Geranyl diphosphate

Geranyl diphosphate is a lipid of Prenol Lipids (PR) class. The involved functions are known as Prenylation, Anabolism, Biochemical Pathway and Methylation. Geranyl diphosphate often locates in Membrane and Plastids. The associated genes with Geranyl diphosphate are GGPS1 gene, NKS1 gene, COQ2 gene and MIB1 gene.

Cross Reference

Introduction

To understand associated biological information of Geranyl diphosphate, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Geranyl diphosphate?

There are no associated biomedical information in the current reference collection.

No disease MeSH terms mapped to the current reference collection.

PubChem Associated disorders and diseases

What pathways are associated with Geranyl diphosphate

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Geranyl diphosphate?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with Geranyl diphosphate?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Geranyl diphosphate?

There are no associated biomedical information in the current reference collection.

What genes are associated with Geranyl diphosphate?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Geranyl diphosphate?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Geranyl diphosphate

Download all related citations
Per page 10 20 50 100 | Total 80
Authors Title Published Journal PubMed Link
pmid:
Loza-Tavera H Monoterpenes in essential oils. Biosynthesis and properties. 1999 Adv. Exp. Med. Biol. pmid:10335385
Pont F et al. Characterization of phosphoantigens by high-performance anion-exchange chromatography-electrospray ionization ion trap mass spectrometry and nanoelectrospray ionization ion trap mass spectrometry. 2001 Anal. Chem. pmid:11510819
Micali E et al. Protein farnesyltransferase isoprenoid substrate discrimination is dependent on isoprene double bonds and branched methyl groups. 2001 Biochemistry pmid:11591144
Gan X et al. Dual mechanisms of ABCA1 regulation by geranylgeranyl pyrophosphate. 2001 J. Biol. Chem. pmid:11641412
Yazaki K et al. Geranyl diphosphate:4-hydroxybenzoate geranyltransferase from Lithospermum erythrorhizon. Cloning and characterization of a ket enzyme in shikonin biosynthesis. 2002 J. Biol. Chem. pmid:11744717
Holstein SA and Hohl RJ Isoprenoids: remarkable diversity of form and function. 2004 Lipids pmid:15357017
van Klink JW et al. Biosynthesis of irregular diterpenes in Anisotome lyallii by head-to-head coupling of geranyl diphosphate. 2005 Org. Biomol. Chem. pmid:15678195
Kuzuyama T et al. Structural basis for the promiscuous biosynthetic prenylation of aromatic natural products. 2005 Nature pmid:15959519
Nogués I et al. Dimethylallyl diphosphate and geranyl diphosphate pools of plant species characterized by different isoprenoid emissions. 2006 Plant Physiol. pmid:16461390
Qiu Y and Li D Bifunctional inhibitors of mevalonate kinase and mevalonate 5-diphosphate decarboxylase. 2006 Org. Lett. pmid:16524256
Qiu Y and Li D Inhibition of mevalonate 5-diphosphate decarboxylase by fluorinated substrate analogs. 2006 Biochim. Biophys. Acta pmid:16626865
Kavanagh KL et al. The molecular mechanism of nitrogen-containing bisphosphonates as antiosteoporosis drugs. 2006 Proc. Natl. Acad. Sci. U.S.A. pmid:16684881
Zahiri HS et al. Biochemical characterization of the decaprenyl diphosphate synthase of Rhodobacter sphaeroides for coenzyme Q10 production. 2006 Appl. Microbiol. Biotechnol. pmid:16896603
Sen SE et al. Juvenile hormone biosynthesis in M. sexta: substrate specificity of insect prenyltransferase utilizing homologous diphosphate analogs. 2006 Insect Biochem. Mol. Biol. pmid:17046596
Thulasiram HV and Poulter CD Farnesyl diphosphate synthase: the art of compromise between substrate selectivity and stereoselectivity. 2006 J. Am. Chem. Soc. pmid:17147392
Glickman JF and Schmid A Farnesyl pyrophosphate synthase: real-time kinetics and inhibition by nitrogen-containing bisphosphonates in a scintillation assay. 2007 Assay Drug Dev Technol pmid:17477829
Yin WB et al. CdpNPT, an N-prenyltransferase from Aspergillus fumigatus: overproduction, purification and biochemical characterisation. 2007 Chembiochem pmid:17525915
Guo RT et al. Bisphosphonates target multiple sites in both cis- and trans-prenyltransferases. 2007 Proc. Natl. Acad. Sci. U.S.A. pmid:17535895
Nagaki M et al. Substrate specificities of wild and mutated farnesyl diphosphate synthases from Bacillus stearothermophilus with artificial substrates. 2007 Biosci. Biotechnol. Biochem. pmid:17617711
Schmidt A and Gershenzon J Cloning and characterization of two different types of geranyl diphosphate synthases from Norway spruce (Picea abies). 2008 Phytochemistry pmid:17673268
Ling Y et al. The farnesyl-diphosphate/geranylgeranyl-diphosphate synthase of Toxoplasma gondii is a bifunctional enzyme and a molecular target of bisphosphonates. 2007 J. Biol. Chem. pmid:17724033
Matsumura Y et al. The carboxyl-terminal region of the geranylgeranyl diphosphate synthase is indispensable for the stabilization of the region involved in substrate binding and catalysis. 2007 J. Biochem. pmid:17846065
