(-)-Menthol

(-)-menthol is a lipid of Prenol Lipids (PR) class. (-)-menthol is associated with abnormalities such as Wiskott-Aldrich Syndrome. The involved functions are known as Agent, Anabolism, Signal Transduction, Binding (Molecular Function) and Signal Transduction Pathways. (-)-menthol often locates in Membrane, Tissue fiber and Dominant hand. The associated genes with (-)-Menthol are REG1A gene, UGT2B7 gene, HM13 gene and SCN10A gene. The related lipids are Steroids and androsterone glucuronide.

Cross Reference

Introduction

To understand associated biological information of (-)-Menthol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with (-)-Menthol?

(-)-Menthol is suspected in and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with (-)-Menthol

MeSH term MeSH ID Detail
Uveitis, Posterior D015866 5 associated lipids
Endophthalmitis D009877 12 associated lipids
Pain D010146 64 associated lipids
Total 3

PubChem Associated disorders and diseases

What pathways are associated with (-)-Menthol

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with (-)-Menthol?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with (-)-Menthol?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with (-)-Menthol?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with (-)-Menthol?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with (-)-Menthol?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with (-)-Menthol

Download all related citations
Per page 10 20 50 100 | Total 2230
Authors Title Published Journal PubMed Link
ELIEL EL The origin of steric hindrance in cyclohexane derivatives. 1953 Experientia pmid:13068384
BOSE AK The conformation of carvomenthols. 1952 Experientia pmid:13021135
Schäfer K et al. Discharge pattern analysis suggests existence of a low-threshold calcium channel in cold receptors. 1991 Experientia pmid:1847881
Kobal G et al. Is there directional smelling? 1989 Experientia pmid:2493388
Patel T and Yosipovitch G Therapy of pruritus. 2010 Expert Opin Pharmacother pmid:20426711
DMITRIEVA NM et al. [Comparative effects of synthetic and natural menthol]. 1962 Farm Zh pmid:13886714
LASHCHENKO DV [TERMONEPHELOMETRIC METHOD FOR THE QUANTITATIVE DETERMINATION OF VALIDOL AND MENTHOL IN TABLETS]. 1965 Farm Zh pmid:14348012
Svishchuk OA and MakhnovskiÄ­ MK [Method of obtaining 1-menthol]. 1974 Farm Zh pmid:4840955
Gella EV et al. [Flavonoids of some varieties of Mentha piperita L]. 1965 Farm Zh pmid:5877453
Svishchuk AA et al. [Method for the identification and quantitative determination of menthol]. 1973 Farm Zh pmid:4702845
Nardi D and Riva M [New quaternary ammonium salts with ganglioplegic and hypotensive activity. Derivatives of menthol]. 1965 Farmaco Sci pmid:4378865
Pasechnik IKh [Study of choleretic properties of flavonoid compounds isolated from Folia Menthae piperitae]. 1966 Nov-Dec Farmakol Toksikol pmid:6000373
Makoeva LD et al. [Comparative study of the effect of trental, menthol and obzidan and their combinations on the function of the cardiorespiratory system in operators under extreme conditions]. 1986 Sep-Oct Farmakol Toksikol pmid:3770182
Artem'ev AI [Possibility of predicting the shelf life of validol tablets]. 1975 Jul-Aug Farmatsiia pmid:1218604
Semenycheva AA and ZbarskiÄ­ VB [Photocolorimetric determination of menthol]. 1970 Jan-Feb Farmatsiia pmid:5441459
Kodash AG et al. [Dynamics of the accumulation of essential oil and menthol in peppermint of the "Polyhybrid-7" variety]. 1974 Farmatsiia pmid:4417705
Kodash AG et al. [Harvesting times for "Kubanskaia-6" peppermint]. 1976 Farmatsiia pmid:131720
Willis DN et al. Menthol attenuates respiratory irritation responses to multiple cigarette smoke irritants. 2011 FASEB J. pmid:21903934
