Acad. Sci. U.S.A. pmid:11078528
Henry LK et al. Orthologs of the archaeal isopentenyl phosphate kinase regulate terpenoid production in plants. 2015 Proc. Natl. Acad. Sci. U.S.A. pmid:26216978
Garg A et al. Targeting protein translation, RNA splicing, and degradation by morpholino-based conjugates in Plasmodium falciparum. 2015 Proc. Natl. Acad. Sci. U.S.A. pmid:26351679
Sun Z et al. Differential expression of two isopentenyl pyrophosphate isomerases and enhanced carotenoid accumulation in a unicellular chlorophyte. 1998 Proc. Natl. Acad. Sci. U.S.A. pmid:9736763
Takahashi S et al. A 1-deoxy-D-xylulose 5-phosphate reductoisomerase catalyzing the formation of 2-C-methyl-D-erythritol 4-phosphate in an alternative nonmevalonate pathway for terpenoid biosynthesis. 1998 Proc. Natl. Acad. Sci. U.S.A. pmid:9707569
Catusse J et al. Proteome-wide characterization of sugarbeet seed vigor and its tissue specific expression. 2008 Proc. Natl. Acad. Sci. U.S.A. pmid:18635686