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Anticandidal Effect and Mechanisms of Monoterpenoid, Perillyl Alcohol against Candida albicans. |
2016 |
PLoS ONE |
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Perillyl Alcohol and Its Drug-Conjugated Derivatives as Potential Novel Methods of Treating Brain Metastases. |
2016 |
Int J Mol Sci |
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Song X et al. |
Temozolomide-perillyl alcohol conjugate induced reactive oxygen species accumulation contributes to its cytotoxicity against non-small cell lung cancer. |
2016 |
Sci Rep |
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In Vivo Anti-Tumor Activity and Toxicological Evaluations of Perillaldehyde 8,9-Epoxide, a Derivative of Perillyl Alcohol. |
2016 |
Int J Mol Sci |
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Therapeutic effect of TMZ-POH on human nasopharyngeal carcinoma depends on reactive oxygen species accumulation. |
2016 |
Oncotarget |
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Garcia DG et al. |
Na/K-ATPase as a target for anticancer drugs: studies with perillyl alcohol. |
2015 |
Mol. Cancer |
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d'Alessio PA et al. |
Skin repair properties of d-Limonene and perillyl alcohol in murine models. |
2014 |
Antiinflamm Antiallergy Agents Med Chem |
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The epoxidation of limonene over the TS-1 and Ti-SBA-15 catalysts. |
2014 |
Molecules |
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Sarkar S et al. |
Chemoprevention gene therapy (CGT) of pancreatic cancer using perillyl alcohol and a novel chimeric serotype cancer terminator virus. |
2014 |
Curr. Mol. Med. |
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Perillyl alcohol suppresses antigen-induced immune responses in the lung. |
2014 |
Biochem. Biophys. Res. Commun. |
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Intranasal administration of perillyl alcohol activates peripheral and bronchus-associated immune system in vivo. |
2014 |
Arch. Immunol. Ther. Exp. (Warsz.) |
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The identification of perillyl alcohol glycosides with improved antiproliferative activity. |
2014 |
J. Med. Chem. |
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Synthesis and antiproliferative effects of amino-modified perillyl alcohol derivatives. |
2014 |
Molecules |
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Chen TC et al. |
A novel temozolomide-perillyl alcohol conjugate exhibits superior activity against breast cancer cells in vitro and intracranial triple-negative tumor growth in vivo. |
2014 |
Mol. Cancer Ther. |
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Metabolic engineering of Escherichia coli for limonene and perillyl alcohol production. |
2013 |
Metab. Eng. |
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4-Bromo-2-(piperidin-1-yl)thiazol-5-yl-phenyl methanone (12b) inhibits Na+/K(+)-ATPase and Ras oncogene activity in cancer cells. |
2013 |
Eur J Med Chem |
pmid:23474907
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Sundin T et al. |
Disruption of an hTERT-mTOR-RAPTOR protein complex by a phytochemical perillyl alcohol and rapamycin. |
2013 |
Mol. Cell. Biochem. |
pmid:23283642
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Koyama M et al. |
Perillyl alcohol causes G1 arrest through p15(INK4b) and p21(WAF1/Cip1) induction. |
2013 |
Oncol. Rep. |
pmid:23233050
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Sultana S et al. |
Perillyl alcohol as a protective modulator against rat hepatocarcinogenesis via amelioration of oxidative damage and cell proliferation. |
2013 |
Hum Exp Toxicol |
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Sundin T et al. |
eIF4E-Overexpression imparts perillyl alcohol and rapamycin-mediated regulation of telomerase reverse transcriptase. |
2013 |
Exp. Cell Res. |
pmid:23747720
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Influence of GSTM1 and GSTT1 polymorphisms on the survival rate of patients with malignant glioma under perillyl alcohol-based therapy. |
2013 |
Genet. Mol. Res. |
pmid:23765968
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Long-term outcome in patients with recurrent malignant glioma treated with Perillyl alcohol inhalation. |
2013 |
Anticancer Res. |
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Cornelissen S et al. |
Whole-cell-based CYP153A6-catalyzed (S)-limonene hydroxylation efficiency depends on host background and profits from monoterpene uptake via AlkL. |
2013 |
Biotechnol. Bioeng. |
pmid:23239244
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Farazuddin M et al. |
Anticancer efficacy of perillyl alcohol-bearing PLGA microparticles. |
2012 |
Int J Nanomedicine |
pmid:22275821
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Jung HJ et al. |
Calcium blockers decrease the bortezomib resistance in mantle cell lymphoma via manipulation of tissue transglutaminase activities. |
2012 |
Blood |
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Perillyl alcohol for the treatment of temozolomide-resistant gliomas. |
2012 |
Mol. Cancer Ther. |
pmid:22933703
