| MeSH term | MeSH ID | Detail |
|---|---|---|
| Adenocarcinoma | D000230 | 166 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Pancreatic Neoplasms | D010190 | 77 associated lipids |
| Mammary Neoplasms, Experimental | D008325 | 67 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
| Edema | D004487 | 152 associated lipids |
| Esophageal Neoplasms | D004938 | 20 associated lipids |
| Precancerous Conditions | D011230 | 48 associated lipids |
| Prostatic Neoplasms | D011471 | 126 associated lipids |
| Brain Neoplasms | D001932 | 15 associated lipids |
(-)-Perillyl alcohol
(-)-perillyl alcohol is a lipid of Prenol Lipids (PR) class. The involved functions are known as Cell Cycle Progression, Cell Cycle, Cell Proliferation, Apoptosis and Isoprenylation. (-)-perillyl alcohol often locates in Cytoplasm, Membrane and Plasma membrane. The associated genes with (-)-Perillyl alcohol are JUN gene, Candidate Disease Gene, IL24 gene, BCL2L1 gene and CFB gene. The related experimental models are Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of (-)-Perillyl alcohol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with (-)-Perillyl alcohol?
There are no associated biomedical information in the current reference collection.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with (-)-Perillyl alcohol
PubChem Associated disorders and diseases
What pathways are associated with (-)-Perillyl alcohol
Lipid pathways are not clear in current pathway databases. We organized associated pathways with (-)-Perillyl alcohol through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with (-)-Perillyl alcohol?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with (-)-Perillyl alcohol?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with (-)-Perillyl alcohol?
There are no associated biomedical information in the current reference collection.
What genes are associated with (-)-Perillyl alcohol?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with (-)-Perillyl alcohol?
Transgenic Model
Transgenic Model are used in the study 'A phase 2a study of topical perillyl alcohol cream for chemoprevention of skin cancer.' (Stratton SP et al., 2010).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with (-)-Perillyl alcohol
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Ansari MA et al. | Anticandidal Effect and Mechanisms of Monoterpenoid, Perillyl Alcohol against Candida albicans. | 2016 | PLoS ONE | pmid:27627759 |
| Chen TC et al. | Perillyl Alcohol and Its Drug-Conjugated Derivatives as Potential Novel Methods of Treating Brain Metastases. | 2016 | Int J Mol Sci | pmid:27598140 |
| Song X et al. | Temozolomide-perillyl alcohol conjugate induced reactive oxygen species accumulation contributes to its cytotoxicity against non-small cell lung cancer. | 2016 | Sci Rep | pmid:26949038 |
| Andrade LN et al. | In Vivo Anti-Tumor Activity and Toxicological Evaluations of Perillaldehyde 8,9-Epoxide, a Derivative of Perillyl Alcohol. | 2016 | Int J Mol Sci | pmid:26742032 |
| Xie L et al. | Therapeutic effect of TMZ-POH on human nasopharyngeal carcinoma depends on reactive oxygen species accumulation. | 2016 | Oncotarget | pmid:26625208 |
| Garcia DG et al. | Na/K-ATPase as a target for anticancer drugs: studies with perillyl alcohol. | 2015 | Mol. Cancer | pmid:25976744 |
| d'Alessio PA et al. | Skin repair properties of d-Limonene and perillyl alcohol in murine models. | 2014 | Antiinflamm Antiallergy Agents Med Chem | pmid:24160248 |
| Wróblewska A | The epoxidation of limonene over the TS-1 and Ti-SBA-15 catalysts. | 2014 | Molecules | pmid:25460313 |
| Sarkar S et al. | Chemoprevention gene therapy (CGT) of pancreatic cancer using perillyl alcohol and a novel chimeric serotype cancer terminator virus. | 2014 | Curr. Mol. Med. | pmid:24236457 |
| Imamura M et al. | Perillyl alcohol suppresses antigen-induced immune responses in the lung. | 2014 | Biochem. Biophys. Res. Commun. | pmid:24309112 |
