| MeSH term | MeSH ID | Detail |
|---|---|---|
| Endophthalmitis | D009877 | 12 associated lipids |
| Pain | D010146 | 64 associated lipids |
| Uveitis, Posterior | D015866 | 5 associated lipids |
Total
3
(-)-Menthol
(-)-menthol is a lipid of Prenol Lipids (PR) class. (-)-menthol is associated with abnormalities such as Wiskott-Aldrich Syndrome. The involved functions are known as Agent, Anabolism, Signal Transduction, Binding (Molecular Function) and Signal Transduction Pathways. (-)-menthol often locates in Membrane, Tissue fiber and Dominant hand. The associated genes with (-)-Menthol are REG1A gene, UGT2B7 gene, HM13 gene and SCN10A gene. The related lipids are Steroids and androsterone glucuronide.
Cross Reference
Introduction
To understand associated biological information of (-)-Menthol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with (-)-Menthol?
(-)-Menthol is suspected in and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with (-)-Menthol
PubChem Associated disorders and diseases
What pathways are associated with (-)-Menthol
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with (-)-Menthol?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with (-)-Menthol?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with (-)-Menthol?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with (-)-Menthol?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with (-)-Menthol?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with (-)-Menthol
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Miyazawa M et al. | Oxidation of 1,8-cineole, the monoterpene cyclic ether originated from eucalyptus polybractea, by cytochrome P450 3A enzymes in rat and human liver microsomes. | 2001 | Drug Metab. Dispos. | pmid:11159812 |
| Chen LJ et al. | Metabolism of (R)-(+)-pulegone in F344 rats. | 2001 | Drug Metab. Dispos. | pmid:11717176 |
| Yamaguchi T et al. | Metabolic fate of [3H]-l-menthol in the rat. | 1994 Jul-Aug | Drug Metab. Dispos. | pmid:7956738 |
| Thulasiram HV et al. | Effect of ring size in R-(+)-pulegone-mediated hepatotoxicity: studies on the metabolism of R-(+)-4-methyl-2-(1-methylethylidene)-cyclopentanone and DL-camphorone in rats. | 2001 | Drug Metab. Dispos. | pmid:11353750 |
| Gordon WP et al. | The metabolism of the abortifacient terpene, (R)-(+)-pulegone, to a proximate toxin, menthofuran. | 1987 Sep-Oct | Drug Metab. Dispos. | pmid:2891472 |
| Madyastha KM and Srivatsan V | Studies on the metabolism of l-menthol in rats. | 1988 Sep-Oct | Drug Metab. Dispos. | pmid:2906604 |
| Coffman BL et al. | The glucuronidation of opioids, other xenobiotics, and androgens by human UGT2B7Y(268) and UGT2B7H(268). | 1998 | Drug Metab. Dispos. | pmid:9443856 |
| Thulasiram HV et al. | Role of C-5 chiral center in R-(+)-pulegone-mediated hepatotoxicity: metabolic disposition and toxicity of 5, 5-dimethyl-2-(1-Methylethylidene)-cyclohexanone in rats. | 2000 | Drug Metab. Dispos. | pmid:10859158 |
| Sarkar M et al. | Metabolism of nicotine and 4-(methylnitrosamino)-l-(3-pyridyl)-lbutanone (NNK) in menthol and non-menthol cigarette smokers. | 2012 | Drug Metab Lett | pmid:23140558 |
| Nsagha DS et al. | Feasibility of home management using ACT for childhood malaria episodes in an urban setting. | 2012 | Drug Healthc Patient Saf | pmid:22328833 |
| Patel NA et al. | Comparative development and evaluation of topical gel and cream formulations of psoralen. | 2009 | Drug Discov Ther | pmid:22495634 |
