Isopentenyl pyrophosphate

Isopentenyl pyrophosphate is a lipid of Prenol Lipids (PR) class. Isopentenyl pyrophosphate is associated with abnormalities such as Tuberculosis, NAVAJO NEUROHEPATOPATHY and Cryptosporidiosis. The involved functions are known as Signal, Anabolism, T-Cell Activation, T-Cell Proliferation and isoprenoid biosynthetic process. Isopentenyl pyrophosphate often locates in Protoplasm, Host Cell, soluble, Plastids and Cell surface. The associated genes with Isopentenyl pyrophosphate are oxytocin, 1-desamino-(O-Et-Tyr)(2)-, HLA-E gene, RAP1A gene, Gene Family and Orthologous Gene. The related lipids are Steroids, Sterols and isopentenol.

Cross Reference

Introduction

To understand associated biological information of Isopentenyl pyrophosphate, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Isopentenyl pyrophosphate?

Isopentenyl pyrophosphate is suspected in Tuberculosis, NAVAJO NEUROHEPATOPATHY, Cryptosporidiosis and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Isopentenyl pyrophosphate

MeSH term MeSH ID Detail
Melanoma D008545 69 associated lipids
Total 1

PubChem Associated disorders and diseases

What pathways are associated with Isopentenyl pyrophosphate

Lipid pathways are not clear in current pathway databases. We organized associated pathways with Isopentenyl pyrophosphate through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
Loading... please refresh the page if content is not showing up.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Isopentenyl pyrophosphate?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with Isopentenyl pyrophosphate?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Isopentenyl pyrophosphate?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with Isopentenyl pyrophosphate?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Isopentenyl pyrophosphate?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Isopentenyl pyrophosphate

