MeSH term | MeSH ID | Detail |
---|---|---|
Gastrointestinal Hemorrhage | D006471 | 27 associated lipids |
Geranial is a lipid of Prenol Lipids (PR) class. Geranial is associated with abnormalities such as Wiskott-Aldrich Syndrome. The involved functions are known as Anabolism, Oxidation, Process, geranial dehydrogenase activity and retinoid X receptor binding. Geranial often locates in soluble. The associated genes with Geranial are CDKN1A gene.
To understand associated biological information of Geranial, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Geranial is suspected in and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Geranial
MeSH term | MeSH ID | Detail |
---|---|---|
Gastrointestinal Hemorrhage | D006471 | 27 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
---|
There are no associated biomedical information in the current reference collection.
Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Segal R and Milo-Goldzweig I | The hemolytic activity of citral--II. Glutathione depletion in citral treated erythrocytes. | 1985 | Biochem. Pharmacol. | pmid:4062979 |
Tamir I et al. | The hemolytic activity of citral: evidence for free radical participation. | 1984 | Biochem. Pharmacol. | pmid:6487347 |
Katsukawa M et al. | Citral, a component of lemongrass oil, activates PPARα and γ and suppresses COX-2 expression. | 2010 | Biochim. Biophys. Acta | pmid:20656057 |
Tomita S et al. | Characteristic properties of a retinoic acid synthetic cytochrome P-450 purified from liver microsomes of 3-methylcholanthrene-induced rats. | 1996 | Biochim. Biophys. Acta | pmid:8765131 |
Sato K et al. | Antimicrobial effect of trans-cinnamaldehyde, (-)-perillaldehyde, (-)-citronellal, citral, eugenol and carvacrol on airborne microbes using an airwasher. | 2006 | Biol. Pharm. Bull. | pmid:17077531 |
Rajak H et al. | Novel limonene and citral based 2,5-disubstituted-1,3,4-oxadiazoles: a natural product coupled approach to semicarbazones for antiepileptic activity. | 2013 | Bioorg. Med. Chem. Lett. | pmid:23265873 |
Kashiwayanagi M et al. | Membrane fluidity changes of liposomes in response to various odorants. Complexity of membrane composition and variety of adsorption sites for odorants. | 1990 | Biophys. J. | pmid:2248993 |
Ramachandran S et al. | Permeabilization and inhibition of the germination of spores of Aspergillus niger for gluconic acid production from glucose. | 2008 | Bioresour. Technol. | pmid:17889524 |
Lin CT et al. | Anti-inflammation activity of fruit essential oil from Cinnamomum insularimontanum Hayata. | 2008 | Bioresour. Technol. | pmid:18513962 |
Lin SY et al. | Volatile organic components of fresh leaves as indicators of indigenous and cultivated citrus species in Taiwan. | 2010 | Biosci. Biotechnol. Biochem. | pmid:20378980 |
Rungsardthong Ruktanonchai U et al. | Encapsulation of citral isomers in extracted lemongrass oil with cyclodextrins: molecular modeling and physicochemical characterizations. | 2011 | Biosci. Biotechnol. Biochem. | pmid:22146714 |
Hassan M et al. | Monoterpene alcohol metabolism: identification, purification, and characterization of two geraniol dehydrogenase isoenzymes from Polygonum minus leaves. | 2012 | Biosci. Biotechnol. Biochem. | pmid:22878188 |
Wolken WA et al. | Toxicity of terpenes to spores and mycelium of Penicillium digitatum. | 2002 | Biotechnol. Bioeng. | pmid:12378610 |
Chen Y and Reese DH | A screen for disruptors of the retinol (vitamin A) signaling pathway. | 2013 | Birth Defects Res. B Dev. Reprod. Toxicol. | pmid:23696197 |
