(-)-perillyl alcohol is a lipid of Prenol Lipids (PR) class. The involved functions are known as Cell Cycle Progression, Cell Cycle, Cell Proliferation, Apoptosis and Isoprenylation. (-)-perillyl alcohol often locates in Cytoplasm, Membrane and Plasma membrane. The associated genes with (-)-Perillyl alcohol are JUN gene, Candidate Disease Gene, IL24 gene, BCL2L1 gene and CFB gene. The related experimental models are Transgenic Model.
To understand associated biological information of (-)-Perillyl alcohol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
There are no associated biomedical information in the current reference collection.
We collected disease MeSH terms mapped to the references associated with (-)-Perillyl alcohol
Lipid pathways are not clear in current pathway databases. We organized associated pathways with (-)-Perillyl alcohol through full-text articles, including metabolic pathways or pathways of biological mechanisms.
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Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
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Transgenic Model are used in the study 'A phase 2a study of topical perillyl alcohol cream for chemoprevention of skin cancer.' (Stratton SP et al., 2010).
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Authors | Title | Published | Journal | PubMed Link |
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Lluria-Prevatt M et al. | Effects of perillyl alcohol on melanoma in the TPras mouse model. | 2002 | Cancer Epidemiol. Biomarkers Prev. | pmid:12050099 |
Yeruva L et al. | Perillyl alcohol and perillic acid induced cell cycle arrest and apoptosis in non small cell lung cancer cells. | 2007 | Cancer Lett. | pmid:17888568 |
Chung BH et al. | Perillyl alcohol inhibits the expression and function of the androgen receptor in human prostate cancer cells. | 2006 | Cancer Lett. | pmid:16029925 |
Ren Z and Gould MN | Inhibition of ubiquinone and cholesterol synthesis by the monoterpene perillyl alcohol. | 1994 | Cancer Lett. | pmid:8149348 |
Gelb MH et al. | The inhibition of protein prenyltransferases by oxygenated metabolites of limonene and perillyl alcohol. | 1995 | Cancer Lett. | pmid:7767906 |
Shi W and Gould MN | Induction of differentiation in neuro-2A cells by the monoterpene perillyl alcohol. | 1995 | Cancer Lett. | pmid:7656215 |
Stark MJ et al. | Chemotherapy of pancreatic cancer with the monoterpene perillyl alcohol. | 1995 | Cancer Lett. | pmid:7553603 |
Bardon S et al. | Monoterpenes inhibit proliferation of human colon cancer cells by modulating cell cycle-related protein expression. | 2002 | Cancer Lett. | pmid:12175534 |
Stratton SP et al. | A phase 2a study of topical perillyl alcohol cream for chemoprevention of skin cancer. | 2010 | Cancer Prev Res (Phila) | pmid:20103724 |
Clifford JL and DiGiovanni J | The promise of natural products for blocking early events in skin carcinogenesis. | 2010 | Cancer Prev Res (Phila) | pmid:20103730 |
Berchtold CM et al. | Perillyl alcohol inhibits a calcium-dependent constitutive nuclear factor-kappaB pathway. | 2005 | Cancer Res. | pmid:16166337 |
Lebedeva IV et al. | Mechanism of in vitro pancreatic cancer cell growth inhibition by melanoma differentiation-associated gene-7/interleukin-24 and perillyl alcohol. | 2008 | Cancer Res. | pmid:18768668 |
Barthelman M et al. | Inhibitory effects of perillyl alcohol on UVB-induced murine skin cancer and AP-1 transactivation. | 1998 | Cancer Res. | pmid:9485025 |
Reddy BS et al. | Chemoprevention of colon carcinogenesis by dietary perillyl alcohol. | 1997 | Cancer Res. | pmid:9012468 |
Mills JJ et al. | Induction of apoptosis in liver tumors by the monoterpene perillyl alcohol. | 1995 | Cancer Res. | pmid:7867007 |
Ariazi EA et al. | Activation of the transforming growth factor beta signaling pathway and induction of cytostasis and apoptosis in mammary carcinomas treated with the anticancer agent perillyl alcohol. | 1999 | Cancer Res. | pmid:10213501 |
Liston BW et al. | Perillyl alcohol as a chemopreventive agent in N-nitrosomethylbenzylamine-induced rat esophageal tumorigenesis. | 2003 | Cancer Res. | pmid:12750258 |
Stayrook KR et al. | Induction of the apoptosis-promoting protein Bak by perillyl alcohol in pancreatic ductal adenocarcinoma relative to untransformed ductal epithelial cells. | 1997 | Carcinogenesis | pmid:9276644 |
Satomi Y et al. | Induction of AP-1 activity by perillyl alcohol in breast cancer cells. | 1999 | Carcinogenesis | pmid:10506111 |
Löw-Baselli A et al. | Failure to demonstrate chemoprevention by the monoterpene perillyl alcohol during early rat hepatocarcinogenesis: a cautionary note. | 2000 | Carcinogenesis | pmid:11023545 |