(-)-Menthol

(-)-menthol is a lipid of Prenol Lipids (PR) class. (-)-menthol is associated with abnormalities such as Wiskott-Aldrich Syndrome. The involved functions are known as Agent, Anabolism, Signal Transduction, Binding (Molecular Function) and Signal Transduction Pathways. (-)-menthol often locates in Membrane, Tissue fiber and Dominant hand. The associated genes with (-)-Menthol are REG1A gene, UGT2B7 gene, HM13 gene and SCN10A gene. The related lipids are Steroids and androsterone glucuronide.

Cross Reference

Introduction

To understand associated biological information of (-)-Menthol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with (-)-Menthol?

(-)-Menthol is suspected in and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with (-)-Menthol

MeSH term MeSH ID Detail
Pain D010146 64 associated lipids
Endophthalmitis D009877 12 associated lipids
Uveitis, Posterior D015866 5 associated lipids
Total 3

PubChem Associated disorders and diseases

What pathways are associated with (-)-Menthol

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with (-)-Menthol?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with (-)-Menthol?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with (-)-Menthol?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with (-)-Menthol?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with (-)-Menthol?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with (-)-Menthol

Download all related citations
Per page 10 20 50 100 | Total 2230
Authors Title Published Journal PubMed Link
Miyazawa M and Nakanishi K Biotransformation of (-)-menthone by human liver microsomes. 2006 Biosci. Biotechnol. Biochem. pmid:16717432
Brauchi S et al. A hot-sensing cold receptor: C-terminal domain determines thermosensation in transient receptor potential channels. 2006 J. Neurosci. pmid:16672657
Liu H et al. Effect of vehicles and enhancers on the topical delivery of cyclosporin A. 2006 Int J Pharm pmid:16439077
Ben Arfa A et al. Antimicrobial activity of carvacrol related to its chemical structure. 2006 Lett. Appl. Microbiol. pmid:16869897
Ammar HO et al. A transdermal delivery system for glipizide. 2006 Curr Drug Deliv pmid:16848735
Hong Z et al. Role of store-operated calcium channels and calcium sensitization in normoxic contraction of the ductus arteriosus. 2006 Circulation pmid:16982938
García DA et al. Allosteric positive interaction of thymol with the GABAA receptor in primary cultures of mouse cortical neurons. 2006 Neuropharmacology pmid:16185724
Bi GQ et al. Recent advances in basic neurosciences and brain disease: from synapses to behavior. 2006 Mol Pain pmid:17196111
Mukerji G et al. Pain during ice water test distinguishes clinical bladder hypersensitivity from overactivity disorders. 2006 BMC Urol pmid:17192176
Almeida MC et al. Neural substrate of cold-seeking behavior in endotoxin shock. 2006 PLoS ONE pmid:17183631
Madrid R et al. Contribution of TRPM8 channels to cold transduction in primary sensory neurons and peripheral nerve terminals. 2006 J. Neurosci. pmid:17135413
McDougall JJ Arthritis and pain. Neurogenic origin of joint pain. 2006 Arthritis Res. Ther. pmid:17118212
Vanden Abeele F et al. Ca2+-independent phospholipase A2-dependent gating of TRPM8 by lysophospholipids. 2006 J. Biol. Chem. pmid:17082190
Ziegler J et al. Comparative transcript and alkaloid profiling in Papaver species identifies a short chain dehydrogenase/reductase involved in morphine biosynthesis. 2006 Plant J. pmid:16968522
Smith PL et al. Bisandrographolide from Andrographis paniculata activates TRPV4 channels. 2006 J. Biol. Chem. pmid:16899456
Damann N et al. Chemosensory properties of murine nasal and cutaneous trigeminal neurons identified by viral tracing. 2006 BMC Neurosci pmid:16762059
Osaki Y et al. Adolescent smoking behaviour and cigarette brand preference in Japan. 2006 Tob Control pmid:16728747
Zhang L and Barritt GJ TRPM8 in prostate cancer cells: a potential diagnostic and prognostic marker with a secretory function? 2006 Endocr. Relat. Cancer pmid:16601277
Ly KA et al. Linear response of mutans streptococci to increasing frequency of xylitol chewing gum use: a randomized controlled trial [ISRCTN43479664]. 2006 BMC Oral Health pmid:16556326
