Isopentenyl pyrophosphate

Isopentenyl pyrophosphate is a lipid of Prenol Lipids (PR) class. Isopentenyl pyrophosphate is associated with abnormalities such as Tuberculosis, NAVAJO NEUROHEPATOPATHY and Cryptosporidiosis. The involved functions are known as Signal, Anabolism, T-Cell Activation, T-Cell Proliferation and isoprenoid biosynthetic process. Isopentenyl pyrophosphate often locates in Protoplasm, Host Cell, soluble, Plastids and Cell surface. The associated genes with Isopentenyl pyrophosphate are oxytocin, 1-desamino-(O-Et-Tyr)(2)-, HLA-E gene, RAP1A gene, Gene Family and Orthologous Gene. The related lipids are Steroids, Sterols and isopentenol.

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Introduction

To understand associated biological information of Isopentenyl pyrophosphate, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Isopentenyl pyrophosphate?

Isopentenyl pyrophosphate is suspected in Tuberculosis, NAVAJO NEUROHEPATOPATHY, Cryptosporidiosis and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Isopentenyl pyrophosphate

MeSH term MeSH ID Detail
Melanoma D008545 69 associated lipids
Total 1

PubChem Associated disorders and diseases

What pathways are associated with Isopentenyl pyrophosphate

Lipid pathways are not clear in current pathway databases. We organized associated pathways with Isopentenyl pyrophosphate through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
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PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Isopentenyl pyrophosphate?

Related references are published most in these journals:

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What functions are associated with Isopentenyl pyrophosphate?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Isopentenyl pyrophosphate?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Isopentenyl pyrophosphate?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Isopentenyl pyrophosphate?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Isopentenyl pyrophosphate

