| MeSH term | MeSH ID | Detail |
|---|---|---|
| Pain | D010146 | 64 associated lipids |
| Endophthalmitis | D009877 | 12 associated lipids |
| Uveitis, Posterior | D015866 | 5 associated lipids |
Total
3
(-)-Menthol
(-)-menthol is a lipid of Prenol Lipids (PR) class. (-)-menthol is associated with abnormalities such as Wiskott-Aldrich Syndrome. The involved functions are known as Agent, Anabolism, Signal Transduction, Binding (Molecular Function) and Signal Transduction Pathways. (-)-menthol often locates in Membrane, Tissue fiber and Dominant hand. The associated genes with (-)-Menthol are REG1A gene, UGT2B7 gene, HM13 gene and SCN10A gene. The related lipids are Steroids and androsterone glucuronide.
Cross Reference
Introduction
To understand associated biological information of (-)-Menthol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with (-)-Menthol?
(-)-Menthol is suspected in and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with (-)-Menthol
PubChem Associated disorders and diseases
What pathways are associated with (-)-Menthol
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with (-)-Menthol?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with (-)-Menthol?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with (-)-Menthol?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with (-)-Menthol?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with (-)-Menthol?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with (-)-Menthol
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Wackowski OA et al. | Risk perceptions of menthol cigarettes compared with nonmenthol cigarettes among New Jersey adults. | 2010 | Nicotine Tob. Res. | pmid:20522521 |
| Squier CA et al. | Effect of menthol on the penetration of tobacco carcinogens and nicotine across porcine oral mucosa ex vivo. | 2010 | Nicotine Tob. Res. | pmid:20511349 |
| Rose JE and Behm FM | Extinguishing the rewarding value of smoke cues: pharmacological and behavioral treatments. | 2004 | Nicotine Tob. Res. | pmid:15203786 |
| Allen B and Unger JB | Sociocultural correlates of menthol cigarette smoking among adult African Americans in Los Angeles. | 2007 | Nicotine Tob. Res. | pmid:17454699 |
| Gardiner P and Clark PI | Menthol cigarettes: moving toward a broader definition of harm. | 2010 | Nicotine Tob. Res. | pmid:21177372 |
| Healton CG et al. | Why we should make menthol cigarettes history. | 2010 | Nicotine Tob. Res. | pmid:21177373 |
| Kreslake JM and Yerger VB | Tobacco industry knowledge of the role of menthol in chemosensory perception of tobacco smoke. | 2010 | Nicotine Tob. Res. | pmid:21177374 |
| Castro FG | Physiological, psychological, social, and cultural influences on the use of menthol cigarettes among Blacks and Hispanics. | 2004 | Nicotine Tob. Res. | pmid:14982707 |
| Ferris Wayne G and Connolly GN | Application, function, and effects of menthol in cigarettes: a survey of tobacco industry documents. | 2004 | Nicotine Tob. Res. | pmid:14982708 |
| Gardiner PS | The African Americanization of menthol cigarette use in the United States. | 2004 | Nicotine Tob. Res. | pmid:14982709 |
| Giovino GA et al. | Epidemiology of menthol cigarette use. | 2004 | Nicotine Tob. Res. | pmid:14982710 |
| Sutton CD and Robinson RG | The marketing of menthol cigarettes in the United States: populations, messages, and channels. | 2004 | Nicotine Tob. Res. | pmid:14982711 |
