(-)-Menthol

(-)-menthol is a lipid of Prenol Lipids (PR) class. (-)-menthol is associated with abnormalities such as Wiskott-Aldrich Syndrome. The involved functions are known as Agent, Anabolism, Signal Transduction, Binding (Molecular Function) and Signal Transduction Pathways. (-)-menthol often locates in Membrane, Tissue fiber and Dominant hand. The associated genes with (-)-Menthol are REG1A gene, UGT2B7 gene, HM13 gene and SCN10A gene. The related lipids are Steroids and androsterone glucuronide.

Cross Reference

Introduction

To understand associated biological information of (-)-Menthol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with (-)-Menthol?

(-)-Menthol is suspected in and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with (-)-Menthol

MeSH term MeSH ID Detail
Pain D010146 64 associated lipids
Endophthalmitis D009877 12 associated lipids
Uveitis, Posterior D015866 5 associated lipids
Total 3

PubChem Associated disorders and diseases

What pathways are associated with (-)-Menthol

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with (-)-Menthol?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with (-)-Menthol?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with (-)-Menthol?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with (-)-Menthol?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with (-)-Menthol?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with (-)-Menthol

Download all related citations
Per page 10 20 50 100 | Total 2230
Authors Title Published Journal PubMed Link
Rachakonda VK et al. Screening of chemical penetration enhancers for transdermal drug delivery using electrical resistance of skin. 2008 Pharm. Res. pmid:18683029
Slominski A Cooling skin cancer: menthol inhibits melanoma growth. Focus on "TRPM8 activation suppresses cellular viability in human melanoma". 2008 Am. J. Physiol., Cell Physiol. pmid:18684990
Wondergem R et al. HGF/SF and menthol increase human glioblastoma cell calcium and migration. 2008 Biochem. Biophys. Res. Commun. pmid:18485891
Mu TW et al. Partial restoration of mutant enzyme homeostasis in three distinct lysosomal storage disease cell lines by altering calcium homeostasis. 2008 PLoS Biol. pmid:18254660
Kim KY et al. TRP-independent inhibition of the phospholipase C pathway by natural sensory ligands. 2008 Biochem. Biophys. Res. Commun. pmid:18371303
Ciftçi O et al. Mentholated cigarette smoking induced alterations in left and right ventricular functions in chronic smokers. 2008 Anadolu Kardiyol Derg pmid:18400631
Wasner G et al. The effect of menthol on cold allodynia in patients with neuropathic pain. 2008 Pain Med pmid:18366513
Brady D et al. Spherezymes: a novel structured self-immobilisation enzyme technology. 2008 BMC Biotechnol. pmid:18237402
Lanfranchi DA et al. Enantiomeric differentiation of oxygenated p-menthane derivatives by 13C NMR using Yb(hfc)3. 2008 Magn Reson Chem pmid:18828150
Meesters RJ et al. Sensitive determination of monoterpene alcohols in urine by HPLC-FLD combined with ESI-MS detection after online-solid phase extraction of the monoterpene-coumarincarbamate derivates. 2008 J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. pmid:18845490
Cal K Skin disposition of menthol after its application in the presence of drug substances. 2008 Biopharm Drug Dispos pmid:18985797
Lu HF et al. (-)-Menthol inhibits WEHI-3 leukemia cells in vitro and in vivo. 2007 Mar-Apr In Vivo pmid:17436578
Gardiner JC et al. A bladder-cooling reflex in the anaesthetised guinea-pig: a model of the positive clinical ice-water test. 2007 Mar-Apr J Pharmacol Toxicol Methods pmid:16905339
Wang NL et al. Two new monoterpene glycosides and a new (+)-jasmololone glucoside from Bidens parviflora Willd. 2007 Apr-Aug J Asian Nat Prod Res pmid:17701564
Mahattanatawee K et al. Comparison of three lychee cultivar odor profiles using gas chromatography-olfactometry and gas chromatography-sulfur detection. 2007 J. Agric. Food Chem. pmid:17266328
Wackowski O and Delnevo CD Menthol cigarettes and indicators of tobacco dependence among adolescents. 2007 Addict Behav pmid:17229528