Yang XR et al. Functional expression of transient receptor potential melastatin- and vanilloid-related channels in pulmonary arterial and aortic smooth muscle. 2006 Am. J. Physiol. Lung Cell Mol. Physiol. pmid:16399784
Nsimba SE and Sussman S Tobacco advertisements and promotion industry on smoking in Tanzania: a review of negative public health implications for current and future generations. 2006 Tob Induc Dis pmid:19570296
Ortiz G and Tena MT Headspace solid-phase microextraction gas chromatography-mass spectrometry method for the identification of cosmetic ingredients causing delamination of packagings. 2006 J Chromatogr A pmid:16246353
Brain KR et al. The role of menthol in skin penetration from topical formulations of ibuprofen 5% in vivo. 2006 Skin Pharmacol Physiol pmid:16247245
Collins CC and Moolchan ET Shorter time to first cigarette of the day in menthol adolescent cigarette smokers. 2006 Addict Behav pmid:16303257
McKay DL and Blumberg JB A review of the bioactivity and potential health benefits of peppermint tea (Mentha piperita L.). 2006 Phytother Res pmid:16767798
Johnson LM Gitksan medicinal plants--cultural choice and efficacy. 2006 J Ethnobiol Ethnomed pmid:16790066
Azzi C et al. Permeation and reservoir formation of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) and benzo[a]pyrene (B[a]P) across porcine esophageal tissue in the presence of ethanol and menthol. 2006 Carcinogenesis pmid:16000402
Ram D et al. Optimization of water and nitrogen application to menthol mint (Mentha arvensis L.) through sugarcane trash mulch in a sandy loam soil of semi-arid subtropical climate. 2006 Bioresour. Technol. pmid:16005209
Pletcher MJ et al. Menthol cigarettes, smoking cessation, atherosclerosis, and pulmonary function: the Coronary Artery Risk Development in Young Adults (CARDIA) Study. 2006 Arch. Intern. Med. pmid:17000950
Huang LJ et al. Total synthesis and biological evaluation of (+)- and (-)-Butyl ester of rosmarinic acid. 2006 J Asian Nat Prod Res pmid:16931433
Ebihara T et al. Effects of menthol on the triggering of the swallowing reflex in elderly patients with dysphagia. 2006 Br J Clin Pharmacol pmid:16934054
Babes A et al. A novel type of cold-sensitive neuron in rat dorsal root ganglia with rapid adaptation to cooling stimuli. 2006 Eur. J. Neurosci. pmid:16848799
Montell C A mint of mutations in TRPM8 leads to cool results. 2006 Nat. Neurosci. pmid:16568102
Kakubari I et al. Formulation and evaluation of ethylene-vinyl acetate copolymer matrix patches containing formoterol fumarate. 2006 Biol. Pharm. Bull. pmid:16508156
Nie Y et al. Domino-cyclisation and hydrogenation of citronellal to menthol over bifunctional Ni/Zr-Beta and Zr-beta/Ni-MCM-41 catalysts. 2006 Chem. Commun. (Camb.) pmid:16465342
Xing H et al. Chemical and cold sensitivity of two distinct populations of TRPM8-expressing somatosensory neurons. 2006 J. Neurophysiol. pmid:16424459
Obata Y et al. The mode of promoting activity of O-ethylmenthol as a transdermal absorption enhancer. 2006 Pharm. Res. pmid:16467993
Nahm MR et al. Metallophosphite-catalyzed asymmetric acylation of alpha,beta-unsaturated amides. 2006 J. Am. Chem. Soc. pmid:16492064
Dragoni I et al. The cold and menthol receptor TRPM8 contains a functionally important double cysteine motif. 2006 J. Biol. Chem. pmid:17015441
Proudfoot CJ et al. Analgesia mediated by the TRPM8 cold receptor in chronic neuropathic pain. 2006 Curr. Biol. pmid:16920620
Hébert R What's new in Nicotine & Tobacco Research? 2006 Nicotine Tob. Res. pmid:16920645
Carroll SP and Loye J PMD, a registered botanical mosquito repellent with deet-like efficacy. 2006 J. Am. Mosq. Control Assoc. pmid:17067054
Rossi HL et al. Characterization of cold sensitivity and thermal preference using an operant orofacial assay. 2006 Mol Pain pmid:17166284
Poison safety. Warnings about accidental poisonings: Triaminic Vapor Patch...and WellPatch Cough and Cold Soothing Vapor Pads...warning about alternative treatment for Lyme disease. 2006 Child Health Alert pmid:17111480
Jaenson TG et al. Repellency of oils of lemon eucalyptus, geranium, and lavender and the mosquito repellent MyggA natural to Ixodes ricinus (Acari: Ixodidae) in the laboratory and field. 2006 J. Med. Entomol. pmid:16892632
