(-)-perillyl alcohol is a lipid of Prenol Lipids (PR) class. The involved functions are known as Cell Cycle Progression, Cell Cycle, Cell Proliferation, Apoptosis and Isoprenylation. (-)-perillyl alcohol often locates in Cytoplasm, Membrane and Plasma membrane. The associated genes with (-)-Perillyl alcohol are JUN gene, Candidate Disease Gene, IL24 gene, BCL2L1 gene and CFB gene. The related experimental models are Transgenic Model.
To understand associated biological information of (-)-Perillyl alcohol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
There are no associated biomedical information in the current reference collection.
We collected disease MeSH terms mapped to the references associated with (-)-Perillyl alcohol
Lipid pathways are not clear in current pathway databases. We organized associated pathways with (-)-Perillyl alcohol through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Gene | Cross reference | Weighted score | Related literatures |
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Transgenic Model are used in the study 'A phase 2a study of topical perillyl alcohol cream for chemoprevention of skin cancer.' (Stratton SP et al., 2010).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Magkouta S et al. | Protective effects of mastic oil from Pistacia lentiscus variation chia against experimental growth of lewis lung carcinoma. | 2009 | Nutr Cancer | pmid:19838938 |
Loutrari H et al. | Mastic oil from Pistacia lentiscus var. chia inhibits growth and survival of human K562 leukemia cells and attenuates angiogenesis. | 2006 | Nutr Cancer | pmid:16965245 |
Stratton SP et al. | Phase 1 study of topical perillyl alcohol cream for chemoprevention of skin cancer. | 2008 | Nutr Cancer | pmid:18444166 |
Bardon S et al. | Monoterpenes inhibit cell growth, cell cycle progression, and cyclin D1 gene expression in human breast cancer cell lines. | 1998 | Nutr Cancer | pmid:9824849 |
Zhou W et al. | Components of lemon essential oil attenuate dementia induced by scopolamine. | 2009 | Nutr Neurosci | pmid:19356307 |
Lewis KA and Hohl RJ | Modulation of RAS expression in human malignant cells by dietary supplements. | 1997 | Nutrition | pmid:9357036 |
Fernandes J et al. | Perillyl alcohol induces apoptosis in human glioblastoma multiforme cells. | 2005 | Oncol. Rep. | pmid:15809762 |
Koyama M et al. | Perillyl alcohol causes G1 arrest through p15(INK4b) and p21(WAF1/Cip1) induction. | 2013 | Oncol. Rep. | pmid:23233050 |
Clark SS | Perillyl alcohol induces c-Myc-dependent apoptosis in Bcr/Abl-transformed leukemia cells. | 2006 | Oncology | pmid:16439861 |
Zweibel J et al. | Clinical trials referral resource. Clinical trials with perillyl alcohol. | 1997 | Oncology (Williston Park, N.Y.) | pmid:9436188 |