Nokhodchi A et al. The effect of terpene concentrations on the skin penetration of diclofenac sodium. 2007 Int J Pharm pmid:17174049
Ota T et al. Concomitant development of photoallergic contact dermatitis from ketoprofen and allergic contact dermatitis from menthol and rosin (colophony) in a compress. 2007 Contact Derm. pmid:17177713
De Petrocellis L et al. Regulation of transient receptor potential channels of melastatin type 8 (TRPM8): effect of cAMP, cannabinoid CB(1) receptors and endovanilloids. 2007 Exp. Cell Res. pmid:17428469
Linte RM et al. Desensitization of cold- and menthol-sensitive rat dorsal root ganglion neurones by inflammatory mediators. 2007 Exp Brain Res pmid:17006682
Chen H et al. Hydrogel-thickened microemulsion for topical administration of drug molecule at an extremely low concentration. 2007 Int J Pharm pmid:17570625
Jantharaprapap R and Stagni G Effects of penetration enhancers on in vitro permeability of meloxicam gels. 2007 Int J Pharm pmid:17531412
Karashima Y et al. Bimodal action of menthol on the transient receptor potential channel TRPA1. 2007 J. Neurosci. pmid:17855602
Benedikt J et al. Ethanol inhibits cold-menthol receptor TRPM8 by modulating its interaction with membrane phosphatidylinositol 4,5-bisphosphate. 2007 J. Neurochem. pmid:17074062
Prasad R et al. Effect of DC/mDC iontophoresis and terpenes on transdermal permeation of methotrexate: in vitro study. 2007 Int J Pharm pmid:17116378
Mint conditions. 2007 Harv Health Lett pmid:17665507
Okuyemi KS et al. Relationship between menthol cigarettes and smoking cessation among African American light smokers. 2007 Addiction pmid:17916223
Chang JS et al. The effect of mixed-solvent and terpenes on percutaneous absorption of meloxicam gel. 2007 Drug Dev Ind Pharm pmid:17891585
Shapira R and Mimran E Isolation and characterization of Escherichia coli mutants exhibiting altered response to thymol. 2007 Microb. Drug Resist. pmid:17949301
Hayashi S et al. Impairment by activation of TRPA1 of gastric epithelial restitution in a wound model using RGM1 cell monolayer. 2007 Inflammopharmacology pmid:17943255
Ditrichova D et al. Oral lichenoid lesions and allergy to dental materials. 2007 Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub pmid:18345274
Bicchi C et al. Reliability of fibres in solid-phase microextraction for routine analysis of the headspace of aromatic and medicinal plants. 2007 J Chromatogr A pmid:17331518
Voets T et al. TRPM8 voltage sensor mutants reveal a mechanism for integrating thermal and chemical stimuli. 2007 Nat. Chem. Biol. pmid:17293875
Andersson M and Hindsén M Rhinitis because of toothpaste and other menthol-containing products. 2007 Allergy pmid:17298356
Ruskin DN et al. Menthol and nicotine oppositely modulate body temperature in the rat. 2007 Eur. J. Pharmacol. pmid:17303112
Murray RP et al. Menthol cigarettes and health risks in Lung Health Study data. 2007 Nicotine Tob. Res. pmid:17365741
Bautista DM et al. The menthol receptor TRPM8 is the principal detector of environmental cold. 2007 Nature pmid:17538622
Takashima Y et al. Diversity in the neural circuitry of cold sensing revealed by genetic axonal labeling of transient receptor potential melastatin 8 neurons. 2007 J. Neurosci. pmid:18094254
Petrus M et al. A role of TRPA1 in mechanical hyperalgesia is revealed by pharmacological inhibition. 2007 Mol Pain pmid:18086313
Bödding M et al. Characterisation of TRPM8 as a pharmacophore receptor. 2007 Cell Calcium pmid:17517434
McDaniel PA and Malone RE "I always thought they were all pure tobacco": American smokers' perceptions of "natural" cigarettes and tobacco industry advertising strategies. 2007 Tob Control pmid:18048597
Wienforth F et al. Smart textiles: a new drug delivery system for symptomatic treatment of a common cold. 2007 J Clin Pharmacol pmid:17442689
Tiemann P et al. Administration of Ratanhia-based herbal oral care products for the prophylaxis of oral mucositis in cancer chemotherapy patients: a clinical trial. 2007 Evid Based Complement Alternat Med pmid:17965768
Dandruff, seborrheic dermatitis, and psoriasis drug products containing coal tar and menthol for over-the-counter human use; amendment to the monograph. Final rule. 2007 Fed Regist pmid:17447341
