Isopentenyl pyrophosphate

Isopentenyl pyrophosphate is a lipid of Prenol Lipids (PR) class. Isopentenyl pyrophosphate is associated with abnormalities such as Tuberculosis, NAVAJO NEUROHEPATOPATHY and Cryptosporidiosis. The involved functions are known as Signal, Anabolism, T-Cell Activation, T-Cell Proliferation and isoprenoid biosynthetic process. Isopentenyl pyrophosphate often locates in Protoplasm, Host Cell, soluble, Plastids and Cell surface. The associated genes with Isopentenyl pyrophosphate are oxytocin, 1-desamino-(O-Et-Tyr)(2)-, HLA-E gene, RAP1A gene, Gene Family and Orthologous Gene. The related lipids are Steroids, Sterols and isopentenol.

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Introduction

To understand associated biological information of Isopentenyl pyrophosphate, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Isopentenyl pyrophosphate?

Isopentenyl pyrophosphate is suspected in Tuberculosis, NAVAJO NEUROHEPATOPATHY, Cryptosporidiosis and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Isopentenyl pyrophosphate

MeSH term MeSH ID Detail
Melanoma D008545 69 associated lipids
Total 1

PubChem Associated disorders and diseases

What pathways are associated with Isopentenyl pyrophosphate

Lipid pathways are not clear in current pathway databases. We organized associated pathways with Isopentenyl pyrophosphate through full-text articles, including metabolic pathways or pathways of biological mechanisms.

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Pathway name Related literatures
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PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Isopentenyl pyrophosphate?

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What functions are associated with Isopentenyl pyrophosphate?


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Function Cross reference Weighted score Related literatures

What lipids are associated with Isopentenyl pyrophosphate?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Isopentenyl pyrophosphate?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Isopentenyl pyrophosphate?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Isopentenyl pyrophosphate