| Yong CS et al. | Enhanced oral bioavailability of ibuprofen in rats by poloxamer gel using poloxamer 188 and menthol. | 2005 | Drug Dev Ind Pharm | pmid:16207608 |
| Prasad R et al. | Studies on in vitro and in vivo transdermal flux enhancement of methotrexate by a combinational approach in comparison to oral delivery. | 2009 | Drug Dev Ind Pharm | pmid:19832628 |
| Zahir A et al. | Effect of menthol on permeability of an optically active and racemic propranolol across guinea pig skin. | 1998 | Drug Dev Ind Pharm | pmid:9876540 |
| Tokuoka Y et al. | Enhancement in skin permeation of 5-aminolevulinic acid using l-menthol and its derivatives. | 2008 | Drug Dev Ind Pharm | pmid:18568909 |
| Takanashi Y et al. | Thiomenthol derivatives as novel percutaneous absorption enhancers. | 1999 | Drug Dev Ind Pharm | pmid:10028423 |
| Fujii M et al. | Enhancement effect of p-menthane-3,8-diol on in vitro permeation of antipyrine and indomethacin through Yucatan micropig skin. | 2004 | Drug Dev Ind Pharm | pmid:15285341 |
| Chang JS et al. | The effect of mixed-solvent and terpenes on percutaneous absorption of meloxicam gel. | 2007 | Drug Dev Ind Pharm | pmid:17891585 |
| Patel M et al. | Quantification of dermal and transdermal delivery of meloxicam gels in rabbits. | 2011 | Drug Dev Ind Pharm | pmid:21469950 |
| Kanikkannan N et al. | Formulation and in vitro evaluation of transdermal patches of melatonin. | 2004 | Drug Dev Ind Pharm | pmid:15089055 |
| Chadha G et al. | In vitro percutaneous absorption of genistein from topical gels through human skin. | 2011 | Drug Dev Ind Pharm | pmid:21126208 |
| Zhao L et al. | Effect of O-acylmenthol and salt formation on the skin permeation of diclofenac acid. | 2009 | Drug Dev Ind Pharm | pmid:19466898 |
| Sammeta SM et al. | Magnetophoresis in combination with chemical enhancers for transdermal drug delivery. | 2011 | Drug Dev Ind Pharm | pmid:21449699 |
| Obata Y et al. | Effect of cyclic monoterpenes on percutaneous absorption in the case of a water-soluble drug (diclofenac sodium). | 1990 | Drug Des. Deliv. | pmid:2083031 |
| Zhang L et al. | Puerarin transport across a Calu-3 cell monolayer - an in vitro model of nasal mucosa permeability and the influence of paeoniflorin and menthol. | 2016 | Drug Des Devel Ther | pmid:27468226 |
| Liu C et al. | Enhanced skin permeation of glabridin using eutectic mixture-based nanoemulsion. | 2017 | Drug Deliv Transl Res | pmid:28188607 |
| Krishnaiah YS et al. | Penetration-enhancing effect of ethanolic solution of menthol on transdermal permeation of ondansetron hydrochloride across rat epidermis. | 2008 | Drug Deliv | pmid:18446568 |
| Aqil M et al. | Transdermal drug delivery systems of a beta blocker: design, in vitro, and in vivo characterization. | 2004 Jan-Feb | Drug Deliv | pmid:15168788 |
| González N and Sumano H | Design of two liquid Ibuprofen-poloxamer-limonene or menthol preparations for dermal administration. | 2007 | Drug Deliv | pmid:17613016 |
| Yong CS et al. | Improved solubility and in vitro dissolution of Ibuprofen from poloxamer gel using eutectic mixture with menthol. | 2003 Jul-Sep | Drug Deliv | pmid:12944138 |
| Babu RJ and Pandit JK | Effect of penetration enhancers on the transdermal delivery of bupranolol through rat skin. | 2005 May-Jun | Drug Deliv | pmid:16025846 |
| Jiang J et al. | Mechanistic investigation and reversible effect of 2-isopropyl-5-methylcyclohexyl heptanoate on the in vitro percutaneous absorption of indomethacin. | 2014 | Drug Deliv | pmid:24134638 |