Garboui SS et al. Repellency of MyggA Natural spray (para-menthane-3,8-diol) and RB86 (neem oil) against the tick Ixodes ricinus (Acari: Ixodidae) in the field in east-central Sweden. 2006 Exp. Appl. Acarol. pmid:17103083
Mukerji G et al. Cool and menthol receptor TRPM8 in human urinary bladder disorders and clinical correlations. 2006 BMC Urol pmid:16519806
Bandell M et al. High-throughput random mutagenesis screen reveals TRPM8 residues specifically required for activation by menthol. 2006 Nat. Neurosci. pmid:16520735
Hatem S et al. Psychophysical study of the effects of topical application of menthol in healthy volunteers. 2006 Pain pmid:16527405
Hersey JC et al. Are menthol cigarettes a starter product for youth? 2006 Nicotine Tob. Res. pmid:16801298
Macpherson LJ et al. More than cool: promiscuous relationships of menthol and other sensory compounds. 2006 Mol. Cell. Neurosci. pmid:16829128
Katsura H et al. Differential expression of capsaicin-, menthol-, and mustard oil-sensitive receptors in naive rat geniculate ganglion neurons. 2006 Chem. Senses pmid:16831854
Charrois TL et al. Peppermint oil. 2006 Pediatr Rev pmid:16815990
Julius D From peppers to peppermints: natural products as probes of the pain pathway. 2005-2006 Harvey Lect. pmid:18030977
Lin JP et al. (-)-Menthol inhibits DNA topoisomerases I, II alpha and beta and promotes NF-kappaB expression in human gastric cancer SNU-5 cells. 2005 May-Jun Anticancer Res. pmid:16158947
Babu RJ and Pandit JK Effect of penetration enhancers on the transdermal delivery of bupranolol through rat skin. 2005 May-Jun Drug Deliv pmid:16025846
Spino C et al. A chiral cyclohexanone linked to polystyrene for solid-phase synthesis of chiral alpha-carbonyls. 2005 Mar-Apr J Comb Chem pmid:15762765
Valverde JM et al. Improvement of table grapes quality and safety by the combination of modified atmosphere packaging (MAP) and eugenol, menthol, or thymol. 2005 J. Agric. Food Chem. pmid:16159173
Thebault S et al. Novel role of cold/menthol-sensitive transient receptor potential melastatine family member 8 (TRPM8) in the activation of store-operated channels in LNCaP human prostate cancer epithelial cells. 2005 J. Biol. Chem. pmid:16174775
Green BG et al. Chemesthesis and taste: evidence of independent processing of sensation intensity. 2005 Physiol. Behav. pmid:16199067
Xu H et al. Camphor activates and strongly desensitizes the transient receptor potential vanilloid subtype 1 channel in a vanilloid-independent mechanism. 2005 J. Neurosci. pmid:16192383
Banchio E et al. Effects of mechanical wounding on essential oil composition and emission of volatiles from Minthostachys mollis. 2005 J. Chem. Ecol. pmid:16124247
Lin YT et al. Enantiomeric analysis of (+)-menthol and (-)-menthol by fluorogenic derivatization and liquid chromatography. 2005 J Chromatogr A pmid:16130717
Huang MH et al. Stimulatory actions of thymol, a natural product, on Ca(2+)-activated K(+) current in pituitary GH(3) cells. 2005 Planta Med. pmid:16395643
Adamczyk S et al. Evaluation of residues of essential oil components in honey after different anti-varroa treatments. 2005 J. Agric. Food Chem. pmid:16366699
Trongtokit Y et al. Efficacy of repellent products against caged and free flying Anopheles stephensi mosquitoes. 2005 Southeast Asian J. Trop. Med. Public Health pmid:16610644
Ringer KL et al. Monoterpene metabolism. Cloning, expression, and characterization of (-)-isopiperitenol/(-)-carveol dehydrogenase of peppermint and spearmint. 2005 Plant Physiol. pmid:15734920
Graham JS et al. Wound healing of cutaneous sulfur mustard injuries: strategies for the development of improved therapies. 2005 J Burns Wounds pmid:16921406
Finger TE et al. ATP signaling is crucial for communication from taste buds to gustatory nerves. 2005 Science pmid:16322458
Zhang YJ et al. Permeation-enhancing effects of chitosan formulations on recombinant hirudin-2 by nasal delivery in vitro and in vivo. 2005 Acta Pharmacol. Sin. pmid:16225765
de la Peña E et al. The contribution of TRPM8 channels to cold sensing in mammalian neurones. 2005 J. Physiol. (Lond.) pmid:15961432
