| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Chen C et al. | Gentiopicroside ameliorates bleomycin-induced pulmonary fibrosis in mice via inhibiting inflammatory and fibrotic process. | 2018 | Biochem. Biophys. Res. Commun. | pmid:29278701 |
| Tang X et al. | Target profiling analyses of bile acids in the evaluation of hepatoprotective effect of gentiopicroside on ANIT-induced cholestatic liver injury in mice. | 2016 | J Ethnopharmacol | pmid:27582267 |
| Amakura Y et al. | Chromatographic Evaluation and Characterization of Components of Gentian Root Extract Used as Food Additives. | 2016 | Chem. Pharm. Bull. | pmid:26726749 |
| Cao X et al. | Transcriptional Responses and Gentiopicroside Biosynthesis in Methyl Jasmonate-Treated Gentiana macrophylla Seedlings. | 2016 | PLoS ONE | pmid:27851826 |
| Zhao L et al. | Gentiopicroside prevents interleukin-1 beta induced inflammation response in rat articular chondrocyte. | 2015 | J Ethnopharmacol | pmid:26116164 |
| Zhang X et al. | De Novo Assembly and Characterization of the Transcriptome of the Chinese Medicinal Herb, Gentiana rigescens. | 2015 | Int J Mol Sci | pmid:26006235 |
| Fan G et al. | Metabolic discrimination of Swertia mussotii and Swertia chirayita known as "Zangyinchen" in traditional Tibetan medicine by (1)H NMR-based metabolomics. | 2014 | J Pharm Biomed Anal | pmid:24992216 |
| Lu CM et al. | Determination and pharmacokinetic study of gentiopicroside, geniposide, baicalin, and swertiamarin in Chinese herbal formulae after oral administration in rats by LC-MS/MS. | 2014 | Molecules | pmid:25532849 |
| Yang H et al. | Spatial variation profiling of four phytochemical constituents in Gentiana straminea (Gentianaceae). | 2014 | J Nat Med | pmid:23604973 |
| Zeng WL et al. | Microbial biotransformation of gentiopicroside by the endophytic fungus Penicillium crustosum 2T01Y01. | 2014 | Appl. Environ. Microbiol. | pmid:24141132 |
| Han H et al. | Combination of UHPLC/Q-TOF-MS, NMR spectroscopy, and ECD calculation for screening and identification of reactive metabolites of gentiopicroside in humans. | 2014 | Anal Bioanal Chem | pmid:24408300 |
| Zeng Y et al. | [Optimum harvest study of Gentiana crassicaulis in Ludian]. | 2014 | Zhongguo Zhong Yao Za Zhi | pmid:25272487 |
| Wang Z et al. | New analytical method for the study of the metabolism of gentiopicroside in rats after oral administration by LC-TOF-MS following picolinoyl derivatization. | 2014 | J Sep Sci | pmid:24376019 |
| Tanaka R et al. | Application of quantitative 1H-NMR method to determination of gentiopicroside in Gentianae radix and Gentianae scabrae radix. | 2014 | J Nat Med | pmid:24687868 |
| Wani BA et al. | Induction of apoptosis in human pancreatic MiaPaCa-2 cells through the loss of mitochondrial membrane potential (ΔΨm) by Gentiana kurroo root extract and LC-ESI-MS analysis of its principal constituents. | 2013 | Phytomedicine | pmid:23453831 |
| Mihailović V et al. | Hepatoprotective effects of Gentiana asclepiadea L. extracts against carbon tetrachloride induced liver injury in rats. | 2013 | Food Chem. Toxicol. | pmid:23146698 |
| Zeng W et al. | Identification of bio-active metabolites of gentiopicroside by UPLC/Q-TOF MS and NMR. | 2013 | Biomed. Chromatogr. | pmid:23733682 |
| Deng Y et al. | In vitro inhibition and induction of human liver cytochrome P450 enzymes by gentiopicroside: potent effect on CYP2A6. | 2013 | Drug Metab. Pharmacokinet. | pmid:23419353 |
| Zhang K et al. | Preparation, characterization, and in vivo pharmacokinetics of nanostructured lipid carriers loaded with oleanolic acid and gentiopicrin. | 2013 | Int J Nanomedicine | pmid:24009420 |
