| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Locatelli M et al. | Optimization of Aqueous Extraction and Biological Activity of Harpagophytum procumbens Root on Ex Vivo Rat Colon Inflammatory Model. | 2017 | Phytother Res | pmid:28447368 |
| Sheu SY et al. | Radix Scrophulariae extracts (harpagoside) suppresses hypoxia-induced microglial activation and neurotoxicity. | 2015 | BMC Complement Altern Med | pmid:26370415 |
| Georgiev MI et al. | Harpagoside: from Kalahari Desert to pharmacy shelf. | 2013 | Phytochemistry | pmid:23642455 |
| Háznagy-Radnai E et al. | Antiinflammatory activities of Hungarian Stachys species and their iridoids. | 2012 | Phytother Res | pmid:21887806 |
| Sun X et al. | Harpagoside attenuates MPTP/MPP⺠induced dopaminergic neurodegeneration and movement disorder via elevating glial cell line-derived neurotrophic factor. | 2012 | J. Neurochem. | pmid:22192054 |
| Boeckenholt C et al. | Effect of silymarin and harpagoside on inflammation reaction of BEAS-2B cells, on ciliary beat frequency (CBF) of trachea explants and on mucociliary clearance (MCC). | 2012 | Planta Med. | pmid:22411727 |
| Zhou W et al. | [HPLC fingerprint of scrophulariae radix from southwest China]. | 2012 | Zhong Yao Cai | pmid:23320352 |
| Tian J et al. | Preparative isolation and purification of harpagoside and angroside C from the root of Scrophularia ningpoensis Hemsley by high-speed counter-current chromatography. | 2012 | J Sep Sci | pmid:23001886 |
| Zhang X et al. | [Simultaneous determination of five constituents in Scrophularia ningpoensis by HPLC]. | 2011 | Zhongguo Zhong Yao Za Zhi | pmid:21710734 |
| Yang S et al. | Harpagoside variation is positively correlated with temperature in Scrophularia ningpoensis Hemsl. | 2011 | J. Agric. Food Chem. | pmid:21322564 |
| Modarai M et al. | The interaction potential of herbal medicinal products: a luminescence-based screening platform assessing effects on cytochrome P450 and its use with devil's claw (Harpagophyti radix) preparations. | 2011 | J. Pharm. Pharmacol. | pmid:21749392 |
| Zhang L et al. | Effects of β-glucosidase hydrolyzed products of harpagide and harpagoside on cyclooxygenase-2 (COX-2) in vitro. | 2011 | Bioorg. Med. Chem. | pmid:21775152 |
| Georgiev MI et al. | Metabolic differentiations and classification of Verbascum species by NMR-based metabolomics. | 2011 | Phytochemistry | pmid:21807390 |
| Bai Y et al. | [Determination of harpagide and harpagoside in Scrophulariae Radix by HPLC-UV]. | 2011 | Zhongguo Zhong Yao Za Zhi | pmid:22242433 |
| Ouitas NA and Heard C | Estimation of the relative antiinflammatory efficacies of six commercial preparations of Harpagophytum procumbens (Devil's Claw). | 2010 | Phytother Res | pmid:19610038 |
| Takeda Y et al. | Morroniside cinnamic acid conjugate as an anti-inflammatory agent. | 2010 | Bioorg. Med. Chem. Lett. | pmid:20621474 |
| Inaba K et al. | Inhibitory effects of devil's claw (secondary root of Harpagophytum procumbens) extract and harpagoside on cytokine production in mouse macrophages. | 2010 | J Nat Med | pmid:20177800 |
| Anauate MC et al. | Effect of isolated fractions of Harpagophytum procumbens D.C. (devil's claw) on COX-1, COX-2 activity and nitric oxide production on whole-blood assay. | 2010 | Phytother Res | pmid:20812280 |
| Romiti N et al. | Effects of Devil's Claw (Harpagophytum procumbens) on the multidrug transporter ABCB1/P-glycoprotein. | 2009 | Phytomedicine | pmid:19577448 |
| Niu Z et al. | [Study on preparation and quantity determination of Scrophularia ningpoensis dispensing granules]. | 2009 | Zhongguo Zhong Yao Za Zhi | pmid:19382447 |