OuYang Q et al. | Transcriptional profiling analysis of Penicillium digitatum, the causal agent of citrus green mold, unravels an inhibited ergosterol biosynthesis pathway in response to citral. | 2016 | BMC Genomics | pmid:27514516 |
Annadurai RS et al. | Next generation sequencing and de novo transcriptome analysis of Costus pictus D. Don, a non-model plant with potent anti-diabetic properties. | 2012 | BMC Genomics | pmid:23176672 |
Youngentob SL and Kent PF | Enhancement of odorant-induced mucosal activity patterns in rats trained on an odorant identification task. | 1995 | Brain Res. | pmid:7719728 |
Prince DJ and Carlone RL | Retinoic acid involvement in the reciprocal neurotrophic interactions between newt spinal cord and limb blastemas in vitro. | 2003 | Brain Res. Dev. Brain Res. | pmid:12524177 |
Pompeu MS and Silveira FA | Reaction of Melipona rufiventris lepeletier to citral and against an attack by the Cleptobiotic bee Lestrimelitta limao (Smith) (Hymenoptera: Apidae: Meliponina). | 2005 | Braz J Biol | pmid:16025918 |
Silva Cde B et al. | Antifungal activity of the lemongrass oil and citral against Candida spp. | 2008 | Braz J Infect Dis | pmid:18553017 |
Ara K et al. | Foot odor due to microbial metabolism and its control. | 2006 | Can. J. Microbiol. | pmid:16699586 |
Queiroz RM et al. | Apoptosis-inducing effects of Melissa officinalis L. essential oil in glioblastoma multiforme cells. | 2014 | Cancer Invest. | pmid:24745610 |
Connor MJ | Modulation of tumor promotion in mouse skin by the food additive citral (3,7-dimethyl-2,6-octadienal). | 1991 | Cancer Lett. | pmid:2004350 |
Connor MJ | Oxidation of retinol to retinoic acid as a requirement for biological activity in mouse epidermis. | 1988 | Cancer Res. | pmid:3191479 |
Binder S et al. | Adverse Phototoxic Effect of Essential Plant Oils on NIH 3T3 Cell Line after UV Light Exposure. | 2016 | Cent. Eur. J. Public Health | pmid:27755863 |
Iersel ML et al. | Inhibition of glutathione S-transferase activity in human melanoma cells by alpha,beta-unsaturated carbonyl derivatives. Effects of acrolein, cinnamaldehyde, citral, crotonaldehyde, curcumin, ethacrynic acid, and trans-2-hexenal. | 1996 | Chem. Biol. Interact. | pmid:8950226 |
Seo KA et al. | The monoterpenoids citral and geraniol are moderate inhibitors of CYP2B6 hydroxylase activity. | 2008 | Chem. Biol. Interact. | pmid:18611395 |
Bchini R et al. | Retinoic acid biosynthesis catalyzed by retinal dehydrogenases relies on a rate-limiting conformational transition associated with substrate recognition. | 2013 | Chem. Biol. Interact. | pmid:23220587 |
Li J et al. | Transient transmembrane secretion of H2O2: a mechanism for the citral-caused inhibition of aflatoxin production from Aspergillus flavus. | 2015 | Chem. Commun. (Camb.) | pmid:26466766 |
Milone C et al. | Selective liquid phase hydrogenation of citral on Au/Fe2O3 catalysts. | 2002 | Chem. Commun. (Camb.) | pmid:12123019 |
Merckel F et al. | Effect of a microemulsion system on hapten-peptide reactivity studies: examples of hydroxycitronellal and citral, fragrance skin sensitizers, with glutathione. | 2010 | Chem. Res. Toxicol. | pmid:20795681 |
Hagvall L et al. | Experimental and theoretical investigations of the autoxidation of geranial: a dioxolane hydroperoxide identified as a skin sensitizer. | 2011 | Chem. Res. Toxicol. | pmid:21823635 |
Laska M and Grimm N | SURE, why not? The SUbstitution-REciprocity method for measurement of odor quality discrimination thresholds: replication and extension to nonhuman primates. | 2003 | Chem. Senses | pmid:12588733 |
Veldhuizen MG et al. | Coactivation of gustatory and olfactory signals in flavor perception. | 2010 | Chem. Senses | pmid:20032112 |
