(-)-Menthol

(-)-menthol is a lipid of Prenol Lipids (PR) class. (-)-menthol is associated with abnormalities such as Wiskott-Aldrich Syndrome. The involved functions are known as Agent, Anabolism, Signal Transduction, Binding (Molecular Function) and Signal Transduction Pathways. (-)-menthol often locates in Membrane, Tissue fiber and Dominant hand. The associated genes with (-)-Menthol are REG1A gene, UGT2B7 gene, HM13 gene and SCN10A gene. The related lipids are Steroids and androsterone glucuronide.

Cross Reference

Introduction

To understand associated biological information of (-)-Menthol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with (-)-Menthol?

(-)-Menthol is suspected in and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with (-)-Menthol

MeSH term MeSH ID Detail
Endophthalmitis D009877 12 associated lipids
Pain D010146 64 associated lipids
Uveitis, Posterior D015866 5 associated lipids
Total 3

PubChem Associated disorders and diseases

What pathways are associated with (-)-Menthol

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with (-)-Menthol?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with (-)-Menthol?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with (-)-Menthol?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with (-)-Menthol?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with (-)-Menthol?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with (-)-Menthol

Download all related citations
Per page 10 20 50 100 | Total 2230
Authors Title Published Journal PubMed Link
Pertusa M et al. Bidirectional modulation of thermal and chemical sensitivity of TRPM8 channels by the initial region of the N-terminal domain. 2014 J. Biol. Chem. pmid:24917670
Curtin GM et al. Primary measures of dependence among menthol compared to non-menthol cigarette smokers in the United States. 2014 Regul. Toxicol. Pharmacol. pmid:24852490
da Silveira NS et al. The aversive, anxiolytic-like, and verapamil-sensitive psychostimulant effects of pulegone. 2014 Biol. Pharm. Bull. pmid:24790000
Lewis M et al. Tobacco control environment in the United States and individual consumer characteristics in relation to continued smoking: differential responses among menthol smokers? 2014 Prev Med pmid:24780527
Klein AH et al. Eugenol and carvacrol excite first- and second-order trigeminal neurons and enhance their heat-evoked responses. 2014 Neuroscience pmid:24759772
Frost-Pineda K et al. Predictors, indicators, and validated measures of dependence in menthol smokers. 2014 J Addict Dis pmid:24738914
Shang L et al. An explanation for the difference in the percutaneous penetration behavior of tamsulosin induced by two different O-acylmenthol derivatives. 2014 AAPS PharmSciTech pmid:24659001
Wackowski OA et al. Young adults' behavioral intentions surrounding a potential menthol cigarette ban. 2014 Nicotine Tob. Res. pmid:24514070
Lau BK et al. Menthol enhances phasic and tonic GABAA receptor-mediated currents in midbrain periaqueductal grey neurons. 2014 Br. J. Pharmacol. pmid:24460753
Rojewski AM et al. Menthol cigarette use predicts treatment outcomes of weight-concerned smokers. 2014 Nicotine Tob. Res. pmid:24113927
Maurer F et al. Wash-out of ambient air contaminations for breath measurements. 2014 J Breath Res pmid:24837657
Cheyne A et al. The debate on regulating menthol cigarettes: closing a dangerous loophole vs freedom of choice. 2014 Am J Public Health pmid:24832437
Zhang Y et al. Effects of caffeine and menthol on cognition and mood during simulated firefighting in the heat. 2014 Appl Ergon pmid:23891504
Mizuno K et al. Goshajinkigan, a traditional Japanese medicine, prevents oxaliplatin-induced acute peripheral neuropathy by suppressing functional alteration of TRP channels in rat. 2014 J. Pharmacol. Sci. pmid:24784702
Xu P et al. Mosquito odorant receptor for DEET and methyl jasmonate. 2014 Proc. Natl. Acad. Sci. U.S.A. pmid:25349401
Hu X et al. Effects of d-menthol stress on the growth of and microcystin release by the freshwater cyanobacterium Microcystis aeruginosa FACHB-905. 2014 Chemosphere pmid:25065786
Jiang J et al. Mechanistic investigation and reversible effect of 2-isopropyl-5-methylcyclohexyl heptanoate on the in vitro percutaneous absorption of indomethacin. 2014 Drug Deliv pmid:24134638
Azagba S and Sharaf MF Binge drinking and marijuana use among menthol and non-menthol adolescent smokers: findings from the youth smoking survey. 2014 Addict Behav pmid:24369112