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Analysis of EGF+61A>G polymorphism and EGF serum levels in Brazilian glioma patients treated with perillyl alcohol-based therapy. |
2012 |
J. Cancer Res. Clin. Oncol. |
pmid:22481252
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The isoprenoid perillyl alcohol inhibits telomerase activity in prostate cancer cells. |
2012 |
Biochimie |
pmid:22902867
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Duelund L et al. |
Influence of the active compounds of Perilla frutescens leaves on lipid membranes. |
2012 |
J. Nat. Prod. |
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Evaluation of the antioxidant and antiproliferative potential of bioflavors. |
2011 |
Food Chem. Toxicol. |
pmid:21540069
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Khan AQ et al. |
Perillyl alcohol protects against ethanol induced acute liver injury in Wistar rats by inhibiting oxidative stress, NFκ-B activation and proinflammatory cytokine production. |
2011 |
Toxicology |
pmid:20923693
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Chemo-resistant protein expression pattern of glioblastoma cells (A172) to perillyl alcohol. |
2011 |
J. Proteome Res. |
pmid:20806975
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Efficacy of monoterpene perillyl alcohol upon survival rate of patients with recurrent glioblastoma. |
2011 |
J. Cancer Res. Clin. Oncol. |
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Nonmelanoma skin cancer chemoprevention. |
2011 |
Dermatol Surg |
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Microbial hydroxylation of S-(-)-perillyl alcohol by Fusarium heterosporium. |
2011 |
Nat Prod Commun |
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Cell physiology rather than enzyme kinetics can determine the efficiency of cytochrome P450-catalyzed C-H-oxyfunctionalization. |
2011 |
J. Ind. Microbiol. Biotechnol. |
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An efficient route to selective bio-oxidation catalysts: an iterative approach comprising modeling, diversification, and screening, based on CYP102A1. |
2011 |
Chembiochem |
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The anticancer drug perillyl alcohol is a Na/K-ATPase inhibitor. |
2010 |
Mol. Cell. Biochem. |
pmid:20689980
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A phase 2a study of topical perillyl alcohol cream for chemoprevention of skin cancer. |
2010 |
Cancer Prev Res (Phila) |
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Clifford JL and DiGiovanni J |
The promise of natural products for blocking early events in skin carcinogenesis. |
2010 |
Cancer Prev Res (Phila) |
pmid:20103730
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Dynamic proteomic overview of glioblastoma cells (A172) exposed to perillyl alcohol. |
2010 |
J Proteomics |
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Perillyl alcohol and methyl jasmonate sensitize cancer cells to cisplatin. |
2010 |
Anticancer Drugs |
pmid:19820395
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Chaudhary SC et al. |
Perillyl alcohol attenuates Ras-ERK signaling to inhibit murine skin inflammation and tumorigenesis. |
2009 |
Chem. Biol. Interact. |
pmid:19161993
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Da Fonseca CO et al. |
Correlation of tumor topography and peritumoral edema of recurrent malignant gliomas with therapeutic response to intranasal administration of perillyl alcohol. |
2009 |
Invest New Drugs |
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Protective effects of mastic oil from Pistacia lentiscus variation chia against experimental growth of lewis lung carcinoma. |
2009 |
Nutr Cancer |
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Components of lemon essential oil attenuate dementia induced by scopolamine. |
2009 |
Nutr Neurosci |
pmid:19356307
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Kim D and Ortiz de Montellano PR |
Tricistronic overexpression of cytochrome P450cam, putidaredoxin, and putidaredoxin reductase provides a useful cell-based catalytic system. |
2009 |
Biotechnol. Lett. |
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Ras pathway activation in gliomas: a strategic target for intranasal administration of perillyl alcohol. |
2008 Jul-Aug |
Arch. Immunol. Ther. Exp. (Warsz.) |
pmid:18726148
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Fischer Jde S et al. |
Anti-thrombin as a prognostic biomarker candidate for patients with recurrent glioblastoma multiform under treatment with perillyl alcohol. |
2008 |
J. Exp. Ther. Oncol. |
pmid:19227008
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High-performance liquid chromatographic and pharmacokinetic analyses of an intravenous submicron emulsion of perillyl alcohol in rats. |
2008 |
J Pharm Biomed Anal |
pmid:18849133
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Bailey HH et al. |
Phase II trial of daily oral perillyl alcohol (NSC 641066) in treatment-refractory metastatic breast cancer. |
2008 |
Cancer Chemother. Pharmacol. |
pmid:17885756
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da Fonseca CO et al. |
Preliminary results from a phase I/II study of perillyl alcohol intranasal administration in adults with recurrent malignant gliomas. |
