(-)-Limonene

(-)-limonene is a lipid of Prenol Lipids (PR) class. (-)-limonene often locates in Kinetochores.

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Introduction

To understand associated biological information of (-)-Limonene, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with (-)-Limonene?

There are no associated biomedical information in the current reference collection.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with (-)-Limonene

MeSH term MeSH ID Detail
Acute Lung Injury D055371 33 associated lipids
Per page 10 20 | Total 11

PubChem Associated disorders and diseases

What pathways are associated with (-)-Limonene

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with (-)-Limonene?

Related references are published most in these journals:

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What functions are associated with (-)-Limonene?

There are no associated biomedical information in the current reference collection.

What lipids are associated with (-)-Limonene?

There are no associated biomedical information in the current reference collection.

What genes are associated with (-)-Limonene?

There are no associated biomedical information in the current reference collection.

What common seen animal models are associated with (-)-Limonene?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with (-)-Limonene

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Authors Title Published Journal PubMed Link
Kurahashi T et al. Suppression of odorant responses by odorants in olfactory receptor cells. 1994 Science pmid:8016645
Lehman-McKeeman LD and Caudill D d-Limonene induced hyaline droplet nephropathy in alpha 2u-globulin transgenic mice. 1994 Fundam Appl Toxicol pmid:7532604
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Karlberg AT et al. Influence of an anti-oxidant on the formation of allergenic compounds during auto-oxidation of d-limonene. 1994 Ann Occup Hyg pmid:8210084
Kurahashi T and Yau KW Co-existence of cationic and chloride components in odorant-induced current of vertebrate olfactory receptor cells. 1993 Nature pmid:7683113
Jonker D et al. Acute (24 hr) toxicity of a combination of four nephrotoxicants in rats compared with the toxicity of the individual compounds. 1993 Food Chem. Toxicol. pmid:8095245
Reicks MM and Crankshaw D Effects of D-limonene on hepatic microsomal monooxygenase activity and paracetamol-induced glutathione depletion in mouse. 1993 Xenobiotica pmid:8237062
Jirtle RL et al. Increased mannose 6-phosphate/insulin-like growth factor II receptor and transforming growth factor beta 1 levels during monoterpene-induced regression of mammary tumors. 1993 Cancer Res. pmid:8358708
d-Limonene. 1993 IARC Monogr Eval Carcinog Risks Hum pmid:8411619
Falk-Filipsson A et al. d-limonene exposure to humans by inhalation: uptake, distribution, elimination, and effects on the pulmonary function. 1993 J Toxicol Environ Health pmid:8421324
Jonker D et al. Subacute (4-wk) oral toxicity of a combination of four nephrotoxins in rats: comparison with the toxicity of the individual compounds. 1993 Food Chem. Toxicol. pmid:8449457
Elegbede JA et al. Effects of anticarcinogenic monoterpenes on phase II hepatic metabolizing enzymes. 1993 Carcinogenesis pmid:8508509
Duchamp-Viret P and Duchamp A GABAergic control of odour-induced activity in the frog olfactory bulb: possible GABAergic modulation of granule cell inhibitory action. 1993 Neuroscience pmid:8284042
Plaisier PW et al. Dissolution of gallstones. 1993 Dig Dis pmid:8370143
Crowell PL et al. Chemoprevention of mammary carcinogenesis by hydroxylated derivatives of d-limonene. 1992 Carcinogenesis pmid:1638695
Igimi H et al. A useful cholesterol solvent for medical dissolution of gallstones. 1992 Gastroenterol. Jpn. pmid:1526435
Frank AA et al. Toxic epidermal necrolysis associated with flea dips. 1992 Vet Hum Toxicol pmid:1621364
