(-)-perillyl alcohol is a lipid of Prenol Lipids (PR) class. The involved functions are known as Cell Cycle Progression, Cell Cycle, Cell Proliferation, Apoptosis and Isoprenylation. (-)-perillyl alcohol often locates in Cytoplasm, Membrane and Plasma membrane. The associated genes with (-)-Perillyl alcohol are JUN gene, Candidate Disease Gene, IL24 gene, BCL2L1 gene and CFB gene. The related experimental models are Transgenic Model.
To understand associated biological information of (-)-Perillyl alcohol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
There are no associated biomedical information in the current reference collection.
We collected disease MeSH terms mapped to the references associated with (-)-Perillyl alcohol
Lipid pathways are not clear in current pathway databases. We organized associated pathways with (-)-Perillyl alcohol through full-text articles, including metabolic pathways or pathways of biological mechanisms.
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Associated locations are in red color. Not associated locations are in black.
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There are no associated biomedical information in the current reference collection.
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Transgenic Model are used in the study 'A phase 2a study of topical perillyl alcohol cream for chemoprevention of skin cancer.' (Stratton SP et al., 2010).
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Authors | Title | Published | Journal | PubMed Link |
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Fischer Jde S et al. | Dynamic proteomic overview of glioblastoma cells (A172) exposed to perillyl alcohol. | 2010 | J Proteomics | pmid:20083244 |
Hohl RJ and Lewis K | Differential effects of monoterpenes and lovastatin on RAS processing. | 1995 | J. Biol. Chem. | pmid:7615555 |
Rajesh D et al. | Perillyl alcohol as a radio-/chemosensitizer in malignant glioma. | 2003 | J. Biol. Chem. | pmid:12805388 |
Bassi AM et al. | Protein and m-RNA expression of farnesyl-transferases, RhoA and RhoB in rat liver hepatocytes: action of perillyl alcohol and vitamin A in vivo. | 2005 | J. Biomed. Sci. | pmid:15959631 |
da Fonseca CO et al. | Efficacy of monoterpene perillyl alcohol upon survival rate of patients with recurrent glioblastoma. | 2011 | J. Cancer Res. Clin. Oncol. | pmid:20401670 |
da Silveira Fd et al. | Analysis of EGF+61A>G polymorphism and EGF serum levels in Brazilian glioma patients treated with perillyl alcohol-based therapy. | 2012 | J. Cancer Res. Clin. Oncol. | pmid:22481252 |
Unlu S et al. | Perillyl alcohol, an inhibitor of geranylgeranyl transferase, induces apoptosis of immortalized human vascular smooth muscle cells in vitro. | 2000 | J. Cardiovasc. Pharmacol. | pmid:10672871 |
Clinical development plan: l-perillyl alcohol. | 1996 | J. Cell. Biochem. Suppl. | pmid:9154174 | |
Lantry LE et al. | Chemopreventive effect of perillyl alcohol on 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone induced tumorigenesis in (C3H/HeJ X A/J)F1 mouse lung. | 1997 | J. Cell. Biochem. Suppl. | pmid:9591189 |
Zhang Z et al. | Gas chromatographic-mass spectrometric analysis of perillyl alcohol and metabolites in plasma. | 1999 | J. Chromatogr. B Biomed. Sci. Appl. | pmid:10379660 |
Fischer Jde S et al. | Anti-thrombin as a prognostic biomarker candidate for patients with recurrent glioblastoma multiform under treatment with perillyl alcohol. | 2008 | J. Exp. Ther. Oncol. | pmid:19227008 |
Fischer Jde S et al. | Effects of perillyl alcohol and heat shock treatment in gene expression of human lung adenocarcinoma cell line A549. | 2006 | J. Exp. Ther. Oncol. | pmid:17024970 |
Chen Y and Hu D | Effects of POH in combination with STI571 on the proliferation and apoptosis of K562 cells. | 2004 | J. Huazhong Univ. Sci. Technol. Med. Sci. | pmid:15165112 |
Cornelissen S et al. | Cell physiology rather than enzyme kinetics can determine the efficiency of cytochrome P450-catalyzed C-H-oxyfunctionalization. | 2011 | J. Ind. Microbiol. Biotechnol. | pmid:21559976 |
Holstein SA and Hohl RJ | Monoterpene regulation of Ras and Ras-related protein expression. | 2003 | J. Lipid Res. | pmid:12671036 |
Nandurkar NS et al. | The identification of perillyl alcohol glycosides with improved antiproliferative activity. | 2014 | J. Med. Chem. | pmid:25121720 |
Duelund L et al. | Influence of the active compounds of Perilla frutescens leaves on lipid membranes. | 2012 | J. Nat. Prod. | pmid:22272932 |
Crowell PL | Prevention and therapy of cancer by dietary monoterpenes. | 1999 | J. Nutr. | pmid:10082788 |
Loutrari H et al. | Perillyl alcohol is an angiogenesis inhibitor. | 2004 | J. Pharmacol. Exp. Ther. | pmid:15210838 |