Download all related citations
Per page 10 20 50 100 | Total 1004
Authors Title Published Journal PubMed Link
Martín JF et al. Conversion of beta-carotene into astaxanthin: Two separate enzymes or a bifunctional hydroxylase-ketolase protein? 2008 Microb. Cell Fact. pmid:18289382
Okada K et al. Genetic evidence for the role of isopentenyl diphosphate isomerases in the mevalonate pathway and plant development in Arabidopsis. 2008 Plant Cell Physiol. pmid:18303110
Boëdec A et al. Synthesis and biological activity of phosphonate analogues and geometric isomers of the highly potent phosphoantigen (E)-1-hydroxy-2-methylbut-2-enyl 4-diphosphate. 2008 J. Med. Chem. pmid:18303828
Wang Y et al. The effect of 24S-hydroxycholesterol on cholesterol homeostasis in neurons: quantitative changes to the cortical neuron proteome. 2008 J. Proteome Res. pmid:18303831
Phillips MA et al. The Arabidopsis thaliana type I Isopentenyl Diphosphate Isomerases are targeted to multiple subcellular compartments and have overlapping functions in isoprenoid biosynthesis. 2008 Plant Cell pmid:18319397
pmid:18345677
Kuo CJ et al. Structure-based inhibitors exhibit differential activities against Helicobacter pylori and Escherichia coli undecaprenyl pyrophosphate synthases. 2008 J. Biomed. Biotechnol. pmid:18382620
Opitz S et al. Increased terpenoid accumulation in cotton (Gossypium hirsutum) foliage is a general wound response. 2008 J. Chem. Ecol. pmid:18386096
de Ruyck J et al. Monoclinic form of isopentenyl diphosphate isomerase: a case of polymorphism in biomolecular crystals. 2008 Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. pmid:18391416
de Ruyck J and Wouters J Structure-based drug design targeting biosynthesis of isoprenoids: a crystallographic state of the art of the involved enzymes. 2008 Curr. Protein Pept. Sci. pmid:18393884
Dupont FM Metabolic pathways of the wheat (Triticum aestivum) endosperm amyloplast revealed by proteomics. 2008 BMC Plant Biol. pmid:18419817
Sgraja T et al. Characterization of Aquifex aeolicus 4-diphosphocytidyl-2C-methyl-d-erythritol kinase - ligand recognition in a template for antimicrobial drug discovery. 2008 FEBS J. pmid:18422643
Mönkkönen H et al. Bisphosphonate-induced ATP analog formation and its effect on inhibition of cancer cell growth. 2008 Anticancer Drugs pmid:18454049
pmid:18460154
Shimizu S et al. Possible involvement of 3-hydroxymethylglutaryl-CoA reductase in determining the side-chain length of ubiquinone in rat heart. 1991 Arch. Biochem. Biophys. pmid:1846516
Vandermoten S et al. Characterization of a novel aphid prenyltransferase displaying dual geranyl/farnesyl diphosphate synthase activity. 2008 FEBS Lett. pmid:18466770
pmid:18473809
Srivastava A et al. Structural analysis of farnesyl pyrophosphate synthase from parasitic protozoa, a potential chemotherapeutic target. 2008 Infect Disord Drug Targets pmid:18473904
Cummings JS et al. Impacts of HIV infection on Vgamma2Vdelta2 T cell phenotype and function: a mechanism for reduced tumor immunity in AIDS. 2008 J. Leukoc. Biol. pmid:18495780
Skorupinska-Tudek K et al. Contribution of the mevalonate and methylerythritol phosphate pathways to the biosynthesis of dolichols in plants. 2008 J. Biol. Chem. pmid:18502754
Leaver MJ et al. Functional genomics reveals increases in cholesterol biosynthetic genes and highly unsaturated fatty acid biosynthesis after dietary substitution of fish oil with vegetable oils in Atlantic salmon (Salmo salar). 2008 BMC Genomics pmid:18577222
Alexander AA et al. Isopentenyl pyrophosphate-activated CD56+ {gamma}{delta} T lymphocytes display potent antitumor activity toward human squamous cell carcinoma. 2008 Clin. Cancer Res. pmid:18594005
Wang W et al. The structural basis of chain length control in Rv1086. 2008 J. Mol. Biol. pmid:18597781
Jackson NM and Kocarek TA Suppression of CYP2B induction by alendronate-mediated farnesyl diphosphate synthase inhibition in primary cultured rat hepatocytes. 2008 Drug Metab. Dispos. pmid:18617600
pmid:18626710
Catusse J et al. Proteome-wide characterization of sugarbeet seed vigor and its tissue specific expression. 2008 Proc. Natl. Acad. Sci. U.S.A. pmid:18635686
Chuang YC et al. Identification of the genetic determinants of Salmonella enterica serotype Typhimurium that may regulate the expression of the type 1 fimbriae in response to solid agar and static broth culture conditions. 2008 BMC Microbiol. pmid:18652702
Crowhurst RN et al. Analysis of expressed sequence tags from Actinidia: applications of a cross species EST database for gene discovery in the areas of flavor, health, color and ripening. 2008 BMC Genomics pmid:18655731
de Ruyck J et al. Crystal structure of type 2 isopentenyl diphosphate isomerase from Thermus thermophilus in complex with inorganic pyrophosphate. 2008 Biochemistry pmid:18693754
Inoue A et al. Involvement of an essential gene, mviN, in murein synthesis in Escherichia coli. 2008 J. Bacteriol. pmid:18708495
pmid:18725204
Jung KH et al. Identification and functional analysis of light-responsive unique genes and gene family members in rice. 2008 PLoS Genet. pmid:18725934
