| MeSH term | MeSH ID | Detail |
|---|---|---|
| Body Weight | D001835 | 333 associated lipids |
(-)-Limonene
(-)-limonene is a lipid of Prenol Lipids (PR) class. (-)-limonene often locates in Kinetochores.
Cross Reference
Introduction
To understand associated biological information of (-)-Limonene, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with (-)-Limonene?
There are no associated biomedical information in the current reference collection.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with (-)-Limonene
PubChem Associated disorders and diseases
What pathways are associated with (-)-Limonene
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with (-)-Limonene?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with (-)-Limonene?
There are no associated biomedical information in the current reference collection.
What lipids are associated with (-)-Limonene?
There are no associated biomedical information in the current reference collection.
What genes are associated with (-)-Limonene?
There are no associated biomedical information in the current reference collection.
What common seen animal models are associated with (-)-Limonene?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with (-)-Limonene
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| pmid:29427589 | ||||
| d-limonene, an anticarcinogenic terpene. | 1988 | Nutr. Rev. | pmid:3067145 | |
| Elegbede JA et al. | Regression of rat primary mammary tumors following dietary d-limonene. | 1986 | J. Natl. Cancer Inst. | pmid:3080636 |
| Neoptolemos JP et al. | Chemical treatment of stones in the biliary tree. | 1986 | Br J Surg | pmid:3089354 |
| Elegbede JA et al. | Mouse skin tumor promoting activity of orange peel oil and d-limonene: a re-evaluation. | 1986 | Carcinogenesis | pmid:3096589 |
| Sugata F | [New therapeutic methods--technics, application, efficacy and problems. Litholysis. c) Present status of direct litholytic agents]. | 1987 | Nippon Rinsho | pmid:3118078 |
| Elson CE et al. | Anti-carcinogenic activity of d-limonene during the initiation and promotion/progression stages of DMBA-induced rat mammary carcinogenesis. | 1988 | Carcinogenesis | pmid:3123086 |
| O'Neill HJ et al. | Identification of isoprenoid-type components in human expired air: a possible shunt pathway in sterol metabolism. | 1987 | Biomed. Chromatogr. | pmid:3147729 |
| Xiao CH | [Application of statistical methods in qualitative and quantitative analyses of orange-peel oil]. | 1985 | Zhong Yao Tong Bao | pmid:3158435 |
| Stel'makh VA | [Toxicologic properties and the nature of the combined effect of a orthomenthane hydrocarbon mixture]. | 1988 | Gig Tr Prof Zabol | pmid:3234846 |
| Powers KA et al. | An evaluation of the acute toxicity of an insecticidal spray containing linalool, d-limonene, and piperonyl butoxide applied topically to domestic cats. | 1988 | Vet Hum Toxicol | pmid:3388747 |
| Laing DG and Willcox ME | An investigation of the mechanisms of odor suppression using physical and dichorhinic mixtures. | 1987 Nov-Dec | Behav. Brain Res. | pmid:3426790 |
| Evans DL et al. | Modulation of immune responses in mice by d-limonene. | 1987 | J Toxicol Environ Health | pmid:3492608 |
| Kanerva RL et al. | Comparison of short-term renal effects due to oral administration of decalin or d-limonene in young adult male Fischer-344 rats. | 1987 | Food Chem. Toxicol. | pmid:3609973 |
| Kanerva RL and Alden CL | Review of kidney sections from a subchronic d-limonene oral dosing study conducted by the National Cancer Institute. | 1987 | Food Chem. Toxicol. | pmid:3609974 |
| Lacy MJ et al. | d-Limonene: an effective vasodilator for use in collecting rabbit blood. | 1987 | Lab. Anim. Sci. | pmid:3669603 |
| Bell GA et al. | Odour mixture suppression: evidence for a peripheral mechanism in human and rat. | 1987 | Brain Res. | pmid:3690320 |
| Hink WF and Fee BJ | Toxicity of D-limonene, the major component of citrus peel oil, to all life stages of the cat flea, Ctenocephalides felis (Siphonaptera: Pulicidae). | 1986 | J. Med. Entomol. | pmid:3735346 |