| D'Alincourt Salazar M et al. | Intranasal administration of perillyl alcohol activates peripheral and bronchus-associated immune system in vivo. | 2014 | Arch. Immunol. Ther. Exp. (Warsz.) | pmid:24257817 |
| Nandurkar NS et al. | The identification of perillyl alcohol glycosides with improved antiproliferative activity. | 2014 | J. Med. Chem. | pmid:25121720 |
| Hui Z et al. | Synthesis and antiproliferative effects of amino-modified perillyl alcohol derivatives. | 2014 | Molecules | pmid:24858099 |
| Chen TC et al. | A novel temozolomide-perillyl alcohol conjugate exhibits superior activity against breast cancer cells in vitro and intracranial triple-negative tumor growth in vivo. | 2014 | Mol. Cancer Ther. | pmid:24623736 |
| Alonso-Gutierrez J et al. | Metabolic engineering of Escherichia coli for limonene and perillyl alcohol production. | 2013 | Metab. Eng. | pmid:23727191 |
| Lefranc F et al. | 4-Bromo-2-(piperidin-1-yl)thiazol-5-yl-phenyl methanone (12b) inhibits Na+/K(+)-ATPase and Ras oncogene activity in cancer cells. | 2013 | Eur J Med Chem | pmid:23474907 |
| Sundin T et al. | Disruption of an hTERT-mTOR-RAPTOR protein complex by a phytochemical perillyl alcohol and rapamycin. | 2013 | Mol. Cell. Biochem. | pmid:23283642 |
| Koyama M et al. | Perillyl alcohol causes G1 arrest through p15(INK4b) and p21(WAF1/Cip1) induction. | 2013 | Oncol. Rep. | pmid:23233050 |
| Sultana S et al. | Perillyl alcohol as a protective modulator against rat hepatocarcinogenesis via amelioration of oxidative damage and cell proliferation. | 2013 | Hum Exp Toxicol | pmid:23536516 |
| Sundin T et al. | eIF4E-Overexpression imparts perillyl alcohol and rapamycin-mediated regulation of telomerase reverse transcriptase. | 2013 | Exp. Cell Res. | pmid:23747720 |
| Silva MM et al. | Influence of GSTM1 and GSTT1 polymorphisms on the survival rate of patients with malignant glioma under perillyl alcohol-based therapy. | 2013 | Genet. Mol. Res. | pmid:23765968 |
| DA Fonseca CO et al. | Long-term outcome in patients with recurrent malignant glioma treated with Perillyl alcohol inhalation. | 2013 | Anticancer Res. | pmid:24324108 |
| Cornelissen S et al. | Whole-cell-based CYP153A6-catalyzed (S)-limonene hydroxylation efficiency depends on host background and profits from monoterpene uptake via AlkL. | 2013 | Biotechnol. Bioeng. | pmid:23239244 |
| Farazuddin M et al. | Anticancer efficacy of perillyl alcohol-bearing PLGA microparticles. | 2012 | Int J Nanomedicine | pmid:22275821 |
| Jung HJ et al. | Calcium blockers decrease the bortezomib resistance in mantle cell lymphoma via manipulation of tissue transglutaminase activities. | 2012 | Blood | pmid:22294726 |
| Cho HY et al. | Perillyl alcohol for the treatment of temozolomide-resistant gliomas. | 2012 | Mol. Cancer Ther. | pmid:22933703 |
| da Silveira Fd et al. | Analysis of EGF+61A>G polymorphism and EGF serum levels in Brazilian glioma patients treated with perillyl alcohol-based therapy. | 2012 | J. Cancer Res. Clin. Oncol. | pmid:22481252 |
| Sundin T et al. | The isoprenoid perillyl alcohol inhibits telomerase activity in prostate cancer cells. | 2012 | Biochimie | pmid:22902867 |
| Duelund L et al. | Influence of the active compounds of Perilla frutescens leaves on lipid membranes. | 2012 | J. Nat. Prod. | pmid:22272932 |
| Bicas JL et al. | Evaluation of the antioxidant and antiproliferative potential of bioflavors. | 2011 | Food Chem. Toxicol. | pmid:21540069 |
| Khan AQ et al. | Perillyl alcohol protects against ethanol induced acute liver injury in Wistar rats by inhibiting oxidative stress, NFκ-B activation and proinflammatory cytokine production. | 2011 | Toxicology | pmid:20923693 |
| de Saldanha da Gama Fischer J et al. | Chemo-resistant protein expression pattern of glioblastoma cells (A172) to perillyl alcohol. | 2011 | J. Proteome Res. | pmid:20806975 |