| Li YL et al. | [Simultaneous determination of five constituents in eight Qingyedan species derived from Swertia plants by HPLC]. | 2013 | Zhongguo Zhong Yao Za Zhi | pmid:23944076 |
| Suyama Y et al. | Rigenolide A, a new secoiridoid glucoside with a cyclobutane skeleton, and three new acylated secoiridoid glucosides from Gentiana rigescens Franch. | 2013 | Fitoterapia | pmid:23994629 |
| Liang J et al. | Rapid preparative separation of six bioactive compounds from Gentiana crassicaulis Duthie ex Burk. using microwave-assisted extraction coupled with high-speed counter-current chromatography. | 2013 | J Sep Sci | pmid:24151213 |
| Feng B et al. | [Comparative study on pharmacokinetics of gentiopicroside and gentianae radix extract in rats]. | 2013 | Zhong Yao Cai | pmid:24218974 |
| Yan Z et al. | Potent Antifungal Activity of Pure Compounds from Traditional Chinese Medicine Extracts against Six Oral Candida Species and the Synergy with Fluconazole against Azole-Resistant Candida albicans. | 2012 | Evid Based Complement Alternat Med | pmid:22454653 |
| Wei S et al. | Inhibitory effects of secoiridoids from the roots of Gentiana straminea on stimulus-induced superoxide generation, phosphorylation and translocation of cytosolic compounds to plasma membrane in human neutrophils. | 2012 | Phytother Res | pmid:21584870 |
| Chang-Liao WL et al. | Isolation of gentiopicroside from Gentianae Radix and its pharmacokinetics on liver ischemia/reperfusion rats. | 2012 | J Ethnopharmacol | pmid:21855624 |
| Liu SB et al. | Gentiopicroside attenuates morphine rewarding effect through downregulation of GluN2B receptors in nucleus accumbens. | 2012 | CNS Neurosci Ther | pmid:22621711 |
| Jiang L et al. | Introgression of the heterologous nuclear DNAs and efficacious compositions from Swertia tetraptera Maxim. into Bupleurum scorzonerifolium Willd. via somatic hybridization. | 2012 | Protoplasma | pmid:21956131 |
| Song B et al. | [Quickly investigating the absorption ingredients of Gentianae Radix et Rhizoma by SEMAC]. | 2012 | Zhongguo Zhong Yao Za Zhi | pmid:22792800 |
| Hou Q et al. | [Callus cultivation and determination of gentiopicroside from Gentiana macrophylla]. | 2012 | Zhong Yao Cai | pmid:23213725 |
| Yang Y et al. | [Determination and quality assessment of 10 ingredients gentiopicroside and sweroside and so on in Tibetan medicine Jia Di (Swertia chirayita)]. | 2012 | Zhongguo Zhong Yao Za Zhi | pmid:23311169 |
| Wang J et al. | Introgression of Swertia mussotii gene into Bupleurum scorzonerifolium via somatic hybridization. | 2011 | BMC Plant Biol. | pmid:21513581 |
| Li HL et al. | Development and validation of a LC-ESI-MS/MS method for the determination of swertiamarin in rat plasma and its application in pharmacokinetics. | 2011 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:21531636 |
| Dou JJ et al. | [Transdermal delivery of Gentiana macrophylla complex components system under micro-needle conditions]. | 2011 | Yao Xue Xue Bao | pmid:22121788 |
| Wu YH et al. | [Study on the quality and genetic diversity of Gentiana macrophylla pall of different habitats]. | 2011 | Zhong Yao Cai | pmid:21809537 |
| Liang X et al. | Effect of Feining on bleomycin-induced pulmonary injuries in rats. | 2011 | J Ethnopharmacol | pmid:21333727 |
| He X et al. | Sensitive determination of gentiopicroside in medicine and bio-fluids using luminol-myoglobin chemiluminescence combined with flow injection technique. | 2010 Sep-Oct | Luminescence | pmid:19743525 |
| Siler B et al. | Antibacterial and antifungal screening of Centaurium pulchellum crude extracts and main secoiridoid compounds. | 2010 | Nat Prod Commun | pmid:21121240 |