Saito K et al. Differences in alpha 2u-globulins increased in male rat kidneys following treatment with several alpha 2u-globulin accumulating agents: cystein protease(s) play(s) an important role in production of kidney-type-alpha 2u-globulin. 1992 Toxicology pmid:1281346
Crowell PL et al. Identification of metabolites of the antitumor agent d-limonene capable of inhibiting protein isoprenylation and cell growth. 1992 Cancer Chemother. Pharmacol. pmid:1464157
Sternal RS and Davis MA In vitro dissolution of cholesterol gallstones. 1992 Invest Radiol pmid:1473922
Kikuchi K et al. Effect of d-limonene on the amounts of ethanol and indomethacin penetrated from aqueous gel ointments to rat skin. 1992 Chem. Pharm. Bull. pmid:1477929
Okabe H et al. Percutaneous absorption of ketoprofen from acrylic gel patches containing d-limonene and ethanol as absorption enhancers. 1992 Chem. Pharm. Bull. pmid:1394713
Karlberg AT et al. Air oxidation of d-limonene (the citrus solvent) creates potent allergens. 1992 Contact Derm. pmid:1395597
Sauerbruch T Non-surgical management of bile duct stones refractory to routine endoscopic measures. 1992 Baillieres Clin. Gastroenterol. pmid:1362502
Zheng GQ et al. Anethofuran, carvone, and limonene: potential cancer chemopreventive agents from dill weed oil and caraway oil. 1992 Planta Med. pmid:1438594
Hansen AP and Heinis JJ Benzaldehyde, citral, and d-limonene flavor perception in the presence of casein and whey proteins. 1992 J. Dairy Sci. pmid:1597575
Priborský J et al. Influence of limonene and laurocapram on percutaneous absorption of nonsteroidal anti-inflammatory drugs. 1992 Arzneimittelforschung pmid:1610418
Wrba H et al. Carcinogenicity testing of some constituents of black pepper (Piper nigrum). 1992 Exp. Toxicol. Pathol. pmid:1617288
Haag JD et al. Limonene-induced regression of mammary carcinomas. 1992 Cancer Res. pmid:1617679
Wattenberg LW and Coccia JB Inhibition of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone carcinogenesis in mice by D-limonene and citrus fruit oils. 1991 Carcinogenesis pmid:1988170
Igimi H et al. Medical dissolution of gallstones. Clinical experience of d-limonene as a simple, safe, and effective solvent. 1991 Dig. Dis. Sci. pmid:1988264
Jensen OC and Petersen I [Occupational asthma caused by scented gravel in cat litter boxes]. 1991 Ugeskr. Laeg. pmid:2024303
Maltzman TH et al. Effects of monoterpenoids on in vivo DMBA-DNA adduct formation and on phase I hepatic metabolizing enzymes. 1991 Carcinogenesis pmid:1934293
Saito K et al. Behavior of alpha 2u-globulin accumulating in kidneys of male rats treated with d-limonene: kidney-type alpha 2u-globulin in the urine as a marker of d-limonene nephropathy. 1991 Toxicology pmid:1722357
Falk A et al. Purpuric rash caused by dermal exposure to d-limonene. 1991 Contact Derm. pmid:1782772
Flamm WG and Lehman-McKeeman LD The human relevance of the renal tumor-inducing potential of d-limonene in male rats: implications for risk assessment. 1991 Regul. Toxicol. Pharmacol. pmid:2024047
Vergunst H et al. In vitro comparison of different gall stone dissolution solvents. 1991 Gut pmid:1864544
Dietrich DR and Swenberg JA The presence of alpha 2u-globulin is necessary for d-limonene promotion of male rat kidney tumors. 1991 Cancer Res. pmid:1711412
Rodriguez PA et al. Design of a gas chromatograph with parallel radioactivity and mass spectrometric detection. Application to the identification of the major metabolite of d-limonene associated with alpha 2u-globulin. 1991 J. Chromatogr. pmid:1711535
Karlberg AT et al. Animal experiments on the allergenicity of d-limonene--the citrus solvent. 1991 Ann Occup Hyg pmid:1836319
Crowell PL et al. Selective inhibition of isoprenylation of 21-26-kDa proteins by the anticarcinogen d-limonene and its metabolites. 1991 J. Biol. Chem. pmid:1894647