| da Fonseca CO et al. | Efficacy of monoterpene perillyl alcohol upon survival rate of patients with recurrent glioblastoma. | 2011 | J. Cancer Res. Clin. Oncol. | pmid:20401670 |
| Prado R et al. | Nonmelanoma skin cancer chemoprevention. | 2011 | Dermatol Surg | pmid:21895847 |
| Kiran I | Microbial hydroxylation of S-(-)-perillyl alcohol by Fusarium heterosporium. | 2011 | Nat Prod Commun | pmid:22312710 |
| Cornelissen S et al. | Cell physiology rather than enzyme kinetics can determine the efficiency of cytochrome P450-catalyzed C-H-oxyfunctionalization. | 2011 | J. Ind. Microbiol. Biotechnol. | pmid:21559976 |
| Seifert A et al. | An efficient route to selective bio-oxidation catalysts: an iterative approach comprising modeling, diversification, and screening, based on CYP102A1. | 2011 | Chembiochem | pmid:21591046 |
| Garcia DG et al. | The anticancer drug perillyl alcohol is a Na/K-ATPase inhibitor. | 2010 | Mol. Cell. Biochem. | pmid:20689980 |
| Stratton SP et al. | A phase 2a study of topical perillyl alcohol cream for chemoprevention of skin cancer. | 2010 | Cancer Prev Res (Phila) | pmid:20103724 |
| Clifford JL and DiGiovanni J | The promise of natural products for blocking early events in skin carcinogenesis. | 2010 | Cancer Prev Res (Phila) | pmid:20103730 |
| Fischer Jde S et al. | Dynamic proteomic overview of glioblastoma cells (A172) exposed to perillyl alcohol. | 2010 | J Proteomics | pmid:20083244 |
| Yeruva L et al. | Perillyl alcohol and methyl jasmonate sensitize cancer cells to cisplatin. | 2010 | Anticancer Drugs | pmid:19820395 |
| Chaudhary SC et al. | Perillyl alcohol attenuates Ras-ERK signaling to inhibit murine skin inflammation and tumorigenesis. | 2009 | Chem. Biol. Interact. | pmid:19161993 |
| Da Fonseca CO et al. | Correlation of tumor topography and peritumoral edema of recurrent malignant gliomas with therapeutic response to intranasal administration of perillyl alcohol. | 2009 | Invest New Drugs | pmid:19139816 |
| Magkouta S et al. | Protective effects of mastic oil from Pistacia lentiscus variation chia against experimental growth of lewis lung carcinoma. | 2009 | Nutr Cancer | pmid:19838938 |
| Zhou W et al. | Components of lemon essential oil attenuate dementia induced by scopolamine. | 2009 | Nutr Neurosci | pmid:19356307 |
| Kim D and Ortiz de Montellano PR | Tricistronic overexpression of cytochrome P450cam, putidaredoxin, and putidaredoxin reductase provides a useful cell-based catalytic system. | 2009 | Biotechnol. Lett. | pmid:19458919 |
| da Fonseca CO et al. | Ras pathway activation in gliomas: a strategic target for intranasal administration of perillyl alcohol. | 2008 Jul-Aug | Arch. Immunol. Ther. Exp. (Warsz.) | pmid:18726148 |
| Fischer Jde S et al. | Anti-thrombin as a prognostic biomarker candidate for patients with recurrent glioblastoma multiform under treatment with perillyl alcohol. | 2008 | J. Exp. Ther. Oncol. | pmid:19227008 |
| Hua HY et al. | High-performance liquid chromatographic and pharmacokinetic analyses of an intravenous submicron emulsion of perillyl alcohol in rats. | 2008 | J Pharm Biomed Anal | pmid:18849133 |
| Bailey HH et al. | Phase II trial of daily oral perillyl alcohol (NSC 641066) in treatment-refractory metastatic breast cancer. | 2008 | Cancer Chemother. Pharmacol. | pmid:17885756 |
| da Fonseca CO et al. | Preliminary results from a phase I/II study of perillyl alcohol intranasal administration in adults with recurrent malignant gliomas. | 2008 | Surg Neurol | pmid:18295834 |
| Bisson JF et al. | Anti-inflammatory senescence actives 5203-L molecule to promote healthy aging and prolongation of lifespan. | 2008 | Rejuvenation Res | pmid:18370605 |
| Matos JM et al. | A pilot study of perillyl alcohol in pancreatic cancer. | 2008 | J. Surg. Res. | pmid:18498869 |
| Stratton SP et al. | Phase 1 study of topical perillyl alcohol cream for chemoprevention of skin cancer. | 2008 | Nutr Cancer | pmid:18444166 |
| Bhatia SP et al. | Fragrance material review on p-mentha-1,8-dien-7-ol. | 2008 | Food Chem. Toxicol. | pmid:18640209 |