2008 |
Surg Neurol |
pmid:18295834
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Bisson JF et al. |
Anti-inflammatory senescence actives 5203-L molecule to promote healthy aging and prolongation of lifespan. |
2008 |
Rejuvenation Res |
pmid:18370605
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A pilot study of perillyl alcohol in pancreatic cancer. |
2008 |
J. Surg. Res. |
pmid:18498869
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Stratton SP et al. |
Phase 1 study of topical perillyl alcohol cream for chemoprevention of skin cancer. |
2008 |
Nutr Cancer |
pmid:18444166
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Fragrance material review on p-mentha-1,8-dien-7-ol. |
2008 |
Food Chem. Toxicol. |
pmid:18640209
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Chemoprevention by perillyl alcohol coupled with viral gene therapy reduces pancreatic cancer pathogenesis. |
2008 |
Mol. Cancer Ther. |
pmid:18645014
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Lebedeva IV et al. |
Mechanism of in vitro pancreatic cancer cell growth inhibition by melanoma differentiation-associated gene-7/interleukin-24 and perillyl alcohol. |
2008 |
Cancer Res. |
pmid:18768668
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Synthesis of phosphatidylated-monoterpene alcohols catalyzed by phospholipase D and their antiproliferative effects on human cancer cells. |
2008 |
Bioorg. Med. Chem. Lett. |
pmid:18556205
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Perillyl alcohol and perillic acid induced cell cycle arrest and apoptosis in non small cell lung cancer cells. |
2007 |
Cancer Lett. |
pmid:17888568
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Peffley DM et al. |
Perillyl alcohol and genistein differentially regulate PKB/Akt and 4E-BP1 phosphorylation as well as eIF4E/eIF4G interactions in human tumor cells. |
2007 |
Arch. Biochem. Biophys. |
pmid:17601486
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Wiseman DA et al. |
Cell cycle arrest by the isoprenoids perillyl alcohol, geraniol, and farnesol is mediated by p21(Cip1) and p27(Kip1) in human pancreatic adenocarcinoma cells. |
2007 |
J. Pharmacol. Exp. Ther. |
pmid:17138864
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Chan NL et al. |
Polycyclic aromatic hydrocarbon-induced CYP1B1 activity is suppressed by perillyl alcohol in MCF-7 cells. |
2006 |
Toxicol. Appl. Pharmacol. |
pmid:16307765
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Chung BH et al. |
Perillyl alcohol inhibits the expression and function of the androgen receptor in human prostate cancer cells. |
2006 |
Cancer Lett. |
pmid:16029925
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Clark SS |
Perillyl alcohol induces c-Myc-dependent apoptosis in Bcr/Abl-transformed leukemia cells. |
2006 |
Oncology |
pmid:16439861
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da Fonseca CO et al. |
Recent advances in the molecular genetics of malignant gliomas disclose targets for antitumor agent perillyl alcohol. |
2006 |
Surg Neurol |
pmid:16427438
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Fischer Jde S et al. |
Effects of perillyl alcohol and heat shock treatment in gene expression of human lung adenocarcinoma cell line A549. |
2006 |
J. Exp. Ther. Oncol. |
pmid:17024970
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Da Fonseca CO et al. |
Anaplastic oligodendroglioma responding favorably to intranasal delivery of perillyl alcohol: a case report and literature review. |
2006 |
Surg Neurol |
pmid:17145324
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Gómez-Contreras PC et al. |
In vitro induction of apoptosis in U937 cells by perillyl alcohol with sensitization by pentoxifylline: increased BCL-2 and BAX protein expression. |
2006 |
Chemotherapy |
pmid:17008791
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Loutrari H et al. |
Mastic oil from Pistacia lentiscus var. chia inhibits growth and survival of human K562 leukemia cells and attenuates angiogenesis. |
2006 |
Nutr Cancer |
pmid:16965245
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Gupta A et al. |
An HPLC method for quantitation of perillyl alcohol in a topical pharmaceutical cream formulation. |
2005 |
J Pharm Biomed Anal |
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Perillyl alcohol induces apoptosis in human glioblastoma multiforme cells. |
2005 |
Oncol. Rep. |
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Courdavault V et al. |
CaaX-prenyltransferases are essential for expression of genes involvedin the early stages of monoterpenoid biosynthetic pathway in Catharanthus roseus cells. |
2005 |
Plant Mol. Biol. |
pmid:15952070
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Bassi AM et al. |
Protein and m-RNA expression of farnesyl-transferases, RhoA and RhoB in rat liver hepatocytes: action of perillyl alcohol and vitamin A in vivo. |
2005 |
J. Biomed. Sci. |
pmid:15959631
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Effect of D-limonene on immune response in BALB/c mice with lymphoma. |
2005 |
Int. Immunopharmacol. |
pmid:15778119
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Perillyl alcohol inhibits a calcium-dependent constitutive nuclear factor-kappaB pathway. |