Wiseman DA et al. | Cell cycle arrest by the isoprenoids perillyl alcohol, geraniol, and farnesol is mediated by p21(Cip1) and p27(Kip1) in human pancreatic adenocarcinoma cells. | 2007 | J. Pharmacol. Exp. Ther. | pmid:17138864 |
de Saldanha da Gama Fischer J et al. | Chemo-resistant protein expression pattern of glioblastoma cells (A172) to perillyl alcohol. | 2011 | J. Proteome Res. | pmid:20806975 |
Matos JM et al. | A pilot study of perillyl alcohol in pancreatic cancer. | 2008 | J. Surg. Res. | pmid:18498869 |
Fulton GJ et al. | Oral monoterpene therapy (perillyl alcohol) reduces vein graft intimal hyperplasia. | 1997 | J. Surg. Res. | pmid:9202658 |
O'Shaughnessy JA | Chemoprevention of breast cancer. | 1996 | JAMA | pmid:8614122 |
Si MS and Imagawa DK | Prenylation inhibitors to treat proliferative renal disease. | 2000 | Lancet | pmid:10791545 |
Sahin MB et al. | Perillyl alcohol selectively induces G0/G1 arrest and apoptosis in Bcr/Abl-transformed myeloid cell lines. | 1999 | Leukemia | pmid:10516760 |
Clark SS et al. | Antileukemia activity of perillyl alcohol (POH): uncoupling apoptosis from G0/G1 arrest suggests that the primary effect of POH on Bcr/Abl-transformed cells is to induce growth arrest. | 2002 | Leukemia | pmid:11840288 |
Elegbede JA et al. | Perillyl alcohol and perillaldehyde induced cell cycle arrest and cell death in BroTo and A549 cells cultured in vitro. | 2003 | Life Sci. | pmid:14511768 |
Cerda SR et al. | Enhancement of sterol synthesis by the monoterpene perillyl alcohol is unaffected by competitive 3-hydroxy-3-methylglutaryl-CoA reductase inhibition. | 1999 | Lipids | pmid:10405975 |
Alonso-Gutierrez J et al. | Metabolic engineering of Escherichia coli for limonene and perillyl alcohol production. | 2013 | Metab. Eng. | pmid:23727191 |
Luján HD et al. | Isoprenylation of proteins in the protozoan Giardia lamblia. | 1995 | Mol. Biochem. Parasitol. | pmid:8538683 |
Garcia DG et al. | Na/K-ATPase as a target for anticancer drugs: studies with perillyl alcohol. | 2015 | Mol. Cancer | pmid:25976744 |
Lebedeva IV et al. | Chemoprevention by perillyl alcohol coupled with viral gene therapy reduces pancreatic cancer pathogenesis. | 2008 | Mol. Cancer Ther. | pmid:18645014 |
Cho HY et al. | Perillyl alcohol for the treatment of temozolomide-resistant gliomas. | 2012 | Mol. Cancer Ther. | pmid:22933703 |
Chen TC et al. | A novel temozolomide-perillyl alcohol conjugate exhibits superior activity against breast cancer cells in vitro and intracranial triple-negative tumor growth in vivo. | 2014 | Mol. Cancer Ther. | pmid:24623736 |
Garcia DG et al. | The anticancer drug perillyl alcohol is a Na/K-ATPase inhibitor. | 2010 | Mol. Cell. Biochem. | pmid:20689980 |
Sundin T et al. | Disruption of an hTERT-mTOR-RAPTOR protein complex by a phytochemical perillyl alcohol and rapamycin. | 2013 | Mol. Cell. Biochem. | pmid:23283642 |
Wróblewska A | The epoxidation of limonene over the TS-1 and Ti-SBA-15 catalysts. | 2014 | Molecules | pmid:25460313 |
Hui Z et al. | Synthesis and antiproliferative effects of amino-modified perillyl alcohol derivatives. | 2014 | Molecules | pmid:24858099 |
Kiran I | Microbial hydroxylation of S-(-)-perillyl alcohol by Fusarium heterosporium. | 2011 | Nat Prod Commun | pmid:22312710 |
Magkouta S et al. | Protective effects of mastic oil from Pistacia lentiscus variation chia against experimental growth of lewis lung carcinoma. | 2009 | Nutr Cancer | pmid:19838938 |
Loutrari H et al. | Mastic oil from Pistacia lentiscus var. chia inhibits growth and survival of human K562 leukemia cells and attenuates angiogenesis. | 2006 | Nutr Cancer | pmid:16965245 |
Stratton SP et al. | Phase 1 study of topical perillyl alcohol cream for chemoprevention of skin cancer. | 2008 | Nutr Cancer | pmid:18444166 |
Bardon S et al. | Monoterpenes inhibit cell growth, cell cycle progression, and cyclin D1 gene expression in human breast cancer cell lines. | 1998 | Nutr Cancer | pmid:9824849 |
Zhou W et al. | Components of lemon essential oil attenuate dementia induced by scopolamine. | 2009 | Nutr Neurosci | pmid:19356307 |
Lewis KA and Hohl RJ | Modulation of RAS expression in human malignant cells by dietary supplements. | 1997 | Nutrition | pmid:9357036 |
Fernandes J et al. | Perillyl alcohol induces apoptosis in human glioblastoma multiforme cells. | 2005 | Oncol. Rep. | pmid:15809762 |
Koyama M et al. | Perillyl alcohol causes G1 arrest through p15(INK4b) and p21(WAF1/Cip1) induction. | 2013 | Oncol. Rep. | pmid:23233050 |
Clark SS | Perillyl alcohol induces c-Myc-dependent apoptosis in Bcr/Abl-transformed leukemia cells. | 2006 | Oncology | pmid:16439861 |
Zweibel J et al. | Clinical trials referral resource. Clinical trials with perillyl alcohol. | 1997 | Oncology (Williston Park, N.Y.) | pmid:9436188 |