| Hooser SB et al. | Effects of an insecticidal dip containing d-limonene in the cat. | 1986 | J. Am. Vet. Med. Assoc. | pmid:3771360 |
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| Bell GD | Cholelitholytic agents. | 1983 | Pharmacol. Ther. | pmid:6419241 |
| Elegbede JA et al. | Inhibition of DMBA-induced mammary cancer by the monoterpene d-limonene. | 1984 | Carcinogenesis | pmid:6426810 |
| Rycroft RJ | Allergic contact dermatitis from dipentene in honing oil. | 1980 | Contact Derm. | pmid:6448119 |
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| Guin JD et al. | The effect of quenching agents on contact urticaria caused by cinnamic aldehyde. | 1984 | J. Am. Acad. Dermatol. | pmid:6693599 |
| Kjonaas R and Croteau R | Demonstration that limonene is the first cyclic intermediate in the biosynthesis of oxygenated p-menthane monoterpenes in Mentha piperita and other Mentha species. | 1983 | Arch. Biochem. Biophys. | pmid:6830247 |
| Watabe T et al. | Metabolism of d-limonene by hepatic microsomes to non-mutagenic epoxides toward Salmonella typhimurium. | 1980 | Biochem. Pharmacol. | pmid:6992785 |
| Fahrig R | Effects of food additives in the mammalian spot test. | 1982 | Prog. Clin. Biol. Res. | pmid:7167550 |
| Watabe T et al. | A comparative study on the metabolism of d-limonene and 4-vinylcyclohex-1-ene by hepatic microsomes. | 1981 | Xenobiotica | pmid:7293224 |
| Köppel C et al. | Acute poisoning with pine oil - metabolism of monoterpenes. | 1981 | Arch. Toxicol. | pmid:7325802 |
| Schenk J et al. | [Studies on tissue compatibility of d-limonene as a dissolving agent of cholesterol gallstones (author's transl)]. | 1980 | Z Gastroenterol | pmid:7424079 |
| Kristiansen E and Madsen C | Induction of protein droplet (alpha 2 mu-globulin) nephropathy in male rats after short-term dosage with 1,8-cineole and l-limonene. | 1995 | Toxicol. Lett. | pmid:7482582 |
| Lehman-McKeeman LD and Caudill D | d-Limonene induced hyaline droplet nephropathy in alpha 2u-globulin transgenic mice. | 1994 | Fundam Appl Toxicol | pmid:7532604 |
| Cornwell PA et al. | Wide-angle X-ray diffraction of human stratum corneum: effects of hydration and terpene enhancer treatment. | 1994 | J. Pharm. Pharmacol. | pmid:7536240 |
| Touvay C et al. | Effect of limonene and sobrerol on monocrotaline-induced lung alterations and pulmonary hypertension. | 1995 May-Jun | Int. Arch. Allergy Immunol. | pmid:7542078 |
| Ohara N et al. | Combined effect of d-limonene pretreatment and temperature on the rat skin permeation of lipophilic and hydrophilic drugs. | 1995 | Biol. Pharm. Bull. | pmid:7550099 |
| Rosenbaum MR and Kerlin RL | Erythema multiforme major and disseminated intravascular coagulation in a dog following application of a d-limonene-based insecticidal dip. | 1995 | J. Am. Vet. Med. Assoc. | pmid:7591926 |
| Hohl RJ and Lewis K | Differential effects of monoterpenes and lovastatin on RAS processing. | 1995 | J. Biol. Chem. | pmid:7615555 |
| Hursting SD et al. | Chemoprevention of spontaneous tumorigenesis in p53-knockout mice. | 1995 | Cancer Res. | pmid:7664260 |
| Miyazaki S et al. | Percutaneous absorption of indomethacin from pluronic F127 gels in rats. | 1995 | J. Pharm. Pharmacol. | pmid:7674126 |
| Kurahashi T and Yau KW | Co-existence of cationic and chloride components in odorant-induced current of vertebrate olfactory receptor cells. | 1993 | Nature | pmid:7683113 |
| Whalen JD et al. | Xylene substitutes in frozen sections. | 1995 | Dermatol Surg | pmid:7712095 |
| Gelb MH et al. | The inhibition of protein prenyltransferases by oxygenated metabolites of limonene and perillyl alcohol. | 1995 | Cancer Lett. | pmid:7767906 |
| Haag JD and Gould MN | Mammary carcinoma regression induced by perillyl alcohol, a hydroxylated analog of limonene. | 1994 | Cancer Chemother. Pharmacol. | pmid:7923558 |
| Hard GC and Whysner J | Risk assessment of d-limonene: an example of male rat-specific renal tumorigens. | 1994 | Crit. Rev. Toxicol. | pmid:7945892 |
