| MeSH term | MeSH ID | Detail |
|---|---|---|
| Melanoma | D008545 | 69 associated lipids |
Total
1
Isopentenyl pyrophosphate
Isopentenyl pyrophosphate is a lipid of Prenol Lipids (PR) class. Isopentenyl pyrophosphate is associated with abnormalities such as Tuberculosis, NAVAJO NEUROHEPATOPATHY and Cryptosporidiosis. The involved functions are known as Signal, Anabolism, T-Cell Activation, T-Cell Proliferation and isoprenoid biosynthetic process. Isopentenyl pyrophosphate often locates in Protoplasm, Host Cell, soluble, Plastids and Cell surface. The associated genes with Isopentenyl pyrophosphate are oxytocin, 1-desamino-(O-Et-Tyr)(2)-, HLA-E gene, RAP1A gene, Gene Family and Orthologous Gene. The related lipids are Steroids, Sterols and isopentenol.
Cross Reference
Introduction
To understand associated biological information of Isopentenyl pyrophosphate, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Isopentenyl pyrophosphate?
Isopentenyl pyrophosphate is suspected in Tuberculosis, NAVAJO NEUROHEPATOPATHY, Cryptosporidiosis and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Isopentenyl pyrophosphate
PubChem Associated disorders and diseases
What pathways are associated with Isopentenyl pyrophosphate
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Isopentenyl pyrophosphate through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Isopentenyl pyrophosphate?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with Isopentenyl pyrophosphate?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with Isopentenyl pyrophosphate?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with Isopentenyl pyrophosphate?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Isopentenyl pyrophosphate?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with Isopentenyl pyrophosphate
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Fujisaki S et al. | Cloning and nucleotide sequence of the ispA gene responsible for farnesyl diphosphate synthase activity in Escherichia coli. | 1990 | J. Biochem. | pmid:2089044 |
| Kharel Y et al. | Significance of highly conserved aromatic residues in Micrococcus luteus B-P 26 undecaprenyl diphosphate synthase. | 2003 | J. Biochem. | pmid:14769870 |
| Kawasaki T et al. | Interconversion of the product specificity of type I eubacterial farnesyl diphosphate synthase and geranylgeranyl diphosphate synthase through one amino acid substitution. | 2003 | J. Biochem. | pmid:12761202 |
| Koyama T et al. | Isoprenoid enzyme systems of silkworm. I. Partial purification of isopentenyl pyrophosphate isomerase, farnesyl pyrophosphate synthetase, and geranylgeranyl pyrophosphate synthetase. | 1985 | J. Biochem. | pmid:4066649 |
| Koyama T et al. | Isoprenoid enzyme systems of silkworm. II. Formation of the juvenile hormone skeletons by farnesyl pyrophosphate synthetase II. | 1985 | J. Biochem. | pmid:4066650 |
| Fujisaki S et al. | Disruption of the structural gene for farnesyl diphosphate synthase in Escherichia coli. | 2005 | J. Biochem. | pmid:15809342 |
| Sagami H et al. | Biosynthesis of prenyl diphosphates by cell-free extracts from mammalian tissues. | 1993 | J. Biochem. | pmid:8407862 |
| Sagami H et al. | Geranylgeranyl diphosphate synthase catalyzing the single condensation between isopentenyl diphosphate and farnesyl diphosphate. | 1993 | J. Biochem. | pmid:8407863 |
| Takahashi I and Ogura K | Farnesyl pyrophosphate synthetase from Bacillus subtilis. | 1981 | J. Biochem. | pmid:6792191 |
| Nakanishi S et al. | Preparation of 14C-labeled and unlabeled sterol intermediates from yeast using metabolic inhibitors. | 1984 | J. Biochem. | pmid:6397465 |
| Sagami H and Ogura K | Geranylgeranyl pyrophosphate synthetase lacking geranyl-transferring activity from Micrococcus luteus. | 1981 | J. Biochem. | pmid:7275954 |
| Ohnuma S et al. | Effects of random mutagenesis in a putative substrate-binding domain of geranylgeranyl diphosphate synthase upon intermediate formation and substrate specificity. | 1997 | J. Biochem. | pmid:9163520 |
