Isopentenyl pyrophosphate

Isopentenyl pyrophosphate is a lipid of Prenol Lipids (PR) class. Isopentenyl pyrophosphate is associated with abnormalities such as Tuberculosis, NAVAJO NEUROHEPATOPATHY and Cryptosporidiosis. The involved functions are known as Signal, Anabolism, T-Cell Activation, T-Cell Proliferation and isoprenoid biosynthetic process. Isopentenyl pyrophosphate often locates in Protoplasm, Host Cell, soluble, Plastids and Cell surface. The associated genes with Isopentenyl pyrophosphate are oxytocin, 1-desamino-(O-Et-Tyr)(2)-, HLA-E gene, RAP1A gene, Gene Family and Orthologous Gene. The related lipids are Steroids, Sterols and isopentenol.

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Introduction

To understand associated biological information of Isopentenyl pyrophosphate, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Isopentenyl pyrophosphate?

Isopentenyl pyrophosphate is suspected in Tuberculosis, NAVAJO NEUROHEPATOPATHY, Cryptosporidiosis and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Isopentenyl pyrophosphate

MeSH term MeSH ID Detail
Melanoma D008545 69 associated lipids
Total 1

PubChem Associated disorders and diseases

What pathways are associated with Isopentenyl pyrophosphate

Lipid pathways are not clear in current pathway databases. We organized associated pathways with Isopentenyl pyrophosphate through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
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PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Isopentenyl pyrophosphate?

Related references are published most in these journals:

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What functions are associated with Isopentenyl pyrophosphate?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Isopentenyl pyrophosphate?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Isopentenyl pyrophosphate?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Isopentenyl pyrophosphate?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Isopentenyl pyrophosphate

