(-)-perillyl alcohol is a lipid of Prenol Lipids (PR) class. The involved functions are known as Cell Cycle Progression, Cell Cycle, Cell Proliferation, Apoptosis and Isoprenylation. (-)-perillyl alcohol often locates in Cytoplasm, Membrane and Plasma membrane. The associated genes with (-)-Perillyl alcohol are JUN gene, Candidate Disease Gene, IL24 gene, BCL2L1 gene and CFB gene. The related experimental models are Transgenic Model.
To understand associated biological information of (-)-Perillyl alcohol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
There are no associated biomedical information in the current reference collection.
We collected disease MeSH terms mapped to the references associated with (-)-Perillyl alcohol
Lipid pathways are not clear in current pathway databases. We organized associated pathways with (-)-Perillyl alcohol through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Gene | Cross reference | Weighted score | Related literatures |
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Transgenic Model are used in the study 'A phase 2a study of topical perillyl alcohol cream for chemoprevention of skin cancer.' (Stratton SP et al., 2010).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Si MS and Imagawa DK | Prenylation inhibitors to treat proliferative renal disease. | 2000 | Lancet | pmid:10791545 |
O'Shaughnessy JA | Chemoprevention of breast cancer. | 1996 | JAMA | pmid:8614122 |
Matos JM et al. | A pilot study of perillyl alcohol in pancreatic cancer. | 2008 | J. Surg. Res. | pmid:18498869 |
Fulton GJ et al. | Oral monoterpene therapy (perillyl alcohol) reduces vein graft intimal hyperplasia. | 1997 | J. Surg. Res. | pmid:9202658 |
de Saldanha da Gama Fischer J et al. | Chemo-resistant protein expression pattern of glioblastoma cells (A172) to perillyl alcohol. | 2011 | J. Proteome Res. | pmid:20806975 |
Loutrari H et al. | Perillyl alcohol is an angiogenesis inhibitor. | 2004 | J. Pharmacol. Exp. Ther. | pmid:15210838 |
Wiseman DA et al. | Cell cycle arrest by the isoprenoids perillyl alcohol, geraniol, and farnesol is mediated by p21(Cip1) and p27(Kip1) in human pancreatic adenocarcinoma cells. | 2007 | J. Pharmacol. Exp. Ther. | pmid:17138864 |
Crowell PL | Prevention and therapy of cancer by dietary monoterpenes. | 1999 | J. Nutr. | pmid:10082788 |
Duelund L et al. | Influence of the active compounds of Perilla frutescens leaves on lipid membranes. | 2012 | J. Nat. Prod. | pmid:22272932 |
Nandurkar NS et al. | The identification of perillyl alcohol glycosides with improved antiproliferative activity. | 2014 | J. Med. Chem. | pmid:25121720 |