(-)-Menthol

(-)-menthol is a lipid of Prenol Lipids (PR) class. (-)-menthol is associated with abnormalities such as Wiskott-Aldrich Syndrome. The involved functions are known as Agent, Anabolism, Signal Transduction, Binding (Molecular Function) and Signal Transduction Pathways. (-)-menthol often locates in Membrane, Tissue fiber and Dominant hand. The associated genes with (-)-Menthol are REG1A gene, UGT2B7 gene, HM13 gene and SCN10A gene. The related lipids are Steroids and androsterone glucuronide.

Cross Reference

Introduction

To understand associated biological information of (-)-Menthol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with (-)-Menthol?

(-)-Menthol is suspected in and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with (-)-Menthol

MeSH term MeSH ID Detail
Uveitis, Posterior D015866 5 associated lipids
Endophthalmitis D009877 12 associated lipids
Pain D010146 64 associated lipids
Total 3

PubChem Associated disorders and diseases

What pathways are associated with (-)-Menthol

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with (-)-Menthol?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with (-)-Menthol?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with (-)-Menthol?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with (-)-Menthol?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with (-)-Menthol?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with (-)-Menthol

Download all related citations
Per page 10 20 50 100 | Total 2230
Authors Title Published Journal PubMed Link
Watanabe H et al. Effect of l-menthol on the thermotropic behavior of ceramide 2/cholesterol mixtures as a model for the intercellular lipids in stratum corneum. 2009 Colloids Surf B Biointerfaces pmid:19505808
Park CW et al. Development of guideline for rating the physical impairment of otolaryngologic field. 2009 J. Korean Med. Sci. pmid:19503682
Myers BR et al. Evolution of thermal response properties in a cold-activated TRP channel. 2009 PLoS ONE pmid:19492038
Mandadi S et al. Locomotor networks are targets of modulation by sensory transient receptor potential vanilloid 1 and transient receptor potential melastatin 8 channels. 2009 Neuroscience pmid:19482068
Sherkheli MA et al. Monoterpenoids induce agonist-specific desensitization of transient receptor potential vanilloid-3 (TRPV3) ion channels. 2009 J Pharm Pharm Sci pmid:19470296
Zhao L et al. Effect of O-acylmenthol and salt formation on the skin permeation of diclofenac acid. 2009 Drug Dev Ind Pharm pmid:19466898
pmid:19462991
Gohel MC and Nagori SA Fabrication of modified transport fluconazole transdermal spray containing ethyl cellulose and Eudragit RS100 as film formers. 2009 AAPS PharmSciTech pmid:19462250
Randich A et al. Ice water testing reveals hypersensitivity in adult rats that experienced neonatal bladder inflammation: implications for painful bladder syndrome/interstitial cystitis. 2009 J. Urol. pmid:19447422
Zhao L et al. Transdermal delivery of tolterodine by O-acylmenthol: In vitro/in vivo correlation. 2009 Int J Pharm pmid:19446762
Mayo JA and Ritchie JR Acidogenic potential of "sugar-free" cough drops. 2009 Open Dent J pmid:19444340
Chen K and Baran PS Total synthesis of eudesmane terpenes by site-selective C-H oxidations. 2009 Nature pmid:19440196
Wilson N et al. Misperceptions of "light" cigarettes abound: national survey data. 2009 BMC Public Health pmid:19426502
Pongs O TREKing noxious thermosensation. 2009 EMBO J. pmid:19421163
Masamoto Y et al. Intragastric administration of TRPV1, TRPV3, TRPM8, and TRPA1 agonists modulates autonomic thermoregulation in different manners in mice. 2009 Biosci. Biotechnol. Biochem. pmid:19420725