| Lebedeva IV et al. | Chemoprevention by perillyl alcohol coupled with viral gene therapy reduces pancreatic cancer pathogenesis. | 2008 | Mol. Cancer Ther. | pmid:18645014 |
| Lebedeva IV et al. | Mechanism of in vitro pancreatic cancer cell growth inhibition by melanoma differentiation-associated gene-7/interleukin-24 and perillyl alcohol. | 2008 | Cancer Res. | pmid:18768668 |
| Yamamoto Y et al. | Synthesis of phosphatidylated-monoterpene alcohols catalyzed by phospholipase D and their antiproliferative effects on human cancer cells. | 2008 | Bioorg. Med. Chem. Lett. | pmid:18556205 |
| Yeruva L et al. | Perillyl alcohol and perillic acid induced cell cycle arrest and apoptosis in non small cell lung cancer cells. | 2007 | Cancer Lett. | pmid:17888568 |
| Peffley DM et al. | Perillyl alcohol and genistein differentially regulate PKB/Akt and 4E-BP1 phosphorylation as well as eIF4E/eIF4G interactions in human tumor cells. | 2007 | Arch. Biochem. Biophys. | pmid:17601486 |
| Wiseman DA et al. | Cell cycle arrest by the isoprenoids perillyl alcohol, geraniol, and farnesol is mediated by p21(Cip1) and p27(Kip1) in human pancreatic adenocarcinoma cells. | 2007 | J. Pharmacol. Exp. Ther. | pmid:17138864 |
| Chan NL et al. | Polycyclic aromatic hydrocarbon-induced CYP1B1 activity is suppressed by perillyl alcohol in MCF-7 cells. | 2006 | Toxicol. Appl. Pharmacol. | pmid:16307765 |
| Chung BH et al. | Perillyl alcohol inhibits the expression and function of the androgen receptor in human prostate cancer cells. | 2006 | Cancer Lett. | pmid:16029925 |
| Clark SS | Perillyl alcohol induces c-Myc-dependent apoptosis in Bcr/Abl-transformed leukemia cells. | 2006 | Oncology | pmid:16439861 |
| da Fonseca CO et al. | Recent advances in the molecular genetics of malignant gliomas disclose targets for antitumor agent perillyl alcohol. | 2006 | Surg Neurol | pmid:16427438 |
| Fischer Jde S et al. | Effects of perillyl alcohol and heat shock treatment in gene expression of human lung adenocarcinoma cell line A549. | 2006 | J. Exp. Ther. Oncol. | pmid:17024970 |
| Da Fonseca CO et al. | Anaplastic oligodendroglioma responding favorably to intranasal delivery of perillyl alcohol: a case report and literature review. | 2006 | Surg Neurol | pmid:17145324 |
| Gómez-Contreras PC et al. | In vitro induction of apoptosis in U937 cells by perillyl alcohol with sensitization by pentoxifylline: increased BCL-2 and BAX protein expression. | 2006 | Chemotherapy | pmid:17008791 |
| Loutrari H et al. | Mastic oil from Pistacia lentiscus var. chia inhibits growth and survival of human K562 leukemia cells and attenuates angiogenesis. | 2006 | Nutr Cancer | pmid:16965245 |
| Gupta A et al. | An HPLC method for quantitation of perillyl alcohol in a topical pharmaceutical cream formulation. | 2005 | J Pharm Biomed Anal | pmid:15740902 |
| Fernandes J et al. | Perillyl alcohol induces apoptosis in human glioblastoma multiforme cells. | 2005 | Oncol. Rep. | pmid:15809762 |
| Courdavault V et al. | CaaX-prenyltransferases are essential for expression of genes involvedin the early stages of monoterpenoid biosynthetic pathway in Catharanthus roseus cells. | 2005 | Plant Mol. Biol. | pmid:15952070 |
| Bassi AM et al. | Protein and m-RNA expression of farnesyl-transferases, RhoA and RhoB in rat liver hepatocytes: action of perillyl alcohol and vitamin A in vivo. | 2005 | J. Biomed. Sci. | pmid:15959631 |
| Del Toro-Arreola S et al. | Effect of D-limonene on immune response in BALB/c mice with lymphoma. | 2005 | Int. Immunopharmacol. | pmid:15778119 |
| Berchtold CM et al. | Perillyl alcohol inhibits a calcium-dependent constitutive nuclear factor-kappaB pathway. | 2005 | Cancer Res. | pmid:16166337 |
| van Beilen JB et al. | Biocatalytic production of perillyl alcohol from limonene by using a novel Mycobacterium sp. cytochrome P450 alkane hydroxylase expressed in Pseudomonas putida. | 2005 | Appl. Environ. Microbiol. | pmid:15811996 |