Kremer A et al. A 7-dimethylallyltryptophan synthase from Aspergillus fumigatus: overproduction, purification and biochemical characterization. 2007 Microbiology (Reading, Engl.) pmid:17906140
Karp F et al. Inhibition of monoterpene cyclases by inert analogues of geranyl diphosphate and linalyl diphosphate. 2007 Arch. Biochem. Biophys. pmid:17949678
Komatsu M et al. Identification and functional analysis of genes controlling biosynthesis of 2-methylisoborneol. 2008 Proc. Natl. Acad. Sci. U.S.A. pmid:18492804
Davidovich-Rikanati R et al. Overexpression of the lemon basil alpha-zingiberene synthase gene increases both mono- and sesquiterpene contents in tomato fruit. 2008 Plant J. pmid:18643974
Navia-Giné WG et al. Medicago truncatula (E)-beta-ocimene synthase is induced by insect herbivory with corresponding increases in emission of volatile ocimene. 2009 Plant Physiol. Biochem. pmid:19249223
Gilg AB et al. Unique animal prenyltransferase with monoterpene synthase activity. 2009 Naturwissenschaften pmid:19277597
Sillero MA et al. Synthesis of ATP derivatives of compounds of the mevalonate pathway (isopentenyl di- and triphosphate; geranyl di- and triphosphate, farnesyl di- and triphosphate, and dimethylallyl diphosphate) catalyzed by T4 RNA ligase, T4 DNA ligase and other ligases Potential relationship with the effect of bisphosphonates on osteoclasts. 2009 Biochem. Pharmacol. pmid:19414000
Schilmiller AL et al. Monoterpenes in the glandular trichomes of tomato are synthesized from a neryl diphosphate precursor rather than geranyl diphosphate. 2009 Proc. Natl. Acad. Sci. U.S.A. pmid:19487664
Xiao Y et al. Prenyltransferase substrate binding pocket flexibility and its application in isoprenoid profiling. 2009 Mol Biosyst pmid:19668852
Vandermoten S et al. Structural features conferring dual geranyl/farnesyl diphosphate synthase activity to an aphid prenyltransferase. 2009 Insect Biochem. Mol. Biol. pmid:19720147
Holstein SA et al. Quantitative determination of geranyl diphosphate levels in cultured human cells. 2009 Lipids pmid:19856009
Orlova I et al. The small subunit of snapdragon geranyl diphosphate synthase modifies the chain length specificity of tobacco geranylgeranyl diphosphate synthase in planta. 2009 Plant Cell pmid:20028839
Nagegowda DA The small subunit of geranyl diphosphate synthase: a tool to improve aroma and flavour by metabolic engineering. 2010 J. Biosci. pmid:20689171
Hong YJ and Tantillo DJ Quantum chemical dissection of the classic terpinyl/pinyl/bornyl/camphyl cation conundrum-the role of pyrophosphate in manipulating pathways to monoterpenes. 2010 Org. Biomol. Chem. pmid:20725661
Mann FM et al. Rv0989c encodes a novel (E)-geranyl diphosphate synthase facilitating decaprenyl diphosphate biosynthesis in Mycobacterium tuberculosis. 2011 FEBS Lett. pmid:21237161
Tsuji F et al. The geranyl-modified tryptophan residue is crucial for ComXRO-E-2 pheromone biological activity. 2011 Bioorg. Med. Chem. Lett. pmid:21636272
Nakano C et al. Identification of the first bacterial monoterpene cyclase, a 1,8-cineole synthase, that catalyzes the direct conversion of geranyl diphosphate. 2011 Chembiochem pmid:21726035
Schmidt A et al. Induction of isoprenyl diphosphate synthases, plant hormones and defense signalling genes correlates with traumatic resin duct formation in Norway spruce (Picea abies). 2011 Plant Mol. Biol. pmid:22002747
Savage TJ et al. Condensation of the isoprenoid and amino precursors in the biosynthesis of domoic acid. 2012 Toxicon pmid:22041653
Green SA et al. Identification, functional characterization, and regulation of the enzyme responsible for floral (E)-nerolidol biosynthesis in kiwifruit (Actinidia chinensis). 2012 J. Exp. Bot. pmid:22162874
Nagel R et al. Nonradioactive assay for detecting isoprenyl diphosphate synthase activity in crude plant extracts using liquid chromatography coupled with tandem mass spectrometry. 2012 Anal. Biochem. pmid:22266300
Yang Y et al. Catalytic mechanism of aromatic prenylation by NphB. 2012 Biochemistry pmid:22385275
Köksal M et al. Structure of geranyl diphosphate C-methyltransferase from Streptomyces coelicolor and implications for the mechanism of isoprenoid modification. 2012 Biochemistry pmid:22455498
Yoosuf-Aly Z et al. Chemoenzymatic synthesis of the alarm pheromone (+)-verbenone from geranyl diphosphate. 2012 Chem. Commun. (Camb.) pmid:22684271
Zhang YL and Li ZX Functional analysis and molecular docking identify two active short-chain prenyltransferases in the green peach aphid, Myzus persicae. 2012 Arch. Insect Biochem. Physiol. pmid:22696503
Munakata R et al. Characterization of coumarin-specific prenyltransferase activities in Citrus limon peel. 2012 Biosci. Biotechnol. Biochem. pmid:22785469
Frick S et al. Metal ions control product specificity of isoprenyl diphosphate synthases in the insect terpenoid pathway. 2013 Proc. Natl. Acad. Sci. U.S.A. pmid:23440195