Zhao Y et al. cDNA cloning, chromosome mapping and expression characterization of human geranylgeranyl pyrophosphate synthase. 2000 Sci. China, C, Life Sci. pmid:18726356
Noike M et al. Product chain-length determination mechanism of Z,E-farnesyl diphosphate synthase. 2008 Biochem. Biophys. Res. Commun. pmid:18790692
Spencer CT et al. Only a subset of phosphoantigen-responsive gamma9delta2 T cells mediate protective tuberculosis immunity. 2008 J. Immunol. pmid:18802050
Derhovanessian E et al. Immunity, ageing and cancer. 2008 Immun Ageing pmid:18816370
Harada H et al. Efficient synthesis of functional isoprenoids from acetoacetate through metabolic pathway-engineered Escherichia coli. 2009 Appl. Microbiol. Biotechnol. pmid:18836713
Alcaíno J et al. Cloning of the cytochrome p450 reductase (crtR) gene and its involvement in the astaxanthin biosynthesis of Xanthophyllomyces dendrorhous. 2008 BMC Microbiol. pmid:18837978
pmid:18843409
Simoni D et al. Design, synthesis, and biological evaluation of novel aminobisphosphonates possessing an in vivo antitumor activity through a gammadelta-T lymphocytes-mediated activation mechanism. 2008 J. Med. Chem. pmid:18937434
Ferrarini M et al. NF-kappa B modulates sensitivity to apoptosis, proinflammatory and migratory potential in short- versus long-term cultured human gamma delta lymphocytes. 2008 J. Immunol. pmid:18941174
Crick DC et al. Characterization and localization of a long-chain isoprenyltransferase activity in porcine brain: proposed role in the biosynthesis of dolichyl phosphate. 1991 J. Neurochem. pmid:1895109
Argout X et al. Towards the understanding of the cocoa transcriptome: Production and analysis of an exhaustive dataset of ESTs of Theobroma cacao L. generated from various tissues and under various conditions. 2008 BMC Genomics pmid:18973681
Ruangweerayut R et al. Assessment of the pharmacokinetics and dynamics of two combination regimens of fosmidomycin-clindamycin in patients with acute uncomplicated falciparum malaria. 2008 Malar. J. pmid:18973702
Ro DK et al. Induction of multiple pleiotropic drug resistance genes in yeast engineered to produce an increased level of anti-malarial drug precursor, artemisinic acid. 2008 BMC Biotechnol. pmid:18983675
Roelofs AJ et al. Peripheral blood monocytes are responsible for gammadelta T cell activation induced by zoledronic acid through accumulation of IPP/DMAPP. 2009 Br. J. Haematol. pmid:19016713
Sarikonda G et al. Photoaffinity antigens for human gammadelta T cells. 2008 J. Immunol. pmid:19017963
Campos Alberto EJ et al. Differential effects of tumour necrosis factor-alpha and interleukin-12 on isopentenyl pyrophosphate-stimulated interferon-gamma production by cord blood Vgamma9 T cells. 2009 Immunology pmid:19019091
Kervizic G and Corcos L Dynamical modeling of the cholesterol regulatory pathway with Boolean networks. 2008 BMC Syst Biol pmid:19025648
Balibar CJ et al. The mevalonate pathway of Staphylococcus aureus. 2009 J. Bacteriol. pmid:19028897
Rekittke I et al. Structure of (E)-4-hydroxy-3-methyl-but-2-enyl diphosphate reductase, the terminal enzyme of the non-mevalonate pathway. 2008 J. Am. Chem. Soc. pmid:19035630
pmid:19055484
Lu YP et al. Different reaction mechanisms for cis- and trans-prenyltransferases. 2009 Biochem. Biophys. Res. Commun. pmid:19103164
Tian L et al. Transcript and proteomic analysis of developing white lupin (Lupinus albus L.) roots. 2009 BMC Plant Biol. pmid:19123941
Ohto C et al. Prenyl alcohol production by expression of exogenous isopentenyl diphosphate isomerase and farnesyl diphosphate synthase genes in Escherichia coli. 2009 Biosci. Biotechnol. Biochem. pmid:19129660
Williams SL and Andrew McCammon J Conformational dynamics of the flexible catalytic loop in Mycobacterium tuberculosis 1-deoxy-D-xylulose 5-phosphate reductoisomerase. 2009 Chem Biol Drug Des pmid:19152632
Sallaud C et al. A novel pathway for sesquiterpene biosynthesis from Z,Z-farnesyl pyrophosphate in the wild tomato Solanum habrochaites. 2009 Plant Cell pmid:19155349
Unno H et al. New role of flavin as a general acid-base catalyst with no redox function in type 2 isopentenyl-diphosphate isomerase. 2009 J. Biol. Chem. pmid:19158086
Lücker J et al. Generation of a predicted protein database from EST data and application to iTRAQ analyses in grape (Vitis vinifera cv. Cabernet Sauvignon) berries at ripening initiation. 2009 BMC Genomics pmid:19171055
Kenny JG et al. The Staphylococcus aureus response to unsaturated long chain free fatty acids: survival mechanisms and virulence implications. 2009 PLoS ONE pmid:19183815
Ganjewala D et al. An account of cloned genes of Methyl-erythritol-4-phosphate pathway of isoprenoid biosynthesis in plants. 2009 Curr Issues Mol Biol pmid:19193963
pmid:19198899
Liu Q et al. Transcriptome analysis of a spontaneous mutant in sweet orange [Citrus sinensis (L.) Osbeck] during fruit development. 2009 J. Exp. Bot. pmid:19218315
Tsuruta H et al. High-level production of amorpha-4,11-diene, a precursor of the antimalarial agent artemisinin, in Escherichia coli. 2009 PLoS ONE pmid:19221601
