(-)-perillyl alcohol is a lipid of Prenol Lipids (PR) class. The involved functions are known as Cell Cycle Progression, Cell Cycle, Cell Proliferation, Apoptosis and Isoprenylation. (-)-perillyl alcohol often locates in Cytoplasm, Membrane and Plasma membrane. The associated genes with (-)-Perillyl alcohol are JUN gene, Candidate Disease Gene, IL24 gene, BCL2L1 gene and CFB gene. The related experimental models are Transgenic Model.
To understand associated biological information of (-)-Perillyl alcohol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
There are no associated biomedical information in the current reference collection.
We collected disease MeSH terms mapped to the references associated with (-)-Perillyl alcohol
Lipid pathways are not clear in current pathway databases. We organized associated pathways with (-)-Perillyl alcohol through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Gene | Cross reference | Weighted score | Related literatures |
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Transgenic Model are used in the study 'A phase 2a study of topical perillyl alcohol cream for chemoprevention of skin cancer.' (Stratton SP et al., 2010).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Fischer Jde S et al. | Dynamic proteomic overview of glioblastoma cells (A172) exposed to perillyl alcohol. | 2010 | J Proteomics | pmid:20083244 |
Hohl RJ and Lewis K | Differential effects of monoterpenes and lovastatin on RAS processing. | 1995 | J. Biol. Chem. | pmid:7615555 |
Rajesh D et al. | Perillyl alcohol as a radio-/chemosensitizer in malignant glioma. | 2003 | J. Biol. Chem. | pmid:12805388 |
Bassi AM et al. | Protein and m-RNA expression of farnesyl-transferases, RhoA and RhoB in rat liver hepatocytes: action of perillyl alcohol and vitamin A in vivo. | 2005 | J. Biomed. Sci. | pmid:15959631 |
da Fonseca CO et al. | Efficacy of monoterpene perillyl alcohol upon survival rate of patients with recurrent glioblastoma. | 2011 | J. Cancer Res. Clin. Oncol. | pmid:20401670 |
da Silveira Fd et al. | Analysis of EGF+61A>G polymorphism and EGF serum levels in Brazilian glioma patients treated with perillyl alcohol-based therapy. | 2012 | J. Cancer Res. Clin. Oncol. | pmid:22481252 |
Unlu S et al. | Perillyl alcohol, an inhibitor of geranylgeranyl transferase, induces apoptosis of immortalized human vascular smooth muscle cells in vitro. | 2000 | J. Cardiovasc. Pharmacol. | pmid:10672871 |
Clinical development plan: l-perillyl alcohol. | 1996 | J. Cell. Biochem. Suppl. | pmid:9154174 | |
Lantry LE et al. | Chemopreventive effect of perillyl alcohol on 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone induced tumorigenesis in (C3H/HeJ X A/J)F1 mouse lung. | 1997 | J. Cell. Biochem. Suppl. | pmid:9591189 |
Zhang Z et al. | Gas chromatographic-mass spectrometric analysis of perillyl alcohol and metabolites in plasma. | 1999 | J. Chromatogr. B Biomed. Sci. Appl. | pmid:10379660 |