Matta JA and Ahern GP Voltage is a partial activator of rat thermosensitive TRP channels. 2007 J. Physiol. (Lond.) pmid:17932142
da Silveira Novelino AM et al. Evaluation of the acaricide effect of thymol, menthol, salicylic acid, and methyl salicylate on Boophilus microplus (Canestrini 1887) (Acari: Ixodidae) larvae. 2007 Parasitol. Res. pmid:17487509
Phelps CB and Gaudet R The role of the N terminus and transmembrane domain of TRPM8 in channel localization and tetramerization. 2007 J. Biol. Chem. pmid:17908685
Mergler S et al. Transient receptor potential channel TRPM8 agonists stimulate calcium influx and neurotensin secretion in neuroendocrine tumor cells. 2007 Neuroendocrinology pmid:17426390
Millar ID et al. Ion channel diversity, channel expression and function in the choroid plexuses. 2007 Cerebrospinal Fluid Res pmid:17883837
Daniels RL and McKemy DD Mice left out in the cold: commentary on the phenotype of TRPM8-nulls. 2007 Mol Pain pmid:17705869
Lateef F Of pruritus and terrorism... 2007 Singapore Med J pmid:17453092
Schulz M et al. Allelopathic Monoterpenes Interfere with Arabidopsis thaliana Cuticular Waxes and Enhance Transpiration. 2007 Plant Signal Behav pmid:19516993
Panahi Y et al. Phenol and menthol in the treatment of chronic skin lesions following mustard gas exposure. 2007 Singapore Med J pmid:17453095
Facer P et al. Differential expression of the capsaicin receptor TRPV1 and related novel receptors TRPV3, TRPV4 and TRPM8 in normal human tissues and changes in traumatic and diabetic neuropathy. 2007 BMC Neurol pmid:17521436
Allen B and Unger JB Sociocultural correlates of menthol cigarette smoking among adult African Americans in Los Angeles. 2007 Nicotine Tob. Res. pmid:17454699
Colburn RW et al. Attenuated cold sensitivity in TRPM8 null mice. 2007 Neuron pmid:17481392
Patel T et al. Menthol: a refreshing look at this ancient compound. 2007 J. Am. Acad. Dermatol. pmid:17498839
Cortright DN et al. TRP channels and pain. 2007 Biochim. Biophys. Acta pmid:17467247
Hjerling-Leffler J et al. Emergence of functional sensory subtypes as defined by transient receptor potential channel expression. 2007 J. Neurosci. pmid:17344381
Sayyah Melli M et al. Effect of peppermint water on prevention of nipple cracks in lactating primiparous women: a randomized controlled trial. 2007 Int Breastfeed J pmid:17442122
Vidal P et al. A simple method for measuring long-range 1H-13C coupling constants in organic molecules. 2007 J. Org. Chem. pmid:17346082
Vogt-Eisele AK et al. Monoterpenoid agonists of TRPV3. 2007 Br. J. Pharmacol. pmid:17420775
dos Anjos JL et al. Effects of ethanol/l-menthol on the dynamics and partitioning of spin-labeled lipids in the stratum corneum. 2007 Eur J Pharm Biopharm pmid:17350812
Suzuki SC et al. Cadherin-8 is required for the first relay synapses to receive functional inputs from primary sensory afferents for cold sensation. 2007 J. Neurosci. pmid:17392463
Borhani Haghighi A et al. Therapeutic potentials of menthol in migraine headache: possible mechanisms of action. 2007 Med. Hypotheses pmid:17317030
Andersson DA et al. Modulation of the cold-activated channel TRPM8 by lysophospholipids and polyunsaturated fatty acids. 2007 J. Neurosci. pmid:17376995
Moore SJ et al. A low-cost repellent for malaria vectors in the Americas: results of two field trials in Guatemala and Peru. 2007 Malar. J. pmid:17678537
Mälkiä A et al. Bidirectional shifts of TRPM8 channel gating by temperature and chemical agents modulate the cold sensitivity of mammalian thermoreceptors. 2007 J. Physiol. (Lond.) pmid:17317754
Wang CY et al. Enhancing antioxidant, antiproliferation, and free radical scavenging activities in strawberries with essential oils. 2007 J. Agric. Food Chem. pmid:17636936
Headley J and Northstone K Medication administered to children from 0 to 7.5 years in the Avon Longitudinal Study of Parents and Children (ALSPAC). 2007 Eur. J. Clin. Pharmacol. pmid:17200835
Chen J [Effect of quadruple fluid aerosol inhalation on oral mucositis induced by radiotherapy in nasopharyngeal carcinoma and its mechanism]. 2007 Zhong Nan Da Xue Xue Bao Yi Xue Ban pmid:17611340
