(-)-perillyl alcohol is a lipid of Prenol Lipids (PR) class. The involved functions are known as Cell Cycle Progression, Cell Cycle, Cell Proliferation, Apoptosis and Isoprenylation. (-)-perillyl alcohol often locates in Cytoplasm, Membrane and Plasma membrane. The associated genes with (-)-Perillyl alcohol are JUN gene, Candidate Disease Gene, IL24 gene, BCL2L1 gene and CFB gene. The related experimental models are Transgenic Model.
To understand associated biological information of (-)-Perillyl alcohol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
There are no associated biomedical information in the current reference collection.
We collected disease MeSH terms mapped to the references associated with (-)-Perillyl alcohol
Lipid pathways are not clear in current pathway databases. We organized associated pathways with (-)-Perillyl alcohol through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
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Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Gene | Cross reference | Weighted score | Related literatures |
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Transgenic Model are used in the study 'A phase 2a study of topical perillyl alcohol cream for chemoprevention of skin cancer.' (Stratton SP et al., 2010).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Hua HY et al. | High-performance liquid chromatographic and pharmacokinetic analyses of an intravenous submicron emulsion of perillyl alcohol in rats. | 2008 | J Pharm Biomed Anal | pmid:18849133 |
Bailey HH et al. | Phase II trial of daily oral perillyl alcohol (NSC 641066) in treatment-refractory metastatic breast cancer. | 2008 | Cancer Chemother. Pharmacol. | pmid:17885756 |
Matos JM et al. | A pilot study of perillyl alcohol in pancreatic cancer. | 2008 | J. Surg. Res. | pmid:18498869 |
Stratton SP et al. | Phase 1 study of topical perillyl alcohol cream for chemoprevention of skin cancer. | 2008 | Nutr Cancer | pmid:18444166 |
Bhatia SP et al. | Fragrance material review on p-mentha-1,8-dien-7-ol. | 2008 | Food Chem. Toxicol. | pmid:18640209 |
Lebedeva IV et al. | Chemoprevention by perillyl alcohol coupled with viral gene therapy reduces pancreatic cancer pathogenesis. | 2008 | Mol. Cancer Ther. | pmid:18645014 |
Lebedeva IV et al. | Mechanism of in vitro pancreatic cancer cell growth inhibition by melanoma differentiation-associated gene-7/interleukin-24 and perillyl alcohol. | 2008 | Cancer Res. | pmid:18768668 |
da Fonseca CO et al. | Ras pathway activation in gliomas: a strategic target for intranasal administration of perillyl alcohol. | 2008 Jul-Aug | Arch. Immunol. Ther. Exp. (Warsz.) | pmid:18726148 |
Chaudhary SC et al. | Perillyl alcohol attenuates Ras-ERK signaling to inhibit murine skin inflammation and tumorigenesis. | 2009 | Chem. Biol. Interact. | pmid:19161993 |
Kim D and Ortiz de Montellano PR | Tricistronic overexpression of cytochrome P450cam, putidaredoxin, and putidaredoxin reductase provides a useful cell-based catalytic system. | 2009 | Biotechnol. Lett. | pmid:19458919 |