(-)-perillyl alcohol is a lipid of Prenol Lipids (PR) class. The involved functions are known as Cell Cycle Progression, Cell Cycle, Cell Proliferation, Apoptosis and Isoprenylation. (-)-perillyl alcohol often locates in Cytoplasm, Membrane and Plasma membrane. The associated genes with (-)-Perillyl alcohol are JUN gene, Candidate Disease Gene, IL24 gene, BCL2L1 gene and CFB gene. The related experimental models are Transgenic Model.
To understand associated biological information of (-)-Perillyl alcohol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
There are no associated biomedical information in the current reference collection.
We collected disease MeSH terms mapped to the references associated with (-)-Perillyl alcohol
Lipid pathways are not clear in current pathway databases. We organized associated pathways with (-)-Perillyl alcohol through full-text articles, including metabolic pathways or pathways of biological mechanisms.
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Associated locations are in red color. Not associated locations are in black.
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There are no associated biomedical information in the current reference collection.
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Transgenic Model are used in the study 'A phase 2a study of topical perillyl alcohol cream for chemoprevention of skin cancer.' (Stratton SP et al., 2010).
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Authors | Title | Published | Journal | PubMed Link |
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Pan J et al. | [Constituents of essential oils from leaves, stems, and fruits of Perilla frutescens (L.) Britt]. | 1992 | Zhongguo Zhong Yao Za Zhi | pmid:1418538 |
Khan AQ et al. | Perillyl alcohol protects against ethanol induced acute liver injury in Wistar rats by inhibiting oxidative stress, NFκ-B activation and proinflammatory cytokine production. | 2011 | Toxicology | pmid:20923693 |
Chan NL et al. | Polycyclic aromatic hydrocarbon-induced CYP1B1 activity is suppressed by perillyl alcohol in MCF-7 cells. | 2006 | Toxicol. Appl. Pharmacol. | pmid:16307765 |
Xu M et al. | Perillyl alcohol-mediated inhibition of lung cancer cell line proliferation: potential mechanisms for its chemotherapeutic effects. | 2004 | Toxicol. Appl. Pharmacol. | pmid:14998688 |
Boon PJ et al. | Cytotoxicity and biotransformation of the anticancer drug perillyl alcohol in PC12 cells and in the rat. | 2000 | Toxicol. Appl. Pharmacol. | pmid:10936079 |
da Fonseca CO et al. | Preliminary results from a phase I/II study of perillyl alcohol intranasal administration in adults with recurrent malignant gliomas. | 2008 | Surg Neurol | pmid:18295834 |
da Fonseca CO et al. | Recent advances in the molecular genetics of malignant gliomas disclose targets for antitumor agent perillyl alcohol. | 2006 | Surg Neurol | pmid:16427438 |
Da Fonseca CO et al. | Anaplastic oligodendroglioma responding favorably to intranasal delivery of perillyl alcohol: a case report and literature review. | 2006 | Surg Neurol | pmid:17145324 |
Ripple GH and Wilding G | Drug development in prostate cancer. | 1999 | Semin. Oncol. | pmid:10597732 |
Song X et al. | Temozolomide-perillyl alcohol conjugate induced reactive oxygen species accumulation contributes to its cytotoxicity against non-small cell lung cancer. | 2016 | Sci Rep | pmid:26949038 |
Bisson JF et al. | Anti-inflammatory senescence actives 5203-L molecule to promote healthy aging and prolongation of lifespan. | 2008 | Rejuvenation Res | pmid:18370605 |
Rajesh D and Howard SP | Perillyl alcohol mediated radiosensitization via augmentation of the Fas pathway in prostate cancer cells. | 2003 | Prostate | pmid:12886519 |
Ansari MA et al. | Anticandidal Effect and Mechanisms of Monoterpenoid, Perillyl Alcohol against Candida albicans. | 2016 | PLoS ONE | pmid:27627759 |
Courdavault V et al. | CaaX-prenyltransferases are essential for expression of genes involvedin the early stages of monoterpenoid biosynthetic pathway in Catharanthus roseus cells. | 2005 | Plant Mol. Biol. | pmid:15952070 |
Xie L et al. | Therapeutic effect of TMZ-POH on human nasopharyngeal carcinoma depends on reactive oxygen species accumulation. | 2016 | Oncotarget | pmid:26625208 |
Zweibel J et al. | Clinical trials referral resource. Clinical trials with perillyl alcohol. | 1997 | Oncology (Williston Park, N.Y.) | pmid:9436188 |
Clark SS | Perillyl alcohol induces c-Myc-dependent apoptosis in Bcr/Abl-transformed leukemia cells. | 2006 | Oncology | pmid:16439861 |
Fernandes J et al. | Perillyl alcohol induces apoptosis in human glioblastoma multiforme cells. | 2005 | Oncol. Rep. | pmid:15809762 |
Koyama M et al. | Perillyl alcohol causes G1 arrest through p15(INK4b) and p21(WAF1/Cip1) induction. | 2013 | Oncol. Rep. | pmid:23233050 |
