(-)-Perillyl alcohol

(-)-perillyl alcohol is a lipid of Prenol Lipids (PR) class. The involved functions are known as Cell Cycle Progression, Cell Cycle, Cell Proliferation, Apoptosis and Isoprenylation. (-)-perillyl alcohol often locates in Cytoplasm, Membrane and Plasma membrane. The associated genes with (-)-Perillyl alcohol are JUN gene, Candidate Disease Gene, IL24 gene, BCL2L1 gene and CFB gene. The related experimental models are Transgenic Model.

Cross Reference

Introduction

To understand associated biological information of (-)-Perillyl alcohol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with (-)-Perillyl alcohol?

There are no associated biomedical information in the current reference collection.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with (-)-Perillyl alcohol

MeSH term MeSH ID Detail
Lymphoma, Mantle-Cell D020522 5 associated lipids
Brain Neoplasms D001932 15 associated lipids
Esophageal Neoplasms D004938 20 associated lipids
Carcinoma, Lewis Lung D018827 22 associated lipids
Lymphoma, B-Cell D016393 24 associated lipids
Mammary Neoplasms, Animal D015674 27 associated lipids
Glioblastoma D005909 27 associated lipids
Hyperplasia D006965 34 associated lipids
Adenoma D000236 40 associated lipids
Precancerous Conditions D011230 48 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with (-)-Perillyl alcohol

Lipid pathways are not clear in current pathway databases. We organized associated pathways with (-)-Perillyl alcohol through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
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PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with (-)-Perillyl alcohol?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with (-)-Perillyl alcohol?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with (-)-Perillyl alcohol?

There are no associated biomedical information in the current reference collection.

What genes are associated with (-)-Perillyl alcohol?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with (-)-Perillyl alcohol?

Transgenic Model

Transgenic Model are used in the study 'A phase 2a study of topical perillyl alcohol cream for chemoprevention of skin cancer.' (Stratton SP et al., 2010).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with (-)-Perillyl alcohol

Download all related citations
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Authors Title Published Journal PubMed Link
Ansari MA et al. Anticandidal Effect and Mechanisms of Monoterpenoid, Perillyl Alcohol against Candida albicans. 2016 PLoS ONE pmid:27627759
Chen TC et al. Perillyl Alcohol and Its Drug-Conjugated Derivatives as Potential Novel Methods of Treating Brain Metastases. 2016 Int J Mol Sci pmid:27598140
Song X et al. Temozolomide-perillyl alcohol conjugate induced reactive oxygen species accumulation contributes to its cytotoxicity against non-small cell lung cancer. 2016 Sci Rep pmid:26949038
Andrade LN et al. In Vivo Anti-Tumor Activity and Toxicological Evaluations of Perillaldehyde 8,9-Epoxide, a Derivative of Perillyl Alcohol. 2016 Int J Mol Sci pmid:26742032
Xie L et al. Therapeutic effect of TMZ-POH on human nasopharyngeal carcinoma depends on reactive oxygen species accumulation. 2016 Oncotarget pmid:26625208
Garcia DG et al. Na/K-ATPase as a target for anticancer drugs: studies with perillyl alcohol. 2015 Mol. Cancer pmid:25976744
Wróblewska A The epoxidation of limonene over the TS-1 and Ti-SBA-15 catalysts. 2014 Molecules pmid:25460313
Nandurkar NS et al. The identification of perillyl alcohol glycosides with improved antiproliferative activity. 2014 J. Med. Chem. pmid:25121720
Hui Z et al. Synthesis and antiproliferative effects of amino-modified perillyl alcohol derivatives. 2014 Molecules pmid:24858099
Chen TC et al. A novel temozolomide-perillyl alcohol conjugate exhibits superior activity against breast cancer cells in vitro and intracranial triple-negative tumor growth in vivo. 2014 Mol. Cancer Ther. pmid:24623736