Rossato M et al. Human white adipocytes express the cold receptor TRPM8 which activation induces UCP1 expression, mitochondrial activation and heat production. 2014 Mol. Cell. Endocrinol. pmid:24342393
Rozza AL et al. The gastroprotective effect of menthol: involvement of anti-apoptotic, antioxidant and anti-inflammatory activities. 2014 PLoS ONE pmid:24466200
Terada Y et al. Activation and inhibition of thermosensitive TRP channels by voacangine, an alkaloid present in Voacanga africana, an African tree. 2014 J. Nat. Prod. pmid:24484240
Iovinella I et al. A rationale to design longer lasting mosquito repellents. 2014 Parasitol. Res. pmid:24599300
Menger DJ et al. A push-pull system to reduce house entry of malaria mosquitoes. 2014 Malar. J. pmid:24674451
Mirokuji Y et al. The JFFMA assessment of flavoring substances structurally related to menthol and uniquely used in Japan. 2014 Food Chem. Toxicol. pmid:24309148
Anderson EM et al. The effects of a co-application of menthol and capsaicin on nociceptive behaviors of the rat on the operant orofacial pain assessment device. 2014 PLoS ONE pmid:24558480
Ribeiro JC et al. Efficacy of free and nanoencapsulated Eucalyptus citriodora essential oils on sheep gastrointestinal nematodes and toxicity for mice. 2014 Vet. Parasitol. pmid:24929446
Ramos-Filho AC et al. Menthol inhibits detrusor contractility independently of TRPM8 activation. 2014 PLoS ONE pmid:25375115
Kijpornyongpan T et al. Dose-dependent cytotoxic effects of menthol on human malignant melanoma A-375 cells: correlation with TRPM8 transcript expression. 2014 Asian Pac. J. Cancer Prev. pmid:24641366
Zhu S et al. Involvement of transient receptor potential melastatin-8 (TRPM8) in menthol-induced calcium entry, reactive oxygen species production and cell death in rheumatoid arthritis rat synovial fibroblasts. 2014 Eur. J. Pharmacol. pmid:24440691
Raddatz N et al. Temperature and voltage coupling to channel opening in transient receptor potential melastatin 8 (TRPM8). 2014 J. Biol. Chem. pmid:25352597
Romero MC et al. Peppermint (Mentha piperita) and albendazole against anisakiasis in an animal model. 2014 Trop. Med. Int. Health pmid:25330410
Willershausen I et al. Influence of E-smoking liquids on human periodontal ligament fibroblasts. 2014 Head Face Med pmid:25224853
Thihalolipavan S et al. Menthol smokers in large-scale nicotine replacement therapy program. 2014 Am J Public Health pmid:25211736
Low SB et al. Evaluation of a topical gel containing a novel combination of essential oils and antioxidants for reducing oral malodor in dogs. 2014 Am. J. Vet. Res. pmid:24959732
Taberner FJ et al. The region adjacent to the C-end of the inner gate in transient receptor potential melastatin 8 (TRPM8) channels plays a central role in allosteric channel activation. 2014 J. Biol. Chem. pmid:25157108
Zimmermann MH et al. Relighting behaviour among cigarette smokers seeking treatment: implications for tobacco treatment and policy. 2014 Int. J. Clin. Pract. pmid:25113663
Curtin GM et al. Measures of initiation and progression to increased smoking among current menthol compared to non-menthol cigarette smokers based on data from four U.S. government surveys. 2014 Regul. Toxicol. Pharmacol. pmid:25111576
Patel R et al. Anti-hyperalgesic effects of a novel TRPM8 agonist in neuropathic rats: a comparison with topical menthol. 2014 Pain pmid:25083927
Sulsky SI et al. Evaluating the association between menthol cigarette use and the likelihood of being a former versus current smoker. 2014 Regul. Toxicol. Pharmacol. pmid:25017361
Curtin GM et al. Patterns of menthol cigarette use among current smokers, overall and within demographic strata, based on data from four U.S. government surveys. 2014 Regul. Toxicol. Pharmacol. pmid:24997230
Kasza KA et al. Switching between menthol and nonmenthol cigarettes: findings from the U.S. Cohort of the International Tobacco Control Four Country Survey. 2014 Nicotine Tob. Res. pmid:24984878
Chen GY et al. [Decreased amplitude of [Ca²⁺]i elevation induced by menthol in pulmonary arterial smooth muscle cells of pulmonary hypertensive rats]. 2014 Sheng Li Xue Bao pmid:24964842
Minaker LM et al. Flavored tobacco use among Canadian students in grades 9 through 12: prevalence and patterns from the 2010-2011 youth smoking survey. 2014 Prev Chronic Dis pmid:24945240