| Moolchan ET | Adolescent menthol smokers: will they be a harder target for cessation? | 2004 | Nicotine Tob. Res. | pmid:14982712 |
| Rostron B | Methodology, menthol, and mortality. | 2013 | Nicotine Tob. Res. | pmid:23291639 |
| Jiang CH et al. | Gating of the micturition reflex by tonic activation of bladder cold receptors in the cat. | 2009 | Neurourol. Urodyn. | pmid:19260088 |
| Chen Z et al. | Stimulation of skin menthol receptors stimulates detrusor activity in conscious rats. | 2010 | Neurourol. Urodyn. | pmid:19618444 |
| Klein AH et al. | Eugenol and carvacrol excite first- and second-order trigeminal neurons and enhance their heat-evoked responses. | 2014 | Neuroscience | pmid:24759772 |
| Takashima Y et al. | The development of peripheral cold neural circuits based on TRPM8 expression. | 2010 | Neuroscience | pmid:20580783 |
| Dunham JP et al. | Transient receptor potential channel A1 and noxious cold responses in rat cutaneous nociceptors. | 2010 | Neuroscience | pmid:19961905 |
| Klein AH et al. | Topical hindpaw application of L-menthol decreases responsiveness to heat with biphasic effects on cold sensitivity of rat lumbar dorsal horn neurons. | 2012 | Neuroscience | pmid:22687951 |
| Buonviso N and Chaput M | Olfactory experience decreases responsiveness of the olfactory bulb in the adult rat. | 2000 | Neuroscience | pmid:10658611 |
| Frasnelli J et al. | Perception of specific trigeminal chemosensory agonists. | 2011 | Neuroscience | pmid:21575683 |
| Mandadi S et al. | Locomotor networks are targets of modulation by sensory transient receptor potential vanilloid 1 and transient receptor potential melastatin 8 channels. | 2009 | Neuroscience | pmid:19482068 |
| Galeotti N et al. | Menthol: a natural analgesic compound. | 2002 | Neurosci. Lett. | pmid:11897159 |
| Joshi H et al. | Spectrophotometric determination of cation concentrations in olfactory mucus. | 1987 | Neurosci. Lett. | pmid:3501083 |
| Zanotto KL et al. | Cross-desensitization of responses of rat trigeminal subnucleus caudalis neurons to cinnamaldehyde and menthol. | 2008 | Neurosci. Lett. | pmid:18060696 |
| Reid G and Flonta ML | Ion channels activated by cold and menthol in cultured rat dorsal root ganglion neurones. | 2002 | Neurosci. Lett. | pmid:11988352 |
| Wakai J et al. | Expression of Fos protein in brainstem after application of l-menthol to the rat nasal mucosa. | 2008 | Neurosci. Lett. | pmid:18343574 |
| Swandulla D et al. | Calcium channel current inactivation is selectively modulated by menthol. | 1986 | Neurosci. Lett. | pmid:2425308 |
| Vase L et al. | The effects of menthol on cold allodynia and wind-up-like pain in upper limb amputees with different levels of phantom limb pain. | 2013 | Neurosci. Lett. | pmid:23266475 |
| Abe J et al. | Ca2+-dependent PKC activation mediates menthol-induced desensitization of transient receptor potential M8. | 2006 Apr 10-17 | Neurosci. Lett. | pmid:16380208 |
| Ott D et al. | Prostaglandin D2 modulates calcium signals induced by prostaglandin E2 in neurons of rat dorsal root ganglia. | 2015 | Neurosci. Lett. | pmid:25912777 |
| Bromm B et al. | Effects of menthol and cold on histamine-induced itch and skin reactions in man. | 1995 | Neurosci. Lett. | pmid:7624016 |
| Córdova MM et al. | Further antinociceptive effects of myricitrin in chemical models of overt nociception in mice. | 2011 | Neurosci. Lett. | pmid:21315136 |
