Isopentenyl pyrophosphate

Isopentenyl pyrophosphate is a lipid of Prenol Lipids (PR) class. Isopentenyl pyrophosphate is associated with abnormalities such as Tuberculosis, NAVAJO NEUROHEPATOPATHY and Cryptosporidiosis. The involved functions are known as Signal, Anabolism, T-Cell Activation, T-Cell Proliferation and isoprenoid biosynthetic process. Isopentenyl pyrophosphate often locates in Protoplasm, Host Cell, soluble, Plastids and Cell surface. The associated genes with Isopentenyl pyrophosphate are oxytocin, 1-desamino-(O-Et-Tyr)(2)-, HLA-E gene, RAP1A gene, Gene Family and Orthologous Gene. The related lipids are Steroids, Sterols and isopentenol.

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Introduction

To understand associated biological information of Isopentenyl pyrophosphate, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Isopentenyl pyrophosphate?

Isopentenyl pyrophosphate is suspected in Tuberculosis, NAVAJO NEUROHEPATOPATHY, Cryptosporidiosis and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Isopentenyl pyrophosphate

MeSH term MeSH ID Detail
Melanoma D008545 69 associated lipids
Total 1

PubChem Associated disorders and diseases

What pathways are associated with Isopentenyl pyrophosphate

Lipid pathways are not clear in current pathway databases. We organized associated pathways with Isopentenyl pyrophosphate through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
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PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Isopentenyl pyrophosphate?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Isopentenyl pyrophosphate?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Isopentenyl pyrophosphate?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Isopentenyl pyrophosphate?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Isopentenyl pyrophosphate?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Isopentenyl pyrophosphate