| Crowell PL and Gould MN | Chemoprevention and therapy of cancer by d-limonene. | 1994 | Crit Rev Oncog | pmid:7948106 |
| Larsen MC et al. | The induction of five rat hepatic P450 cytochromes by phenobarbital and similarly acting compounds is regulated by a sexually dimorphic, dietary-dependent endocrine factor that is highly strain specific. | 1994 | Arch. Biochem. Biophys. | pmid:7979401 |
| Yoshii H et al. | Minimum number of water molecules required for inclusion of d-limonene in the cyclodextrin cavity. | 1994 | J. Biochem. | pmid:7982877 |
| Crowell PL et al. | Human metabolism of the experimental cancer therapeutic agent d-limonene. | 1994 | Cancer Chemother. Pharmacol. | pmid:7987974 |
| Koyama Y et al. | Comparative analysis of percutaneous absorption enhancement by d-limonene and oleic acid based on a skin diffusion model. | 1994 | Pharm. Res. | pmid:8008702 |
| Wang YY and Wang H | [Analysis of chemical constituents of essential oil from dechengqi decoction]. | 1994 | Zhongguo Zhong Yao Za Zhi | pmid:8011141 |
| Gould MN et al. | Limonene chemoprevention of mammary carcinoma induction following direct in situ transfer of v-Ha-ras. | 1994 | Cancer Res. | pmid:8012978 |
| Kurahashi T et al. | Suppression of odorant responses by odorants in olfactory receptor cells. | 1994 | Science | pmid:8016645 |
| Friedman MI et al. | Limonene in expired lung air of patients with liver disease. | 1994 | Dig. Dis. Sci. | pmid:8050315 |
| Jonker D et al. | Acute (24 hr) toxicity of a combination of four nephrotoxicants in rats compared with the toxicity of the individual compounds. | 1993 | Food Chem. Toxicol. | pmid:8095245 |
| Karlberg AT et al. | Hydroperoxides in oxidized d-limonene identified as potent contact allergens. | 1994 | Arch. Dermatol. Res. | pmid:8154930 |
| Chander SK et al. | Effectiveness of combined limonene and 4-hydroxyandrostenedione in the treatment of NMU-induced rat mammary tumours. | 1994 | Br. J. Cancer | pmid:8180018 |
| Crowell PL et al. | Structure-activity relationships among monoterpene inhibitors of protein isoprenylation and cell proliferation. | 1994 | Biochem. Pharmacol. | pmid:8185648 |
| Meding B et al. | Hand eczema in car mechanics. | 1994 | Contact Derm. | pmid:8187510 |
| Kawata S et al. | Modulation of the mevalonate pathway and cell growth by pravastatin and d-limonene in a human hepatoma cell line (Hep G2). | 1994 | Br. J. Cancer | pmid:8198962 |
| Sybilska D et al. | Chromatographic studies of the enantiomeric composition of some therapeutic compositions applied in the treatment of liver and kidney diseases. | 1994 | J Chromatogr A | pmid:8205230 |
| Karlberg AT et al. | Influence of an anti-oxidant on the formation of allergenic compounds during auto-oxidation of d-limonene. | 1994 | Ann Occup Hyg | pmid:8210084 |
| Reicks MM and Crankshaw D | Effects of D-limonene on hepatic microsomal monooxygenase activity and paracetamol-induced glutathione depletion in mouse. | 1993 | Xenobiotica | pmid:8237062 |
| Duchamp-Viret P and Duchamp A | GABAergic control of odour-induced activity in the frog olfactory bulb: possible GABAergic modulation of granule cell inhibitory action. | 1993 | Neuroscience | pmid:8284042 |
| Schulz S et al. | Prenylated proteins and lymphocyte proliferation: inhibition by d-limonene related monoterpenes. | 1994 | Eur. J. Immunol. | pmid:8299679 |
| Jirtle RL et al. | Increased mannose 6-phosphate/insulin-like growth factor II receptor and transforming growth factor beta 1 levels during monoterpene-induced regression of mammary tumors. | 1993 | Cancer Res. | pmid:8358708 |
| Plaisier PW et al. | Dissolution of gallstones. | 1993 | Dig Dis | pmid:8370143 |
| d-Limonene. | 1993 | IARC Monogr Eval Carcinog Risks Hum | pmid:8411619 | |
| Falk-Filipsson A et al. | d-limonene exposure to humans by inhalation: uptake, distribution, elimination, and effects on the pulmonary function. | 1993 | J Toxicol Environ Health | pmid:8421324 |
