(-)-perillyl alcohol is a lipid of Prenol Lipids (PR) class. The involved functions are known as Cell Cycle Progression, Cell Cycle, Cell Proliferation, Apoptosis and Isoprenylation. (-)-perillyl alcohol often locates in Cytoplasm, Membrane and Plasma membrane. The associated genes with (-)-Perillyl alcohol are JUN gene, Candidate Disease Gene, IL24 gene, BCL2L1 gene and CFB gene. The related experimental models are Transgenic Model.
To understand associated biological information of (-)-Perillyl alcohol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
There are no associated biomedical information in the current reference collection.
We collected disease MeSH terms mapped to the references associated with (-)-Perillyl alcohol
Lipid pathways are not clear in current pathway databases. We organized associated pathways with (-)-Perillyl alcohol through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
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Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Gene | Cross reference | Weighted score | Related literatures |
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Transgenic Model are used in the study 'A phase 2a study of topical perillyl alcohol cream for chemoprevention of skin cancer.' (Stratton SP et al., 2010).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Belanger JT | Perillyl alcohol: applications in oncology. | 1998 | Altern Med Rev | pmid:9855569 |
Bardon S et al. | Monoterpenes inhibit cell growth, cell cycle progression, and cyclin D1 gene expression in human breast cancer cell lines. | 1998 | Nutr Cancer | pmid:9824849 |
Stayrook KR et al. | Effects of the antitumor agent perillyl alcohol on H-Ras vs. K-Ras farnesylation and signal transduction in pancreatic cells. | 1998 Mar-Apr | Anticancer Res. | pmid:9615726 |
Ripple GH et al. | Phase I clinical trial of perillyl alcohol administered daily. | 1998 | Clin. Cancer Res. | pmid:9607573 |
Lantry LE et al. | Chemopreventive effect of perillyl alcohol on 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone induced tumorigenesis in (C3H/HeJ X A/J)F1 mouse lung. | 1997 | J. Cell. Biochem. Suppl. | pmid:9591189 |
Barthelman M et al. | Inhibitory effects of perillyl alcohol on UVB-induced murine skin cancer and AP-1 transactivation. | 1998 | Cancer Res. | pmid:9485025 |
Tao L and Pereira MA | Quantification of carvone, cineole, perillaldehyde, perillyl alcohol and sobrerol by isocratic high-performance liquid chromatography. | 1998 | J Chromatogr A | pmid:9468652 |
Zweibel J et al. | Clinical trials referral resource. Clinical trials with perillyl alcohol. | 1997 | Oncology (Williston Park, N.Y.) | pmid:9436188 |
Lewis KA and Hohl RJ | Modulation of RAS expression in human malignant cells by dietary supplements. | 1997 | Nutrition | pmid:9357036 |
Ren Z et al. | Inhibition of type I and type II geranylgeranyl-protein transferases by the monoterpene perillyl alcohol in NIH3T3 cells. | 1997 | Biochem. Pharmacol. | pmid:9296357 |
Stayrook KR et al. | Induction of the apoptosis-promoting protein Bak by perillyl alcohol in pancreatic ductal adenocarcinoma relative to untransformed ductal epithelial cells. | 1997 | Carcinogenesis | pmid:9276644 |
Fulton GJ et al. | Oral monoterpene therapy (perillyl alcohol) reduces vein graft intimal hyperplasia. | 1997 | J. Surg. Res. | pmid:9202658 |
Clinical development plan: l-perillyl alcohol. | 1996 | J. Cell. Biochem. Suppl. | pmid:9154174 | |
Reddy BS et al. | Chemoprevention of colon carcinogenesis by dietary perillyl alcohol. | 1997 | Cancer Res. | pmid:9012468 |