Smith SS et al. Smoking cessation in smokers who smoke menthol and non-menthol cigarettes. 2014 Addiction pmid:24938369
Topp R et al. Topical menthol, ice, peripheral blood flow, and perceived discomfort. 2013 Mar-Apr J Athl Train pmid:23672386
Pereira EJ et al. The effect of inhaled menthol on upper airway resistance in humans: a randomized controlled crossover study. 2013 Jan-Feb Can. Respir. J. pmid:23457678
Topp R et al. The effect of either topical menthol or a placebo on functioning and knee pain among patients with knee OA. 2013 Apr-Jun J Geriatr Phys Ther pmid:22976810
Acharya SA et al. Hydrogel-stabilized droplet bilayers for high speed solution exchange. 2013 Sci Rep pmid:24190577
Kong G et al. Menthol cigarette and marijuana use among adolescents. 2013 Nicotine Tob. Res. pmid:23884319
Ali MS et al. In vitro antioxidant, cytotoxic, thrombolytic activities and phytochemical evaluation of methanol extract of the A. philippense L. leaves. 2013 Asian Pac J Trop Biomed pmid:23730559
Reitzel LR et al. Race moderates the effect of menthol cigarette use on short-term smoking abstinence. 2013 Nicotine Tob. Res. pmid:23288873
Rajput SB and Karuppayil SM Small molecules inhibit growth, viability and ergosterol biosynthesis in Candida albicans. 2013 Springerplus pmid:23449869
Smith AP and Boden C Effects of chewing menthol gum on the alertness of healthy volunteers and those with an upper respiratory tract illness. 2013 Stress Health pmid:22674677
Chooluck K et al. Plasma and dermal pharmacokinetics of terpinen-4-ol in rats following intravenous administration. 2013 Pharmazie pmid:23469686
Kurose M and Meng ID Corneal dry-responsive neurons in the spinal trigeminal nucleus respond to innocuous cooling in the rat. 2013 J. Neurophysiol. pmid:23446686
Gillissen A et al. A multi-centre, randomised, double-blind, placebo-controlled clinical trial on the efficacy and tolerability of GeloMyrtol® forte in acute bronchitis. 2013 Drug Res (Stuttg) pmid:23447044
Villanti AC et al. Flavored tobacco product use among U.S. young adults. 2013 Am J Prev Med pmid:23498105
Liu XR et al. Down-regulation of TRPM8 in pulmonary arteries of pulmonary hypertensive rats. 2013 Cell. Physiol. Biochem. pmid:23817166
Ngo-Thi MT et al. Enantioselective hydrolysis of dl-menthyl benzoate by cell-free extract of newly isolated Acinetobacter sp. ECU2040. 2013 Appl. Biochem. Biotechnol. pmid:23801098
Vahabi B et al. TRPM8 agonists modulate contraction of the pig urinary bladder. 2013 Can. J. Physiol. Pharmacol. pmid:23826977
Selescu T et al. Camphor activates and sensitizes transient receptor potential melastatin 8 (TRPM8) to cooling and icilin. 2013 Chem. Senses pmid:23828908
Kurose M and Meng ID Dry eye modifies the thermal and menthol responses in rat corneal primary afferent cool cells. 2013 J. Neurophysiol. pmid:23636717
Plevkova J et al. The role of trigeminal nasal TRPM8-expressing afferent neurons in the antitussive effects of menthol. 2013 J. Appl. Physiol. pmid:23640596
Kurohane K et al. Lack of transient receptor potential melastatin 8 activation by phthalate esters that enhance contact hypersensitivity in mice. 2013 Toxicol. Lett. pmid:23296101
Bharti N et al. The greater effectiveness of Glomus mosseae and Glomus intraradices in improving productivity, oil content and tolerance of salt-stressed menthol mint (Mentha arvensis). 2013 J. Sci. Food Agric. pmid:23288591
Jones MR et al. Menthol cigarettes, race/ethnicity, and biomarkers of tobacco use in U.S. adults: the 1999-2010 National Health and Nutrition Examination Survey (NHANES). 2013 Cancer Epidemiol. Biomarkers Prev. pmid:23250935
Kolassa N Menthol differs from other terpenic essential oil constituents. 2013 Regul. Toxicol. Pharmacol. pmid:23207345
Jones MR et al. Smoking, menthol cigarettes, and peripheral artery disease in U.S. adults. 2013 Nicotine Tob. Res. pmid:23212436
Maji D et al. A natural plant growth promoter calliterpenone from a plant Callicarpa macrophylla Vahl improves the plant growth promoting effects of plant growth promoting rhizobacteria (PGPRs). 2013 World J. Microbiol. Biotechnol. pmid:23271460
Carter L Commentary on Nonnemaker et al. (2013): Banning menthol cigarettes - is it time to conduct the experiment? 2013 Addiction pmid:23279359
Cheang WS et al. Menthol relaxes rat aortae, mesenteric and coronary arteries by inhibiting calcium influx. 2013 Eur. J. Pharmacol. pmid:23380688