| Jonker D et al. | Subacute (4-wk) oral toxicity of a combination of four nephrotoxins in rats: comparison with the toxicity of the individual compounds. | 1993 | Food Chem. Toxicol. | pmid:8449457 |
| Elegbede JA et al. | Effects of anticarcinogenic monoterpenes on phase II hepatic metabolizing enzymes. | 1993 | Carcinogenesis | pmid:8508509 |
| Scheuplein RJ | The use of biological data in addition to the carcinogen bioassay in quantitative risk assessment. | 1995 | Prog. Clin. Biol. Res. | pmid:8532727 |
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| Gould MN | Prevention and therapy of mammary cancer by monoterpenes. | 1995 | J. Cell. Biochem. Suppl. | pmid:8538191 |
| Luján HD et al. | Isoprenylation of proteins in the protozoan Giardia lamblia. | 1995 | Mol. Biochem. Parasitol. | pmid:8538683 |
| Martins C et al. | Allergic contact dermatitis from dipentene in wax polish. | 1995 | Contact Derm. | pmid:8549131 |
| Saito K et al. | Alpha 2u-globulins in the urine of male rats: a reliable indicator for alpha 2u-globulin accumulation in the kidney. | 1996 | Toxicology | pmid:8571386 |
| York M et al. | Skin irritation testing in man for hazard assessment--evaluation of four patch systems. | 1995 | Hum Exp Toxicol | pmid:8579884 |
| Von Burg R | Limonene. | 1995 Nov-Dec | J Appl Toxicol | pmid:8603937 |
| O'Shaughnessy JA | Chemoprevention of breast cancer. | 1996 | JAMA | pmid:8614122 |
| Alvares K et al. | Ciprofibrate represses alpha 2u-globulin expression in liver and inhibits d-limonene nephrotoxicity. | 1996 | Carcinogenesis | pmid:8625456 |
| Jansen LA and Jongen WM | The use of initiated cells as a test system for the detection of inhibitors of gap junctional intercellular communication. | 1996 | Carcinogenesis | pmid:8625460 |
| Kawamori T et al. | Inhibitory effects of d-limonene on the development of colonic aberrant crypt foci induced by azoxymethane in F344 rats. | 1996 | Carcinogenesis | pmid:8625465 |
| Morse MA and Toburen AL | Inhibition of metabolic activation of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone by limonene. | 1996 | Cancer Lett. | pmid:8665490 |
| Williams GM and Whysner J | Epigenetic carcinogens: evaluation and risk assessment. | 1996 | Exp. Toxicol. Pathol. | pmid:8672874 |
| Poon GK et al. | Identification and characterization of limonene metabolites in patients with advanced cancer by liquid chromatography/mass spectrometry. | 1996 | Drug Metab. Dispos. | pmid:8723738 |
| Kimura J et al. | Lack of chemoprevention effects of the monoterpene d-limonene in a rat multi-organ carcinogenesis model. | 1996 | Jpn. J. Cancer Res. | pmid:8766522 |
| Adam KP et al. | Partial purification and characterization of a monoterpene cyclase, limonene synthase, from the liverwort Ricciocarpos natans. | 1996 | Arch. Biochem. Biophys. | pmid:8806745 |
| Karlson J et al. | Inhibition of tumor cell growth by monoterpenes in vitro: evidence of a Ras-independent mechanism of action. | 1996 | Anticancer Drugs | pmid:8826611 |
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| Crowell PL et al. | Antitumorigenic effects of limonene and perillyl alcohol against pancreatic and breast cancer. | 1996 | Adv. Exp. Med. Biol. | pmid:8886131 |
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| Whysner J and Williams GM | d-limonene mechanistic data and risk assessment: absolute species-specific cytotoxicity, enhanced cell proliferation, and tumor promotion. | 1996 | Pharmacol. Ther. | pmid:8910952 |
| el-Bayoumy K et al. | Effects of 1,4-phenylenebis(methylene)selenocyanate, phenethyl isothiocyanate, indole-3-carbinol, and d-limonene individually and in combination on the tumorigenicity of the tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in A/J mouse lung. | 1996 Sep-Oct | Anticancer Res. | pmid:8917375 |
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| Karlberg AT and Dooms-Goossens A | Contact allergy to oxidized d-limonene among dermatitis patients. | 1997 | Contact Derm. | pmid:9165203 |