Isopentenyl pyrophosphate

Isopentenyl pyrophosphate is a lipid of Prenol Lipids (PR) class. Isopentenyl pyrophosphate is associated with abnormalities such as Tuberculosis, NAVAJO NEUROHEPATOPATHY and Cryptosporidiosis. The involved functions are known as Signal, Anabolism, T-Cell Activation, T-Cell Proliferation and isoprenoid biosynthetic process. Isopentenyl pyrophosphate often locates in Protoplasm, Host Cell, soluble, Plastids and Cell surface. The associated genes with Isopentenyl pyrophosphate are oxytocin, 1-desamino-(O-Et-Tyr)(2)-, HLA-E gene, RAP1A gene, Gene Family and Orthologous Gene. The related lipids are Steroids, Sterols and isopentenol.

Cross Reference

Introduction

To understand associated biological information of Isopentenyl pyrophosphate, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Isopentenyl pyrophosphate?

Isopentenyl pyrophosphate is suspected in Tuberculosis, NAVAJO NEUROHEPATOPATHY, Cryptosporidiosis and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Isopentenyl pyrophosphate

MeSH term MeSH ID Detail
Melanoma D008545 69 associated lipids
Total 1

PubChem Associated disorders and diseases

What pathways are associated with Isopentenyl pyrophosphate

Lipid pathways are not clear in current pathway databases. We organized associated pathways with Isopentenyl pyrophosphate through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
Loading... please refresh the page if content is not showing up.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Isopentenyl pyrophosphate?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with Isopentenyl pyrophosphate?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Isopentenyl pyrophosphate?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with Isopentenyl pyrophosphate?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Isopentenyl pyrophosphate?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Isopentenyl pyrophosphate