Eberl M et al. A rapid crosstalk of human gammadelta T cells and monocytes drives the acute inflammation in bacterial infections. 2009 PLoS Pathog. pmid:19229322
pmid:19245203
Gilg AB et al. Unique animal prenyltransferase with monoterpene synthase activity. 2009 Naturwissenschaften pmid:19277597
Sunyecz J Optimizing dosing frequencies for bisphosphonates in the management of postmenopausal osteoporosis: patient considerations. 2008 Clin Interv Aging pmid:19281054
Kastenmüller G et al. Uncovering metabolic pathways relevant to phenotypic traits of microbial genomes. 2009 Genome Biol. pmid:19284550
pmid:19309001
pmid:19318289
Ramsden NL et al. A structure-based approach to ligand discovery for 2C-methyl-D-erythritol-2,4-cyclodiphosphate synthase: a target for antimicrobial therapy. 2009 J. Med. Chem. pmid:19320487
Vallabhaneni R and Wurtzel ET Timing and biosynthetic potential for carotenoid accumulation in genetically diverse germplasm of maize. 2009 Plant Physiol. pmid:19346441
Suzuki M et al. Complete blockage of the mevalonate pathway results in male gametophyte lethality. 2009 J. Exp. Bot. pmid:19363204
Whitaker JW et al. The transferome of metabolic genes explored: analysis of the horizontal transfer of enzyme encoding genes in unicellular eukaryotes. 2009 Genome Biol. pmid:19368726
Paniagua-Michel J et al. The carotenogenesis pathway via the isoprenoid-beta-carotene interference approach in a new strain of Dunaliella salina isolated from Baja California Mexico. 2009 Mar Drugs pmid:19370170
Räikkönen J et al. Zoledronic acid induces formation of a pro-apoptotic ATP analogue and isopentenyl pyrophosphate in osteoclasts in vivo and in MCF-7 cells in vitro. 2009 Br. J. Pharmacol. pmid:19371349
Sillero MA et al. Synthesis of ATP derivatives of compounds of the mevalonate pathway (isopentenyl di- and triphosphate; geranyl di- and triphosphate, farnesyl di- and triphosphate, and dimethylallyl diphosphate) catalyzed by T4 RNA ligase, T4 DNA ligase and other ligases Potential relationship with the effect of bisphosphonates on osteoclasts. 2009 Biochem. Pharmacol. pmid:19414000
pmid:19447338
Breccia P et al. Thiopyrophosphoantigens: solid-phase synthesis and in vitro characterization of a new class of Vgamma9 Vdelta2 T cells activators. 2009 J. Med. Chem. pmid:19453173
French CE Synthetic biology and biomass conversion: a match made in heaven? 2009 J R Soc Interface pmid:19454530
Oswald E et al. Reduced numbers of circulating gammadelta T cells in patients with bullous pemphigoid. 2009 Exp. Dermatol. pmid:19469889
Vinella D et al. Iron-sulfur (Fe/S) protein biogenesis: phylogenomic and genetic studies of A-type carriers. 2009 PLoS Genet. pmid:19478995
Correia DV et al. Highly active microbial phosphoantigen induces rapid yet sustained MEK/Erk- and PI-3K/Akt-mediated signal transduction in anti-tumor human gammadelta T-cells. 2009 PLoS ONE pmid:19479075
Schilmiller AL et al. Monoterpenes in the glandular trichomes of tomato are synthesized from a neryl diphosphate precursor rather than geranyl diphosphate. 2009 Proc. Natl. Acad. Sci. U.S.A. pmid:19487664
Li J et al. Reduced expression of the mevalonate pathway enzyme farnesyl pyrophosphate synthase unveils recognition of tumor cells by Vgamma9Vdelta2 T cells. 2009 J. Immunol. pmid:19494338
Nieuwenhuizen NJ et al. Two terpene synthases are responsible for the major sesquiterpenes emitted from the flowers of kiwifruit (Actinidia deliciosa). 2009 J. Exp. Bot. pmid:19516075
pmid:19521917
Saikia S and Scott B Functional analysis and subcellular localization of two geranylgeranyl diphosphate synthases from Penicillium paxilli. 2009 Mol. Genet. Genomics pmid:19529962
Bohlmann J and Gershenzon J Old substrates for new enzymes of terpenoid biosynthesis. 2009 Proc. Natl. Acad. Sci. U.S.A. pmid:19553206
Lai D et al. Reconstruction of the archaeal isoprenoid ether lipid biosynthesis pathway in Escherichia coli through digeranylgeranylglyceryl phosphate. 2009 Metab. Eng. pmid:19558961
Kroll J et al. Establishment of a novel anabolism-based addiction system with an artificially introduced mevalonate pathway: complete stabilization of plasmids as universal application in white biotechnology. 2009 Metab. Eng. pmid:19558962
pmid:19559030
Rubio-Aliaga I et al. Dll1 haploinsufficiency in adult mice leads to a complex phenotype affecting metabolic and immunological processes. 2009 PLoS ONE pmid:19562077
Gräwert T et al. Structure of active IspH enzyme from Escherichia coli provides mechanistic insights into substrate reduction. 2009 Angew. Chem. Int. Ed. Engl. pmid:19569147
Chaudhuri RR et al. Comprehensive identification of essential Staphylococcus aureus genes using Transposon-Mediated Differential Hybridisation (TMDH). 2009 BMC Genomics pmid:19570206
pmid:19583210
Yamada Y et al. Efficient in vitro synthesis of cis-polyisoprenes using a thermostable cis-prenyltransferase from a hyperthermophilic archaeon Thermococcus kodakaraensis. 2009 J. Biotechnol. pmid:19583987
pmid:19589616
Gunawardana D et al. A comprehensive bioinformatics analysis of the Nudix superfamily in Arabidopsis thaliana. 2009 Comp. Funct. Genomics pmid:19590748