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Authors Title Published Journal PubMed Link
Tian L et al. Transcript and proteomic analysis of developing white lupin (Lupinus albus L.) roots. 2009 BMC Plant Biol. pmid:19123941
Kumar S et al. Comparative analysis of the complete sequence of the plastid genome of Parthenium argentatum and identification of DNA barcodes to differentiate Parthenium species and lines. 2009 BMC Plant Biol. pmid:19917140
Olofsson L et al. Relative expression of genes of terpene metabolism in different tissues of Artemisia annua L. 2011 BMC Plant Biol. pmid:21388533
Rodriguez-Medina C et al. Macromolecular composition of phloem exudate from white lupin (Lupinus albus L.). 2011 BMC Plant Biol. pmid:21342527
Emanuelli F et al. A candidate gene association study on muscat flavor in grapevine (Vitis vinifera L.). 2010 BMC Plant Biol. pmid:21062440
Luo H et al. Comparison of 454-ESTs from Huperzia serrata and Phlegmariurus carinatus reveals putative genes involved in lycopodium alkaloid biosynthesis and developmental regulation. 2010 BMC Plant Biol. pmid:20854695
Rotter A et al. Gene expression profiling in susceptible interaction of grapevine with its fungal pathogen Eutypa lata: extending MapMan ontology for grapevine. 2009 BMC Plant Biol. pmid:19656401
Dupont FM Metabolic pathways of the wheat (Triticum aestivum) endosperm amyloplast revealed by proteomics. 2008 BMC Plant Biol. pmid:18419817
Hsiao YY et al. Comparison of transcripts in Phalaenopsis bellina and Phalaenopsis equestris (Orchidaceae) flowers to deduce monoterpene biosynthesis pathway. 2006 BMC Plant Biol. pmid:16836766
Engprasert S et al. Molecular cloning and functional expression of geranylgeranyl pyrophosphate synthase from Coleus forskohlii Briq. 2004 BMC Plant Biol. pmid:15550168
Park J et al. Ternary complex structures of human farnesyl pyrophosphate synthase bound with a novel inhibitor and secondary ligands provide insights into the molecular details of the enzyme's active site closure. 2012 BMC Struct. Biol. pmid:23234314
Sgraja T et al. Structure, substrate recognition and reactivity of Leishmania major mevalonate kinase. 2007 BMC Struct. Biol. pmid:17397541
Buetow L et al. The structure of Mycobacteria 2C-methyl-D-erythritol-2,4-cyclodiphosphate synthase, an essential enzyme, provides a platform for drug discovery. 2007 BMC Struct. Biol. pmid:17956607
Kervizic G and Corcos L Dynamical modeling of the cholesterol regulatory pathway with Boolean networks. 2008 BMC Syst Biol pmid:19025648
Chung BK and Lee DY Flux-sum analysis: a metabolite-centric approach for understanding the metabolic network. 2009 BMC Syst Biol pmid:20021680
Huthmacher C et al. Antimalarial drug targets in Plasmodium falciparum predicted by stage-specific metabolic network analysis. 2010 BMC Syst Biol pmid:20807400
Meier S et al. A transcriptional analysis of carotenoid, chlorophyll and plastidial isoprenoid biosynthesis genes during development and osmotic stress responses in Arabidopsis thaliana. 2011 BMC Syst Biol pmid:21595952
Plaimas K et al. Identifying essential genes in bacterial metabolic networks with machine learning methods. 2010 BMC Syst Biol pmid:20438628
Mitrofan LM et al. The level of ATP analog and isopentenyl pyrophosphate correlates with zoledronic acid-induced apoptosis in cancer cells in vitro. 2009 Bone pmid:19699819
Riebeling C et al. The bisphosphonate pamidronate induces apoptosis in human melanoma cells in vitro. 2002 Br. J. Cancer pmid:12177810
Forsea AM et al. Nitrogen-containing bisphosphonates inhibit cell cycle progression in human melanoma cells. 2004 Br. J. Cancer pmid:15280922
Roelofs AJ et al. Peripheral blood monocytes are responsible for gammadelta T cell activation induced by zoledronic acid through accumulation of IPP/DMAPP. 2009 Br. J. Haematol. pmid:19016713
Räikkönen J et al. Zoledronic acid induces formation of a pro-apoptotic ATP analogue and isopentenyl pyrophosphate in osteoclasts in vivo and in MCF-7 cells in vitro. 2009 Br. J. Pharmacol. pmid:19371349
Bang S et al. Resolvin D1 attenuates activation of sensory transient receptor potential channels leading to multiple anti-nociception. 2010 Br. J. Pharmacol. pmid:20880407