Cold, cough, allergy, bronchodilator, and antiasthmatic drug products for over-the-counter human use; amendment of final monograph for OTC antitussive drug products. Food and Drug Administration, HHS. Final rule. 2000 Fed Regist pmid:11067707
Dandruff, seborrheic dermatitis, and psoriasis drug products containing coal tar and menthol for over-the-counter human use; amendment to the monograph. Final rule. 2007 Fed Regist pmid:17447341
Rossi YE et al. Molecular response of Musca domestica L. to Mintostachys verticillata essential oil, (4R)+-pulegone and menthone. 2012 Fitoterapia pmid:22155595
Kozyreva TV and Tkachenko EIa [Effect of menthol on human temperature sensitivity]. 2008 Mar-Apr Fiziol Cheloveka pmid:18472579
Kozyreva TV et al. [Relationship of single-nucleotide polymorphism rs11562975 in thermo-sensitive ion channel TRPM8 gene with human sensitivity to cold and menthol]. 2011 Mar-Apr Fiziol Cheloveka pmid:21542321
Kondrats'kyÄ­ AP et al. [A hyperpolarization-activated current in rat menthol-sensitive sensory neurons]. 2008 Fiziol Zh pmid:18756770
Vladymyrova IA et al. [Comparative effects of menthol and icilin on the induced contraction of the smooth muscles of the vas deferens of normal and castrated rats]. 2011 Fiziol Zh pmid:22164406
Paduraru OM et al. [Urothelium-dependent modulation of urinary bladder smooth muscle contractions by menthol]. 2011 Fiziol Zh pmid:22420154
Kondrats'kyÄ­ AP et al. [Functional identification of the TRPM8 cold receptor in rat prostate epithelial cells]. 2007 Fiziol Zh pmid:18080488
Filippov IB et al. [Modulation of the smooth muscle contractions of the rat vas deferens by TRPM8 channel agonist menthol]. 2009 Fiziol Zh pmid:20201386
Kannan A et al. Estimation of menthol in Pan Masala samples by a spectrophotometric method. 1997 May-Jun Food Addit Contam pmid:9205565
Bhatia SP et al. Fragrance material review on geranodyle. 2008 Food Chem. Toxicol. pmid:18640183
Bhatia SP et al. Fragrance material review on menthol. 2008 Food Chem. Toxicol. pmid:18640186
Bhatia SP et al. Fragrance material review on menthol racemic. 2008 Food Chem. Toxicol. pmid:18640189
Bhatia SP et al. Fragrance material review on d,l-menthol. 2008 Food Chem. Toxicol. pmid:18640200
Bhatia SP et al. Fragrance material review on d-menthol. 2008 Food Chem. Toxicol. pmid:18640220
Bhatia SP et al. Fragrance material review on 4-carvomenthenol. 2008 Food Chem. Toxicol. pmid:18640221
Bhatia SP et al. Fragrance material review on l-menthol. 2008 Food Chem. Toxicol. pmid:18640225
Heck JD A review and assessment of menthol employed as a cigarette flavoring ingredient. 2010 Food Chem. Toxicol. pmid:20113860
Chen C et al. Levels of mint and wintergreen flavorants: smokeless tobacco products vs. confectionery products. 2010 Food Chem. Toxicol. pmid:20034536
Lachenmeier DW et al. What happens if people start drinking mouthwash as surrogate alcohol? A quantitative risk assessment. 2013 Food Chem. Toxicol. pmid:23041419
Mirokuji Y et al. The JFFMA assessment of flavoring substances structurally related to menthol and uniquely used in Japan. 2014 Food Chem. Toxicol. pmid:24309148
Gaworski CL et al. 13-week inhalation toxicity study of menthol cigarette smoke. 1997 Food Chem. Toxicol. pmid:9301652
Le Bourhis B and Soenen AM [Psychotropic action of some aromatic substances used in food]. 1973 Food Cosmet Toxicol pmid:4146062
Opdyke DL Monographs on fragrance raw materials. 1976 Food Cosmet Toxicol pmid:1010512
Ulmer WT and Schött D [Chronic obstructive bronchitis. Effect of Gelomyrtol forte in a placebo-controlled double-blind study]. 1991 Fortschr. Med. pmid:1794831
Isbary JW and Zeller H [Experiences with Sportgel in the ambulatory treatment of athletic injuries]. 1983 Fortschr. Med. pmid:6618393