| Smith MP et al. | Cold-sensitive, menthol-insensitive neurons in the murine sympathetic nervous system. | 2004 | Neuroreport | pmid:15194861 |
| Jiang CH and Hermanson O | Cooling of the urinary bladder activates neurons in the dorsal horn of the spinal cord. | 2004 | Neuroreport | pmid:15076767 |
| Tani M et al. | Menthol inhibits the respiratory rhythm in brainstem preparations of the newborn rats. | 2010 | Neuroreport | pmid:20890230 |
| Namer B et al. | TRPA1 and TRPM8 activation in humans: effects of cinnamaldehyde and menthol. | 2005 | Neuroreport | pmid:15931068 |
| Okazawa M et al. | l-Menthol-induced [Ca2+]i increase and impulses in cultured sensory neurons. | 2000 | Neuroreport | pmid:10923661 |
| Brunzell DH and McIntosh JM | Alpha7 nicotinic acetylcholine receptors modulate motivation to self-administer nicotine: implications for smoking and schizophrenia. | 2012 | Neuropsychopharmacology | pmid:22169946 |
| Zuo Y et al. | Sex-specific effects of cigarette mentholation on brain nicotine accumulation and smoking behavior. | 2015 | Neuropsychopharmacology | pmid:25267342 |
| GarcÃa DA et al. | Allosteric positive interaction of thymol with the GABAA receptor in primary cultures of mouse cortical neurons. | 2006 | Neuropharmacology | pmid:16185724 |
| Naono-Nakayama R et al. | Differential effects of substance P or hemokinin-1 on transient receptor potential channels, TRPV1, TRPA1 and TRPM8, in the rat. | 2010 | Neuropeptides | pmid:19926130 |
| Chuang HH et al. | The super-cooling agent icilin reveals a mechanism of coincidence detection by a temperature-sensitive TRP channel. | 2004 | Neuron | pmid:15363396 |
| Colburn RW et al. | Attenuated cold sensitivity in TRPM8 null mice. | 2007 | Neuron | pmid:17481392 |
| Bandell M et al. | Noxious cold ion channel TRPA1 is activated by pungent compounds and bradykinin. | 2004 | Neuron | pmid:15046718 |
| Mergler S et al. | Transient receptor potential channel TRPM8 agonists stimulate calcium influx and neurotensin secretion in neuroendocrine tumor cells. | 2007 | Neuroendocrinology | pmid:17426390 |
| Naziroğlu M and Ozgül C | Effects of antagonists and heat on TRPM8 channel currents in dorsal root ganglion neuron activated by nociceptive cold stress and menthol. | 2012 | Neurochem. Res. | pmid:21964764 |
| Petersen M et al. | Modulation of calcium-currents by capsaicin in a subpopulation of sensory neurones of guinea pig. | 1989 Jan-Feb | Naunyn Schmiedebergs Arch. Pharmacol. | pmid:2542804 |
| Lehto SG et al. | AMG2850, a potent and selective TRPM8 antagonist, is not effective in rat models of inflammatory mechanical hypersensitivity and neuropathic tactile allodynia. | 2015 | Naunyn Schmiedebergs Arch. Pharmacol. | pmid:25662185 |
| Croteau RB et al. | (-)-Menthol biosynthesis and molecular genetics. | 2005 | Naturwissenschaften | pmid:16292524 |
| Menini A et al. | Quantal-like current fluctuations induced by odorants in olfactory receptor cells. | 1995 | Nature | pmid:7830795 |
| Schmeltz I and Schlotzhauer WS | Benzo(a)pyrene, phenols and other products from pyrolysis of the cigarette additive, (d,1)-menthol. | 1968 | Nature | pmid:5662150 |
| Voets T et al. | The principle of temperature-dependent gating in cold- and heat-sensitive TRP channels. | 2004 | Nature | pmid:15306801 |
| Reid G and Flonta ML | Physiology. Cold current in thermoreceptive neurons. | 2001 | Nature | pmid:11586349 |
| Zuker CS | Neurobiology: a cool ion channel. | 2002 | Nature | pmid:11882874 |