Uyar T et al. Electrospinning of functional poly(methyl methacrylate) nanofibers containing cyclodextrin-menthol inclusion complexes. 2009 Nanotechnology pmid:19420480
pmid:19412756
pmid:19407152
Zakharian E et al. Inorganic polyphosphate modulates TRPM8 channels. 2009 PLoS ONE pmid:19404398
Gannu R et al. Optimization of hydrogels for transdermal delivery of lisinopril by Box-Behnken statistical design. 2009 AAPS PharmSciTech pmid:19399627
The common cold. 2009 Prescrire Int pmid:19391294
Vicks Vapo-Rub--How dangerous for children? 2009 Child Health Alert pmid:19378371
Wrigley PJ et al. Primary afferents with TRPM8 and TRPA1 profiles target distinct subpopulations of rat superficial dorsal horn neurones. 2009 Br. J. Pharmacol. pmid:19371346
Johnson CD et al. Transient receptor potential melastatin 8 channel involvement in the regulation of vascular tone. 2009 Am. J. Physiol. Heart Circ. Physiol. pmid:19363131
Kigasawa K et al. In vivo transdermal delivery of diclofenac by ion-exchange iontophoresis with geraniol. 2009 Biol. Pharm. Bull. pmid:19336905
Flühr K et al. Capsaicin or menthol sensitization induces quantitative but no qualitative changes to thermal and mechanical pain thresholds. 2009 Clin J Pain pmid:19333158
Lechner SG et al. Developmental waves of mechanosensitivity acquisition in sensory neuron subtypes during embryonic development. 2009 EMBO J. pmid:19322198
pmid:19321114
Songkro S et al. Effects of some terpenes on the in vitro permeation of LHRH through newborn pig skin. 2009 Pharmazie pmid:19320284
Park EJ et al. Menthol Enhances an Antiproliferative Activity of 1alpha,25-Dihydroxyvitamin D(3) in LNCaP Cells. 2009 J Clin Biochem Nutr pmid:19308266
Vriens J et al. Herbal compounds and toxins modulating TRP channels. 2008 Curr Neuropharmacol pmid:19305789
Mandadi S and Roufogalis BD ThermoTRP channels in nociceptors: taking a lead from capsaicin receptor TRPV1. 2008 Curr Neuropharmacol pmid:19305786
Du J et al. Expression of TRPM8 in the distal cerebrospinal fluid-contacting neurons in the brain mesencephalon of rats. 2009 Cerebrospinal Fluid Res pmid:19292918
Orio P et al. Characteristics and physiological role of hyperpolarization activated currents in mouse cold thermoreceptors. 2009 J. Physiol. (Lond.) pmid:19273581
Song YH et al. The effects of terpenes on the permeation of lidocaine and ofloxacin from moisture-activated patches. 2009 Drug Deliv pmid:19267298
Hofmann D [Is inhalation therapy for bacterial bronchitis obsolete?]. 2009 Med Monatsschr Pharm pmid:19263915
Jiang CH et al. Gating of the micturition reflex by tonic activation of bladder cold receptors in the cat. 2009 Neurourol. Urodyn. pmid:19260088
pmid:19259875
Pedretti A et al. Comparative modeling of the quaternary structure for the human TRPM8 channel and analysis of its binding features. 2009 Biochim. Biophys. Acta pmid:19230823
Persson AK et al. Correlational analysis for identifying genes whose regulation contributes to chronic neuropathic pain. 2009 Mol Pain pmid:19228393
Rafati H et al. Quality by design: optimization of a liquid filled pH-responsive macroparticles using Draper-Lin composite design. 2009 J Pharm Sci pmid:19226624
St Charles FK et al. Post-puff respiration measures on smokers of different tar yield cigarettes. 2009 Inhal Toxicol pmid:19225967
Gandhi KK et al. Lower quit rates among African American and Latino menthol cigarette smokers at a tobacco treatment clinic. 2009 Int. J. Clin. Pract. pmid:19222622
Alenmyr L et al. TRPV1-mediated itch in seasonal allergic rhinitis. 2009 Allergy pmid:19220220
pmid:19217275