Holen I and Coleman RE Anti-tumour activity of bisphosphonates in preclinical models of breast cancer. 2010 Breast Cancer Res. pmid:21176176
Klawitter J et al. Effects of lovastatin on breast cancer cells: a proteo-metabonomic study. 2010 Breast Cancer Res. pmid:20205716
Kushwaha SC et al. Enzymatic synthesis of C40 carotenes by cell-free preparation from Halobacterium cutirubrum. 1976 Can. J. Biochem. pmid:971465
Depasquale I and Wheatley DN Action of Lovastatin (Mevinolin) on an in vitro model of angiogenesis and its co-culture with malignant melanoma cell lines. 2006 Cancer Cell Int. pmid:16573823
Cabillic F et al. Aminobisphosphonate-pretreated dendritic cells trigger successful Vgamma9Vdelta2 T cell amplification for immunotherapy in advanced cancer patients. 2010 Cancer Immunol. Immunother. pmid:20582413
Fowler DW et al. Mycobacteria activate γδ T-cell anti-tumour responses via cytokines from type 1 myeloid dendritic cells: a mechanism of action for cancer immunotherapy. 2012 Cancer Immunol. Immunother. pmid:22002242
Hebbeler AM et al. Individual Vgamma2-Jgamma1.2+ T cells respond to both isopentenyl pyrophosphate and Daudi cell stimulation: generating tumor effectors with low molecular weight phosphoantigens. 2007 Cancer Immunol. Immunother. pmid:17131122
Benzaïd I et al. High phosphoantigen levels in bisphosphonate-treated human breast tumors promote Vgamma9Vdelta2 T-cell chemotaxis and cytotoxicity in vivo. 2011 Cancer Res. pmid:21646473
Idrees AS et al. Comparison of γδ T cell responses and farnesyl diphosphate synthase inhibition in tumor cells pretreated with zoledronic acid. 2013 Cancer Sci. pmid:23387443
Wang YD et al. Salicylic acid-induced taxol production and isopentenyl pyrophosphate biosynthesis in suspension cultures of Taxus chinensis var. mairei. 2007 Cell Biol. Int. pmid:17521928
Wesch D et al. Differentiation of resting human peripheral blood gamma delta T cells toward Th1- or Th2-phenotype. 2001 Cell. Immunol. pmid:11748927
Li J et al. Vγ9Vδ2-T lymphocytes have impaired antiviral function in small-for-gestational-age and preterm neonates. 2013 Cell. Mol. Immunol. pmid:23524656
Legut M et al. The promise of γδ T cells and the γδ T cell receptor for cancer immunotherapy. 2015 Cell. Mol. Immunol. pmid:25864915
Hu C et al. Antigen-presenting effects of effector memory Vγ9Vδ2 T cells in rheumatoid arthritis. 2012 Cell. Mol. Immunol. pmid:22139198
Vandermoten S et al. New insights into short-chain prenyltransferases: structural features, evolutionary history and potential for selective inhibition. 2009 Cell. Mol. Life Sci. pmid:19633972
Williams SL and Andrew McCammon J Conformational dynamics of the flexible catalytic loop in Mycobacterium tuberculosis 1-deoxy-D-xylulose 5-phosphate reductoisomerase. 2009 Chem Biol Drug Des pmid:19152632
Laupitz R et al. Stereochemical studies on the making and unmaking of isopentenyl diphosphate in different biological systems. 2004 Chem. Biodivers. pmid:17191914
Narayanasamy P et al. Synthesis of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate and kinetic studies of Mycobacterium tuberculosis IspF. 2010 Chem. Biol. pmid:20189102
Arens J et al. Exploration of biosynthetic access to the shared precursor of the fusicoccane diterpenoid family. 2013 Chem. Commun. (Camb.) pmid:23295536
Kojima N et al. Geranylgeranyl diphosphate synthases from Scoparia dulcis and Croton sublyratus. cDNA cloning, functional expression, and conversion to a farnesyl diphosphate synthase. 2000 Chem. Pharm. Bull. pmid:10923851
Sitthithaworn W et al. Geranylgeranyl diphosphate synthase from Scoparia dulcis and Croton sublyratus. Plastid localization and conversion to a farnesyl diphosphate synthase by mutagenesis. 2001 Chem. Pharm. Bull. pmid:11217109
Nes WD Biosynthesis of cholesterol and other sterols. 2011 Chem. Rev. pmid:21902244
Mahmud T et al. A biosynthetic pathway to isovaleryl-CoA in myxobacteria: the involvement of the mevalonate pathway. 2005 Chembiochem pmid:15619721