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Authors Title Published Journal PubMed Link
Haussig JM et al. Inactivation of a Plasmodium apicoplast protein attenuates formation of liver merozoites. 2011 Mol. Microbiol. pmid:21848587
Boucher Y and Doolittle WF The role of lateral gene transfer in the evolution of isoprenoid biosynthesis pathways. 2000 Mol. Microbiol. pmid:10972794
Teng KH and Liang PH Undecaprenyl diphosphate synthase, a cis-prenyltransferase synthesizing lipid carrier for bacterial cell wall biosynthesis. 2012 Mol. Membr. Biol. pmid:22471620
Huang L and Pardee AB Suberoylanilide hydroxamic acid as a potential therapeutic agent for human breast cancer treatment. 2000 Mol. Med. pmid:11126200
Wang P and Malkovsky M Different roles of the CD2 and LFA-1 T-cell co-receptors for regulating cytotoxic, proliferative, and cytokine responses of human V gamma 9/V delta 2 T cells. 2000 Mol. Med. pmid:10965495
Poccia F et al. In vivo gammadelta T cell priming to mycobacterial antigens by primary Mycobacterium tuberculosis infection and exposure to nonpeptidic ligands. 1999 Mol. Med. pmid:10449808
Hogenboom S et al. Cholesterol biosynthesis is not defective in peroxisome biogenesis defective fibroblasts. 2003 Mol. Genet. Metab. pmid:14680974
Saikia S and Scott B Functional analysis and subcellular localization of two geranylgeranyl diphosphate synthases from Penicillium paxilli. 2009 Mol. Genet. Genomics pmid:19529962
Dairi T et al. Cloning of the gene encoding 3-hydroxy-3-methylglutaryl coenzyme A reductase from terpenoid antibiotic-producing Streptomyces strains. 2000 Mol. Gen. Genet. pmid:10660057
Kaneko Y et al. Stage-specific regulation of juvenile hormone biosynthesis by ecdysteroid in Bombyx mori. 2011 Mol. Cell. Endocrinol. pmid:21256183
Ebert R et al. Probenecid as a sensitizer of bisphosphonate-mediated effects in breast cancer cells. 2014 Mol. Cancer pmid:25496233
Thabet I et al. Characterization and subcellular localization of geranylgeranyl diphosphate synthase from Catharanthus roseus. 2012 Mol. Biol. Rep. pmid:21706164
Caballero MC et al. Characterization of acyl carrier protein and LytB in Babesia bovis apicoplast. 2012 Mol. Biochem. Parasitol. pmid:22057350
Nisar N et al. Carotenoid metabolism in plants. 2015 Mol Plant pmid:25578273
Khan WA et al. Context-based FISH localization of genomic rearrangements within chromosome 15q11.2q13 duplicons. 2011 Mol Cytogenet pmid:21824424
Sasaki H et al. Copy number loss of (src homology 2 domain containing)-transforming protein 2 (SHC2) gene: discordant loss in monozygotic twins and frequent loss in patients with multiple system atrophy. 2011 Mol Brain pmid:21658278
Majumdar A et al. Probing phosphorylation by non-mammalian isoprenoid biosynthetic enzymes using (1)H-(31)P-(31)P correlation NMR spectroscopy. 2009 Mol Biosyst pmid:19668858
Takaichi S et al. Carotenoids of Gemmatimonas aurantiaca (Gemmatimonadetes): identification of a novel carotenoid, deoxyoscillol 2-rhamnoside, and proposed biosynthetic pathway of oscillol 2,2'-dirhamnoside. 2010 Microbiology (Reading, Engl.) pmid:19959572
Morita CT et al. Recognition of nonpeptide prenyl pyrophosphate antigens by human gammadelta T cells. 1999 Microbes Infect. pmid:10801228
Schoel B and Kaufmann SH Influence of mycobacterial virulence and culture condition on gamma delta T cell activation. 1998 Microb. Pathog. pmid:9514640
Ignea C et al. Improving yeast strains using recyclable integration cassettes, for the production of plant terpenoids. 2011 Microb. Cell Fact. pmid:21276210
Martín JF et al. Conversion of beta-carotene into astaxanthin: Two separate enzymes or a bifunctional hydroxylase-ketolase protein? 2008 Microb. Cell Fact. pmid:18289382
Chemler JA et al. Biosynthesis of isoprenoids, polyunsaturated fatty acids and flavonoids in Saccharomyces cerevisiae. 2006 Microb. Cell Fact. pmid:16719921
Jang HJ et al. Retinoid production using metabolically engineered Escherichia coli with a two-phase culture system. 2011 Microb. Cell Fact. pmid:21801353
Lemuth K et al. Engineering of a plasmid-free Escherichia coli strain for improved in vivo biosynthesis of astaxanthin. 2011 Microb. Cell Fact. pmid:21521516
Dellomonaco C et al. The path to next generation biofuels: successes and challenges in the era of synthetic biology. 2010 Microb. Cell Fact. pmid:20089184
Hasunuma T et al. Metabolic engineering by plastid transformation as a strategy to modulate isoprenoid yield in plants. 2010 Methods Mol. Biol. pmid:20552454
Davisson VJ et al. Synthesis of allylic and homoallylic isoprenoid pyrophosphates. 1985 Meth. Enzymol. pmid:2991702
Allen CM and Baba T Photolabile analogs of the allylic pyrophosphate substrate of prenyltransferases. 1985 Meth. Enzymol. pmid:4021809
Barnard GF Prenyltransferase from human liver. 1985 Meth. Enzymol. pmid:4021811
Chojnacki T Preparation of tritium-labeled 3-methyl-3-buten-1[3H]-yl diphosphate (3H-isopentenyl diphosphate). 2004 Meth. Enzymol. pmid:15038965
Cornish K and Xie W Natural rubber biosynthesis in plants: rubber transferase. 2012 Meth. Enzymol. pmid:22999170
Jones KL et al. Low-copy plasmids can perform as well as or better than high-copy plasmids for metabolic engineering of bacteria. 2000 Metab. Eng. pmid:11120644
Lai D et al. Reconstruction of the archaeal isoprenoid ether lipid biosynthesis pathway in Escherichia coli through digeranylgeranylglyceryl phosphate. 2009 Metab. Eng. pmid:19558961
Zahiri HS et al. Coenzyme Q10 production in recombinant Escherichia coli strains engineered with a heterologous decaprenyl diphosphate synthase gene and foreign mevalonate pathway. 2006 Metab. Eng. pmid:16815062
Kroll J et al. Establishment of a novel anabolism-based addiction system with an artificially introduced mevalonate pathway: complete stabilization of plasmids as universal application in white biotechnology. 2009 Metab. Eng. pmid:19558962
Cassera MB et al. Effect of fosmidomycin on metabolic and transcript profiles of the methylerythritol phosphate pathway in Plasmodium falciparum. 2007 Mem. Inst. Oswaldo Cruz pmid:17568945
Dunne MR et al. Preferential Th1 cytokine profile of phosphoantigen-stimulated human Vγ9Vδ2 T cells. 2010 Mediators Inflamm. pmid:21403900
Paniagua-Michel J et al. The carotenogenesis pathway via the isoprenoid-beta-carotene interference approach in a new strain of Dunaliella salina isolated from Baja California Mexico. 2009 Mar Drugs pmid:19370170
Guella G et al. Structures, biological activities and phylogenetic relationships of terpenoids from marine ciliates of the genus Euplotes. 2010 Mar Drugs pmid:20714425
Misawa N Carotenoid β-ring hydroxylase and ketolase from marine bacteria-promiscuous enzymes for synthesizing functional xanthophylls. 2011 Mar Drugs pmid:21673887
Ruangweerayut R et al. Assessment of the pharmacokinetics and dynamics of two combination regimens of fosmidomycin-clindamycin in patients with acute uncomplicated falciparum malaria. 2008 Malar. J. pmid:18973702
Na-Bangchang K et al. Pharmacokinetics and pharmacodynamics of fosmidomycin monotherapy and combination therapy with clindamycin in the treatment of multidrug resistant falciparum malaria. 2007 Malar. J. pmid:17531088
Rauthan M and Pilon M The mevalonate pathway in C. elegans. 2011 Lipids Health Dis pmid:22204706
Mönkkönen H et al. Zoledronic acid-induced IPP/ApppI production in vivo. 2007 Life Sci. pmid:17850825
Modi ND and Lentzsch S Bisphosphonates as antimyeloma drugs. 2012 Leukemia pmid:22005788
Qin G et al. Type 1 responses of human Vγ9Vδ2 T cells to influenza A viruses. 2011 J. Virol. pmid:21752902
Begley DW et al. Leveraging structure determination with fragment screening for infectious disease drug targets: MECP synthase from Burkholderia pseudomallei. 2011 J. Struct. Funct. Genomics pmid:21359640
Berkun Y et al. GammadeltaT cells in juvenile idiopathic arthritis: higher percentages of synovial Vdelta1+ and Vgamma9+ T cell subsets are associated with milder disease. 2011 J. Rheumatol. pmid:21406498
Wang Y et al. The effect of 24S-hydroxycholesterol on cholesterol homeostasis in neurons: quantitative changes to the cortical neuron proteome. 2008 J. Proteome Res. pmid:18303831