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Authors Title Published Journal PubMed Link
Vance DE and Van den Bosch H Cholesterol in the year 2000. 2000 Biochim. Biophys. Acta pmid:11111073
Olivier LM and Krisans SK Peroxisomal protein targeting and identification of peroxisomal targeting signals in cholesterol biosynthetic enzymes. 2000 Biochim. Biophys. Acta pmid:11111079
Stanley Fernandez SM et al. Farnesyl diphosphate synthase. Altering the catalytic site to select for geranyl diphosphate activity. 2000 Biochemistry pmid:11112517
Cunillera N et al. Spatial and temporal patterns of GUS expression directed by 5' regions of the Arabidopsis thaliana farnesyl diphosphate synthase genes FPS1 and FPS2. 2000 Plant Mol. Biol. pmid:11202437
Lange BM and Croteau R Isopentenyl diphosphate biosynthesis via a mevalonate-independent pathway: isopentenyl monophosphate kinase catalyzes the terminal enzymatic step. 1999 Proc. Natl. Acad. Sci. U.S.A. pmid:10570138
Leyes AE and Poulter CD Synthesis of (R)-[2-2H]isopentenyl diphosphate and determination of its enantiopurity by 2H NMR spectroscopy in a lyotropic medium. 1999 Org. Lett. pmid:10825959
Morita CT et al. Recognition of nonpeptide prenyl pyrophosphate antigens by human gammadelta T cells. 1999 Microbes Infect. pmid:10801228
Lange BM and Croteau R Isoprenoid biosynthesis via a mevalonate-independent pathway in plants: cloning and heterologous expression of 1-deoxy-D-xylulose-5-phosphate reductoisomerase from peppermint. 1999 Arch. Biochem. Biophys. pmid:10222052
Jomaa H et al. Vgamma9/Vdelta2 T cell activation induced by bacterial low molecular mass compounds depends on the 1-deoxy-D-xylulose 5-phosphate pathway of isoprenoid biosynthesis. 1999 FEMS Immunol. Med. Microbiol. pmid:10497868
Ridley RG Planting the seeds of new antimalarial drugs. 1999 Science pmid:10498534
Jomaa H et al. Inhibitors of the nonmevalonate pathway of isoprenoid biosynthesis as antimalarial drugs. 1999 Science pmid:10477522
Poccia F et al. Phosphoantigen-reactive Vgamma9Vdelta2 T lymphocytes suppress in vitro human immunodeficiency virus type 1 replication by cell-released antiviral factors including CC chemokines. 1999 J. Infect. Dis. pmid:10438380
Poccia F et al. In vivo gammadelta T cell priming to mycobacterial antigens by primary Mycobacterium tuberculosis infection and exposure to nonpeptidic ligands. 1999 Mol. Med. pmid:10449808
Keller RK and Fliesler SJ Mechanism of aminobisphosphonate action: characterization of alendronate inhibition of the isoprenoid pathway. 1999 Biochem. Biophys. Res. Commun. pmid:10600541
Disch A et al. Distribution of the mevalonate and glyceraldehyde phosphate/pyruvate pathways for isoprenoid biosynthesis in unicellular algae and the cyanobacterium Synechocystis PCC 6714. 1998 Biochem. J. pmid:9657979
Lange BM et al. A family of transketolases that directs isoprenoid biosynthesis via a mevalonate-independent pathway. 1998 Proc. Natl. Acad. Sci. U.S.A. pmid:9482845
Paseshnichenko VA A new alternative non-mevalonate pathway for isoprenoid biosynthesis in eubacteria and plants. 1998 Biochemistry Mosc. pmid:9526105
Disch A et al. Mevalonate-derived isopentenyl diphosphate is the biosynthetic precursor of ubiquinone prenyl side chain in tobacco BY-2 cells. 1998 Biochem. J. pmid:9531505
Schoel B and Kaufmann SH Influence of mycobacterial virulence and culture condition on gamma delta T cell activation. 1998 Microb. Pathog. pmid:9514640
Nagaki M et al. Substrate specificity of thermostable farnesyl diphosphate synthase with alkyl group homologs of isopentenyl diphosphate. 1998 Bioorg. Med. Chem. Lett. pmid:9873578
Sun Z et al. Differential expression of two isopentenyl pyrophosphate isomerases and enhanced carotenoid accumulation in a unicellular chlorophyte. 1998 Proc. Natl. Acad. Sci. U.S.A. pmid:9736763
Contin A et al. The iridoid glucoside secologanin is derived from the novel triose phosphate/pyruvate pathway in a Catharanthus roseus cell culture. 1998 FEBS Lett. pmid:9742965
Rohmer M Isoprenoid biosynthesis via the mevalonate-independent route, a novel target for antibacterial drugs? 1998 Prog Drug Res pmid:9670778