Faria JM et al. Biotransformation of menthol and geraniol by hairy root cultures of Anethum graveolens: effect on growth and volatile components. 2009 Biotechnol. Lett. pmid:19205895
Heck JD Smokers of menthol and nonmenthol cigarettes exhibit similar levels of biomarkers of smoke exposure. 2009 Cancer Epidemiol. Biomarkers Prev. pmid:19190153
Lee K et al. The strategic targeting of females by transnational tobacco companies in South Korea following trade liberalization. 2009 Global Health pmid:19183443
Morenilla-Palao C et al. Lipid raft segregation modulates TRPM8 channel activity. 2009 J. Biol. Chem. pmid:19176480
Gannu R et al. In vitro permeation of carvedilol through porcine skin: effect of vehicles and penetration enhancers. 2008 Jul-Aug PDA J Pharm Sci Technol pmid:19174954
Elmhalli FH et al. Acaricidal effects of Corymbia citriodora oil containing para-menthane-3,8-diol against nymphs of Ixodes ricinus (Acari: Ixodidae). 2009 Exp. Appl. Acarol. pmid:19169833
Chen J et al. Pore dilation occurs in TRPA1 but not in TRPM8 channels. 2009 Mol Pain pmid:19159452
Kullmann FA et al. Functional TRP and ASIC-like channels in cultured urothelial cells from the rat. 2009 Am. J. Physiol. Renal Physiol. pmid:19158342
Chantasart D et al. Effects of oxygen-containing terpenes as skin permeation enhancers on the lipoidal pathways of human epidermal membrane. 2009 J Pharm Sci pmid:19156845
Nunes IS et al. Menthol and geraniol biotransformation and glycosylation capacity of Levisticum officinale hairy roots. 2009 Planta Med. pmid:19156598
Soković MD et al. Chemical composition of essential oils of Thymus and Mentha species and their antifungal activities. 2009 Molecules pmid:19136911
Parnas M et al. Carvacrol is a novel inhibitor of Drosophila TRPL and mammalian TRPM7 channels. 2009 Cell Calcium pmid:19135721
Muscat JE et al. Effects of menthol on tobacco smoke exposure, nicotine dependence, and NNAL glucuronidation. 2009 Cancer Epidemiol. Biomarkers Prev. pmid:19124478
pmid:19123820
Kühn FJ et al. Inhibition of TRPM8 by icilin distinct from desensitization induced by menthol and menthol derivatives. 2009 J. Biol. Chem. pmid:19095656
Hummel T et al. Kallmann's syndrome and chemosensory evoked potentials. 1991 Eur Arch Otorhinolaryngol pmid:1909532
Muilenburg JL and Legge JS African American adolescents and menthol cigarettes: smoking behavior among secondary school students. 2008 J Adolesc Health pmid:19027645
Ruskin DN et al. Chronic menthol attenuates the effect of nicotine on body temperature in adolescent rats. 2008 Nicotine Tob. Res. pmid:19023826
Daniels RL et al. Activity of the neuronal cold sensor TRPM8 is regulated by phospholipase C via the phospholipid phosphoinositol 4,5-bisphosphate. 2009 J. Biol. Chem. pmid:19019830
Taber DF et al. Convenient synthetic route to an enantiomerically pure FMOC alpha-amino acid. 2008 J. Org. Chem. pmid:18986204
Cal K Skin disposition of menthol after its application in the presence of drug substances. 2008 Biopharm Drug Dispos pmid:18985797
pmid:18985178
pmid:18981044
Kim SH et al. Menthol regulates TRPM8-independent processes in PC-3 prostate cancer cells. 2009 Biochim. Biophys. Acta pmid:18955132
pmid:18942282
Momin A et al. Role of the hyperpolarization-activated current Ih in somatosensory neurons. 2008 J. Physiol. (Lond.) pmid:18936078
Cheng HM et al. Inhibition of lipopolysaccharide-induced interleukin-1beta and tumor necrosis factor-alpha production by menthone through nuclear factor-kappaB signaling pathway in HaCat cells. 2008 Chin J Physiol pmid:18935911
Ma S et al. Menthol derivative WS-12 selectively activates transient receptor potential melastatin-8 (TRPM8) ion channels. 2008 Pak J Pharm Sci pmid:18930858