| Song YH et al. | The effects of terpenes on the permeation of lidocaine and ofloxacin from moisture-activated patches. | 2009 | Drug Deliv | pmid:19267298 |
| Rose JE and Behm FM | Inhalation of vapor from black pepper extract reduces smoking withdrawal symptoms. | 1994 | Drug Alcohol Depend | pmid:8033760 |
| Fagan P et al. | Comparisons of three nicotine dependence scales in a multiethnic sample of young adult menthol and non-menthol smokers. | 2015 | Drug Alcohol Depend | pmid:25744873 |
| Winhusen TM et al. | A tale of two stimulants: mentholated cigarettes may play a role in cocaine, but not methamphetamine, dependence. | 2013 | Drug Alcohol Depend | pmid:24075226 |
| Malta E et al. | Functions of base flipping in E. coli nucleotide excision repair. | 2008 | DNA Repair (Amst.) | pmid:18638572 |
| Myrer JW et al. | Topical analgesic added to paraffin enhances paraffin bath treatment of individuals with hand osteoarthritis. | 2011 | Disabil Rehabil | pmid:20617919 |
| Signorello LB et al. | Racial differences in serum cotinine levels of smokers. | 2009 | Dis. Markers | pmid:20037205 |
| Santos FA and Rao VS | 1,8-cineol, a food flavoring agent, prevents ethanol-induced gastric injury in rats. | 2001 | Dig. Dis. Sci. | pmid:11281182 |
| Hiki N et al. | Multicenter phase II randomized study evaluating dose-response of antiperistaltic effect of L-menthol sprayed onto the gastric mucosa for upper gastrointestinal endoscopy. | 2012 | Dig Endosc | pmid:22348831 |
| Terry LM and Johanson IB | Effects of altered olfactory experiences on the development of infant rats' responses to odors. | 1996 | Dev Psychobiol | pmid:8732808 |
| Gall H et al. | Anaphylactic shock reaction to dibutyl-phthalate-containing capsules. | 1999 | Dermatology (Basel) | pmid:10559589 |
| Laugier P et al. | [Glandular uranitis]. | 1971 | Dermatologica | pmid:5130259 |
| PASCHOUD JM | [SOME CASES OF CONTACT ECZEMA WITH GROUP SENSITIZATION]. | 1963 | Dermatologica | pmid:14055606 |
| Noiles K and Pratt M | Contact dermatitis to Vicks VapoRub. | 2010 May-Jun | Dermatitis | pmid:20487662 |
| Cugati N | Is flavor component in dental product therapeutic? | 2012 | Dent Res J (Isfahan) | pmid:22363374 |
| Fujisawa S and Kadoma Y | Effect of phenolic compounds on the polymerization of methyl methacrylate. | 1992 | Dent Mater | pmid:1303375 |
| Godau T et al. | Cu(I) catalysed cyclopropanation with enantiopure scorpionate type ligands derived from (+)-camphor or (-)-menthone. | 2011 | Dalton Trans | pmid:21584295 |
| Wochna-Sobańska M | [Treatment of pulp diseases in milk teeth with chlorocamphomenthol]. | 1990 | Czas Stomatol | pmid:2133295 |
| Wochna-Sobańska M | [Experimental studies of the inflammation-inducing action of various agents used in the treatment of pulp diseases in deciduous teeth]. | 1987 | Czas Stomatol | pmid:3119295 |
| Stawinski K et al. | [Mundisal-gel and its use in various diseases of the oral cavity]. | 1977 | Czas Stomatol | pmid:266440 |
| Fisher AA | Reactions to menthol. | 1986 | Cutis | pmid:3731860 |
| Heng MC | Local necrosis and interstitial nephritis due to topical methyl salicylate and menthol. | 1987 | Cutis | pmid:3556044 |
| Jordt SE et al. | Lessons from peppers and peppermint: the molecular logic of thermosensation. | 2003 | Curr. Opin. Neurobiol. | pmid:12965298 |
| Proudfoot CJ et al. | Analgesia mediated by the TRPM8 cold receptor in chronic neuropathic pain. | 2006 | Curr. Biol. | pmid:16920620 |
| Babes A et al. | TRPM8, a sensor for mild cooling in mammalian sensory nerve endings. | 2011 | Curr Pharm Biotechnol | pmid:20932256 |