Amold M and Hofrichter G [Can local medication promote the resorption of hematomas?]. 1973 Fortschr. Med. pmid:4702390
Freichel M et al. The Role of TRP Proteins in Mast Cells. 2012 Front Immunol pmid:22701456
Lawhern V et al. Spike rate and spike timing contributions to coding taste quality information in rat periphery. 2011 Front Integr Neurosci pmid:21617730
Hyldgaard M et al. Essential oils in food preservation: mode of action, synergies, and interactions with food matrix components. 2012 Front Microbiol pmid:22291693
Bevilacqua A et al. Use of essential oils to inhibit alicyclobacillus acidoterrestris: a short overview of the literature. 2011 Front Microbiol pmid:21991262
Hodge JJ Ion channels to inactivate neurons in Drosophila. 2009 Front Mol Neurosci pmid:19750193
Hunt D et al. Activating transcription factor 3 and the nervous system. 2012 Front Mol Neurosci pmid:22347845
Jeske NA Somatosensory scaffolding structures. 2012 Front Mol Neurosci pmid:22291616
Kikuchi H et al. CLINICAL APPLICATION OF L-MENTHOL IN THE UPPER GASTROINTESTINAL ENDOSCOPIC PROCEDURE. 2015 Fukushima J Med Sci pmid:26632191
Hiki N et al. Antiperistaltic effect and safety of L-menthol sprayed on the gastric mucosa for upper GI endoscopy: a phase III, multicenter, randomized, double-blind, placebo-controlled study. 2011 Gastrointest. Endosc. pmid:21353674
Sharara AI Lozenge-induced esophagitis. 2000 Gastrointest. Endosc. pmid:10805861
Sharara AI et al. Sugar-free menthol candy drops improve the palatability and bowel cleansing effect of polyethylene glycol electrolyte solution. 2013 Gastrointest. Endosc. pmid:23769143
MARCHE J [Recent data on the therapeutic properties of hydrosoluble terpene oxides]. 1953 Gaz Med Fr pmid:13052196
Morse DR and Wilcko JM Gutta percha-eucapercha: a pilot clinical study. 1980 May-Jun Gen Dent pmid:6936326
White DB et al. African Americans' responses to genetic explanations of lung cancer disparities and their willingness to participate in clinical genetics research. 2010 Genet. Med. pmid:20613544
Papaioannou VE Mice get their annual check-up. 2004 Genome Biol. pmid:15575981
Nilius B and Owsianik G The transient receptor potential family of ion channels. 2011 Genome Biol. pmid:21401968
Lee K et al. The strategic targeting of females by transnational tobacco companies in South Korea following trade liberalization. 2009 Global Health pmid:19183443
Hummel T et al. Smell and taste disorders. 2011 GMS Curr Top Otorhinolaryngol Head Neck Surg pmid:22558054
Xu X et al. Effect of menthol on ocular drug delivery. 2011 Graefes Arch. Clin. Exp. Ophthalmol. pmid:21597947
Lysy J et al. Topical capsaicin--a novel and effective treatment for idiopathic intractable pruritus ani: a randomised, placebo controlled, crossover study. 2003 Gut pmid:12912865
Anand P Capsaicin and menthol in the treatment of itch and pain: recently cloned receptors provide the key. 2003 Gut pmid:12912849
Leuschner M et al. Dissolution of gall stones with an ursodeoxycholic acid menthol preparation: a controlled prospective double blind trial. 1988 Gut pmid:3286383
Chey WD et al. Pharmacologic and complementary and alternative medicine therapies for irritable bowel syndrome. 2011 Gut Liver pmid:21927652
Rodu B The scientific foundation for tobacco harm reduction, 2006-2011. 2011 Harm Reduct J pmid:21801389
Mint conditions. 2007 Harv Health Lett pmid:17665507
Julius D From peppers to peppermints: natural products as probes of the pain pathway. 2005-2006 Harvey Lect. pmid:18030977
Brehm G and Korting GW [Reticular hyperplasia of the skin due to a menthol derivative]. 1967 Hautarzt pmid:5596436
Willershausen I et al. Influence of E-smoking liquids on human periodontal ligament fibroblasts. 2014 Head Face Med pmid:25224853