Neundorf I et al. Evidence for the combined participation of a C10 and a C15 precursor in the biosynthesis of moenocinol, the lipid part of the moenomycin antibiotics. 2003 Chembiochem pmid:14613112
Sunyecz J Optimizing dosing frequencies for bisphosphonates in the management of postmenopausal osteoporosis: patient considerations. 2008 Clin Interv Aging pmid:19281054
Benzaïd I et al. In vivo phosphoantigen levels in bisphosphonate-treated human breast tumors trigger Vγ9Vδ2 T-cell antitumor cytotoxicity through ICAM-1 engagement. 2012 Clin. Cancer Res. pmid:23032740
Alexander AA et al. Isopentenyl pyrophosphate-activated CD56+ {gamma}{delta} T lymphocytes display potent antitumor activity toward human squamous cell carcinoma. 2008 Clin. Cancer Res. pmid:18594005
Urban EM et al. Repertoire development and the control of cytotoxic/effector function in human gammadelta T cells. 2010 Clin. Dev. Immunol. pmid:20396597
Meraviglia S et al. γδ T cells cross-link innate and adaptive immunity in Mycobacterium tuberculosis infection. 2011 Clin. Dev. Immunol. pmid:21253470
Meraviglia S et al. In vivo manipulation of Vgamma9Vdelta2 T cells with zoledronate and low-dose interleukin-2 for immunotherapy of advanced breast cancer patients. 2010 Clin. Exp. Immunol. pmid:20491785
Schneiders FL et al. Activated iNKT cells promote Vγ9Vδ2-T cell anti-tumor effector functions through the production of TNF-α. 2012 Clin. Immunol. pmid:22122798
Gunawardana D et al. A comprehensive bioinformatics analysis of the Nudix superfamily in Arabidopsis thaliana. 2009 Comp. Funct. Genomics pmid:19590748
Ganjewala D et al. An account of cloned genes of Methyl-erythritol-4-phosphate pathway of isoprenoid biosynthesis in plants. 2009 Curr Issues Mol Biol pmid:19193963
Chang WC et al. Current development in isoprenoid precursor biosynthesis and regulation. 2013 Curr Opin Chem Biol pmid:23891475
Rohdich F et al. The non-mevalonate pathway of isoprenoids: genes, enzymes and intermediates. 2001 Curr Opin Chem Biol pmid:11578926
Hunter WN Isoprenoid precursor biosynthesis offers potential targets for drug discovery against diseases caused by apicomplexan parasites. 2011 Curr Top Med Chem pmid:21619509
Schirra F et al. Androgen influence on cholesterogenic enzyme mRNA levels in the mouse meibomian gland. 2007 Curr. Eye Res. pmid:17514523
Mosqueda J et al. Current advances in detection and treatment of babesiosis. 2012 Curr. Med. Chem. pmid:22360483
Ohno K et al. Computational insights into binding of bisphosphates to farnesyl pyrophosphate synthase. 2011 Curr. Med. Chem. pmid:21110804
de Ruyck J and Wouters J Structure-based drug design targeting biosynthesis of isoprenoids: a crystallographic state of the art of the involved enzymes. 2008 Curr. Protein Pept. Sci. pmid:18393884
Poonia B and Pauza CD Gamma delta T cells from HIV+ donors can be expanded in vitro by zoledronate/interleukin-2 to become cytotoxic effectors for antibody-dependent cellular cytotoxicity. 2012 Cytotherapy pmid:22029653
Dalle Carbonare L et al. Safety and tolerability of zoledronic acid and other bisphosphonates in osteoporosis management. 2010 Drug Healthc Patient Saf pmid:21701624
Jackson NM and Kocarek TA Suppression of CYP2B induction by alendronate-mediated farnesyl diphosphate synthase inhibition in primary cultured rat hepatocytes. 2008 Drug Metab. Dispos. pmid:18617600
Baker SK and Tarnopolsky MA Statin-associated neuromyotoxicity. 2005 Drugs Today pmid:16034491
Harrison KD et al. Nogo-B receptor is necessary for cellular dolichol biosynthesis and protein N-glycosylation. 2011 EMBO J. pmid:21572394
Bhavnani BR et al. Formation of steroids by the pregnant mare. V. Metabolism of 14C-isopentenylpyrophosphate and 3H-dehydroisoandrosterone injected into the fetus. 1975 Endocrinology pmid:164338
Gonzalez-Pacanowska D et al. Influence of cholestyramine feeding on mevalonate-activating enzymes. 1988 Enzyme pmid:2840276
Wiley JD et al. Isoprenoid precursor biosynthesis is the essential metabolic role of the apicoplast during gametocytogenesis in Plasmodium falciparum. 2015 Eukaryotic Cell pmid:25446055
Brodelius M et al. Fusion of farnesyldiphosphate synthase and epi-aristolochene synthase, a sesquiterpene cyclase involved in capsidiol biosynthesis in Nicotiana tabacum. 2002 Eur. J. Biochem. pmid:12135497