Shibata Y et al. Comparison of pharmaceutical properties of topical non-steroidal anti-inflammatory drug preparations on quality of life. 2005 Yakugaku Zasshi pmid:15863971
McKemy DD How cold is it? TRPM8 and TRPA1 in the molecular logic of cold sensation. 2005 Mol Pain pmid:15847696
Wilson SE et al. Racial differences in exposure to environmental tobacco smoke among children. 2005 Environ. Health Perspect. pmid:15743729
Kobler C and Effenberger F Stereoselective synthesis of cis-p-menth-8-ene-1,7-diol, cis-p-menthane-1,7-diol, and cis-p-menthane-1,7,8-triol. 2005 Chemistry pmid:15736149
Green BG Lingual heat and cold sensitivity following exposure to capsaicin or menthol. 2005 Chem. Senses pmid:15738114
Zhou N et al. One pot conjugation of the polypeptides directed by phosphorus oxychloride. 2005 J. Pept. Res. pmid:15813889
Gelal A et al. Effect of menthol on the pharmacokinetics and pharmacodynamics of felodipine in healthy subjects. 2005 Eur. J. Clin. Pharmacol. pmid:15592925
Jain AK and Panchagnula R Transdermal delivery of imipramine hydrochloride: development and evaluation (in vitro and in vivo) of reservoir gel formulation. 2005 Biopharm Drug Dispos pmid:15614831
Kassebaum PJ et al. Possible warfarin interaction with menthol cough drops. 2005 Ann Pharmacother pmid:15644472
Premkumar LS et al. Downregulation of transient receptor potential melastatin 8 by protein kinase C-mediated dephosphorylation. 2005 J. Neurosci. pmid:16339027
Aulenta F et al. Fragrance release from the surface of branched poly (amide)s. 2005 Molecules pmid:18007278
Croteau RB et al. (-)-Menthol biosynthesis and molecular genetics. 2005 Naturwissenschaften pmid:16292524
Liu Y et al. Menthol facilitates the skin analgesic effect of tetracaine gel. 2005 Int J Pharm pmid:16219435
Reid G ThermoTRP channels and cold sensing: what are they really up to? 2005 Pflugers Arch. pmid:16075243
Banchio E et al. Quantitative variations in the essential oil of Minthostachys mollis (Kunth.) Griseb. in response to insects with different feeding habits. 2005 J. Agric. Food Chem. pmid:16104818
Celebucki CC et al. Characterization of measured menthol in 48 U.S. cigarette sub-brands. 2005 Nicotine Tob. Res. pmid:16085523
Mustonen TK et al. The influence of gender, race, and menthol content on tobacco exposure measures. 2005 Nicotine Tob. Res. pmid:16085529
Ribeiro A et al. Simple measurement of gluconeogenesis by direct 2H NMR analysis of menthol glucuronide enrichment from 2H2O. 2005 Magn Reson Med pmid:16032678
Narishetty ST and Panchagnula R Effect of L-menthol and 1,8-cineole on phase behavior and molecular organization of SC lipids and skin permeation of zidovudine. 2005 J Control Release pmid:15653134
Liu B and Qin F Functional control of cold- and menthol-sensitive TRPM8 ion channels by phosphatidylinositol 4,5-bisphosphate. 2005 J. Neurosci. pmid:15716403
Bashir SJ et al. Cutaneous bioassay of salicylic acid as a keratolytic. 2005 Int J Pharm pmid:15725565
Davis EM et al. Monoterpene metabolism. Cloning, expression, and characterization of menthone reductases from peppermint. 2005 Plant Physiol. pmid:15728344
Tsukimi Y et al. Cold response of the bladder in guinea pig: involvement of transient receptor potential channel, TRPM8. 2005 Urology pmid:15708076
Rohloff J et al. Effect of harvest time and drying method on biomass production, essential oil yield, and quality of peppermint (Mentha x piperita L.). 2005 J. Agric. Food Chem. pmid:15884852
Rohács T et al. PI(4,5)P2 regulates the activation and desensitization of TRPM8 channels through the TRP domain. 2005 Nat. Neurosci. pmid:15852009
Kraemer WJ et al. A cetylated fatty acid topical cream with menthol reduces pain and improves functional performance in individuals with arthritis. 2005 J Strength Cond Res pmid:15903393
Hui K et al. Biophysical properties of menthol-activated cold receptor TRPM8 channels. 2005 Biochem. Biophys. Res. Commun. pmid:15950184
Namer B et al. TRPA1 and TRPM8 activation in humans: effects of cinnamaldehyde and menthol. 2005 Neuroreport pmid:15931068
Trombetta D et al. Mechanisms of antibacterial action of three monoterpenes. 2005 Antimicrob. Agents Chemother. pmid:15917549