| Lei Y et al. | [Preparation of gentiopicroside from the extract of Swertia mussotii Franch by preparative high performance liquid chromatography]. | 2010 | Se Pu | pmid:21171291 |
| Lian LH et al. | Anti-apoptotic activity of gentiopicroside in D-galactosamine/lipopolysaccharide-induced murine fulminant hepatic failure. | 2010 | Chem. Biol. Interact. | pmid:20558151 |
| Mustafayeva K et al. | DNA-damaging, mutagenic, and clastogenic activities of gentiopicroside isolated from Cephalaria kotschyi roots. | 2010 | J. Nat. Prod. | pmid:20055434 |
| Yin H et al. | Gentiopicrin-producing endophytic fungus isolated from Gentiana macrophylla. | 2009 | Phytomedicine | pmid:19200701 |
| Xu K et al. | [Determination of six active components in three species of genus Swertia by HPLC multiwavelength with detection]. | 2009 | Zhongguo Zhong Yao Za Zhi | pmid:19771868 |
| Chen LY et al. | Changes of gentiopicroside synthesis during somatic embryogenesis in Gentiana macrophylla. | 2009 | Planta Med. | pmid:19548190 |
| Jonville MC et al. | Fagraldehyde, a secoiridoid isolated from Fagraea fragrans. | 2008 | J. Nat. Prod. | pmid:19053508 |
| Chen L et al. | Down-regulation of NR2B receptors partially contributes to analgesic effects of Gentiopicroside in persistent inflammatory pain. | 2008 | Neuropharmacology | pmid:18410946 |
| Guarrera PM and Lucia LM | Ethnobotanical remarks on Central and Southern Italy. | 2007 | J Ethnobiol Ethnomed | pmid:17537240 |
| Wang CH et al. | Pharmacokinetics and bioavailability of gentiopicroside from decoctions of Gentianae and Longdan Xiegan Tang after oral administration in rats--comparison with gentiopicroside alone. | 2007 | J Pharm Biomed Anal | pmid:17560062 |
| Wang CH et al. | Pharmacokinetic behavior of gentiopicroside from decoction of Radix Gentianae, Gentiana macrophylla after oral administration in rats: a pharmacokinetic comaprison with gentiopicroside after oral and intravenous administration alone. | 2007 | Arch. Pharm. Res. | pmid:17958334 |
| Wang D et al. | Biotransformation of gentiopicroside by asexual mycelia of Cordyceps sinensis. | 2007 | Bioorg. Med. Chem. Lett. | pmid:17400449 |
| Li WL et al. | [Content of gentiopicroside and loganic acid in Radix gentianae and their fingerprints]. | 2007 | Yao Xue Xue Bao | pmid:17703785 |
| Zhang XQ et al. | [Determination of three glycosides from herbs of Swertia punicea by RP-HPLC]. | 2007 | Zhongguo Zhong Yao Za Zhi | pmid:17802883 |
| Xu YW et al. | [Preparative separation of gentiopicrin from Radix Gentianae by high-speed counter-current chromatography with macroporous resin]. | 2007 | Zhongguo Zhong Yao Za Zhi | pmid:18338594 |
| Zhao Y et al. | [Enrichment process of gentiopicroside from the leaves of Gentiana macropylla with macroporous resin]. | 2007 | Zhong Yao Cai | pmid:18422193 |
| Tiwari RK et al. | Genetic transformation of Gentiana macrophylla with Agrobacterium rhizogenes: growth and production of secoiridoid glucoside gentiopicroside in transformed hairy root cultures. | 2007 | Plant Cell Rep. | pmid:16972092 |
| Oztürk N et al. | Effects of gentiopicroside, sweroside and swertiamarine, secoiridoids from gentian (Gentiana lutea ssp. symphyandra), on cultured chicken embryonic fibroblasts. | 2006 | Planta Med. | pmid:16557467 |
| Wang CH et al. | Pharmacokinetics and tissue distribution of gentiopicroside following oral and intravenous administration in mice. | 2004 Jul-Sep | Eur J Drug Metab Pharmacokinet | pmid:15537172 |
| Chen X et al. | Simultaneous determination of some active ingredients in anti-viral preparations of traditional Chinese medicine by micellar electrokinetic chromatography. | 2004 | Biomed. Chromatogr. | pmid:15386499 |