Yamashita S et al. Type 2 isopentenyl diphosphate isomerase from a thermoacidophilic archaeon Sulfolobus shibatae. 2004 Eur. J. Biochem. pmid:15009187
Ericsson J et al. Characterization and distribution of cis-prenyl transferase participating in liver microsomal polyisoprenoid biosynthesis. 1991 Eur. J. Biochem. pmid:1765092
Mettal U et al. Biosynthesis of monoterpene hydrocarbons by isolated chromoplasts from daffodil flowers. 1988 Eur. J. Biochem. pmid:3338457
Wungsintaweekul J et al. Phosphorylation of 1-deoxy-D-xylulose by D-xylulokinase of Escherichia coli. 2001 Eur. J. Biochem. pmid:11168365
Kreuz K and Kleinig H Synthesis of prenyl lipids in cells of spinach leaf. Compartmentation of enzymes for formation of isopentenyl diphosphate. 1984 Eur. J. Biochem. pmid:6086332
Lütke-Brinkhaus F et al. On the biosynthesis of ubiquinones in plant mitochondria. 1984 Eur. J. Biochem. pmid:6745257
Camara B et al. Sites of biosynthesis of carotenoids in Capsicum chromoplasts. 1982 Eur. J. Biochem. pmid:7140767
Laupitz R et al. Biochemical characterization of Bacillus subtilis type II isopentenyl diphosphate isomerase, and phylogenetic distribution of isoprenoid biosynthesis pathways. 2004 Eur. J. Biochem. pmid:15206931
Mau CJ et al. Protein farnesyltransferase inhibitors interfere with farnesyl diphosphate binding by rubber transferase. 2003 Eur. J. Biochem. pmid:14511375
Liang PH et al. Structure, mechanism and function of prenyltransferases. 2002 Eur. J. Biochem. pmid:12135472
Richardson PG et al. The Medical Research Council Myeloma IX trial: the impact on treatment paradigms. 2012 Eur. J. Haematol. pmid:21991938
Dagna L et al. Skewing of cytotoxic activity and chemokine production, but not of chemokine receptor expression, in human type-1/-2 gamma delta T lymphocytes. 2002 Eur. J. Immunol. pmid:12355447
Biswas P et al. Double-edged effect of Vgamma9/Vdelta2 T lymphocytes on viral expression in an in vitro model of HIV-1/mycobacteria co-infection. 2003 Eur. J. Immunol. pmid:12594854
Poggi A et al. Regulation of gammadelta T cell survival by soluble HLA-I: involvement of CD8 and activating killer Ig-like receptors. 2005 Eur. J. Immunol. pmid:16114098
Wesch D et al. Comparative analysis of alpha beta and gamma delta T cell activation by Mycobacterium tuberculosis and isopentenyl pyrophosphate. 1997 Eur. J. Immunol. pmid:9130649
Kudo H et al. Frequent loss of genome gap region in 4p16.3 subtelomere in early-onset type 2 diabetes mellitus. 2011 Exp Diabetes Res pmid:21754918
Kumar M et al. Cholesterol-lowering probiotics as potential biotherapeutics for metabolic diseases. 2012 Exp Diabetes Res pmid:22611376
Oswald E et al. Reduced numbers of circulating gammadelta T cells in patients with bullous pemphigoid. 2009 Exp. Dermatol. pmid:19469889
Re F et al. Skewed representation of functionally distinct populations of Vgamma9Vdelta2 T lymphocytes in aging. 2005 Jan-Feb Exp. Gerontol. pmid:15664733
Moreno SN and Li ZH Anti-infectives targeting the isoprenoid pathway of Toxoplasma gondii. 2008 Expert Opin. Ther. Targets pmid:18269336
Falb M et al. Metabolism of halophilic archaea. 2008 Extremophiles pmid:18278431
Kabelitz D Human γδ T lymphocytes for immunotherapeutic strategies against cancer. 2010 F1000 Med Rep pmid:20948839
Sgraja T et al. Characterization of Aquifex aeolicus 4-diphosphocytidyl-2C-methyl-d-erythritol kinase - ligand recognition in a template for antimicrobial drug discovery. 2008 FEBS J. pmid:18422643
Kharel Y et al. Manipulation of prenyl chain length determination mechanism of cis-prenyltransferases. 2006 FEBS J. pmid:16420487
Heider SA et al. IdsA is the major geranylgeranyl pyrophosphate synthase involved in carotenogenesis in Corynebacterium glutamicum. 2014 FEBS J. pmid:25181035
Altincicek B et al. LytB protein catalyzes the terminal step of the 2-C-methyl-D-erythritol-4-phosphate pathway of isoprenoid biosynthesis. 2002 FEBS Lett. pmid:12482608
Raina M et al. Association of a multi-synthetase complex with translating ribosomes in the archaeon Thermococcus kodakarensis. 2012 FEBS Lett. pmid:22683511