| Wu Q et al. | An in vivo microdialysis measurement of harpagoside in rat blood and bile for predicting hepatobiliary excretion and its interaction with cyclosporin A and verapamil. | 2009 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:19237327 |
| Li J et al. | Study of chemical composition and antimicrobial activity of leaves and roots of Scrophularia ningpoensis. | 2009 | Nat. Prod. Res. | pmid:19418360 |
| Jeong EJ et al. | Cognitive-enhancing and antioxidant activities of iridoid glycosides from Scrophularia buergeriana in scopolamine-treated mice. | 2008 | Eur. J. Pharmacol. | pmid:18462717 |
| Wang SJ et al. | Simultaneous determination of harpagoside and cinnamic acid in rat plasma by liquid chromatography electrospray ionization mass spectrometry and its application to pharmacokinetic studies. | 2008 | Biomed. Chromatogr. | pmid:17853386 |
| Colas C et al. | Optimization of solid-phase extraction for the liquid chromatography-mass spectrometry analysis of harpagoside, 8-para-coumaroyl harpagide, and harpagide in equine plasma and urine. | 2008 | J Chromatogr Sci | pmid:18366880 |
| Abdelouahab N and Heard C | Effect of the major glycosides of Harpagophytum procumbens (Devil's Claw) on epidermal cyclooxygenase-2 (COX-2) in vitro. | 2008 | J. Nat. Prod. | pmid:18412394 |
| Wagner S et al. | Validated HPTLC methods for the determination of salicin in Salix sp. and of harpagoside in Harpagophytum [corrected] procumbens. | 2008 | J Pharm Biomed Anal | pmid:18602786 |
| Li P et al. | Simultaneous determination of harpagoside and cinnamic acid in rat plasma by high-performance liquid chromatography: application to a pharmacokinetic study. | 2007 | Anal Bioanal Chem | pmid:17899026 |
| Tong S et al. | Preparative isolation and purification of harpagoside from Scrophularia ningpoensis hemsley by high-speed counter-current chromatography. | 2006 Nov-Dec | Phytochem Anal | pmid:17144248 |
| Günther M et al. | High anti-inflammatory activity of harpagoside-enriched extracts obtained from solvent-modified super- and subcritical carbon dioxide extractions of the roots of Harpagophytum procumbens. | 2006 Jan-Feb | Phytochem Anal | pmid:16454469 |
| Colas C et al. | Liquid chromatography/electrospray ionization mass spectrometric characterization of Harpagophytum in equine urine and plasma. | 2006 | Rapid Commun. Mass Spectrom. | pmid:17044124 |
| Huang TH et al. | Harpagoside suppresses lipopolysaccharide-induced iNOS and COX-2 expression through inhibition of NF-kappa B activation. | 2006 | J Ethnopharmacol | pmid:16203115 |
| Günther M and Schmidt PC | Comparison between HPLC and HPTLC-densitometry for the determination of harpagoside from Harpagophytum procumbens CO(2)-extracts. | 2005 | J Pharm Biomed Anal | pmid:15797807 |
| Baranska M et al. | Quality control of Harpagophytum procumbens and its related phytopharmaceutical products by means of NIR-FT-Raman spectroscopy. | 2005 | Biopolymers | pmid:15558669 |
| Chrubasik S et al. | A 1-year follow-up after a pilot study with Doloteffin for low back pain. | 2005 | Phytomedicine | pmid:15693701 |
| Joubert E et al. | Rapid measurement and evaluation of the effect of drying conditions on harpagoside content in Harpagophytum procumbens (devil's claw) root. | 2005 | J. Agric. Food Chem. | pmid:15853393 |
| Gagnier JJ et al. | Harpgophytum procumbens for osteoarthritis and low back pain: a systematic review. | 2004 | BMC Complement Altern Med | pmid:15369596 |
| Kaszkin M et al. | Downregulation of iNOS expression in rat mesangial cells by special extracts of Harpagophytum procumbens derives from harpagoside-dependent and independent effects. | 2004 | Phytomedicine | pmid:15636171 |
| Chrubasik S et al. | Effectiveness of Harpagophytum extracts and clinical efficacy. | 2004 | Phytother Res | pmid:15022177 |