Reitlinger A [Side effects of some commonly used drugs in otorhinolaryngology in young children]. 1967 HNO pmid:5608332
Lesoine W [Dangers and complications in the administration of menthol containing preparations in otorhinolaryngology]. 1965 HNO pmid:5840783
Richardson T Menthol cigarette use in African Americans. 1996 Hosp Pract (1995) pmid:9119925
Sun J et al. Activation of cold-sensing transient receptor potential melastatin subtype 8 antagonizes vasoconstriction and hypertension through attenuating RhoA/Rho kinase pathway. 2014 Hypertension pmid:24637663
Lyle RE et al. Electronic properties of the nitrosamine function. 1978 IARC Sci Publ pmid:680749
Lin JP et al. Effects of (-)-menthol on the distribution and metabolism of 2-aminofluorene in various tissues of Sprague-Dawley rats. 2003 Sep-Oct In Vivo pmid:14598608
Lu HF et al. (-)-Menthol inhibits WEHI-3 leukemia cells in vitro and in vivo. 2007 Mar-Apr In Vivo pmid:17436578
Lu HF et al. The role of Ca2+ in (-)-menthol-induced human promyelocytic leukemia HL-60 cell death. 2006 Jan-Feb In Vivo pmid:16433031
Dangwal SK Colorimetric methods of determination of menthol in air. 1980 Ind Health pmid:7251399
Chandola HC and Chakraborty A Fibromyalgia and myofascial pain syndrome-a dilemma. 2009 Indian J Anaesth pmid:20640108
Yadav S and Bajaj AK Management of difficult urticaria. 2009 Indian J Dermatol pmid:20161863
Goh CL and Tan KT Chronic autoimmune urticaria: where we stand? 2009 Indian J Dermatol pmid:20161862
Godse KV Chronic urticaria and treatment options. 2009 Indian J Dermatol pmid:20101328
Sekar CS et al. Aquagenic pruritus: beneath water "lies". 2011 Indian J Dermatol pmid:21965864
Gohel MC and Nagori SA Resolving issues of content uniformity and low permeability using eutectic blend of camphor and menthol. 2009 Indian J Pharm Sci pmid:20376214
Patel DM and Patel MM Optimization of fast dissolving etoricoxib tablets prepared by sublimation technique. 2008 Indian J Pharm Sci pmid:20390084
Nirale NM and Menon MD Topical formulations of serratiopeptidase: development and pharmacodynamic evaluation. 2010 Indian J Pharm Sci pmid:20582192
Shirwaikar A et al. Herbal excipients in novel drug delivery systems. 2008 Jul-Aug Indian J Pharm Sci pmid:20046764
Shishu VR et al. Development of taste masked oral formulation of ornidazole. 2010 Indian J Pharm Sci pmid:20838525
Shabir GA and Bradshaw TK Determination of 1,7,7-Trimethyl-bicyclo(2,2,1)heptan-2-one in a Cream Pharmaceutical Formulation by Reversed-phase Liquid Chromatography. 2010 Indian J Pharm Sci pmid:21969761
Das PK et al. Effect on ciliary movements of some agents which come in contact with the respiratory tract. 1970 Indian J. Physiol. Pharmacol. pmid:5526137
Hart PH et al. Terpinen-4-ol, the main component of the essential oil of Melaleuca alternifolia (tea tree oil), suppresses inflammatory mediator production by activated human monocytes. 2000 Inflamm. Res. pmid:11131302
Brand C et al. The water-soluble components of the essential oil of Melaleuca alternifolia (tea tree oil) suppress the production of superoxide by human monocytes, but not neutrophils, activated in vitro. 2001 Inflamm. Res. pmid:11392609
Hayashi S et al. Impairment by activation of TRPA1 of gastric epithelial restitution in a wound model using RGM1 cell monolayer. 2007 Inflammopharmacology pmid:17943255
Moennikes O et al. Reduced toxicological activity of cigarette smoke by the addition of ammonia magnesium phosphate to the paper of an electrically heated cigarette: subchronic inhalation toxicology. 2008 Inhal Toxicol pmid:18464053
Brinkman MC et al. Exposure to and deposition of fine and ultrafine particles in smokers of menthol and nonmenthol cigarettes. 2012 Inhal Toxicol pmid:22486344