Harpagoside

Harpagoside is a lipid of Prenol Lipids (PR) class.

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There are no associated biomedical information in the current reference collection.

Current reference collection contains 264 references associated with Harpagoside in LipidPedia. Due to lack of full text of references or no associated biomedical terms are recognized in our current text-mining method, we cannot extract any biomedical terms related to diseases, pathways, locations, functions, genes, lipids, and animal models from the associated reference collection.

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Li P et al. Simultaneous determination of harpagoside and cinnamic acid in rat plasma by high-performance liquid chromatography: application to a pharmacokinetic study. 2007 Anal Bioanal Chem pmid:17899026
Mestdagh O and Torck M [Quality evaluation of Harpagophyton capsules]. 1995 Ann Pharm Fr pmid:7677395
Sagare AP et al. De novo regeneration of Scrophularia yoshimurae Yamazaki (Scrophulariaceae) and quantitative analysis of harpagoside, an iridoid glucoside, formed in aerial and underground parts of in vitro propagated and wild plants by HPLC. 2001 Biol. Pharm. Bull. pmid:11725970
Ahmed B et al. Scropolioside-D2 and harpagoside-B: two new iridoid glycosides from Scrophularia deserti and their antidiabetic and antiinflammatory activity. 2003 Biol. Pharm. Bull. pmid:12673026
Wang SJ et al. Simultaneous determination of harpagoside and cinnamic acid in rat plasma by liquid chromatography electrospray ionization mass spectrometry and its application to pharmacokinetic studies. 2008 Biomed. Chromatogr. pmid:17853386
Zhang L et al. Effects of β-glucosidase hydrolyzed products of harpagide and harpagoside on cyclooxygenase-2 (COX-2) in vitro. 2011 Bioorg. Med. Chem. pmid:21775152
Takeda Y et al. Morroniside cinnamic acid conjugate as an anti-inflammatory agent. 2010 Bioorg. Med. Chem. Lett. pmid:20621474
Baranska M et al. Quality control of Harpagophytum procumbens and its related phytopharmaceutical products by means of NIR-FT-Raman spectroscopy. 2005 Biopolymers pmid:15558669
Gagnier JJ et al. Harpgophytum procumbens for osteoarthritis and low back pain: a systematic review. 2004 BMC Complement Altern Med pmid:15369596
Sheu SY et al. Radix Scrophulariae extracts (harpagoside) suppresses hypoxia-induced microglial activation and neurotoxicity. 2015 BMC Complement Altern Med pmid:26370415
Loew D et al. Investigations on the pharmacokinetic properties of Harpagophytum extracts and their effects on eicosanoid biosynthesis in vitro and ex vivo. 2001 Clin. Pharmacol. Ther. pmid:11372004
Chrubasik S et al. Effectiveness of Harpagophytum extract WS 1531 in the treatment of exacerbation of low back pain: a randomized, placebo-controlled, double-blind study. 1999 Eur J Anaesthesiol pmid:10101629
Jeong EJ et al. Cognitive-enhancing and antioxidant activities of iridoid glycosides from Scrophularia buergeriana in scopolamine-treated mice. 2008 Eur. J. Pharmacol. pmid:18462717
García D et al. Antiinflammatory effects of different extracts and harpagoside isolated from Scrophularia frutescens L. 1996 Farmaco pmid:8766229
Colas C et al. Optimization of solid-phase extraction for the liquid chromatography-mass spectrometry analysis of harpagoside, 8-para-coumaroyl harpagide, and harpagide in equine plasma and urine. 2008 J Chromatogr Sci pmid:18366880
Huang TH et al. Harpagoside suppresses lipopolysaccharide-induced iNOS and COX-2 expression through inhibition of NF-kappa B activation. 2006 J Ethnopharmacol pmid:16203115
Costa De Pasquale R et al. A drug used in traditional medicine: Harpagophytum procumbens DC. III. Effects on hyperkinetic ventricular arrhythmias by reperfusion. 1985 J Ethnopharmacol pmid:4021516