| Mandadi S and Roufogalis BD | ThermoTRP channels in nociceptors: taking a lead from capsaicin receptor TRPV1. | 2008 | Curr Neuropharmacol | pmid:19305786 |
| Vriens J et al. | Herbal compounds and toxins modulating TRP channels. | 2008 | Curr Neuropharmacol | pmid:19305789 |
| Jiang LH et al. | Properties and therapeutic potential of transient receptor potential channels with putative roles in adversity: focus on TRPC5, TRPM2 and TRPA1. | 2011 | Curr Drug Targets | pmid:21291387 |
| Krishnaiah YS and Bhaskar P | Studies on the transdermal delivery of nimodipine from a menthol-based TTS in human volunteers. | 2004 | Curr Drug Deliv | pmid:16305374 |
| Ammar HO et al. | A transdermal delivery system for glipizide. | 2006 | Curr Drug Deliv | pmid:16848735 |
| Vaghani SS et al. | Effect of iontophoresis and permeation enhancers on the permeation of an acyclovir gel. | 2010 | Curr Drug Deliv | pmid:20695844 |
| Bhattacharjee AK | In silico stereo-electronic analysis of PMD (p-Menthane-3-8-Diol) and its derivatives for pharmacophore development may aid discovery of novel insect repellents. | 2013 | Curr Comput Aided Drug Des | pmid:24010930 |
| Eccles R | Menthol: effects on nasal sensation of airflow and the drive to breathe. | 2003 | Curr Allergy Asthma Rep | pmid:12662469 |
| Roemer E et al. | Scientific assessment of the use of sugars as cigarette tobacco ingredients: a review of published and other publicly available studies. | 2012 | Crit. Rev. Toxicol. | pmid:22263649 |
| Molassiotis A et al. | Clinical expert guidelines for the management of cough in lung cancer: report of a UK task group on cough. | 2010 | Cough | pmid:20925935 |
| Yamasaki M et al. | Cough reflex and oral chemesthesis induced by capsaicin and capsiate in healthy never-smokers. | 2007 | Cough | pmid:17971242 |
| Ternesten-Hasséus E et al. | Symptoms induced by environmental irritants and health-related quality of life in patients with chronic cough - A cross-sectional study. | 2011 | Cough | pmid:21981855 |
| Konidala U et al. | Efficacy of various disinfectants on microbially contaminated toothbrushes due to brushing. | 2011 | Contemp Clin Dent | pmid:22346157 |
| Ota T et al. | Concomitant development of photoallergic contact dermatitis from ketoprofen and allergic contact dermatitis from menthol and rosin (colophony) in a compress. | 2007 | Contact Derm. | pmid:17177713 |
| Fleming CJ and Forsyth A | D5 patch test reactions to menthol and peppermint. | 1998 | Contact Derm. | pmid:9687034 |
| Wilkinson SM and Beck MH | Allergic contact dermatitis from menthol in peppermint. | 1994 | Contact Derm. | pmid:8156763 |
| Aguirre A et al. | Allergic contact dermatitis from Reflex spray. | 1994 | Contact Derm. | pmid:8156772 |
| Lewis FM et al. | Contact sensitivity to food additives can cause oral and perioral symptoms. | 1995 | Contact Derm. | pmid:8706405 |
| Foti C et al. | Contact dermatitis from peppermint and menthol in a local action transcutaneous patch. | 2003 | Contact Derm. | pmid:15025712 |
| Morton CA et al. | Contact sensitivity to menthol and peppermint in patients with intra-oral symptoms. | 1995 | Contact Derm. | pmid:7634781 |
| Nakagawa S et al. | Erythema multiforme-like generalized contact dermatitis to l-menthol contained in anti-inflammatory medical compresses as an ingredient. | 2009 | Contact Derm. | pmid:19780777 |
| Vilaplana J and Romaguera C | Allergic contact dermatitis due to eucalyptol in an anti-inflammatory cream. | 2000 | Contact Derm. | pmid:10945757 |