Müller-Schwarze D and Thoss V Defense on the rocks: low monoterpenoid levels in plants on pillars without mammalian herbivores. 2008 J. Chem. Ecol. pmid:18925383
Zhang XB et al. A-type GABA receptor as a central target of TRPM8 agonist menthol. 2008 PLoS ONE pmid:18852885
Meesters RJ et al. Sensitive determination of monoterpene alcohols in urine by HPLC-FLD combined with ESI-MS detection after online-solid phase extraction of the monoterpene-coumarincarbamate derivates. 2008 J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. pmid:18845490
Neubert JK et al. Characterization of mouse orofacial pain and the effects of lesioning TRPV1-expressing neurons on operant behavior. 2008 Mol Pain pmid:18828909
Lanfranchi DA et al. Enantiomeric differentiation of oxygenated p-menthane derivatives by 13C NMR using Yb(hfc)3. 2008 Magn Reson Chem pmid:18828150
pmid:18825335
Johnson DM et al. Designing a tobacco counter-marketing campaign for African American youth. 2008 Tob Induc Dis pmid:18822164
Patel NA et al. Formulation and evaluation of curcumin gel for topical application. 2009 Pharm Dev Technol pmid:18821270
Xiao B et al. Identification of transmembrane domain 5 as a critical molecular determinant of menthol sensitivity in mammalian TRPA1 channels. 2008 J. Neurosci. pmid:18815250
Colvin LA et al. From bench to bedside: a case of rapid reversal of bortezomib-induced neuropathic pain by the TRPM8 activator, menthol. 2008 J. Clin. Oncol. pmid:18802169
Jankowski R et al. [Advantages of the L-menthol test in assessing chronic nasal obstruction]. 2008 Ann Otolaryngol Chir Cervicofac pmid:18774552
Kondrats'kyÄ­ AP et al. [A hyperpolarization-activated current in rat menthol-sensitive sensory neurons]. 2008 Fiziol Zh pmid:18756770
pmid:18729100
Umezu T Evidence for dopamine involvement in ambulation promoted by menthone in mice. 2009 Pharmacol. Biochem. Behav. pmid:18718482
Lindemann J et al. Impact of menthol inhalation on nasal mucosal temperature and nasal patency. 2008 Jul-Aug Am J Rhinol pmid:18702906
Corvalán NA et al. Stereo-selective activity of menthol on GABA(A) receptor. 2009 Chirality pmid:18698645
Mwenifumbo JC et al. Socioeconomic and drug use determinants of smoking status in an urban adult population of Black African descent. 2008 Nicotine Tob. Res. pmid:18686179
pmid:18686176
Slominski A Cooling skin cancer: menthol inhibits melanoma growth. Focus on "TRPM8 activation suppresses cellular viability in human melanoma". 2008 Am. J. Physiol., Cell Physiol. pmid:18684990
Rachakonda VK et al. Screening of chemical penetration enhancers for transdermal drug delivery using electrical resistance of skin. 2008 Pharm. Res. pmid:18683029
Zeng Z et al. Recent advances in the compound-oriented and pattern-oriented approaches to the quality control of herbal medicines. 2008 Chin Med pmid:18680568
Cruz-Orengo L et al. Cutaneous nociception evoked by 15-delta PGJ2 via activation of ion channel TRPA1. 2008 Mol Pain pmid:18671867
Wasner G et al. Residual spinothalamic tract pathways predict development of central pain after spinal cord injury. 2008 Brain pmid:18669485
Cal K and Sopala M Ex vivo skin absorption of terpenes from Vicks VapoRub ointment. 2008 Med. Sci. Monit. pmid:18668006
Fajardo O et al. TRPA1 channels mediate cold temperature sensing in mammalian vagal sensory neurons: pharmacological and genetic evidence. 2008 J. Neurosci. pmid:18667618
Shim WS and Oh U Histamine-induced itch and its relationship with pain. 2008 Mol Pain pmid:18667087
Patel D et al. Design, development, and optimization of orally disintegrating tablets of etoricoxib using vacuum-drying approach. 2008 May-Jun PDA J Pharm Sci Technol pmid:18661871