Takiguchi N et al. | Performance of mice in discrimination of liquor odors: behavioral evidence for olfactory attention. | 2008 | Chem. Senses | pmid:18178544 |
Hallowell ES et al. | Flavor Identification and Intensity: Effects of Stimulus Context. | 2016 | Chem. Senses | pmid:26830499 |
Shepard TG et al. | Response Times to Gustatory-Olfactory Flavor Mixtures: Role of Congruence. | 2015 | Chem. Senses | pmid:26304508 |
Brewer JM et al. | Identification of gustatory-olfactory flavor mixtures: effects of linguistic labeling. | 2013 | Chem. Senses | pmid:23329730 |
Osada K et al. | Evaluation of the masking of dimethyl sulfide odors by citronellal, limonene and citral through the use of trained odor sensor mice. | 2013 | Chem. Senses | pmid:23071142 |
Brossard C et al. | Perceptual interactions between characteristic notes smelled above aqueous solutions of odorant mixtures. | 2007 | Chem. Senses | pmid:17301061 |
Gallert T et al. | Microwave-assisted partial hydrogenation of citral by using ionic liquid-coated porous glass catalysts. | 2011 | ChemSusChem | pmid:21826800 |
Engelstein D et al. | Citral and testosterone interactions in inducing benign and atypical prostatic hyperplasia in rats. | 1996 | Comp. Biochem. Physiol. C, Pharmacol. Toxicol. Endocrinol. | pmid:9568365 |
Heydorn S et al. | Citral a fragrance allergen and irritant. | 2003 | Contact Derm. | pmid:14641118 |
Heydorn S et al. | Fragrance allergy in patients with hand eczema - a clinical study. | 2003 | Contact Derm. | pmid:14531870 |
Allenby CF et al. | An arm immersion model of compromised skin (I). Influence on irritation reactions. | 1993 | Contact Derm. | pmid:8458223 |
Bakker CV et al. | Ascaridole, a sensitizing component of tea tree oil, patch tested at 1% and 5% in two series of patients. | 2011 | Contact Derm. | pmid:21906073 |
Hindle E et al. | Chelitis from contact allergy to citral in lip salve. | 2007 | Contact Derm. | pmid:17627658 |
Frosch PJ et al. | Patch testing with a new fragrance mix detects additional patients sensitive to perfumes and missed by the current fragrance mix. | 2005 | Contact Derm. | pmid:15859993 |
Frosch PJ et al. | Patch testing with a new fragrance mix - reactivity to the individual constituents and chemical detection in relevant cosmetic products. | 2005 | Contact Derm. | pmid:15859994 |
Frosch PJ et al. | Patch testing with fragrances: results of a multicenter study of the European Environmental and Contact Dermatitis Research Group with 48 frequently used constituents of perfumes. | 1995 | Contact Derm. | pmid:8565489 |
Hagvall L et al. | Contact allergy to air-exposed geraniol: clinical observations and report of 14 cases. | 2012 | Contact Derm. | pmid:22681463 |
Rastogi SC et al. | Natural ingredients based cosmetics. Content of selected fragrance sensitizers. | 1996 | Contact Derm. | pmid:8879930 |
McKim JM et al. | A new in vitro method for identifying chemical sensitizers combining peptide binding with ARE/EpRE-mediated gene expression in human skin cells. | 2010 | Cutan Ocul Toxicol | pmid:20491607 |
Marie Api A et al. | Quantitative risk assessment of contact sensitization: clinical data to assess utility of the model. | 2010 Jul-Aug | Dermatitis | pmid:20646672 |
Scheman A et al. | European Directive fragrances in natural products. | 2014 Mar-Apr | Dermatitis | pmid:24603515 |
Didierjean L et al. | Biological activities of topical retinaldehyde. | 1999 | Dermatology (Basel) | pmid:10473955 |
Pedersen PE and Blass EM | Prenatal and postnatal determinants of the 1st suckling episode in albino rats. | 1982 | Dev Psychobiol | pmid:7106394 |