| Camarasa G and Alomar A | Menthol dermatitis from cigarettes. | 1978 | Contact Derm. | pmid:668352 |
| Wiseman EJ and McMillan DE | Rationale for cigarette smoking and for mentholation preference in cocaine- and nicotine-dependent outpatients. | 1998 Nov-Dec | Compr Psychiatry | pmid:9829143 |
| Morse DR et al. | Gutta-percha/eucapercha, Part I: Characteristics and an update of the technique. | 1987 | Compendium | pmid:3481290 |
| Morse DR et al. | Gutta-percha/eucapercha, Part II: Indications, representative cases, and pitfall management. | 1987 Nov-Dec | Compendium | pmid:3481559 |
| Morse DR | Internal root resorption obturated by the gutta-percha-eucapercha endodontic method: report of a case. | 1985 | Compend Contin Educ Dent | pmid:3902353 |
| Woodall AJ and McCrohan CR | Excitatory actions of propofol and ketamine in the snail Lymnaea stagnalis. | 2000 | Comp. Biochem. Physiol. C Toxicol. Pharmacol. | pmid:11246501 |
| Liapis P et al. | Characterisation of tolbutamide hydroxylase activity in the common brushtail possum, (Trichosurus vulpecula) and koala (Phascolarctos cinereus): inhibition by the eucalyptus terpene 1,8-cineole. | 2000 | Comp. Biochem. Physiol. C Toxicol. Pharmacol. | pmid:11246507 |
| Boyle R et al. | Metabolites of dietary 1,8-cineole in the male koala (Phascolarctos cinereus). | 2001 | Comp. Biochem. Physiol. C Toxicol. Pharmacol. | pmid:11489436 |
| Watanabe H et al. | Effect of l-menthol on the thermotropic behavior of ceramide 2/cholesterol mixtures as a model for the intercellular lipids in stratum corneum. | 2009 | Colloids Surf B Biointerfaces | pmid:19505808 |
| Gelal A et al. | Disposition kinetics and effects of menthol. | 1999 | Clin. Pharmacol. Ther. | pmid:10460066 |
| Hiki N et al. | A phase I study evaluating tolerability, pharmacokinetics, and preliminary efficacy of L-menthol in upper gastrointestinal endoscopy. | 2011 | Clin. Pharmacol. Ther. | pmid:21544078 |
| Benowitz NL | Clinical pharmacology of nicotine: implications for understanding, preventing, and treating tobacco addiction. | 2008 | Clin. Pharmacol. Ther. | pmid:18305452 |
| Hohenwallner W | [Menthol and bilirubin inhibition of 4-methylumbelliferone glucuroconjugation in vitro by rat and human liver]. | 1970 | Clin. Chim. Acta | pmid:5463172 |
| Cardona V et al. | Allergic diseases in the elderly. | 2011 | Clin Transl Allergy | pmid:22409889 |
| Higashi Y et al. | Efficacy and safety profile of a topical methyl salicylate and menthol patch in adult patients with mild to moderate muscle strain: a randomized, double-blind, parallel-group, placebo-controlled, multicenter study. | 2010 | Clin Ther | pmid:20171409 |
| Silvers WS et al. | Comparative taste evaluation of aerosolized formulations of triamcinolone acetonide, flunisolide, and flunisolide with menthol. | 1993 Nov-Dec | Clin Ther | pmid:8111818 |
| Borgatti E | [Hemorrhoids: clinical and therapeutic considerations]. | 1985 | Clin Ter | pmid:2863027 |
| Vecchi GP | [Hemorrhoid syndrome in the aged. A particular pharmacotherapeutic approach]. | 1985 | Clin Ter | pmid:4017464 |
| Gipperich L and Palmari V | [Clinical experiences with an antihemorrhoidal preparation]. | 1971 | Clin Ter | pmid:4110359 |
| Giulietti M | [Therapeutic activity in an oto-rhino-pharyngeal solution]. | 1979 | Clin Ter | pmid:544158 |
| Alenmyr L et al. | TRPV1 and TRPA1 stimulation induces MUC5B secretion in the human nasal airway in vivo. | 2011 | Clin Physiol Funct Imaging | pmid:21981454 |