2005 |
Cancer Res. |
pmid:16166337
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van Beilen JB et al. |
Biocatalytic production of perillyl alcohol from limonene by using a novel Mycobacterium sp. cytochrome P450 alkane hydroxylase expressed in Pseudomonas putida. |
2005 |
Appl. Environ. Microbiol. |
pmid:15811996
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Monoterpenes enhanced the sensitivity of head and neck cancer cells to radiation treatment in vitro. |
2004 Sep-Oct |
Anticancer Res. |
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Bailey HH et al. |
A phase I trial of perillyl alcohol administered four times daily for 14 days out of 28 days. |
2004 |
Cancer Chemother. Pharmacol. |
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Loutrari H et al. |
Perillyl alcohol is an angiogenesis inhibitor. |
2004 |
J. Pharmacol. Exp. Ther. |
pmid:15210838
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Gupta A and Myrdal PB |
Development of a perillyl alcohol topical cream formulation. |
2004 |
Int J Pharm |
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A pilot surrogate end point biomarker trial of perillyl alcohol in breast neoplasia. |
2004 |
Clin. Cancer Res. |
pmid:15569989
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Perillyl alcohol-mediated inhibition of lung cancer cell line proliferation: potential mechanisms for its chemotherapeutic effects. |
2004 |
Toxicol. Appl. Pharmacol. |
pmid:14998688
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Perillyl alcohol inhibits human breast cancer cell growth in vitro and in vivo. |
2004 |
Breast Cancer Res. Treat. |
pmid:15026623
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Chen Y and Hu D |
Effects of POH in combination with STI571 on the proliferation and apoptosis of K562 cells. |
2004 |
J. Huazhong Univ. Sci. Technol. Med. Sci. |
pmid:15165112
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Kennedy S et al. |
Effect of antiproliferative agents on vascular function in normal and in vitro balloon-injured porcine coronary arteries. |
2003 |
Eur. J. Pharmacol. |
pmid:14637181
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Ahn KJ et al. |
Cytotoxicity of perillyl alcohol against cancer cells is potentiated by hyperthermia. |
2003 |
Int. J. Radiat. Oncol. Biol. Phys. |
pmid:14529788
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Clark SS et al. |
Anti-leukemia effect of perillyl alcohol in Bcr/Abl-transformed cells indirectly inhibits signaling through Mek in a Ras- and Raf-independent fashion. |
2003 |
Clin. Cancer Res. |
pmid:14555523
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Liu G et al. |
Phase II trial of perillyl alcohol (NSC 641066) administered daily in patients with metastatic androgen independent prostate cancer. |
2003 |
Invest New Drugs |
pmid:14578686
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Russell J and Ling CC |
Studies with cytotoxic agents suggest that apoptosis is not a major determinant of clonogenic death in neuroblastoma cells. |
2003 |
Eur. J. Cancer |
pmid:14522384
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Holstein SA and Hohl RJ |
Monoterpene regulation of Ras and Ras-related protein expression. |
2003 |
J. Lipid Res. |
pmid:12671036
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Perillyl alcohol as a radio-/chemosensitizer in malignant glioma. |
2003 |
J. Biol. Chem. |
pmid:12805388
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Perillyl alcohol as a chemopreventive agent in N-nitrosomethylbenzylamine-induced rat esophageal tumorigenesis. |
2003 |
Cancer Res. |
pmid:12750258
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A phase I trial of perillyl alcohol in patients with advanced solid tumors. |
2003 |
Cancer Chemother. Pharmacol. |
pmid:12695855
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Morgan-Meadows S et al. |
Phase I trial of perillyl alcohol administered four times daily continuously. |
2003 |
Cancer Chemother. Pharmacol. |
pmid:12904896
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Rajesh D and Howard SP |
Perillyl alcohol mediated radiosensitization via augmentation of the Fas pathway in prostate cancer cells. |
2003 |
Prostate |
pmid:12886519
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Elegbede JA et al. |
Perillyl alcohol and perillaldehyde induced cell cycle arrest and cell death in BroTo and A549 cells cultured in vitro. |
2003 |
Life Sci. |
pmid:14511768
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Burke YD et al. |
Effects of the isoprenoids perillyl alcohol and farnesol on apoptosis biomarkers in pancreatic cancer chemoprevention. |
2002 Nov-Dec |
Anticancer Res. |
pmid:12530055
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Phase I study of perillyl alcohol in patients with refractory malignancies. |
2002 Mar-Apr |
Cancer Biol. Ther. |
pmid:12170772
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Miyazawa M et al. |
Metabolism of (+)- and (-)-limonenes to respective carveols and perillyl alcohols by CYP2C9 and CYP2C19 in human liver microsomes. |
2002 |
Drug Metab. Dispos. |
pmid:11950794
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