| McKemy DD et al. | Identification of a cold receptor reveals a general role for TRP channels in thermosensation. | 2002 | Nature | pmid:11882888 |
| Bautista DM et al. | The menthol receptor TRPM8 is the principal detector of environmental cold. | 2007 | Nature | pmid:17538622 |
| Chen K and Baran PS | Total synthesis of eudesmane terpenes by site-selective C-H oxidations. | 2009 | Nature | pmid:19440196 |
| Gold GH and Lowe G | Single odorant molecules? | 1995 | Nature | pmid:7646719 |
| Chessa M et al. | Chemical composition and antibacterial activity of the essential oil from Mentha requienii Bentham. | 2013 | Nat. Prod. Res. | pmid:22385272 |
| Kasrati A et al. | Essential oil composition and antimicrobial activity of wild and cultivated mint timija (Mentha suaveolens subsp. timija (Briq.) Harley), an endemic and threatened medicinal species in Morocco. | 2013 | Nat. Prod. Res. | pmid:22838406 |
| Miyazawa M et al. | Biopreparation of (-)-(1S,3R,4S,6S)-6-hydroxymenthol and (-)-(1S,3R,4S)-1-hydroxymenthol from 1-menthol by Rhizoctonia solani AG-1-IA and IB. | 2003 | Nat. Prod. Res. | pmid:14526907 |
| Esmaeili A et al. | Biotransformation of one monoterpene by sporulated surface cultures of Aspergillus niger and Penicillium sp. | 2009 | Nat. Prod. Res. | pmid:19521921 |
| Viana F et al. | Specificity of cold thermotransduction is determined by differential ionic channel expression. | 2002 | Nat. Neurosci. | pmid:11836533 |
| Shigetomi E et al. | TRPA1 channels regulate astrocyte resting calcium and inhibitory synapse efficacy through GAT-3. | 2011 | Nat. Neurosci. | pmid:22158513 |
| Talavera K et al. | Nicotine activates the chemosensory cation channel TRPA1. | 2009 | Nat. Neurosci. | pmid:19749751 |
| Rohács T et al. | PI(4,5)P2 regulates the activation and desensitization of TRPM8 channels through the TRP domain. | 2005 | Nat. Neurosci. | pmid:15852009 |
| Montell C | A mint of mutations in TRPM8 leads to cool results. | 2006 | Nat. Neurosci. | pmid:16568102 |
| Bandell M et al. | High-throughput random mutagenesis screen reveals TRPM8 residues specifically required for activation by menthol. | 2006 | Nat. Neurosci. | pmid:16520735 |
| Parra A et al. | Ocular surface wetness is regulated by TRPM8-dependent cold thermoreceptors of the cornea. | 2010 | Nat. Med. | pmid:21076394 |
| Voets T et al. | TRPM8 voltage sensor mutants reveal a mechanism for integrating thermal and chemical stimuli. | 2007 | Nat. Chem. Biol. | pmid:17293875 |
| Baranska M and Chruszcz-Lipska K | Raman optical activity: a powerful technique to investigate essential oil components. | 2010 | Nat Prod Commun | pmid:20923000 |
| Sharopov FS and Setzer WN | Chemical diversity of Ziziphora clinopodioides: composition of the essential oil of Z. clinopodioides from Tajikistan. | 2011 | Nat Prod Commun | pmid:21615034 |
| Chen J et al. | Species differences and molecular determinant of TRPA1 cold sensitivity. | 2013 | Nat Commun | pmid:24071625 |
| Tang Z et al. | Pirt functions as an endogenous regulator of TRPM8. | 2013 | Nat Commun | pmid:23863968 |
| Narayan AR et al. | Enzymatic hydroxylation of an unactivated methylene C-H bond guided by molecular dynamics simulations. | 2015 | Nat Chem | pmid:26201742 |
| Uyar T et al. | Electrospinning of functional poly(methyl methacrylate) nanofibers containing cyclodextrin-menthol inclusion complexes. | 2009 | Nanotechnology | pmid:19420480 |