Wang T et al. Neurturin overexpression in skin enhances expression of TRPM8 in cutaneous sensory neurons and leads to behavioral sensitivity to cool and menthol. 2013 J. Neurosci. pmid:23365243
Journigan VB and Zaveri NT TRPM8 ion channel ligands for new therapeutic applications and as probes to study menthol pharmacology. 2013 Life Sci. pmid:23159643
Averbeck B et al. Thermal grill-evoked sensations of heat correlate with cold pain threshold and are enhanced by menthol and cinnamaldehyde. 2013 Eur J Pain pmid:23138876
Wilson MD et al. Efficacy of DEET and non-DEET-based insect repellents against bites of Simulium damnosum vectors of onchocerciasis. 2013 Med. Vet. Entomol. pmid:23167529
Brody AL et al. Up-regulation of nicotinic acetylcholine receptors in menthol cigarette smokers. 2013 Int. J. Neuropsychopharmacol. pmid:23171716
Villanti AC et al. Menthol cigarettes and mortality: keeping focus on the public health standard. 2013 Nicotine Tob. Res. pmid:22990220
Farco JA and Grundmann O Menthol--pharmacology of an important naturally medicinal "cool". 2013 Mini Rev Med Chem pmid:23061635
Motilal S and Maharaj RG Nutmeg extracts for painful diabetic neuropathy: a randomized, double-blind, controlled study. 2013 J Altern Complement Med pmid:23098698
Lachenmeier DW et al. What happens if people start drinking mouthwash as surrogate alcohol? A quantitative risk assessment. 2013 Food Chem. Toxicol. pmid:23041419
Bose SK et al. Effect of gibberellic acid and calliterpenone on plant growth attributes, trichomes, essential oil biosynthesis and pathway gene expression in differential manner in Mentha arvensis L. 2013 Plant Physiol. Biochem. pmid:23514759
Ashoor A et al. Menthol binding and inhibition of α7-nicotinic acetylcholine receptors. 2013 PLoS ONE pmid:23935840
Jones MR et al. Smoking, menthol cigarettes and all-cause, cancer and cardiovascular mortality: evidence from the National Health and Nutrition Examination Survey (NHANES) and a meta-analysis. 2013 PLoS ONE pmid:24205038
Chen J et al. Species differences and molecular determinant of TRPA1 cold sensitivity. 2013 Nat Commun pmid:24071625
Moreland-Russell S et al. Disparities and menthol marketing: additional evidence in support of point of sale policies. 2013 Int J Environ Res Public Health pmid:24071922
Kamatou GP et al. Menthol: a simple monoterpene with remarkable biological properties. 2013 Phytochemistry pmid:24054028
Alpizar YA et al. Lack of correlation between the amplitudes of TRP channel-mediated responses to weak and strong stimuli in intracellular Ca(2+) imaging experiments. 2013 Cell Calcium pmid:24079971
Amato A et al. Tetrodotoxin-dependent effects of menthol on mouse gastric motor function. 2013 Eur. J. Pharmacol. pmid:24041922
Tang Z et al. Pirt functions as an endogenous regulator of TRPM8. 2013 Nat Commun pmid:23863968
Rozza AL et al. Effect of menthol in experimentally induced ulcers: pathways of gastroprotection. 2013 Chem. Biol. Interact. pmid:24121185
Ostacolo C et al. Isoxazole derivatives as potent transient receptor potential melastatin type 8 (TRPM8) agonists. 2013 Eur J Med Chem pmid:24095758
Vetter I et al. Amplified cold transduction in native nociceptors by M-channel inhibition. 2013 J. Neurosci. pmid:24133266
Nuisin R et al. Microencapsulation of menthol by crosslinked chitosan via porous glass membrane emulsification technique and their controlled release properties. 2013 J Microencapsul pmid:23398357
Flores-Rizo JO et al. 8-Alkoxy- and 8-aryloxy-BODIPYs: straightforward fluorescent tagging of alcohols and phenols. 2013 J. Org. Chem. pmid:23721096
Liu B et al. TRPM8 is the principal mediator of menthol-induced analgesia of acute and inflammatory pain. 2013 Pain pmid:23820004
Li S et al. Cytotoxic compounds from invasive giant salvinia (Salvinia molesta) against human tumor cells. 2013 Bioorg. Med. Chem. Lett. pmid:24210499
Barkin RL The pharmacology of topical analgesics. 2013 Postgrad Med pmid:24547599
Ashoor A et al. Menthol inhibits 5-HT3 receptor-mediated currents. 2013 J. Pharmacol. Exp. Ther. pmid:23965380
Winhusen TM et al. A tale of two stimulants: mentholated cigarettes may play a role in cocaine, but not methamphetamine, dependence. 2013 Drug Alcohol Depend pmid:24075226
Sharara AI et al. Sugar-free menthol candy drops improve the palatability and bowel cleansing effect of polyethylene glycol electrolyte solution. 2013 Gastrointest. Endosc. pmid:23769143