(-)-perillyl alcohol is a lipid of Prenol Lipids (PR) class. The involved functions are known as Cell Cycle Progression, Cell Cycle, Cell Proliferation, Apoptosis and Isoprenylation. (-)-perillyl alcohol often locates in Cytoplasm, Membrane and Plasma membrane. The associated genes with (-)-Perillyl alcohol are JUN gene, Candidate Disease Gene, IL24 gene, BCL2L1 gene and CFB gene. The related experimental models are Transgenic Model.
To understand associated biological information of (-)-Perillyl alcohol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
There are no associated biomedical information in the current reference collection.
We collected disease MeSH terms mapped to the references associated with (-)-Perillyl alcohol
Lipid pathways are not clear in current pathway databases. We organized associated pathways with (-)-Perillyl alcohol through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
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Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Gene | Cross reference | Weighted score | Related literatures |
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Transgenic Model are used in the study 'A phase 2a study of topical perillyl alcohol cream for chemoprevention of skin cancer.' (Stratton SP et al., 2010).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Xie L et al. | Therapeutic effect of TMZ-POH on human nasopharyngeal carcinoma depends on reactive oxygen species accumulation. | 2016 | Oncotarget | pmid:26625208 |
Courdavault V et al. | CaaX-prenyltransferases are essential for expression of genes involvedin the early stages of monoterpenoid biosynthetic pathway in Catharanthus roseus cells. | 2005 | Plant Mol. Biol. | pmid:15952070 |
Ansari MA et al. | Anticandidal Effect and Mechanisms of Monoterpenoid, Perillyl Alcohol against Candida albicans. | 2016 | PLoS ONE | pmid:27627759 |
Rajesh D and Howard SP | Perillyl alcohol mediated radiosensitization via augmentation of the Fas pathway in prostate cancer cells. | 2003 | Prostate | pmid:12886519 |
Bisson JF et al. | Anti-inflammatory senescence actives 5203-L molecule to promote healthy aging and prolongation of lifespan. | 2008 | Rejuvenation Res | pmid:18370605 |
Song X et al. | Temozolomide-perillyl alcohol conjugate induced reactive oxygen species accumulation contributes to its cytotoxicity against non-small cell lung cancer. | 2016 | Sci Rep | pmid:26949038 |
Ripple GH and Wilding G | Drug development in prostate cancer. | 1999 | Semin. Oncol. | pmid:10597732 |
da Fonseca CO et al. | Preliminary results from a phase I/II study of perillyl alcohol intranasal administration in adults with recurrent malignant gliomas. | 2008 | Surg Neurol | pmid:18295834 |
da Fonseca CO et al. | Recent advances in the molecular genetics of malignant gliomas disclose targets for antitumor agent perillyl alcohol. | 2006 | Surg Neurol | pmid:16427438 |
Da Fonseca CO et al. | Anaplastic oligodendroglioma responding favorably to intranasal delivery of perillyl alcohol: a case report and literature review. | 2006 | Surg Neurol | pmid:17145324 |
Chan NL et al. | Polycyclic aromatic hydrocarbon-induced CYP1B1 activity is suppressed by perillyl alcohol in MCF-7 cells. | 2006 | Toxicol. Appl. Pharmacol. | pmid:16307765 |
Xu M et al. | Perillyl alcohol-mediated inhibition of lung cancer cell line proliferation: potential mechanisms for its chemotherapeutic effects. | 2004 | Toxicol. Appl. Pharmacol. | pmid:14998688 |
Boon PJ et al. | Cytotoxicity and biotransformation of the anticancer drug perillyl alcohol in PC12 cells and in the rat. | 2000 | Toxicol. Appl. Pharmacol. | pmid:10936079 |
Khan AQ et al. | Perillyl alcohol protects against ethanol induced acute liver injury in Wistar rats by inhibiting oxidative stress, NFκ-B activation and proinflammatory cytokine production. | 2011 | Toxicology | pmid:20923693 |
Pan J et al. | [Constituents of essential oils from leaves, stems, and fruits of Perilla frutescens (L.) Britt]. | 1992 | Zhongguo Zhong Yao Za Zhi | pmid:1418538 |