Occhiuto F et al. A drug used in traditional medicine: Harpagophytum procumbens DC. IV. Effects on some isolated muscle preparations. 1985 J Ethnopharmacol pmid:4021517
Circosta C et al. A drug used in traditional medicine: Harpagophytum procumbens DC. II. Cardiovascular activity. 1984 J Ethnopharmacol pmid:6482477
Inaba K et al. Inhibitory effects of devil's claw (secondary root of Harpagophytum procumbens) extract and harpagoside on cytokine production in mouse macrophages. 2010 J Nat Med pmid:20177800
Fontaine J et al. [Biological analysis of Harpagophytum procumbens D.C. II. Pharmacological analysis of the effects of harpagoside, harpagide and harpagogenine on the isolated guinea-pig ileum (author's transl)]. 1981 Sep-Oct J Pharm Belg pmid:7310625
Günther M and Schmidt PC Comparison between HPLC and HPTLC-densitometry for the determination of harpagoside from Harpagophytum procumbens CO(2)-extracts. 2005 J Pharm Biomed Anal pmid:15797807
Wagner S et al. Validated HPTLC methods for the determination of salicin in Salix sp. and of harpagoside in Harpagophytum [corrected] procumbens. 2008 J Pharm Biomed Anal pmid:18602786
Tian J et al. Preparative isolation and purification of harpagoside and angroside C from the root of Scrophularia ningpoensis Hemsley by high-speed counter-current chromatography. 2012 J Sep Sci pmid:23001886
Yang S et al. Harpagoside variation is positively correlated with temperature in Scrophularia ningpoensis Hemsl. 2011 J. Agric. Food Chem. pmid:21322564
Joubert E et al. Rapid measurement and evaluation of the effect of drying conditions on harpagoside content in Harpagophytum procumbens (devil's claw) root. 2005 J. Agric. Food Chem. pmid:15853393
Wu Q et al. An in vivo microdialysis measurement of harpagoside in rat blood and bile for predicting hepatobiliary excretion and its interaction with cyclosporin A and verapamil. 2009 J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. pmid:19237327
Abdelouahab N and Heard C Effect of the major glycosides of Harpagophytum procumbens (Devil's Claw) on epidermal cyclooxygenase-2 (COX-2) in vitro. 2008 J. Nat. Prod. pmid:18412394
Kim SR et al. Four new neuroprotective iridoid glycosides from Scrophularia buergeriana roots. 2002 J. Nat. Prod. pmid:12444706
Sun X et al. Harpagoside attenuates MPTP/MPP⁺ induced dopaminergic neurodegeneration and movement disorder via elevating glial cell line-derived neurotrophic factor. 2012 J. Neurochem. pmid:22192054
Modarai M et al. The interaction potential of herbal medicinal products: a luminescence-based screening platform assessing effects on cytochrome P450 and its use with devil's claw (Harpagophyti radix) preparations. 2011 J. Pharm. Pharmacol. pmid:21749392
Leblan D et al. Harpagophytum procumbens in the treatment of knee and hip osteoarthritis. Four-month results of a prospective, multicenter, double-blind trial versus diacerhein. 2000 Joint Bone Spine pmid:11143915
Lequesne M and Samson M Reports of equivalence trials should not mask negative or mediocre results. 2001 Joint Bone Spine pmid:11324938
Li J et al. Study of chemical composition and antimicrobial activity of leaves and roots of Scrophularia ningpoensis. 2009 Nat. Prod. Res. pmid:19418360
Günther M et al. High anti-inflammatory activity of harpagoside-enriched extracts obtained from solvent-modified super- and subcritical carbon dioxide extractions of the roots of Harpagophytum procumbens. 2006 Jan-Feb Phytochem Anal pmid:16454469
Tong S et al. Preparative isolation and purification of harpagoside from Scrophularia ningpoensis hemsley by high-speed counter-current chromatography. 2006 Nov-Dec Phytochem Anal pmid:17144248
Georgiev MI et al. Metabolic differentiations and classification of Verbascum species by NMR-based metabolomics. 2011 Phytochemistry pmid:21807390

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