| Sutherlin A et al. | Enterococcus faecalis 3-hydroxy-3-methylglutaryl coenzyme A synthase, an enzyme of isopentenyl diphosphate biosynthesis. | 2002 | J. Bacteriol. | pmid:12107122 |
| Kuzuyama T et al. | Cloning and characterization of 1-deoxy-D-xylulose 5-phosphate synthase from Streptomyces sp. Strain CL190, which uses both the mevalonate and nonmevalonate pathways for isopentenyl diphosphate biosynthesis. | 2000 | J. Bacteriol. | pmid:10648511 |
| Hahn FM et al. | 1-Deoxy-D-xylulose 5-phosphate synthase, the gene product of open reading frame (ORF) 2816 and ORF 2895 in Rhodobacter capsulatus. | 2001 | J. Bacteriol. | pmid:11114895 |
| Nakatani H et al. | Substrate-induced change in the quaternary structure of type 2 isopentenyl diphosphate isomerase from Sulfolobus shibatae. | 2012 | J. Bacteriol. | pmid:22505674 |
| Takagi M et al. | A gene cluster for the mevalonate pathway from Streptomyces sp. Strain CL190. | 2000 | J. Bacteriol. | pmid:10894721 |
| Wilding EI et al. | Identification, evolution, and essentiality of the mevalonate pathway for isopentenyl diphosphate biosynthesis in gram-positive cocci. | 2000 | J. Bacteriol. | pmid:10894743 |
| Fujisaki S et al. | Isolation and characterization of an Escherichia coli mutant having temperature-sensitive farnesyl diphosphate synthase. | 1989 | J. Bacteriol. | pmid:2676985 |
| Balibar CJ et al. | The mevalonate pathway of Staphylococcus aureus. | 2009 | J. Bacteriol. | pmid:19028897 |
| Altincicek B et al. | GcpE is involved in the 2-C-methyl-D-erythritol 4-phosphate pathway of isoprenoid biosynthesis in Escherichia coli. | 2001 | J. Bacteriol. | pmid:11274098 |
| Grochowski LL et al. | Methanocaldococcus jannaschii uses a modified mevalonate pathway for biosynthesis of isopentenyl diphosphate. | 2006 | J. Bacteriol. | pmid:16621811 |
| Ershov YV et al. | Isoprenoid biosynthesis in Synechocystis sp. strain PCC6803 is stimulated by compounds of the pentose phosphate cycle but not by pyruvate or deoxyxylulose-5-phosphate. | 2002 | J. Bacteriol. | pmid:12193620 |
| Inoue A et al. | Involvement of an essential gene, mviN, in murein synthesis in Escherichia coli. | 2008 | J. Bacteriol. | pmid:18708495 |
| Cunningham FX et al. | Evidence of a role for LytB in the nonmevalonate pathway of isoprenoid biosynthesis. | 2000 | J. Bacteriol. | pmid:11004185 |
| Hedl M et al. | Enterococcus faecalis acetoacetyl-coenzyme A thiolase/3-hydroxy-3-methylglutaryl-coenzyme A reductase, a dual-function protein of isopentenyl diphosphate biosynthesis. | 2002 | J. Bacteriol. | pmid:11914342 |
| Poliquin K et al. | Inactivation of sll1556 in Synechocystis strain PCC 6803 impairs isoprenoid biosynthesis from pentose phosphate cycle substrates in vitro. | 2004 | J. Bacteriol. | pmid:15231801 |
| Morikawa S et al. | Analysis of the global RNA expression profiles of skeletal muscle cells treated with statins. | 2005 | J. Atheroscler. Thromb. | pmid:16020911 |
| Terano T et al. | Geranylgeranylpyrophosphate plays a key role for the G1 to S transition in vascular smooth muscle cells. | 1998 | J. Atheroscler. Thromb. | pmid:10077451 |
| Zenitani S et al. | Gerfelin, a novel inhibitor of geranylgeranyl diphosphate synthase from Beauveria felina QN22047. I. Taxonomy, fermentation, isolation, and biological activities. | 2003 | J. Antibiot. | pmid:14513904 |
| Kawasaki T et al. | A relationship between the mevalonate pathway and isoprenoid production in actinomycetes. | 2003 | J. Antibiot. | pmid:14763562 |
| Rekittke I et al. | Structure of (E)-4-hydroxy-3-methyl-but-2-enyl diphosphate reductase, the terminal enzyme of the non-mevalonate pathway. | 2008 | J. Am. Chem. Soc. | pmid:19035630 |
| Wouters J et al. | A crystallographic investigation of phosphoantigen binding to isopentenyl pyrophosphate/dimethylallyl pyrophosphate isomerase. | 2005 | J. Am. Chem. Soc. | pmid:15643873 |