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Authors Title Published Journal PubMed Link
Towler MJ and Weathers PJ Evidence of artemisinin production from IPP stemming from both the mevalonate and the nonmevalonate pathways. 2007 Plant Cell Rep. pmid:17710406
Flores-Sánchez IJ et al. Biosynthesis of sterols and triterpenes in cell suspension cultures of Uncaria tomentosa. 2002 Plant Cell Physiol. pmid:12514247
Miyazawa Y et al. Amyloplast formation in cultured tobacco BY-2 cells requires a high cytokinin content. 2002 Plant Cell Physiol. pmid:12514251
Cunningham FX and Gantt E Identification of multi-gene families encoding isopentenyl diphosphate isomerase in plants by heterologous complementation in Escherichia coli. 2000 Plant Cell Physiol. pmid:10750717
Okada K et al. Genetic evidence for the role of isopentenyl diphosphate isomerases in the mevalonate pathway and plant development in Arabidopsis. 2008 Plant Cell Physiol. pmid:18303110
Orlova I et al. The small subunit of snapdragon geranyl diphosphate synthase modifies the chain length specificity of tobacco geranylgeranyl diphosphate synthase in planta. 2009 Plant Cell pmid:20028839
Chang TH et al. Structure of a heterotetrameric geranyl pyrophosphate synthase from mint (Mentha piperita) reveals intersubunit regulation. 2010 Plant Cell pmid:20139160
Sallaud C et al. A novel pathway for sesquiterpene biosynthesis from Z,Z-farnesyl pyrophosphate in the wild tomato Solanum habrochaites. 2009 Plant Cell pmid:19155349
Phillips MA et al. The Arabidopsis thaliana type I Isopentenyl Diphosphate Isomerases are targeted to multiple subcellular compartments and have overlapping functions in isoprenoid biosynthesis. 2008 Plant Cell pmid:18319397
Guevara-García A et al. Characterization of the Arabidopsis clb6 mutant illustrates the importance of posttranscriptional regulation of the methyl-D-erythritol 4-phosphate pathway. 2005 Plant Cell pmid:15659625
Enfissi EM et al. Metabolic engineering of the mevalonate and non-mevalonate isopentenyl diphosphate-forming pathways for the production of health-promoting isoprenoids in tomato. 2005 Plant Biotechnol. J. pmid:17168896
Flügge UI and Gao W Transport of isoprenoid intermediates across chloroplast envelope membranes. 2005 Plant Biol (Stuttg) pmid:15666208
Lopes AA et al. Biosynthetic origins of the isoprene units of gaudichaudianic acid in Piper gaudichaudianum (Piperaceae). 2007 Phytochemistry pmid:17574633
Schmidt A and Gershenzon J Cloning and characterization of two different types of geranyl diphosphate synthases from Norway spruce (Picea abies). 2008 Phytochemistry pmid:17673268
Carter OA et al. Monoterpene biosynthesis pathway construction in Escherichia coli. 2003 Phytochemistry pmid:12943759
Han YS et al. Biosynthesis of anthraquinones in cell cultures of Cinchona 'Robusta' proceeds via the methylerythritol 4-phosphate pathway. 2002 Phytochemistry pmid:11754943
Lim L and McFadden GI The evolution, metabolism and functions of the apicoplast. 2010 Philos. Trans. R. Soc. Lond., B, Biol. Sci. pmid:20124342
Maurice T et al. Neuro(active)steroids actions at the neuromodulatory sigma1 (sigma1) receptor: biochemical and physiological evidences, consequences in neuroprotection. 2006 Pharmacol. Biochem. Behav. pmid:16945406
Wen W and Yu R Artemisinin biosynthesis and its regulatory enzymes: Progress and perspective. 2011 Pharmacogn Rev pmid:22279377
Baikar S and Malpathak N Secondary metabolites as DNA topoisomerase inhibitors: A new era towards designing of anticancer drugs. 2010 Pharmacogn Rev pmid:22228937
Simonsen HT et al. Perspectives on using physcomitrella patens as an alternative production platform for thapsigargin and other terpenoid drug candidates. 2009 Perspect Medicin Chem pmid:19812738
Ueno A et al. Farsenyl pyrophosphate synthase is a potential molecular drug target of risedronate in Babesia bovis. 2013 Parasitol. Int. pmid:23276703
Bang S et al. Isopentenyl pyrophosphate is a novel antinociceptive substance that inhibits TRPV3 and TRPA1 ion channels. 2011 Pain pmid:21353389
Silverman SL et al. Effect of acetaminophen and fluvastatin on post-dose symptoms following infusion of zoledronic acid. 2011 Osteoporos Int pmid:21116816
Leyes AE and Poulter CD Synthesis of (R)-[2-2H]isopentenyl diphosphate and determination of its enantiopurity by 2H NMR spectroscopy in a lyotropic medium. 1999 Org. Lett. pmid:10825959
Barkley SJ et al. Proton exchange in type II isopentenyl diphosphate isomerase. 2004 Org. Lett. pmid:15606125
Xiao Y et al. Study of IspH, a key enzyme in the methylerythritol phosphate pathway using fluoro-substituted substrate analogues. 2011 Org. Lett. pmid:21981393
Kao CL et al. Stereochemical analysis of isopentenyl diphosphate isomerase type II from Staphylococcus aureus using chemically synthesized (S)- and (R)-[2-2H]isopentenyl diphosphates. 2005 Org. Lett. pmid:16321020
Scholte AA and Vederas JC Incorporation of deuterium-labelled analogs of isopentenyl diphosphate for the elucidation of the stereochemistry of rubber biosynthesis. 2006 Org. Biomol. Chem. pmid:16467948
Kumari U and Heese K Cardiovascular dementia - a different perspective. 2010 Open Biochem J pmid:20448820
Dong L et al. Monoterpene biosynthesis potential of plant subcellular compartments. 2016 New Phytol. pmid:26356766
Quinzii CM et al. Human coenzyme Q10 deficiency. 2007 Apr-May Neurochem. Res. pmid:17094036
Gilg AB et al. Unique animal prenyltransferase with monoterpene synthase activity. 2009 Naturwissenschaften pmid:19277597
Tanaka Y et al. Natural and synthetic non-peptide antigens recognized by human gamma delta T cells. 1995 Nature pmid:7753173
Ralph SA et al. Tropical infectious diseases: metabolic maps and functions of the Plasmodium falciparum apicoplast. 2004 Nat. Rev. Microbiol. pmid:15083156
Vavassori S et al. Butyrophilin 3A1 binds phosphorylated antigens and stimulates human γδ T cells. 2013 Nat. Immunol. pmid:23872678
Kuzuyama T and Seto H Diversity of the biosynthesis of the isoprene units. 2003 Nat Prod Rep pmid:12735695
Banerjee A and Sharkey TD Methylerythritol 4-phosphate (MEP) pathway metabolic regulation. 2014 Nat Prod Rep pmid:24921065
Ganjewala D and Luthra R Essential oil biosynthesis and regulation in the genus Cymbopogon. 2010 Nat Prod Commun pmid:20184044
Radakovits R et al. Draft genome sequence and genetic transformation of the oleaginous alga Nannochloropis gaditana. 2012 Nat Commun pmid:22353717
Chou HH and Keasling JD Programming adaptive control to evolve increased metabolite production. 2013 Nat Commun pmid:24131951
Peralta-Yahya PP et al. Identification and microbial production of a terpene-based advanced biofuel. 2011 Nat Commun pmid:21952217
Span I et al. Discovery of acetylene hydratase activity of the iron-sulphur protein IspH. 2012 Nat Commun pmid:22948824
Ling S et al. Genoprotective pathways. II. Attenuation of oxidative DNA damage by isopentenyl diphosphate. 2004 Mutat. Res. pmid:15450402
Zhang X et al. Functional Analysis of the Isopentenyl Diphosphate Isomerase of Salvia miltiorrhiza via Color Complementation and RNA Interference. 2015 Molecules pmid:26569204
Gajjar D et al. Quantification of dolichol in the human lens with different types of cataracts. 2009 Mol. Vis. pmid:19693292
Kim J et al. Three serendipitous pathways in E. coli can bypass a block in pyridoxal-5'-phosphate synthesis. 2010 Mol. Syst. Biol. pmid:21119630
Plata G et al. Reconstruction and flux-balance analysis of the Plasmodium falciparum metabolic network. 2010 Mol. Syst. Biol. pmid:20823846
Forster AC and Church GM Towards synthesis of a minimal cell. 2006 Mol. Syst. Biol. pmid:16924266
Haussig JM et al. Inactivation of a Plasmodium apicoplast protein attenuates formation of liver merozoites. 2011 Mol. Microbiol. pmid:21848587