Download all related citations
Per page 10 20 50 100 | Total 1004
Authors Title Published Journal PubMed Link
Nerdal PT et al. Butyrophilin 3A/CD277-Dependent Activation of Human γδ T Cells: Accessory Cell Capacity of Distinct Leukocyte Populations. 2016 J. Immunol. pmid:27619996
Corvaisier M et al. V gamma 9V delta 2 T cell response to colon carcinoma cells. 2005 J. Immunol. pmid:16210656
Sicard H et al. In vivo immunomanipulation of V gamma 9V delta 2 T cells with a synthetic phosphoantigen in a preclinical nonhuman primate model. 2005 J. Immunol. pmid:16210655
Spencer CT et al. Only a subset of phosphoantigen-responsive gamma9delta2 T cells mediate protective tuberculosis immunity. 2008 J. Immunol. pmid:18802050
Li J et al. Reduced expression of the mevalonate pathway enzyme farnesyl pyrophosphate synthase unveils recognition of tumor cells by Vgamma9Vdelta2 T cells. 2009 J. Immunol. pmid:19494338
Wang H and Morita CT Sensor Function for Butyrophilin 3A1 in Prenyl Pyrophosphate Stimulation of Human Vγ2Vδ2 T Cells. 2015 J. Immunol. pmid:26475929
Castella B et al. Immune modulation by zoledronic acid in human myeloma: an advantageous cross-talk between Vγ9Vδ2 T cells, αβ CD8+ T cells, regulatory T cells, and dendritic cells. 2011 J. Immunol. pmid:21753152
Casetti R et al. Drug-induced expansion and differentiation of V gamma 9V delta 2 T cells in vivo: the role of exogenous IL-2. 2005 J. Immunol. pmid:16034098
García VE et al. Single-cell cytokine analysis of gamma delta T cell responses to nonpeptide mycobacterial antigens. 1997 J. Immunol. pmid:9233629
Chen L et al. Transcriptional profiling of gamma delta T cells identifies a role for vitamin D in the immunoregulation of the V gamma 9V delta 2 response to phosphate-containing ligands. 2005 J. Immunol. pmid:15879110
Cipriani B et al. Curcumin inhibits activation of Vgamma9Vdelta2 T cells by phosphoantigens and induces apoptosis involving apoptosis-inducing factor and large scale DNA fragmentation. 2001 J. Immunol. pmid:11544338
Bieback K et al. Expansion of human gamma/delta T cells in vitro is differentially regulated by the measles virus glycoproteins. 2003 J. Gen. Virol. pmid:12692283
Bürk MR et al. Functional inactivation in the whole population of human V gamma 9/V delta 2 T lymphocytes induced by a nonpeptidic antagonist. 1997 J. Exp. Med. pmid:8996245
Voskens CJ et al. Ex-vivo expanded human NK cells express activating receptors that mediate cytotoxicity of allogeneic and autologous cancer cell lines by direct recognition and antibody directed cellular cytotoxicity. 2010 J. Exp. Clin. Cancer Res. pmid:20937115
Almeida J et al. Genetic dissection of vitamin E biosynthesis in tomato. 2011 J. Exp. Bot. pmid:21527625
Ma Y et al. Genome-wide identification and characterization of novel genes involved in terpenoid biosynthesis in Salvia miltiorrhiza. 2012 J. Exp. Bot. pmid:22291132
Zhang F et al. An L1 box binding protein, GbML1, interacts with GbMYB25 to control cotton fibre development. 2010 J. Exp. Bot. pmid:20667961
Pan IL et al. Functional diversification of AGAMOUS lineage genes in regulating tomato flower and fruit development. 2010 J. Exp. Bot. pmid:20335407
Fu X et al. Plastid structure and carotenogenic gene expression in red- and white-fleshed loquat (Eriobotrya japonica) fruits. 2012 J. Exp. Bot. pmid:21994170
Yamamizo C et al. Carotenoid composition and carotenogenic gene expression during Ipomoea petal development. 2010 J. Exp. Bot. pmid:19933319
Liu Q et al. Transcriptome analysis of a spontaneous mutant in sweet orange [Citrus sinensis (L.) Osbeck] during fruit development. 2009 J. Exp. Bot. pmid:19218315
Green SA et al. Identification, functional characterization, and regulation of the enzyme responsible for floral (E)-nerolidol biosynthesis in kiwifruit (Actinidia chinensis). 2012 J. Exp. Bot. pmid:22162874
Zhong YJ et al. Functional characterization of various algal carotenoid ketolases reveals that ketolating zeaxanthin efficiently is essential for high production of astaxanthin in transgenic Arabidopsis. 2011 J. Exp. Bot. pmid:21398427
Nieuwenhuizen NJ et al. Two terpene synthases are responsible for the major sesquiterpenes emitted from the flowers of kiwifruit (Actinidia deliciosa). 2009 J. Exp. Bot. pmid:19516075
Suzuki M et al. Complete blockage of the mevalonate pathway results in male gametophyte lethality. 2009 J. Exp. Bot. pmid:19363204
Battilana J et al. Functional effect of grapevine 1-deoxy-D-xylulose 5-phosphate synthase substitution K284N on Muscat flavour formation. 2011 J. Exp. Bot. pmid:21868399