Karlson J et al. | Inhibition of tumor cell growth by monoterpenes in vitro: evidence of a Ras-independent mechanism of action. | 1996 | Anticancer Drugs | pmid:8826611 |
O'Shaughnessy JA | Chemoprevention of breast cancer. | 1996 | JAMA | pmid:8614122 |
Luján HD et al. | Isoprenylation of proteins in the protozoan Giardia lamblia. | 1995 | Mol. Biochem. Parasitol. | pmid:8538683 |
Ren Z and Gould MN | Inhibition of ubiquinone and cholesterol synthesis by the monoterpene perillyl alcohol. | 1994 | Cancer Lett. | pmid:8149348 |
Mills JJ et al. | Induction of apoptosis in liver tumors by the monoterpene perillyl alcohol. | 1995 | Cancer Res. | pmid:7867007 |
Gelb MH et al. | The inhibition of protein prenyltransferases by oxygenated metabolites of limonene and perillyl alcohol. | 1995 | Cancer Lett. | pmid:7767906 |
Shi W and Gould MN | Induction of differentiation in neuro-2A cells by the monoterpene perillyl alcohol. | 1995 | Cancer Lett. | pmid:7656215 |
Hohl RJ and Lewis K | Differential effects of monoterpenes and lovastatin on RAS processing. | 1995 | J. Biol. Chem. | pmid:7615555 |
Phillips LR et al. | Pharmacokinetics of active drug metabolites after oral administration of perillyl alcohol, an investigational antineoplastic agent, to the dog. | 1995 | Drug Metab. Dispos. | pmid:7587953 |
Alison M | Promoting apoptosis. | 1995 | Hum Exp Toxicol | pmid:7576838 |
Stark MJ et al. | Chemotherapy of pancreatic cancer with the monoterpene perillyl alcohol. | 1995 | Cancer Lett. | pmid:7553603 |
Opdyke DL | Monographs on fragrance raw materials. | 1981 | Food Cosmet Toxicol | pmid:7286874 |
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Ansari MA et al. | Anticandidal Effect and Mechanisms of Monoterpenoid, Perillyl Alcohol against Candida albicans. | 2016 | PLoS ONE | pmid:27627759 |
Chen TC et al. | Perillyl Alcohol and Its Drug-Conjugated Derivatives as Potential Novel Methods of Treating Brain Metastases. | 2016 | Int J Mol Sci | pmid:27598140 |
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Song X et al. | Temozolomide-perillyl alcohol conjugate induced reactive oxygen species accumulation contributes to its cytotoxicity against non-small cell lung cancer. | 2016 | Sci Rep | pmid:26949038 |
Andrade LN et al. | In Vivo Anti-Tumor Activity and Toxicological Evaluations of Perillaldehyde 8,9-Epoxide, a Derivative of Perillyl Alcohol. | 2016 | Int J Mol Sci | pmid:26742032 |
Xie L et al. | Therapeutic effect of TMZ-POH on human nasopharyngeal carcinoma depends on reactive oxygen species accumulation. | 2016 | Oncotarget | pmid:26625208 |
pmid:26475687 | ||||
Garcia DG et al. | Na/K-ATPase as a target for anticancer drugs: studies with perillyl alcohol. | 2015 | Mol. Cancer | pmid:25976744 |
pmid:25497898 | ||||
Wróblewska A | The epoxidation of limonene over the TS-1 and Ti-SBA-15 catalysts. | 2014 | Molecules | pmid:25460313 |
pmid:25240714 | ||||
Nandurkar NS et al. | The identification of perillyl alcohol glycosides with improved antiproliferative activity. | 2014 | J. Med. Chem. | pmid:25121720 |
Hui Z et al. | Synthesis and antiproliferative effects of amino-modified perillyl alcohol derivatives. | 2014 | Molecules | pmid:24858099 |
Chen TC et al. | A novel temozolomide-perillyl alcohol conjugate exhibits superior activity against breast cancer cells in vitro and intracranial triple-negative tumor growth in vivo. | 2014 | Mol. Cancer Ther. | pmid:24623736 |
DA Fonseca CO et al. | Long-term outcome in patients with recurrent malignant glioma treated with Perillyl alcohol inhalation. | 2013 | Anticancer Res. | pmid:24324108 |