| Kawasaki H et al. | [Congenital non-hemolytic and non-conjugating-type hyperbilirubinemia]. | 1971 | Naika | pmid:5572497 |
| Koizumi T and Kamata T | [Alternate hyperbilirubinemia]. | 1971 | Naika | pmid:5572498 |
| Siegel M | A lost opportunity for public health--the FDA advisory committee report on menthol. | 2011 | N. Engl. J. Med. | pmid:21542736 |
| Benowitz NL and Samet JM | The threat of menthol cigarettes to U.S. public health. | 2011 | N. Engl. J. Med. | pmid:21542737 |
| Bell JW | Kri i Paste. | 1969 | N Z Dent J | pmid:5254341 |
| Steinmetz MD et al. | Transmission and scanning electronmicroscopy study of the action of sage and rosemary essential oils and eucalyptol on Candida albicans. | 1988 | Mycoses | pmid:3287155 |
| Albino AP et al. | gammaH2AX: A potential DNA damage response biomarker for assessing toxicological risk of tobacco products. | 2009 | Mutat. Res. | pmid:19591958 |
| Storer RD et al. | Revalidation of the in vitro alkaline elution/rat hepatocyte assay for DNA damage: improved criteria for assessment of cytotoxicity and genotoxicity and results for 81 compounds. | 1996 | Mutat. Res. | pmid:8684406 |
| Andersen PH and Jensen NJ | Mutagenic investigation of peppermint oil in the Salmonella/mammalian-microsome test. | 1984 | Mutat. Res. | pmid:6387476 |
| Gomes-Carneiro MR et al. | Mutagenicity testing (+/-)-camphor, 1,8-cineole, citral, citronellal, (-)-menthol and terpineol with the Salmonella/microsome assay. | 1998 | Mutat. Res. | pmid:9725999 |
| MATZKE H | [Interval treatment of angina pectoris with Nitrodurat]. | 1962 | Munch Med Wochenschr | pmid:13933949 |
| BETTECKEN F | [NIL NOCERE'. TOXIC SYMPTOMS IN INFANTS AFTER USE OF METHOL-CONTAINING OINTMENTS]. | 1964 | Munch Med Wochenschr | pmid:14255788 |
| Brünger H | [Local therapy of contusions using an analgetic and antiexsudative gel]. | 1973 | Munch Med Wochenschr | pmid:4740457 |
| MESSEK H | [The effect of different vasoconstrictors on various qualities of the nasal mucosa]. | 1962 | Monatsschr Ohrenheilkd Laryngorhinol | pmid:13935128 |
| Jerković I et al. | Volatile organic compounds from Centaurium erythraea Rafn (Croatia) and the antimicrobial potential of its essential oil. | 2012 | Molecules | pmid:22349896 |
| Bassolé IH et al. | Composition and antimicrobial activities of Lippia multiflora Moldenke, Mentha x piperita L. and Ocimum basilicum L. essential oils and their major monoterpene alcohols alone and in combination. | 2010 | Molecules | pmid:21060291 |
| Li J et al. | Determination of the volatile composition in essential oil of Descurainia sophia (L.) Webb ex Prantl (Flixweed) by gas chromatography/mass spectrometry (GC/MS). | 2010 | Molecules | pmid:20110886 |
| Soković MD et al. | Chemical composition of essential oils of Thymus and Mentha species and their antifungal activities. | 2009 | Molecules | pmid:19136911 |
| Soković M et al. | Antibacterial effects of the essential oils of commonly consumed medicinal herbs using an in vitro model. | 2010 | Molecules | pmid:21030907 |
| Carballeira JD et al. | High throughput screening and QSAR-3D/CoMFA: useful tools to design predictive models of substrate specificity for biocatalysts. | 2004 | Molecules | pmid:18007469 |
| Aulenta F et al. | Fragrance release from the surface of branched poly (amide)s. | 2005 | Molecules | pmid:18007278 |
| Cirlini M et al. | Phenolic and Volatile Composition of a Dry Spearmint (Mentha spicata L.) Extract. | 2016 | Molecules | pmid:27527127 |