Zeng Y et al. A proteomic analysis of the chromoplasts isolated from sweet orange fruits [Citrus sinensis (L.) Osbeck]. 2011 J. Exp. Bot. pmid:21841170
Chow KS et al. Metabolic routes affecting rubber biosynthesis in Hevea brasiliensis latex. 2012 J. Exp. Bot. pmid:22162870
Ohara K et al. Two solanesyl diphosphate synthases with different subcellular localizations and their respective physiological roles in Oryza sativa. 2010 J. Exp. Bot. pmid:20421194
Aros D et al. Volatile emissions of scented Alstroemeria genotypes are dominated by terpenes, and a myrcene synthase gene is highly expressed in scented Alstroemeria flowers. 2012 J. Exp. Bot. pmid:22268153
Ibrahim MA et al. Elevation of night-time temperature increases terpenoid emissions from Betula pendula and Populus tremula. 2010 J. Exp. Bot. pmid:20181662
Leblond JD et al. Sterol composition and biosynthetic genes of the recently discovered photosynthetic alveolate, Chromera velia (chromerida), a close relative of apicomplexans. 2012 May-Jun J. Eukaryot. Microbiol. pmid:22313428
Martino A et al. Complementary function of gamma delta T-lymphocytes and dendritic cells in the response to isopentenyl-pyrophosphate and lipopolysaccharide antigens. 2005 J. Clin. Immunol. pmid:15981088
Jauhiainen M et al. Analysis of endogenous ATP analogs and mevalonate pathway metabolites in cancer cell cultures using liquid chromatography-electrospray ionization mass spectrometry. 2009 J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. pmid:19665949
Opitz S et al. Increased terpenoid accumulation in cotton (Gossypium hirsutum) foliage is a general wound response. 2008 J. Chem. Ecol. pmid:18386096
Workalemahu G et al. Expression of metalloproteinase-7 (matrilysin) in human blood and bronchoalveolar gamma/delta T-lymphocytes. Selective upregulation by the soluble non-peptidic mycobacterial phosphoantigen (isopentenyl pyrophosphate). 2006 J. Cell. Physiol. pmid:16250011
Grove JE et al. The intracellular target for the antiresorptive aminobisphosphonate drugs in Dictyostelium discoideum is the enzyme farnesyl diphosphate synthase. 2000 J. Bone Miner. Res. pmid:10804029
Hokugo A et al. Increased prevalence of bisphosphonate-related osteonecrosis of the jaw with vitamin D deficiency in rats. 2010 J. Bone Miner. Res. pmid:20200938
Thompson K and Rogers MJ Statins prevent bisphosphonate-induced gamma,delta-T-cell proliferation and activation in vitro. 2004 J. Bone Miner. Res. pmid:14969398
Yamada Y et al. Efficient in vitro synthesis of cis-polyisoprenes using a thermostable cis-prenyltransferase from a hyperthermophilic archaeon Thermococcus kodakaraensis. 2009 J. Biotechnol. pmid:19583987
Palazón J et al. Inhibition of paclitaxel and baccatin III accumulation by mevinolin and fosmidomycin in suspension cultures of Taxus baccata. 2003 J. Biotechnol. pmid:12568744
Rojruthai P et al. In vitro synthesis of high molecular weight rubber by Hevea small rubber particles. 2010 J. Biosci. Bioeng. pmid:20129092
Saito K et al. Short-chain prenyl diphosphate synthase that condenses isopentenyl diphosphate with dimethylallyl diphosphate in ispA null Escherichia coli strain lacking farnesyl diphosphate synthase. 2007 J. Biosci. Bioeng. pmid:17630132
Saxena B et al. Metabolic engineering of chloroplasts for artemisinic acid biosynthesis and impact on plant growth. 2014 J. Biosci. pmid:24499788
Kuo CJ et al. Structure-based inhibitors exhibit differential activities against Helicobacter pylori and Escherichia coli undecaprenyl pyrophosphate synthases. 2008 J. Biomed. Biotechnol. pmid:18382620
Havel C et al. Isopentenoid synthesis in isolated embryonic Drosophila cells. Possible regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity by shunted mevalonate carbon. 1986 J. Biol. Chem. pmid:3733706
Kuzuyama T et al. Characterization of 1-deoxy-D-xylulose 5-phosphate reductoisomerase, an enzyme involved in isopentenyl diphosphate biosynthesis, and identification of its catalytic amino acid residues. 2000 J. Biol. Chem. pmid:10787409
Skorupinska-Tudek K et al. Contribution of the mevalonate and methylerythritol phosphate pathways to the biosynthesis of dolichols in plants. 2008 J. Biol. Chem. pmid:18502754
Light DR and Dennis MS Purification of a prenyltransferase that elongates cis-polyisoprene rubber from the latex of Hevea brasiliensis. 1989 J. Biol. Chem. pmid:2808388
Hemmerlin A et al. Cross-talk between the cytosolic mevalonate and the plastidial methylerythritol phosphate pathways in tobacco bright yellow-2 cells. 2003 J. Biol. Chem. pmid:12736259