MeSH term | MeSH ID | Detail |
---|---|---|
Mammary Neoplasms, Animal | D015674 | 27 associated lipids |
Lymphoma, B-Cell | D016393 | 24 associated lipids |
(-)-perillyl alcohol is a lipid of Prenol Lipids (PR) class. The involved functions are known as Cell Cycle Progression, Cell Cycle, Cell Proliferation, Apoptosis and Isoprenylation. (-)-perillyl alcohol often locates in Cytoplasm, Membrane and Plasma membrane. The associated genes with (-)-Perillyl alcohol are JUN gene, Candidate Disease Gene, IL24 gene, BCL2L1 gene and CFB gene. The related experimental models are Transgenic Model.
To understand associated biological information of (-)-Perillyl alcohol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
There are no associated biomedical information in the current reference collection.
We collected disease MeSH terms mapped to the references associated with (-)-Perillyl alcohol
Lipid pathways are not clear in current pathway databases. We organized associated pathways with (-)-Perillyl alcohol through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Gene | Cross reference | Weighted score | Related literatures |
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Transgenic Model are used in the study 'A phase 2a study of topical perillyl alcohol cream for chemoprevention of skin cancer.' (Stratton SP et al., 2010).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Clark SS et al. | Anti-leukemia effect of perillyl alcohol in Bcr/Abl-transformed cells indirectly inhibits signaling through Mek in a Ras- and Raf-independent fashion. | 2003 | Clin. Cancer Res. | pmid:14555523 |
Sarkar S et al. | Chemoprevention gene therapy (CGT) of pancreatic cancer using perillyl alcohol and a novel chimeric serotype cancer terminator virus. | 2014 | Curr. Mol. Med. | pmid:24236457 |
Prado R et al. | Nonmelanoma skin cancer chemoprevention. | 2011 | Dermatol Surg | pmid:21895847 |
Phillips LR et al. | Pharmacokinetics of active drug metabolites after oral administration of perillyl alcohol, an investigational antineoplastic agent, to the dog. | 1995 | Drug Metab. Dispos. | pmid:7587953 |
Miyazawa M et al. | Metabolism of (+)- and (-)-limonenes to respective carveols and perillyl alcohols by CYP2C9 and CYP2C19 in human liver microsomes. | 2002 | Drug Metab. Dispos. | pmid:11950794 |
Lefranc F et al. | 4-Bromo-2-(piperidin-1-yl)thiazol-5-yl-phenyl methanone (12b) inhibits Na+/K(+)-ATPase and Ras oncogene activity in cancer cells. | 2013 | Eur J Med Chem | pmid:23474907 |
Russell J and Ling CC | Studies with cytotoxic agents suggest that apoptosis is not a major determinant of clonogenic death in neuroblastoma cells. | 2003 | Eur. J. Cancer | pmid:14522384 |
Kennedy S et al. | Effect of antiproliferative agents on vascular function in normal and in vitro balloon-injured porcine coronary arteries. | 2003 | Eur. J. Pharmacol. | pmid:14637181 |
Sundin T et al. | eIF4E-Overexpression imparts perillyl alcohol and rapamycin-mediated regulation of telomerase reverse transcriptase. | 2013 | Exp. Cell Res. | pmid:23747720 |
Lantry LE et al. | Chemopreventive efficacy of promising farnesyltransferase inhibitors. | 2000 | Exp. Lung Res. | pmid:11195470 |