Song Y et al. | Control of retinoic acid synthesis and FGF expression in the nasal pit is required to pattern the craniofacial skeleton. | 2004 | Dev. Biol. | pmid:15581867 |
Ijpenberg A et al. | Wt1 and retinoic acid signaling are essential for stellate cell development and liver morphogenesis. | 2007 | Dev. Biol. | pmid:18028902 |
Tanaka M et al. | Citral, an inhibitor of retinoic acid synthesis, modifies chick limb development. | 1996 | Dev. Biol. | pmid:8626029 |
Perz-Edwards A et al. | Retinoic acid-mediated gene expression in transgenic reporter zebrafish. | 2001 | Dev. Biol. | pmid:11133156 |
Lampert JM et al. | Provitamin A conversion to retinal via the beta,beta-carotene-15,15'-oxygenase (bcox) is essential for pattern formation and differentiation during zebrafish embryogenesis. | 2003 | Development | pmid:12668631 |
Schuh TJ et al. | v-erbA and citral reduce the teratogenic effects of all-trans retinoic acid and retinol, respectively, in Xenopus embryogenesis. | 1993 | Development | pmid:7910550 |
Mutalik S et al. | A combined approach of chemical enhancers and sonophoresis for the transdermal delivery of tizanidine hydrochloride. | 2009 | Drug Deliv | pmid:19267299 |
Zhang W and Lim LY | Effects of spice constituents on P-glycoprotein-mediated transport and CYP3A4-mediated metabolism in vitro. | 2008 | Drug Metab. Dispos. | pmid:18385293 |
Boyer CS and Petersen DR | The metabolism of 3,7-dimethyl-2,6-octadienal (citral) in rat hepatic mitochondrial and cytosolic fractions. Interactions with aldehyde and alcohol dehydrogenases. | 1991 Jan-Feb | Drug Metab. Dispos. | pmid:1673427 |
Diliberto JJ et al. | Metabolism of citral, an alpha,beta-unsaturated aldehyde, in male F344 rats. | 1990 Nov-Dec | Drug Metab. Dispos. | pmid:1981530 |
Diliberto JJ et al. | Disposition of citral in male Fischer rats. | 1988 Sep-Oct | Drug Metab. Dispos. | pmid:2906597 |
Faraone N et al. | Electrophysiological and behavioral responses of oriental fruit moth to the monoterpenoid citral alone and in combination with sex pheromone. | 2013 | Environ. Entomol. | pmid:23575022 |
Duerksen-Hughes PJ et al. | p53 induction as a genotoxic test for twenty-five chemicals undergoing in vivo carcinogenicity testing. | 1999 | Environ. Health Perspect. | pmid:10504146 |
Wolfe MS | NTP announces bioassay results. | 2001 | Environ. Health Perspect. | pmid:11564635 |
Schoff PK and Ankley GT | Effects of methoprene, its metabolites, and breakdown products on retinoid-activated pathways in transfected cell lines. | 2004 | Environ. Toxicol. Chem. | pmid:15180384 |
Wolken WA et al. | A novel, inducible, citral lyase purified from spores of Penicillium digitatum. | 2002 | Eur. J. Biochem. | pmid:12444979 |
Kikonyogo A et al. | Mechanism of inhibition of aldehyde dehydrogenase by citral, a retinoid antagonist. | 1999 | Eur. J. Biochem. | pmid:10411631 |
Pottek M and Weiler R | Light-adaptive effects of retinoic acid on receptive field properties of retinal horizontal cells. | 2000 | Eur. J. Neurosci. | pmid:10712624 |
Okutani F et al. | Modulation of olfactory learning in young rats through intrabulbar GABA(B) receptors. | 2003 | Eur. J. Neurosci. | pmid:14622236 |
Galizia CG et al. | Odour coding is bilaterally symmetrical in the antennal lobes of honeybees (Apis mellifera). | 1998 | Eur. J. Neurosci. | pmid:9758166 |
Servadio C et al. | Early stages of the pathogenesis of rat ventral prostate hyperplasia induced by citral. | 1986 | Eur. Urol. | pmid:2423338 |
Sakata T et al. | Chemical ecology of oribatid mites III. Chemical composition of oil gland exudates from two oribatid mites, Trhypochthoniellus sp. and Trhypochthonius japonicus (Acari: Trhypochthoniidae). | 2003 | Exp. Appl. Acarol. | pmid:14635814 |