| Lin P et al. | [Content determination of loganic acid and gentiopicroside in Tebitan herbal medicines Gentiana macrophylla and G. straminea by HPLC]. | 2004 | Zhong Yao Cai | pmid:15810586 |
| Ni H et al. | [Determination and comparision of gentiopicroside of various parts of five species of genus Gentiana collected from Xinjiang by TLCS]. | 2004 | Zhong Yao Cai | pmid:15551965 |
| Wang C et al. | [Determination of gentiopicroside in different morphological types of cultivated Gentiana manshurica population]. | 2004 | Zhongguo Zhong Yao Za Zhi | pmid:15575198 |
| Wang XJ et al. | [Influence of gentian leaf blight on the output and quality of Chinese gentian]. | 2004 | Zhongguo Zhong Yao Za Zhi | pmid:15506279 |
| Zhao S et al. | Separation and determination of gentiopicroside and swertiamarin in Tibetan medicines by micellar electrokinetic electrophoresis. | 2004 | Biomed. Chromatogr. | pmid:14872543 |
| Kumarasamy Y et al. | Bioactivity of gentiopicroside from the aerial parts of Centaurium erythraea. | 2003 | Fitoterapia | pmid:12628413 |
| Oztürk N et al. | Effects of Gentiana lutea ssp. symphyandra on the central nervous system in mice. | 2002 | Phytother Res | pmid:12410542 |
| Rojas A et al. | Smooth muscle relaxing activity of gentiopicroside isolated from Gentiana spathacea. | 2000 | Planta Med. | pmid:11199140 |
| Yang XF and Song CQ | [Studies on the metabolism of gentiopicroside by rat intestinal flora]. | 2000 | Zhongguo Zhong Yao Za Zhi | pmid:12525070 |
| Tan RX and Kong LD | Secoiridoids from Gentiana siphonantha. | 1997 | Phytochemistry | pmid:9396170 |
| Lin SJ et al. | Determination of gentiopicroside, mangiferin, palmatine, berberine, baicalin, wogonin and glycyrrhizin in the traditional Chinese medicinal preparation sann-joong-kuey-jian-tang by high-performance liquid chromatography. | 1996 | J Chromatogr A | pmid:8680588 |
| Kondo Y et al. | Suppression of chemically and immunologically induced hepatic injuries by gentiopicroside in mice. | 1994 | Planta Med. | pmid:7997467 |
| Zhang JS et al. | [Simultaneous determination of five bitter secoiridoid glycosides in nine Chinese Gentiana species used as the Chinese drug "long dan" by high performance liquid chromatography]. | 1991 | Yao Xue Xue Bao | pmid:1823982 |
| el-Sedawy AI et al. | Metabolism of gentiopicroside (gentiopicrin) by human intestinal bacteria. | 1989 | Chem. Pharm. Bull. | pmid:2605687 |
| Song QS | [High speed liquid chromatographic determination of gentiopicroside in radix Gentianae]. | 1988 | Zhong Yao Tong Bao | pmid:3409427 |
| Song QS et al. | [Isolation and identification of gentiopicroside from the roots of Gentiana triflora Pall]. | 1987 | Zhong Yao Tong Bao | pmid:3446393 |
| Lu YR | [Comparison of the gentiopicroside content and preparation of the root of Gentiana scabra collected in different seasons and in different growing years]. | 1986 | Zhong Yao Tong Bao | pmid:2944662 |
| Song WZ | [General survey on medicinal plants of the Gentianaceae family in China]. | 1986 | Zhong Yao Tong Bao | pmid:2952322 |
| Luo JP and Lou ZC | [TLC-densitometry determination of bitter glycosides in the Chinese drug longdan, radix gentianae, and its quality evaluation]. | 1986 | Yao Xue Xue Bao | pmid:3728034 |
| Akada Y et al. | [High-speed liquid chromatographic analysis of drugs. IX. Determination of gentiopicroside in Swertiae Herba (author's transl)]. | 1980 | Yakugaku Zasshi | pmid:7463316 |
| Akada Y et al. | [High-speed liquid chromatographic analysis of drugs. VI. Rapid estimation of gentiopicroside in Gentianae scabrae radix and Gentianae radix (author's transl)]. | 1979 | Yakugaku Zasshi | pmid:575655 |
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Gentiopicrin
Gentiopicrin is a lipid of Prenol Lipids (PR) class.
Cross Reference