Lehman-McKeeman LD et al. Comparative disposition of d-limonene in rats and mice: relevance to male-rat-specific nephrotoxicity. 1990 Toxicol. Lett. pmid:1699301
Karp F et al. Monoterpene biosynthesis: specificity of the hydroxylations of (-)-limonene by enzyme preparations from peppermint (Mentha piperita), spearmint (Mentha spicata), and perilla (Perilla frutescens) leaves. 1990 Arch. Biochem. Biophys. pmid:2297225
Huang Y and Pu F [Chemical components of the essential oil from Ligusticum brachylobum Franch]. 1990 Zhongguo Zhong Yao Za Zhi pmid:2261075
Webb DR et al. Assessment of the subchronic oral toxicity of d-limonene in dogs. 1990 Food Chem. Toxicol. pmid:2276695
Falk A et al. Liquid/air partition coefficients of four terpenes. 1990 Br J Ind Med pmid:2310709
Hooser SB Toxicology of selected pesticides, drugs, and chemicals. D-limonene, linalool, and crude citrus oil extracts. 1990 Vet. Clin. North Am. Small Anim. Pract. pmid:2180184
Yang S et al. [Effect of disintegrating method on quantity extracted and constituents of essential oil in fructus Aurantii]. 1990 Zhongguo Zhong Yao Za Zhi pmid:2206386
Gould MN et al. Chemoprevention and chemotherapy of mammary tumors by monoterpenoids. 1990 Prog. Clin. Biol. Res. pmid:2217395
Okabe H et al. Percutaneous absorption enhancing effect and skin irritation of monocyclic monoterpenes. 1990 Drug Des. Deliv. pmid:2076182
Matsuoka H et al. Evaluation of antifungal volatile compounds on the basis of the elongation rate of a single hypha. 1990 Appl. Environ. Microbiol. pmid:2082824
Gollnick K and Held S Merbromin (mercurochrome)--a photosensitizer for singlet oxygen reactions. 1990 J. Photochem. Photobiol. B, Biol. pmid:1692875
Lehman-McKeeman LD et al. d-Limonene-induced male rat-specific nephrotoxicity: evaluation of the association between d-limonene and alpha 2u-globulin. 1989 Toxicol. Appl. Pharmacol. pmid:2472019
Webb DR et al. Acute and subchronic nephrotoxicity of d-limonene in Fischer 344 rats. 1989 Food Chem. Toxicol. pmid:2481635
Maltzman TH et al. The prevention of nitrosomethylurea-induced mammary tumors by d-limonene and orange oil. 1989 Carcinogenesis pmid:2702727
Wattenberg LW et al. Inhibition of N-nitrosodiethylamine carcinogenesis in mice by naturally occurring organosulfur compounds and monoterpenes. 1989 Cancer Res. pmid:2713853
Cardullo AC et al. Allergic contact dermatitis resulting from sensitivity to citrus peel, geraniol, and citral. 1989 J. Am. Acad. Dermatol. pmid:2526827
Wellis DP et al. Discrimination among odorants by single neurons of the rat olfactory bulb. 1989 J. Neurophysiol. pmid:2746317
Laing DG et al. Odor masking in the rat. 1989 Physiol. Behav. pmid:2780835
d-limonene, an anticarcinogenic terpene. 1988 Nutr. Rev. pmid:3067145
Powers KA et al. An evaluation of the acute toxicity of an insecticidal spray containing linalool, d-limonene, and piperonyl butoxide applied topically to domestic cats. 1988 Vet Hum Toxicol pmid:3388747
Stel'makh VA [Toxicologic properties and the nature of the combined effect of a orthomenthane hydrocarbon mixture]. 1988 Gig Tr Prof Zabol pmid:3234846
Elson CE et al. Anti-carcinogenic activity of d-limonene during the initiation and promotion/progression stages of DMBA-induced rat mammary carcinogenesis. 1988 Carcinogenesis pmid:3123086
Laing DG and Willcox ME An investigation of the mechanisms of odor suppression using physical and dichorhinic mixtures. 1987 Nov-Dec Behav. Brain Res. pmid:3426790
Sugata F [New therapeutic methods--technics, application, efficacy and problems. Litholysis. c) Present status of direct litholytic agents]. 1987 Nippon Rinsho pmid:3118078
Evans DL et al. Modulation of immune responses in mice by d-limonene. 1987 J Toxicol Environ Health pmid:3492608
Lacy MJ et al. d-Limonene: an effective vasodilator for use in collecting rabbit blood. 1987 Lab. Anim. Sci. pmid:3669603
