MeSH term | MeSH ID | Detail |
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Carcinoma, Lewis Lung | D018827 | 22 associated lipids |
Lymphoma, Mantle-Cell | D020522 | 5 associated lipids |
(-)-perillyl alcohol is a lipid of Prenol Lipids (PR) class. The involved functions are known as Cell Cycle Progression, Cell Cycle, Cell Proliferation, Apoptosis and Isoprenylation. (-)-perillyl alcohol often locates in Cytoplasm, Membrane and Plasma membrane. The associated genes with (-)-Perillyl alcohol are JUN gene, Candidate Disease Gene, IL24 gene, BCL2L1 gene and CFB gene. The related experimental models are Transgenic Model.
To understand associated biological information of (-)-Perillyl alcohol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
There are no associated biomedical information in the current reference collection.
We collected disease MeSH terms mapped to the references associated with (-)-Perillyl alcohol
Lipid pathways are not clear in current pathway databases. We organized associated pathways with (-)-Perillyl alcohol through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Gene | Cross reference | Weighted score | Related literatures |
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Transgenic Model are used in the study 'A phase 2a study of topical perillyl alcohol cream for chemoprevention of skin cancer.' (Stratton SP et al., 2010).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Teruszkin Balassiano I et al. | Effects of perillyl alcohol in glial C6 cell line in vitro and anti-metastatic activity in chorioallantoic membrane model. | 2002 | Int. J. Mol. Med. | pmid:12430008 |
Bardon S et al. | Monoterpenes inhibit proliferation of human colon cancer cells by modulating cell cycle-related protein expression. | 2002 | Cancer Lett. | pmid:12175534 |
Murren JR et al. | Phase I study of perillyl alcohol in patients with refractory malignancies. | 2002 Mar-Apr | Cancer Biol. Ther. | pmid:12170772 |
Bailey HH et al. | A phase II trial of daily perillyl alcohol in patients with advanced ovarian cancer: Eastern Cooperative Oncology Group Study E2E96. | 2002 | Gynecol. Oncol. | pmid:12051875 |
Lluria-Prevatt M et al. | Effects of perillyl alcohol on melanoma in the TPras mouse model. | 2002 | Cancer Epidemiol. Biomarkers Prev. | pmid:12050099 |
Miyazawa M et al. | Metabolism of (+)- and (-)-limonenes to respective carveols and perillyl alcohols by CYP2C9 and CYP2C19 in human liver microsomes. | 2002 | Drug Metab. Dispos. | pmid:11950794 |
Clark SS et al. | Antileukemia activity of perillyl alcohol (POH): uncoupling apoptosis from G0/G1 arrest suggests that the primary effect of POH on Bcr/Abl-transformed cells is to induce growth arrest. | 2002 | Leukemia | pmid:11840288 |
Miyazawa M et al. | Sex differences in the metabolism of (+)- and (-)-limonene enantiomers to carveol and perillyl alcohol derivatives by cytochrome p450 enzymes in rat liver microsomes. | 2002 | Chem. Res. Toxicol. | pmid:11800592 |
Shi W and Gould MN | Induction of cytostasis in mammary carcinoma cells treated with the anticancer agent perillyl alcohol. | 2002 | Carcinogenesis | pmid:11756234 |
Lantry LE et al. | Chemopreventive efficacy of promising farnesyltransferase inhibitors. | 2000 | Exp. Lung Res. | pmid:11195470 |
Löw-Baselli A et al. | Failure to demonstrate chemoprevention by the monoterpene perillyl alcohol during early rat hepatocarcinogenesis: a cautionary note. | 2000 | Carcinogenesis | pmid:11023545 |
Hudes GR et al. | Phase I pharmacokinetic trial of perillyl alcohol (NSC 641066) in patients with refractory solid malignancies. | 2000 | Clin. Cancer Res. | pmid:10955786 |
Boon PJ et al. | Cytotoxicity and biotransformation of the anticancer drug perillyl alcohol in PC12 cells and in the rat. | 2000 | Toxicol. Appl. Pharmacol. | pmid:10936079 |
Wei X et al. | Perillyl alcohol inhibits TCR-mediated [Ca(2+)](i) signaling, alters cell shape and motility, and induces apoptosis in T lymphocytes. | 2000 | Cell. Immunol. | pmid:10805968 |
Si MS and Imagawa DK | Prenylation inhibitors to treat proliferative renal disease. | 2000 | Lancet | pmid:10791545 |
Ripple GH et al. | Phase I clinical and pharmacokinetic study of perillyl alcohol administered four times a day. | 2000 | Clin. Cancer Res. | pmid:10690515 |
Unlu S et al. | Perillyl alcohol, an inhibitor of geranylgeranyl transferase, induces apoptosis of immortalized human vascular smooth muscle cells in vitro. | 2000 | J. Cardiovasc. Pharmacol. | pmid:10672871 |
Ripple GH and Wilding G | Drug development in prostate cancer. | 1999 | Semin. Oncol. | pmid:10597732 |
Sahin MB et al. | Perillyl alcohol selectively induces G0/G1 arrest and apoptosis in Bcr/Abl-transformed myeloid cell lines. | 1999 | Leukemia | pmid:10516760 |
Satomi Y et al. | Induction of AP-1 activity by perillyl alcohol in breast cancer cells. | 1999 | Carcinogenesis | pmid:10506111 |