Lewis KA and Hohl RJ | Modulation of RAS expression in human malignant cells by dietary supplements. | 1997 | Nutrition | pmid:9357036 |
Zhou W et al. | Components of lemon essential oil attenuate dementia induced by scopolamine. | 2009 | Nutr Neurosci | pmid:19356307 |
Magkouta S et al. | Protective effects of mastic oil from Pistacia lentiscus variation chia against experimental growth of lewis lung carcinoma. | 2009 | Nutr Cancer | pmid:19838938 |
Loutrari H et al. | Mastic oil from Pistacia lentiscus var. chia inhibits growth and survival of human K562 leukemia cells and attenuates angiogenesis. | 2006 | Nutr Cancer | pmid:16965245 |
Stratton SP et al. | Phase 1 study of topical perillyl alcohol cream for chemoprevention of skin cancer. | 2008 | Nutr Cancer | pmid:18444166 |
Bardon S et al. | Monoterpenes inhibit cell growth, cell cycle progression, and cyclin D1 gene expression in human breast cancer cell lines. | 1998 | Nutr Cancer | pmid:9824849 |
Kiran I | Microbial hydroxylation of S-(-)-perillyl alcohol by Fusarium heterosporium. | 2011 | Nat Prod Commun | pmid:22312710 |
Wróblewska A | The epoxidation of limonene over the TS-1 and Ti-SBA-15 catalysts. | 2014 | Molecules | pmid:25460313 |
Hui Z et al. | Synthesis and antiproliferative effects of amino-modified perillyl alcohol derivatives. | 2014 | Molecules | pmid:24858099 |
Garcia DG et al. | The anticancer drug perillyl alcohol is a Na/K-ATPase inhibitor. | 2010 | Mol. Cell. Biochem. | pmid:20689980 |
Sundin T et al. | Disruption of an hTERT-mTOR-RAPTOR protein complex by a phytochemical perillyl alcohol and rapamycin. | 2013 | Mol. Cell. Biochem. | pmid:23283642 |
Lebedeva IV et al. | Chemoprevention by perillyl alcohol coupled with viral gene therapy reduces pancreatic cancer pathogenesis. | 2008 | Mol. Cancer Ther. | pmid:18645014 |
Cho HY et al. | Perillyl alcohol for the treatment of temozolomide-resistant gliomas. | 2012 | Mol. Cancer Ther. | pmid:22933703 |
Chen TC et al. | A novel temozolomide-perillyl alcohol conjugate exhibits superior activity against breast cancer cells in vitro and intracranial triple-negative tumor growth in vivo. | 2014 | Mol. Cancer Ther. | pmid:24623736 |
Garcia DG et al. | Na/K-ATPase as a target for anticancer drugs: studies with perillyl alcohol. | 2015 | Mol. Cancer | pmid:25976744 |
Luján HD et al. | Isoprenylation of proteins in the protozoan Giardia lamblia. | 1995 | Mol. Biochem. Parasitol. | pmid:8538683 |
Alonso-Gutierrez J et al. | Metabolic engineering of Escherichia coli for limonene and perillyl alcohol production. | 2013 | Metab. Eng. | pmid:23727191 |
Cerda SR et al. | Enhancement of sterol synthesis by the monoterpene perillyl alcohol is unaffected by competitive 3-hydroxy-3-methylglutaryl-CoA reductase inhibition. | 1999 | Lipids | pmid:10405975 |
Elegbede JA et al. | Perillyl alcohol and perillaldehyde induced cell cycle arrest and cell death in BroTo and A549 cells cultured in vitro. | 2003 | Life Sci. | pmid:14511768 |
Sahin MB et al. | Perillyl alcohol selectively induces G0/G1 arrest and apoptosis in Bcr/Abl-transformed myeloid cell lines. | 1999 | Leukemia | pmid:10516760 |
Clark SS et al. | Antileukemia activity of perillyl alcohol (POH): uncoupling apoptosis from G0/G1 arrest suggests that the primary effect of POH on Bcr/Abl-transformed cells is to induce growth arrest. | 2002 | Leukemia | pmid:11840288 |
Si MS and Imagawa DK | Prenylation inhibitors to treat proliferative renal disease. | 2000 | Lancet | pmid:10791545 |
O'Shaughnessy JA | Chemoprevention of breast cancer. | 1996 | JAMA | pmid:8614122 |
Matos JM et al. | A pilot study of perillyl alcohol in pancreatic cancer. | 2008 | J. Surg. Res. | pmid:18498869 |
Fulton GJ et al. | Oral monoterpene therapy (perillyl alcohol) reduces vein graft intimal hyperplasia. | 1997 | J. Surg. Res. | pmid:9202658 |
de Saldanha da Gama Fischer J et al. | Chemo-resistant protein expression pattern of glioblastoma cells (A172) to perillyl alcohol. | 2011 | J. Proteome Res. | pmid:20806975 |
Loutrari H et al. | Perillyl alcohol is an angiogenesis inhibitor. | 2004 | J. Pharmacol. Exp. Ther. | pmid:15210838 |
Wiseman DA et al. | Cell cycle arrest by the isoprenoids perillyl alcohol, geraniol, and farnesol is mediated by p21(Cip1) and p27(Kip1) in human pancreatic adenocarcinoma cells. | 2007 | J. Pharmacol. Exp. Ther. | pmid:17138864 |
Crowell PL | Prevention and therapy of cancer by dietary monoterpenes. | 1999 | J. Nutr. | pmid:10082788 |
Duelund L et al. | Influence of the active compounds of Perilla frutescens leaves on lipid membranes. | 2012 | J. Nat. Prod. | pmid:22272932 |
Nandurkar NS et al. | The identification of perillyl alcohol glycosides with improved antiproliferative activity. | 2014 | J. Med. Chem. | pmid:25121720 |