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1999 |
Carcinogenesis |
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1999 |
Leukemia |
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2000 |
Lancet |
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Perillyl alcohol inhibits TCR-mediated [Ca(2+)](i) signaling, alters cell shape and motility, and induces apoptosis in T lymphocytes. |
2000 |
Cell. Immunol. |
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Cytotoxicity and biotransformation of the anticancer drug perillyl alcohol in PC12 cells and in the rat. |
2000 |
Toxicol. Appl. Pharmacol. |
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Phase I pharmacokinetic trial of perillyl alcohol (NSC 641066) in patients with refractory solid malignancies. |
2000 |
Clin. Cancer Res. |
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2000 |
Carcinogenesis |
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2000 |
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2002 |
Carcinogenesis |
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Antileukemia activity of perillyl alcohol (POH): uncoupling apoptosis from G0/G1 arrest suggests that the primary effect of POH on Bcr/Abl-transformed cells is to induce growth arrest. |
2002 |
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2002 |
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2002 |
Cancer Epidemiol. Biomarkers Prev. |
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A phase II trial of daily perillyl alcohol in patients with advanced ovarian cancer: Eastern Cooperative Oncology Group Study E2E96. |
2002 |
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Phase I study of perillyl alcohol in patients with refractory malignancies. |
2002 Mar-Apr |
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2002 |
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Effects of the isoprenoids perillyl alcohol and farnesol on apoptosis biomarkers in pancreatic cancer chemoprevention. |
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2003 |
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Phase II trial of perillyl alcohol in patients with metastatic colorectal cancer. |
2002 |
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2003 |
Prostate |
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2003 |
Cancer Chemother. Pharmacol. |
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2003 |
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2003 |
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2003 |
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2003 |
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Phase II trial of perillyl alcohol (NSC 641066) administered daily in patients with metastatic androgen independent prostate cancer. |
2003 |
Invest New Drugs |
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2003 |
Eur. J. Pharmacol. |
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Development of a perillyl alcohol topical cream formulation. |
2004 |
Int J Pharm |
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2004 |
Toxicol. Appl. Pharmacol. |
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2004 |
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2004 |
Cancer Chemother. Pharmacol. |
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Perillyl alcohol is an angiogenesis inhibitor. |
2004 |
J. Pharmacol. Exp. Ther. |
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2004 Sep-Oct |
Anticancer Res. |
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2004 |
Clin. Cancer Res. |
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An HPLC method for quantitation of perillyl alcohol in a topical pharmaceutical cream formulation. |
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J Pharm Biomed Anal |
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Plant Mol. Biol. |
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J. Biomed. Sci. |
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Perillyl alcohol inhibits the expression and function of the androgen receptor in human prostate cancer cells. |
2006 |
Cancer Lett. |
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Perillyl alcohol inhibits a calcium-dependent constitutive nuclear factor-kappaB pathway. |
2005 |
Cancer Res. |
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Polycyclic aromatic hydrocarbon-induced CYP1B1 activity is suppressed by perillyl alcohol in MCF-7 cells. |
2006 |
Toxicol. Appl. Pharmacol. |
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Recent advances in the molecular genetics of malignant gliomas disclose targets for antitumor agent perillyl alcohol. |
2006 |
Surg Neurol |
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Clark SS |
Perillyl alcohol induces c-Myc-dependent apoptosis in Bcr/Abl-transformed leukemia cells. |
2006 |
Oncology |
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Mastic oil from Pistacia lentiscus var. chia inhibits growth and survival of human K562 leukemia cells and attenuates angiogenesis. |
2006 |
Nutr Cancer |
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In vitro induction of apoptosis in U937 cells by perillyl alcohol with sensitization by pentoxifylline: increased BCL-2 and BAX protein expression. |
2006 |
Chemotherapy |
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2006 |
J. Exp. Ther. Oncol. |
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Cell cycle arrest by the isoprenoids perillyl alcohol, geraniol, and farnesol is mediated by p21(Cip1) and p27(Kip1) in human pancreatic adenocarcinoma cells. |
2007 |
J. Pharmacol. Exp. Ther. |
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Anaplastic oligodendroglioma responding favorably to intranasal delivery of perillyl alcohol: a case report and literature review. |
2006 |
Surg Neurol |
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Perillyl alcohol and genistein differentially regulate PKB/Akt and 4E-BP1 phosphorylation as well as eIF4E/eIF4G interactions in human tumor cells. |
2007 |
Arch. Biochem. Biophys. |
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Bailey HH et al. |
Phase II trial of daily oral perillyl alcohol (NSC 641066) in treatment-refractory metastatic breast cancer. |
2008 |
Cancer Chemother. Pharmacol. |