| Samaila D et al. | Monoterpenes enhanced the sensitivity of head and neck cancer cells to radiation treatment in vitro. | 2004 Sep-Oct | Anticancer Res. | pmid:15517920 |
| Bailey HH et al. | A phase I trial of perillyl alcohol administered four times daily for 14 days out of 28 days. | 2004 | Cancer Chemother. Pharmacol. | pmid:15205914 |
| Loutrari H et al. | Perillyl alcohol is an angiogenesis inhibitor. | 2004 | J. Pharmacol. Exp. Ther. | pmid:15210838 |
| Gupta A and Myrdal PB | Development of a perillyl alcohol topical cream formulation. | 2004 | Int J Pharm | pmid:14706249 |
| Stearns V et al. | A pilot surrogate end point biomarker trial of perillyl alcohol in breast neoplasia. | 2004 | Clin. Cancer Res. | pmid:15569989 |
| Xu M et al. | Perillyl alcohol-mediated inhibition of lung cancer cell line proliferation: potential mechanisms for its chemotherapeutic effects. | 2004 | Toxicol. Appl. Pharmacol. | pmid:14998688 |
| Yuri T et al. | Perillyl alcohol inhibits human breast cancer cell growth in vitro and in vivo. | 2004 | Breast Cancer Res. Treat. | pmid:15026623 |
| Chen Y and Hu D | Effects of POH in combination with STI571 on the proliferation and apoptosis of K562 cells. | 2004 | J. Huazhong Univ. Sci. Technol. Med. Sci. | pmid:15165112 |
| Kennedy S et al. | Effect of antiproliferative agents on vascular function in normal and in vitro balloon-injured porcine coronary arteries. | 2003 | Eur. J. Pharmacol. | pmid:14637181 |
| Ahn KJ et al. | Cytotoxicity of perillyl alcohol against cancer cells is potentiated by hyperthermia. | 2003 | Int. J. Radiat. Oncol. Biol. Phys. | pmid:14529788 |
| Clark SS et al. | Anti-leukemia effect of perillyl alcohol in Bcr/Abl-transformed cells indirectly inhibits signaling through Mek in a Ras- and Raf-independent fashion. | 2003 | Clin. Cancer Res. | pmid:14555523 |
| Liu G et al. | Phase II trial of perillyl alcohol (NSC 641066) administered daily in patients with metastatic androgen independent prostate cancer. | 2003 | Invest New Drugs | pmid:14578686 |
| Russell J and Ling CC | Studies with cytotoxic agents suggest that apoptosis is not a major determinant of clonogenic death in neuroblastoma cells. | 2003 | Eur. J. Cancer | pmid:14522384 |
| Holstein SA and Hohl RJ | Monoterpene regulation of Ras and Ras-related protein expression. | 2003 | J. Lipid Res. | pmid:12671036 |
| Rajesh D et al. | Perillyl alcohol as a radio-/chemosensitizer in malignant glioma. | 2003 | J. Biol. Chem. | pmid:12805388 |
| Liston BW et al. | Perillyl alcohol as a chemopreventive agent in N-nitrosomethylbenzylamine-induced rat esophageal tumorigenesis. | 2003 | Cancer Res. | pmid:12750258 |
| Azzoli CG et al. | A phase I trial of perillyl alcohol in patients with advanced solid tumors. | 2003 | Cancer Chemother. Pharmacol. | pmid:12695855 |
| Morgan-Meadows S et al. | Phase I trial of perillyl alcohol administered four times daily continuously. | 2003 | Cancer Chemother. Pharmacol. | pmid:12904896 |
| Rajesh D and Howard SP | Perillyl alcohol mediated radiosensitization via augmentation of the Fas pathway in prostate cancer cells. | 2003 | Prostate | pmid:12886519 |
| Elegbede JA et al. | Perillyl alcohol and perillaldehyde induced cell cycle arrest and cell death in BroTo and A549 cells cultured in vitro. | 2003 | Life Sci. | pmid:14511768 |
| Burke YD et al. | Effects of the isoprenoids perillyl alcohol and farnesol on apoptosis biomarkers in pancreatic cancer chemoprevention. | 2002 Nov-Dec | Anticancer Res. | pmid:12530055 |
| Murren JR et al. | Phase I study of perillyl alcohol in patients with refractory malignancies. | 2002 Mar-Apr | Cancer Biol. Ther. | pmid:12170772 |
| Clark SS et al. | Antileukemia activity of perillyl alcohol (POH): uncoupling apoptosis from G0/G1 arrest suggests that the primary effect of POH on Bcr/Abl-transformed cells is to induce growth arrest. | 2002 | Leukemia | pmid:11840288 |