| Ahmed B et al. | Scropolioside-D2 and harpagoside-B: two new iridoid glycosides from Scrophularia deserti and their antidiabetic and antiinflammatory activity. | 2003 | Biol. Pharm. Bull. | pmid:12673026 |
| Kim SR et al. | Four new neuroprotective iridoid glycosides from Scrophularia buergeriana roots. | 2002 | J. Nat. Prod. | pmid:12444706 |
| Loew D et al. | Investigations on the pharmacokinetic properties of Harpagophytum extracts and their effects on eicosanoid biosynthesis in vitro and ex vivo. | 2001 | Clin. Pharmacol. Ther. | pmid:11372004 |
| Sagare AP et al. | De novo regeneration of Scrophularia yoshimurae Yamazaki (Scrophulariaceae) and quantitative analysis of harpagoside, an iridoid glucoside, formed in aerial and underground parts of in vitro propagated and wild plants by HPLC. | 2001 | Biol. Pharm. Bull. | pmid:11725970 |
| Lequesne M and Samson M | Reports of equivalence trials should not mask negative or mediocre results. | 2001 | Joint Bone Spine | pmid:11324938 |
| De Santos GalÃndez J et al. | Seasonal variations in the harpagoside content of Scrophularia scorodonia L. | 2000 Nov-Dec | Z. Naturforsch., C, J. Biosci. | pmid:11204183 |
| Xie LH et al. | [Establishment of a TLC identification method for xuanshen(radix scrophulariae)]. | 2000 | Zhongguo Zhong Yao Za Zhi | pmid:12525068 |
| Chrubasik S et al. | Physicochemical properties of harpagoside and its in vitro release from Harpagophytum procumbens extract tablets. | 2000 | Phytomedicine | pmid:10715851 |
| Leblan D et al. | Harpagophytum procumbens in the treatment of knee and hip osteoarthritis. Four-month results of a prospective, multicenter, double-blind trial versus diacerhein. | 2000 | Joint Bone Spine | pmid:11143915 |
| Chantre P et al. | Efficacy and tolerance of Harpagophytum procumbens versus diacerhein in treatment of osteoarthritis. | 2000 | Phytomedicine | pmid:11185727 |
| Chrubasik S et al. | Effectiveness of Harpagophytum extract WS 1531 in the treatment of exacerbation of low back pain: a randomized, placebo-controlled, double-blind study. | 1999 | Eur J Anaesthesiol | pmid:10101629 |
| Baghdikian B et al. | Formation of nitrogen-containing metabolites from the main iridoids of Harpagophytum procumbens and H. zeyheri by human intestinal bacteria. | 1999 | Planta Med. | pmid:10193209 |
| Qian H and Xie P | [TLC analysis of harpagoside in devil claw extract and its tablets]. | 1998 | Zhongguo Zhong Yao Za Zhi | pmid:12242821 |
| GarcÃa D et al. | Antiinflammatory effects of different extracts and harpagoside isolated from Scrophularia frutescens L. | 1996 | Farmaco | pmid:8766229 |
| Mestdagh O and Torck M | [Quality evaluation of Harpagophyton capsules]. | 1995 | Ann Pharm Fr | pmid:7677395 |
| Costa De Pasquale R et al. | A drug used in traditional medicine: Harpagophytum procumbens DC. III. Effects on hyperkinetic ventricular arrhythmias by reperfusion. | 1985 | J Ethnopharmacol | pmid:4021516 |
| Occhiuto F et al. | A drug used in traditional medicine: Harpagophytum procumbens DC. IV. Effects on some isolated muscle preparations. | 1985 | J Ethnopharmacol | pmid:4021517 |
| Circosta C et al. | A drug used in traditional medicine: Harpagophytum procumbens DC. II. Cardiovascular activity. | 1984 | J Ethnopharmacol | pmid:6482477 |
| Fontaine J et al. | [Biological analysis of Harpagophytum procumbens D.C. II. Pharmacological analysis of the effects of harpagoside, harpagide and harpagogenine on the isolated guinea-pig ileum (author's transl)]. | 1981 Sep-Oct | J Pharm Belg | pmid:7310625 |
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Harpagoside
Harpagoside is a lipid of Prenol Lipids (PR) class.
Cross Reference