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Perillyl alcohol and perillic acid induced cell cycle arrest and apoptosis in non small cell lung cancer cells. |
2007 |
Cancer Lett. |
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Preliminary results from a phase I/II study of perillyl alcohol intranasal administration in adults with recurrent malignant gliomas. |
2008 |
Surg Neurol |
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Anti-inflammatory senescence actives 5203-L molecule to promote healthy aging and prolongation of lifespan. |
2008 |
Rejuvenation Res |
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Phase 1 study of topical perillyl alcohol cream for chemoprevention of skin cancer. |
2008 |
Nutr Cancer |
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A pilot study of perillyl alcohol in pancreatic cancer. |
2008 |
J. Surg. Res. |
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Synthesis of phosphatidylated-monoterpene alcohols catalyzed by phospholipase D and their antiproliferative effects on human cancer cells. |
2008 |
Bioorg. Med. Chem. Lett. |
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Fragrance material review on p-mentha-1,8-dien-7-ol. |
2008 |
Food Chem. Toxicol. |
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Chemoprevention by perillyl alcohol coupled with viral gene therapy reduces pancreatic cancer pathogenesis. |
2008 |
Mol. Cancer Ther. |
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Ras pathway activation in gliomas: a strategic target for intranasal administration of perillyl alcohol. |
2008 Jul-Aug |
Arch. Immunol. Ther. Exp. (Warsz.) |
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Mechanism of in vitro pancreatic cancer cell growth inhibition by melanoma differentiation-associated gene-7/interleukin-24 and perillyl alcohol. |
2008 |
Cancer Res. |
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High-performance liquid chromatographic and pharmacokinetic analyses of an intravenous submicron emulsion of perillyl alcohol in rats. |
2008 |
J Pharm Biomed Anal |
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Da Fonseca CO et al. |
Correlation of tumor topography and peritumoral edema of recurrent malignant gliomas with therapeutic response to intranasal administration of perillyl alcohol. |
2009 |
Invest New Drugs |
pmid:19139816
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Perillyl alcohol attenuates Ras-ERK signaling to inhibit murine skin inflammation and tumorigenesis. |
2009 |
Chem. Biol. Interact. |
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Anti-thrombin as a prognostic biomarker candidate for patients with recurrent glioblastoma multiform under treatment with perillyl alcohol. |
2008 |
J. Exp. Ther. Oncol. |
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Components of lemon essential oil attenuate dementia induced by scopolamine. |
2009 |
Nutr Neurosci |
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Tricistronic overexpression of cytochrome P450cam, putidaredoxin, and putidaredoxin reductase provides a useful cell-based catalytic system. |
2009 |
Biotechnol. Lett. |
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Perillyl alcohol and methyl jasmonate sensitize cancer cells to cisplatin. |
2010 |
Anticancer Drugs |
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Protective effects of mastic oil from Pistacia lentiscus variation chia against experimental growth of lewis lung carcinoma. |
2009 |
Nutr Cancer |
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Dynamic proteomic overview of glioblastoma cells (A172) exposed to perillyl alcohol. |
2010 |
J Proteomics |
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A phase 2a study of topical perillyl alcohol cream for chemoprevention of skin cancer. |
2010 |
Cancer Prev Res (Phila) |
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Clifford JL and DiGiovanni J |
The promise of natural products for blocking early events in skin carcinogenesis. |
2010 |
Cancer Prev Res (Phila) |
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Efficacy of monoterpene perillyl alcohol upon survival rate of patients with recurrent glioblastoma. |
2011 |
J. Cancer Res. Clin. Oncol. |
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The anticancer drug perillyl alcohol is a Na/K-ATPase inhibitor. |
2010 |
Mol. Cell. Biochem. |
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Chemo-resistant protein expression pattern of glioblastoma cells (A172) to perillyl alcohol. |
2011 |
J. Proteome Res. |
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Perillyl alcohol protects against ethanol induced acute liver injury in Wistar rats by inhibiting oxidative stress, NFκ-B activation and proinflammatory cytokine production. |
2011 |
Toxicology |
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Evaluation of the antioxidant and antiproliferative potential of bioflavors. |
2011 |
Food Chem. Toxicol. |
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2011 |
J. Ind. Microbiol. Biotechnol. |
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An efficient route to selective bio-oxidation catalysts: an iterative approach comprising modeling, diversification, and screening, based on CYP102A1. |
2011 |
Chembiochem |
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Nonmelanoma skin cancer chemoprevention. |
2011 |
Dermatol Surg |
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Influence of the active compounds of Perilla frutescens leaves on lipid membranes. |
2012 |
J. Nat. Prod. |
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2012 |
Int J Nanomedicine |
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Calcium blockers decrease the bortezomib resistance in mantle cell lymphoma via manipulation of tissue transglutaminase activities. |
2012 |
Blood |
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Microbial hydroxylation of S-(-)-perillyl alcohol by Fusarium heterosporium. |
2011 |
Nat Prod Commun |
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Analysis of EGF+61A>G polymorphism and EGF serum levels in Brazilian glioma patients treated with perillyl alcohol-based therapy. |
2012 |
J. Cancer Res. Clin. Oncol. |
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