| Wu Z et al. | Isopentenyl diphosphate isomerase. Mechanism-based inhibition by diene analogues of isopentenyl diphosphate and dimethylallyl diphosphate. | 2005 | J. Am. Chem. Soc. | pmid:16332094 |
| Heaps NA and Poulter CD | Type-2 isopentenyl diphosphate isomerase: evidence for a stepwise mechanism. | 2011 | J. Am. Chem. Soc. | pmid:22047048 |
| Chen AP et al. | Synthesis and application of a fluorescent substrate analogue to study ligand interactions for undecaprenyl pyrophosphate synthase. | 2002 | J. Am. Chem. Soc. | pmid:12487597 |
| Thulasiram HV and Poulter CD | Farnesyl diphosphate synthase: the art of compromise between substrate selectivity and stereoselectivity. | 2006 | J. Am. Chem. Soc. | pmid:17147392 |
| Thibodeaux CJ et al. | Linear free energy relationships demonstrate a catalytic role for the flavin mononucleotide coenzyme of the type II isopentenyl diphosphate:dimethylallyl diphosphate isomerase. | 2010 | J. Am. Chem. Soc. | pmid:20593767 |
| Kakinuma K et al. | New approach to multiply deuterated isoprenoids using triply engineered Escherichia coli and its potential as a tool for mechanistic enzymology. | 2001 | J. Am. Chem. Soc. | pmid:11456682 |
| Jonnalagadda V et al. | Isopentenyl diphosphate isomerase catalyzed reactions in D2O: product release limits the rate of this sluggish enzyme-catalyzed reaction. | 2012 | J. Am. Chem. Soc. | pmid:22471428 |
| Kondo M et al. | Expansion of human peripheral blood γδ T cells using zoledronate. | 2011 | J Vis Exp | pmid:21931292 |
| Pan J et al. | ATP synthase ecto-α-subunit: a novel therapeutic target for breast cancer. | 2011 | J Transl Med | pmid:22152132 |
| Rogers TL and Holen I | Tumour macrophages as potential targets of bisphosphonates. | 2011 | J Transl Med | pmid:22005011 |
| French CE | Synthetic biology and biomass conversion: a match made in heaven? | 2009 | J R Soc Interface | pmid:19454530 |
| Gresh N et al. | Analysis of the interactions taking place in the recognition site of a bimetallic Mg(II)-Zn(II) enzyme, isopentenyl diphosphate isomerase. a parallel quantum-chemical and polarizable molecular mechanics study. | 2010 | J Phys Chem B | pmid:20329783 |
| Hussain MS et al. | Current approaches toward production of secondary plant metabolites. | 2012 | J Pharm Bioallied Sci | pmid:22368394 |
| Brannian J et al. | Progressive obesity leads to altered ovarian gene expression in the Lethal Yellow mouse: a microarray study. | 2009 | J Ovarian Res | pmid:19650929 |
| Bock O et al. | Common musculoskeletal adverse effects of oral treatment with once weekly alendronate and risedronate in patients with osteoporosis and ways for their prevention. | 2007 Apr-Jun | J Musculoskelet Neuronal Interact | pmid:17627083 |
| de Souza W and Rodrigues JC | Sterol Biosynthesis Pathway as Target for Anti-trypanosomatid Drugs. | 2009 | Interdiscip Perspect Infect Dis | pmid:19680554 |
| Zhang J et al. | Modeling studies with Helicobacter pylori octaprenyl pyrophosphate synthase reveal the enzymatic mechanism of trans-prenyltransferases. | 2012 | Int. J. Biochem. Cell Biol. | pmid:22982238 |
| Puan KJ et al. | Preferential recognition of a microbial metabolite by human Vgamma2Vdelta2 T cells. | 2007 | Int. Immunol. | pmid:17446209 |
| Chang CW et al. | Identification and categorization of liver toxicity markers induced by a related pair of drugs. | 2011 | Int J Mol Sci | pmid:21845099 |
| Song AA et al. | Functional expression of an orchid fragrance gene in Lactococcus lactis. | 2012 | Int J Mol Sci | pmid:22408409 |
| Iriti M and Faoro F | Chemical diversity and defence metabolism: how plants cope with pathogens and ozone pollution. | 2009 | Int J Mol Sci | pmid:20111684 |
| Li X et al. | Epithelial Cell Gene Expression Induced by Intracellular Staphylococcus aureus. | 2009 | Int J Microbiol | pmid:20016671 |
| Diaz ME et al. | Characterization of an isopentenyl diphosphate isomerase involved in the juvenile hormone pathway in Aedes aegypti. | 2012 | Insect Biochem. Mol. Biol. | pmid:22782071 |