Kanerva RL et al. Comparison of short-term renal effects due to oral administration of decalin or d-limonene in young adult male Fischer-344 rats. 1987 Food Chem. Toxicol. pmid:3609973
Kanerva RL and Alden CL Review of kidney sections from a subchronic d-limonene oral dosing study conducted by the National Cancer Institute. 1987 Food Chem. Toxicol. pmid:3609974
Bell GA et al. Odour mixture suppression: evidence for a peripheral mechanism in human and rat. 1987 Brain Res. pmid:3690320
O'Neill HJ et al. Identification of isoprenoid-type components in human expired air: a possible shunt pathway in sterol metabolism. 1987 Biomed. Chromatogr. pmid:3147729
Neoptolemos JP et al. Chemical treatment of stones in the biliary tree. 1986 Br J Surg pmid:3089354
Elegbede JA et al. Mouse skin tumor promoting activity of orange peel oil and d-limonene: a re-evaluation. 1986 Carcinogenesis pmid:3096589
Elegbede JA et al. Regression of rat primary mammary tumors following dietary d-limonene. 1986 J. Natl. Cancer Inst. pmid:3080636
Hooser SB et al. Effects of an insecticidal dip containing d-limonene in the cat. 1986 J. Am. Vet. Med. Assoc. pmid:3771360
Hink WF and Fee BJ Toxicity of D-limonene, the major component of citrus peel oil, to all life stages of the cat flea, Ctenocephalides felis (Siphonaptera: Pulicidae). 1986 J. Med. Entomol. pmid:3735346
Collart MG and Hink WF Development of resistance to malathion in cat flea (Siphonaptera: Pulicidae). 1986 J. Econ. Entomol. pmid:3805485
Pei DK [Dissolution of retained biliary stones with a compound prescription of orange-peel emulsion--a clinical analysis of 134 cases]. 1985 Zhong Xi Yi Jie He Za Zhi pmid:2938796
Fu HG et al. [Clinical study of an emulsion of orange-peel oil and CDTA to dissolve retained bile duct stones]. 1985 Zhong Xi Yi Jie He Za Zhi pmid:2938797
Xiao CH [Application of statistical methods in qualitative and quantitative analyses of orange-peel oil]. 1985 Zhong Yao Tong Bao pmid:3158435
Abraham WR et al. Microbial transformations of some monoterpenoids and sesquiterpenoids. 1985 Ciba Found. Symp. pmid:3848377
Elegbede JA et al. Inhibition of DMBA-induced mammary cancer by the monoterpene d-limonene. 1984 Carcinogenesis pmid:6426810
Ighimi H [Gallstone solubilizers]. 1984 Nihon Geka Gakkai Zasshi pmid:6503981
Guin JD et al. The effect of quenching agents on contact urticaria caused by cinnamic aldehyde. 1984 J. Am. Acad. Dermatol. pmid:6693599
Bell GD Cholelitholytic agents. 1983 Pharmacol. Ther. pmid:6419241
Kjonaas R and Croteau R Demonstration that limonene is the first cyclic intermediate in the biosynthesis of oxygenated p-menthane monoterpenes in Mentha piperita and other Mentha species. 1983 Arch. Biochem. Biophys. pmid:6830247
Fahrig R Effects of food additives in the mammalian spot test. 1982 Prog. Clin. Biol. Res. pmid:7167550
Watabe T et al. A comparative study on the metabolism of d-limonene and 4-vinylcyclohex-1-ene by hepatic microsomes. 1981 Xenobiotica pmid:7293224
Köppel C et al. Acute poisoning with pine oil - metabolism of monoterpenes. 1981 Arch. Toxicol. pmid:7325802
Schenk J et al. [Studies on tissue compatibility of d-limonene as a dissolving agent of cholesterol gallstones (author's transl)]. 1980 Z Gastroenterol pmid:7424079
Rycroft RJ Allergic contact dermatitis from dipentene in honing oil. 1980 Contact Derm. pmid:6448119
Watabe T et al. Metabolism of d-limonene by hepatic microsomes to non-mutagenic epoxides toward Salmonella typhimurium. 1980 Biochem. Pharmacol. pmid:6992785
CARDOSO HT and GONCALVES NB [Experiment on the dehydrogenation of limonene]. 1956 Mem. Inst. Oswaldo Cruz pmid:13369149
ROSSI A [Not Available]. 1947 Mar-Apr Farmaco Sci Tec pmid:20261998
IPATIEFF VN and PINES H Studies in the terpene series; cyclic isomerization of limonene. 1947 J. Org. Chem. pmid:20280735
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