Machado M et al. | Monoterpenic aldehydes as potential anti-Leishmania agents: activity of Cymbopogon citratus and citral on L. infantum, L. tropica and L. major. | 2012 | Exp. Parasitol. | pmid:22227102 |
Noge K et al. | Geraniol dehydrogenase, the key enzyme in biosynthesis of the alarm pheromone, from the astigmatid mite Carpoglyphus lactis (Acari: Carpoglyphidae). | 2008 | FEBS J. | pmid:18422649 |
Apolónio J et al. | No induction of antimicrobial resistance in Staphylococcus aureus and Listeria monocytogenes during continuous exposure to eugenol and citral. | 2014 | FEMS Microbiol. Lett. | pmid:24716611 |
Sadraei H et al. | Relaxant effect of essential oil of Melissa officinalis and citral on rat ileum contractions. | 2003 | Fitoterapia | pmid:12837359 |
Park MJ et al. | Effect of citral, eugenol, nerolidol and alpha-terpineol on the ultrastructural changes of Trichophyton mentagrophytes. | 2009 | Fitoterapia | pmid:19345255 |
Mangprayool T et al. | Participation of citral in the bronchodilatory effect of ginger oil and possible mechanism of action. | 2013 | Fitoterapia | pmid:23685048 |
Maswal M and Dar AA | Inhibition of citral degradation in an acidic aqueous environment by polyoxyethylene alkylether surfactants. | 2013 | Food Chem | pmid:23497896 |
Tian H et al. | Development of a solid phase microextraction protocol for the GC-MS determination of volatile off-flavour compounds from citral degradation in oil-in-water emulsions. | 2013 | Food Chem | pmid:23768338 |
Giteru SG et al. | Physicochemical and antimicrobial properties of citral and quercetin incorporated kafirin-based bioactive films. | 2015 | Food Chem | pmid:25172719 |
Lalko J and Api AM | Investigation of the dermal sensitization potential of various essential oils in the local lymph node assay. | 2006 | Food Chem. Toxicol. | pmid:16324777 |
Roffey SJ et al. | Hepatic peroxisomal and microsomal enzyme induction by citral and linalool in rats. | 1990 | Food Chem. Toxicol. | pmid:2210513 |
Gaworski CL et al. | Developmental toxicity evaluation of inhaled citral in Sprague-Dawley rats. | 1992 | Food Chem. Toxicol. | pmid:1628861 |
Jackson GM et al. | Comparison of the short-term hepatic effects of orally administered citral in Long Evans hooded and Wistar albino rats. | 1987 | Food Chem. Toxicol. | pmid:3623339 |
Dieter MP et al. | Comparison of the toxicity of citral in F344 rats and B6C3F1 mice when administrated by microencapsulation in feed or by corn-oil gavage. | 1993 | Food Chem. Toxicol. | pmid:8340024 |
Steltenkamp RJ et al. | Citral: A survey of consumer patch-test sensitization. | 1980 | Food Cosmet Toxicol | pmid:7461522 |
Kuhn GO et al. | Application of microencapsulation technology to improve the stability of citral in rodent diets. | 1991 | Fundam Appl Toxicol | pmid:1794663 |
Chaouki W et al. | Citral inhibits cell proliferation and induces apoptosis and cell cycle arrest in MCF-7 cells. | 2009 | Fundam Clin Pharmacol | pmid:19656204 |
Chang CL et al. | Retinoic acid-induced glandular differentiation of the oesophagus. | 2007 | Gut | pmid:17185354 |
Massas R et al. | Immunocytochemistry of epithelial markers in citral-induced prostate hyperplasia in rats. | 1991 | Histol. Histopathol. | pmid:1724934 |
Le Bouffant R et al. | Meiosis initiation in the human ovary requires intrinsic retinoic acid synthesis. | 2010 | Hum. Reprod. | pmid:20670969 |
RodrÃguez A et al. | Retinoids during the in vitro transition from bovine morula to blastocyst. | 2006 | Hum. Reprod. | pmid:16606641 |