Takahashi S et al. A 1-deoxy-D-xylulose 5-phosphate reductoisomerase catalyzing the formation of 2-C-methyl-D-erythritol 4-phosphate in an alternative nonmevalonate pathway for terpenoid biosynthesis. 1998 Proc. Natl. Acad. Sci. U.S.A. pmid:9707569
Bouvier F et al. Dedicated roles of plastid transketolases during the early onset of isoprenoid biogenesis in pepper fruits1. 1998 Plant Physiol. pmid:9701598
Terano T et al. Geranylgeranylpyrophosphate plays a key role for the G1 to S transition in vascular smooth muscle cells. 1998 J. Atheroscler. Thromb. pmid:10077451
Disch A and Rohmer M On the absence of the glyceraldehyde 3-phosphate/pyruvate pathway for isoprenoid biosynthesis in fungi and yeasts. 1998 FEMS Microbiol. Lett. pmid:9835029
Seto H [Non-mevalonate pathway. A new pathway for the biosynthesis of isopentenyl diphosphate]. 1997 Tanpakushitsu Kakusan Koso pmid:9404155
Hinson DD et al. Post-translational regulation of mevalonate kinase by intermediates of the cholesterol and nonsterol isoprene biosynthetic pathways. 1997 J. Lipid Res. pmid:9392419
García VE et al. Single-cell cytokine analysis of gamma delta T cell responses to nonpeptide mycobacterial antigens. 1997 J. Immunol. pmid:9233629
Wesch D et al. Comparative analysis of alpha beta and gamma delta T cell activation by Mycobacterium tuberculosis and isopentenyl pyrophosphate. 1997 Eur. J. Immunol. pmid:9130649
Lichtenthaler HK et al. Biosynthesis of isoprenoids in higher plant chloroplasts proceeds via a mevalonate-independent pathway. 1997 FEBS Lett. pmid:9009212
Bürk MR et al. Functional inactivation in the whole population of human V gamma 9/V delta 2 T lymphocytes induced by a nonpeptidic antagonist. 1997 J. Exp. Med. pmid:8996245
Schwender J et al. Incorporation of 1-deoxy-D-xylulose into isoprene and phytol by higher plants and algae. 1997 FEBS Lett. pmid:9305746
Ohnuma S et al. Effects of random mutagenesis in a putative substrate-binding domain of geranylgeranyl diphosphate synthase upon intermediate formation and substrate specificity. 1997 J. Biochem. pmid:9163520
Sireci G et al. Patterns of phosphoantigen stimulation of human Vgamma9/Vdelta2 T cell clones include Th0 cytokines. 1997 Hum. Immunol. pmid:9475336
Srinivasan V et al. Metabolic inhibitors, elicitors, and precursors as tools for probing yield limitation in taxane production by Taxus chinensis cell cultures. 1996 Jul-Aug Biotechnol. Prog. pmid:8987474
Keller RK Squalene synthase inhibition alters metabolism of nonsterols in rat liver. 1996 Biochim. Biophys. Acta pmid:8908150
Hahn FM et al. Human isopentenyl diphosphate: dimethylallyl diphosphate isomerase: overproduction, purification, and characterization. 1996 Arch. Biochem. Biophys. pmid:8806705
Sagami H et al. Enzymatic formation of dehydrodolichal and dolichal, new products related to yeast dolichol biosynthesis. 1996 J. Biol. Chem. pmid:8621629
Zhang XD et al. Expression of the isopentenyl transferase gene is regulated by auxin in transgenic tobacco tissues. 1996 Transgenic Res. pmid:8589740
Morita CT et al. Direct presentation of non-peptide prenyl pyrophosphate antigens to human gamma delta T cells. 1996 Res. Immunol. pmid:8876064
Re EB et al. Co-expression of native and introduced genes reveals cryptic regulation of HMG CoA reductase expression in Arabidopsis. 1995 Plant J. pmid:7773308
Tanaka Y et al. Natural and synthetic non-peptide antigens recognized by human gamma delta T cells. 1995 Nature pmid:7753173
Runquist M et al. Isoprenoid biosynthesis in rat liver mitochondria. Studies on farnesyl pyrophosphate synthase and trans-prenyltransferase. 1994 J. Biol. Chem. pmid:8119922
Christensen DJ and Poulter CD Enzymatic synthesis of isotopically labeled isoprenoid diphosphates. 1994 Bioorg. Med. Chem. pmid:7858969
Giron MD et al. Isopentenoid synthesis in eukaryotic cells. An initiating role for post-translational control of 3-hydroxy-3-methylglutaryl coenzyme A reductase. 1993 Arch. Biochem. Biophys. pmid:8097083
Sahm H et al. Biochemistry and physiology of hopanoids in bacteria. 1993 Adv. Microb. Physiol. pmid:8310881
Sagami H et al. Biosynthesis of prenyl diphosphates by cell-free extracts from mammalian tissues. 1993 J. Biochem. pmid:8407862
Sagami H et al. Geranylgeranyl diphosphate synthase catalyzing the single condensation between isopentenyl diphosphate and farnesyl diphosphate. 1993 J. Biochem. pmid:8407863