González N and Sumano H Design of two liquid Ibuprofen-poloxamer-limonene or menthol preparations for dermal administration. 2007 Drug Deliv pmid:17613016
Williams JM et al. Higher nicotine and carbon monoxide levels in menthol cigarette smokers with and without schizophrenia. 2007 Nicotine Tob. Res. pmid:17654300
Xing H et al. TRPM8 mechanism of cold allodynia after chronic nerve injury. 2007 J. Neurosci. pmid:18077679
Kondrats'kyÄ­ AP et al. [Functional identification of the TRPM8 cold receptor in rat prostate epithelial cells]. 2007 Fiziol Zh pmid:18080488
Olivella MS et al. Effects of dimethylformamide and L-menthol permeation enhancers on transdermal delivery of quercetin. 2007 Pharm Dev Technol pmid:17963148
Tajino K et al. Application of menthol to the skin of whole trunk in mice induces autonomic and behavioral heat-gain responses. 2007 Am. J. Physiol. Regul. Integr. Comp. Physiol. pmid:17761510
Ferguson LJ et al. 14C-labeled pulegone and metabolites binding to alpha2u-globulin in kidneys of male F-344 rats. 2007 J. Toxicol. Environ. Health Part A pmid:17687727
Penuelas A et al. Contractile effect of TRPA1 receptor agonists in the isolated mouse intestine. 2007 Eur. J. Pharmacol. pmid:17825279
Yamasaki M et al. Cough reflex and oral chemesthesis induced by capsaicin and capsiate in healthy never-smokers. 2007 Cough pmid:17971242
Deluc LG et al. Transcriptomic and metabolite analyses of Cabernet Sauvignon grape berry development. 2007 BMC Genomics pmid:18034876
Kalantzis A et al. Effects of capsaicin and menthol on oral thermal sensory thresholds. 2007 Arch. Oral Biol. pmid:17045956
Beck B et al. Prospects for prostate cancer imaging and therapy using high-affinity TRPM8 activators. 2007 Cell Calcium pmid:16949669
Mahieu F et al. TRPM8-independent menthol-induced Ca2+ release from endoplasmic reticulum and Golgi. 2007 J. Biol. Chem. pmid:17142461
Green BG and Schoen KL Thermal and nociceptive sensations from menthol and their suppression by dynamic contact. 2007 Behav. Brain Res. pmid:17092576
Zanotto KL et al. Neurons in superficial trigeminal subnucleus caudalis responsive to oral cooling, menthol, and other irritant stimuli. 2007 J. Neurophysiol. pmid:17151223
Werley MS et al. Possible effects on smokers of cigarette mentholation: a review of the evidence relating to key research questions. 2007 Regul. Toxicol. Pharmacol. pmid:17097785
Abd-ElGawad AE et al. Comparison of different perrmeation enhancers on topical ketoconazole formulations. 2007 Arzneimittelforschung pmid:17341008
Cinelli G et al. Use of Rhodotorula minuta live cells hosted in water-in-oil macroemulsion for biotrasformation reaction. 2006 May-Jun Biotechnol. Prog. pmid:16739950
Pigarelli DL OTC product: SudaCare Shower Soothers. 2006 Jul-Aug J Am Pharm Assoc (2003) pmid:16913400
Lu HF et al. The role of Ca2+ in (-)-menthol-induced human promyelocytic leukemia HL-60 cell death. 2006 Jan-Feb In Vivo pmid:16433031
Abe J et al. Ca2+-dependent PKC activation mediates menthol-induced desensitization of transient receptor potential M8. 2006 Apr 10-17 Neurosci. Lett. pmid:16380208
Ammar HO et al. A transdermal delivery system for glipizide. 2006 Curr Drug Deliv pmid:16848735
McDougall JJ Arthritis and pain. Neurogenic origin of joint pain. 2006 Arthritis Res. Ther. pmid:17118212
Vanden Abeele F et al. Ca2+-independent phospholipase A2-dependent gating of TRPM8 by lysophospholipids. 2006 J. Biol. Chem. pmid:17082190
Ortiz G and Tena MT Headspace solid-phase microextraction gas chromatography-mass spectrometry method for the identification of cosmetic ingredients causing delamination of packagings. 2006 J Chromatogr A pmid:16246353
McKay DL and Blumberg JB A review of the bioactivity and potential health benefits of peppermint tea (Mentha piperita L.). 2006 Phytother Res pmid:16767798
Hatem S et al. Psychophysical study of the effects of topical application of menthol in healthy volunteers. 2006 Pain pmid:16527405
Hersey JC et al. Are menthol cigarettes a starter product for youth? 2006 Nicotine Tob. Res. pmid:16801298
Macpherson LJ et al. More than cool: promiscuous relationships of menthol and other sensory compounds. 2006 Mol. Cell. Neurosci. pmid:16829128