MeSH term | MeSH ID | Detail |
---|---|---|
Brain Neoplasms | D001932 | 15 associated lipids |
Lymphoma, Mantle-Cell | D020522 | 5 associated lipids |
(-)-perillyl alcohol is a lipid of Prenol Lipids (PR) class. The involved functions are known as Cell Cycle Progression, Cell Cycle, Cell Proliferation, Apoptosis and Isoprenylation. (-)-perillyl alcohol often locates in Cytoplasm, Membrane and Plasma membrane. The associated genes with (-)-Perillyl alcohol are JUN gene, Candidate Disease Gene, IL24 gene, BCL2L1 gene and CFB gene. The related experimental models are Transgenic Model.
To understand associated biological information of (-)-Perillyl alcohol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
There are no associated biomedical information in the current reference collection.
We collected disease MeSH terms mapped to the references associated with (-)-Perillyl alcohol
Lipid pathways are not clear in current pathway databases. We organized associated pathways with (-)-Perillyl alcohol through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Gene | Cross reference | Weighted score | Related literatures |
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Transgenic Model are used in the study 'A phase 2a study of topical perillyl alcohol cream for chemoprevention of skin cancer.' (Stratton SP et al., 2010).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Phillips LR et al. | Pharmacokinetics of active drug metabolites after oral administration of perillyl alcohol, an investigational antineoplastic agent, to the dog. | 1995 | Drug Metab. Dispos. | pmid:7587953 |
Miyazawa M et al. | Metabolism of (+)- and (-)-limonenes to respective carveols and perillyl alcohols by CYP2C9 and CYP2C19 in human liver microsomes. | 2002 | Drug Metab. Dispos. | pmid:11950794 |
Prado R et al. | Nonmelanoma skin cancer chemoprevention. | 2011 | Dermatol Surg | pmid:21895847 |
Sarkar S et al. | Chemoprevention gene therapy (CGT) of pancreatic cancer using perillyl alcohol and a novel chimeric serotype cancer terminator virus. | 2014 | Curr. Mol. Med. | pmid:24236457 |
Clark SS et al. | Anti-leukemia effect of perillyl alcohol in Bcr/Abl-transformed cells indirectly inhibits signaling through Mek in a Ras- and Raf-independent fashion. | 2003 | Clin. Cancer Res. | pmid:14555523 |
Stearns V et al. | A pilot surrogate end point biomarker trial of perillyl alcohol in breast neoplasia. | 2004 | Clin. Cancer Res. | pmid:15569989 |
Ripple GH et al. | Phase I clinical trial of perillyl alcohol administered daily. | 1998 | Clin. Cancer Res. | pmid:9607573 |
Hudes GR et al. | Phase I pharmacokinetic trial of perillyl alcohol (NSC 641066) in patients with refractory solid malignancies. | 2000 | Clin. Cancer Res. | pmid:10955786 |
Ripple GH et al. | Phase I clinical and pharmacokinetic study of perillyl alcohol administered four times a day. | 2000 | Clin. Cancer Res. | pmid:10690515 |
Gómez-Contreras PC et al. | In vitro induction of apoptosis in U937 cells by perillyl alcohol with sensitization by pentoxifylline: increased BCL-2 and BAX protein expression. | 2006 | Chemotherapy | pmid:17008791 |