| Kinjoh T et al. | Control of juvenile hormone biosynthesis in Bombyx mori: cloning of the enzymes in the mevalonate pathway and assessment of their developmental expression in the corpora allata. | 2007 | Insect Biochem. Mol. Biol. | pmid:17628279 |
| Sicard H and Fournie JJ | Metabolic routes as targets for immunological discrimination of host and parasite. | 2000 | Infect. Immun. | pmid:10899832 |
| Xia M et al. | A Subset of Protective γ9δ2 T Cells Is Activated by Novel Mycobacterial Glycolipid Components. | 2016 | Infect. Immun. | pmid:27297390 |
| Srivastava A et al. | Structural analysis of farnesyl pyrophosphate synthase from parasitic protozoa, a potential chemotherapeutic target. | 2008 | Infect Disord Drug Targets | pmid:18473904 |
| Gogoi D and Chiplunkar SV | Targeting gamma delta T cells for cancer immunotherapy: bench to bedside. | 2013 | Indian J. Med. Res. | pmid:24434328 |
| Srivastava NK and Srivastava AK | Influence of Some Heavy Metals on Growth, Alkaloid Content and Composition in Catharanthus roseus L. | 2010 | Indian J Pharm Sci | pmid:21969751 |
| Martini F et al. | gammadelta T-cell anergy in human immunodeficiency virus-infected persons with opportunistic infections and recovery after highly active antiretroviral therapy. | 2000 | Immunology | pmid:10929075 |
| Kunzmann V et al. | Polyinosinic-polycytidylic acid-mediated stimulation of human gammadelta T cells via CD11c dendritic cell-derived type I interferons. | 2004 | Immunology | pmid:15196204 |
| Li H and David Pauza C | Interplay of T-cell receptor and interleukin-2 signalling in Vγ2Vδ2 T-cell cytotoxicity. | 2011 | Immunology | pmid:20738419 |
| Campos Alberto EJ et al. | Differential effects of tumour necrosis factor-alpha and interleukin-12 on isopentenyl pyrophosphate-stimulated interferon-gamma production by cord blood Vgamma9 T cells. | 2009 | Immunology | pmid:19019091 |
| Cairo C et al. | The Vgamma2/Vdelta2 T-cell repertoire in Macaca fascicularis: functional responses to phosphoantigen stimulation by the Vgamma2/Jgamma1.2 subset. | 2005 | Immunology | pmid:15885125 |
| Evans PS et al. | In vitro stimulation with a non-peptidic alkylphosphate expands cells expressing Vgamma2-Jgamma1.2/Vdelta2 T-cell receptors. | 2001 | Immunology | pmid:11576216 |
| Herzig C et al. | Bovine T cell receptor gamma variable and constant genes: combinatorial usage by circulating gammadelta T cells. | 2006 | Immunogenetics | pmid:16541255 |
| Amslinger S et al. | Stimulation of Vgamma9/Vdelta2 T-lymphocyte proliferation by the isoprenoid precursor, (E)-1-hydroxy-2-methyl-but-2-enyl 4-diphosphate. | 2007 | Immunobiology | pmid:17270709 |
| Omoigui S | The Interleukin-6 inflammation pathway from cholesterol to aging--role of statins, bisphosphonates and plant polyphenols in aging and age-related diseases. | 2007 | Immun Ageing | pmid:17374166 |
| Derhovanessian E et al. | Immunity, ageing and cancer. | 2008 | Immun Ageing | pmid:18816370 |
| Sireci G et al. | Patterns of phosphoantigen stimulation of human Vgamma9/Vdelta2 T cell clones include Th0 cytokines. | 1997 | Hum. Immunol. | pmid:9475336 |
| Klein O and Porra RJ | The participation of the Shemin and C5 pathways in 5-aminolaevulinate and chlorophyll formation in higher plants and facultative photosynthetic bacteria. | 1982 | Hoppe-Seyler's Z. Physiol. Chem. | pmid:7106702 |
| Smit A and Mushegian A | Biosynthesis of isoprenoids via mevalonate in Archaea: the lost pathway. | 2000 | Genome Res. | pmid:11042147 |
| Gibon Y et al. | Integration of metabolite with transcript and enzyme activity profiling during diurnal cycles in Arabidopsis rosettes. | 2006 | Genome Biol. | pmid:16916443 |
| Hackl H et al. | Molecular processes during fat cell development revealed by gene expression profiling and functional annotation. | 2005 | Genome Biol. | pmid:16420668 |
