(-)-perillyl alcohol is a lipid of Prenol Lipids (PR) class. The involved functions are known as Cell Cycle Progression, Cell Cycle, Cell Proliferation, Apoptosis and Isoprenylation. (-)-perillyl alcohol often locates in Cytoplasm, Membrane and Plasma membrane. The associated genes with (-)-Perillyl alcohol are JUN gene, Candidate Disease Gene, IL24 gene, BCL2L1 gene and CFB gene. The related experimental models are Transgenic Model.
To understand associated biological information of (-)-Perillyl alcohol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
There are no associated biomedical information in the current reference collection.
We collected disease MeSH terms mapped to the references associated with (-)-Perillyl alcohol
Lipid pathways are not clear in current pathway databases. We organized associated pathways with (-)-Perillyl alcohol through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
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Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Gene | Cross reference | Weighted score | Related literatures |
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Transgenic Model are used in the study 'A phase 2a study of topical perillyl alcohol cream for chemoprevention of skin cancer.' (Stratton SP et al., 2010).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Lantry LE et al. | Chemopreventive efficacy of promising farnesyltransferase inhibitors. | 2000 | Exp. Lung Res. | pmid:11195470 |
Wei X et al. | Perillyl alcohol inhibits TCR-mediated [Ca(2+)](i) signaling, alters cell shape and motility, and induces apoptosis in T lymphocytes. | 2000 | Cell. Immunol. | pmid:10805968 |
Hudes GR et al. | Phase I pharmacokinetic trial of perillyl alcohol (NSC 641066) in patients with refractory solid malignancies. | 2000 | Clin. Cancer Res. | pmid:10955786 |
Löw-Baselli A et al. | Failure to demonstrate chemoprevention by the monoterpene perillyl alcohol during early rat hepatocarcinogenesis: a cautionary note. | 2000 | Carcinogenesis | pmid:11023545 |
Unlu S et al. | Perillyl alcohol, an inhibitor of geranylgeranyl transferase, induces apoptosis of immortalized human vascular smooth muscle cells in vitro. | 2000 | J. Cardiovasc. Pharmacol. | pmid:10672871 |
Ripple GH et al. | Phase I clinical and pharmacokinetic study of perillyl alcohol administered four times a day. | 2000 | Clin. Cancer Res. | pmid:10690515 |
Ariazi EA et al. | Activation of the transforming growth factor beta signaling pathway and induction of cytostasis and apoptosis in mammary carcinomas treated with the anticancer agent perillyl alcohol. | 1999 | Cancer Res. | pmid:10213501 |
Zhang Z et al. | Gas chromatographic-mass spectrometric analysis of perillyl alcohol and metabolites in plasma. | 1999 | J. Chromatogr. B Biomed. Sci. Appl. | pmid:10379660 |
Cerda SR et al. | Enhancement of sterol synthesis by the monoterpene perillyl alcohol is unaffected by competitive 3-hydroxy-3-methylglutaryl-CoA reductase inhibition. | 1999 | Lipids | pmid:10405975 |
Sahin MB et al. | Perillyl alcohol selectively induces G0/G1 arrest and apoptosis in Bcr/Abl-transformed myeloid cell lines. | 1999 | Leukemia | pmid:10516760 |