| Huang J and Gogarten JP | Did an ancient chlamydial endosymbiosis facilitate the establishment of primary plastids? | 2007 | Genome Biol. | pmid:17547748 |
| Glazko GV and Mushegian AR | Detection of evolutionarily stable fragments of cellular pathways by hierarchical clustering of phyletic patterns. | 2004 | Genome Biol. | pmid:15128446 |
| Sharman A | The many uses of a genome sequence. | 2001 | Genome Biol. | pmid:11423005 |
| Kastenmüller G et al. | Uncovering metabolic pathways relevant to phenotypic traits of microbial genomes. | 2009 | Genome Biol. | pmid:19284550 |
| Wille A et al. | Sparse graphical Gaussian modeling of the isoprenoid gene network in Arabidopsis thaliana. | 2004 | Genome Biol. | pmid:15535868 |
| Whitaker JW et al. | The transferome of metabolic genes explored: analysis of the horizontal transfer of enzyme encoding genes in unicellular eukaryotes. | 2009 | Genome Biol. | pmid:19368726 |
| Desmond E and Gribaldo S | Phylogenomics of sterol synthesis: insights into the origin, evolution, and diversity of a key eukaryotic feature. | 2009 | Genome Biol Evol | pmid:20333205 |
| Bulashevska S et al. | New insights into the genetic regulation of Plasmodium falciparum obtained by Bayesian modeling. | 2007 | Gene Regul Syst Bio | pmid:19936084 |
| Hümbelin M et al. | Genetics of isoprenoid biosynthesis in Paracoccus zeaxanthinifaciens. | 2002 | Gene | pmid:12384294 |
| Sawai S and Saito K | Triterpenoid biosynthesis and engineering in plants. | 2011 | Front Plant Sci | pmid:22639586 |
| Wurtzel ET et al. | Maize provitamin a carotenoids, current resources, and future metabolic engineering challenges. | 2012 | Front Plant Sci | pmid:22645578 |
| Lamsen EN and Atsumi S | Recent progress in synthetic biology for microbial production of C3-C10 alcohols. | 2012 | Front Microbiol | pmid:22701113 |
| Grolle S et al. | Isolation of the dxr gene of Zymomonas mobilis and characterization of the 1-deoxy-D-xylulose 5-phosphate reductoisomerase. | 2000 | FEMS Microbiol. Lett. | pmid:11004410 |
| Horbach S et al. | Isoprenoid biosynthesis in bacteria: two different pathways? | 1993 | FEMS Microbiol. Lett. | pmid:8405922 |
| Disch A and Rohmer M | On the absence of the glyceraldehyde 3-phosphate/pyruvate pathway for isoprenoid biosynthesis in fungi and yeasts. | 1998 | FEMS Microbiol. Lett. | pmid:9835029 |
| Jomaa H et al. | Vgamma9/Vdelta2 T cell activation induced by bacterial low molecular mass compounds depends on the 1-deoxy-D-xylulose 5-phosphate pathway of isoprenoid biosynthesis. | 1999 | FEMS Immunol. Med. Microbiol. | pmid:10497868 |
| Wolff M et al. | Isoprenoid biosynthesis via the methylerythritol phosphate pathway: the (E)-4-hydroxy-3-methylbut-2-enyl diphosphate reductase (LytB/IspH) from Escherichia coli is a [4Fe-4S] protein. | 2003 | FEBS Lett. | pmid:12706830 |
| Laten HM et al. | An antisuppressor mutant of Saccharomyces cerevisiae deficient in isopentenylated tRNA has reduced delta 2-isopentenylpyrophosphate: tRNA-delta 2-isopentenyl transferase activity. | 1985 | FEBS Lett. | pmid:3881278 |
| Nakamura A et al. | Two distinct isopentenyl diphosphate isomerases in cytosol and plastid are differentially induced by environmental stresses in tobacco. | 2001 | FEBS Lett. | pmid:11591371 |
| Lichtenthaler HK et al. | Biosynthesis of isoprenoids in higher plant chloroplasts proceeds via a mevalonate-independent pathway. | 1997 | FEBS Lett. | pmid:9009212 |
| Schwender J et al. | Incorporation of 1-deoxy-D-xylulose into isoprene and phytol by higher plants and algae. | 1997 | FEBS Lett. | pmid:9305746 |
| RodrÃguez-Concepción M et al. | Genetic evidence of branching in the isoprenoid pathway for the production of isopentenyl diphosphate and dimethylallyl diphosphate in Escherichia coli. | 2000 | FEBS Lett. | pmid:10818234 |
| Miller B et al. | Functional involvement of a deoxy-D-xylulose 5-phosphate reductoisomerase gene harboring locus of Synechococcus leopoliensis in isoprenoid biosynthesis. | 2000 | FEBS Lett. | pmid:11007968 |