(-)-Perillyl alcohol

(-)-perillyl alcohol is a lipid of Prenol Lipids (PR) class. The involved functions are known as Cell Cycle Progression, Cell Cycle, Cell Proliferation, Apoptosis and Isoprenylation. (-)-perillyl alcohol often locates in Cytoplasm, Membrane and Plasma membrane. The associated genes with (-)-Perillyl alcohol are JUN gene, Candidate Disease Gene, IL24 gene, BCL2L1 gene and CFB gene. The related experimental models are Transgenic Model.

Cross Reference


To understand associated biological information of (-)-Perillyl alcohol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with (-)-Perillyl alcohol?

There are no associated biomedical information in the current reference collection.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with (-)-Perillyl alcohol

MeSH term MeSH ID Detail
Adenocarcinoma D000230 166 associated lipids
Lung Neoplasms D008175 171 associated lipids
Pancreatic Neoplasms D010190 77 associated lipids
Mammary Neoplasms, Experimental D008325 67 associated lipids
Body Weight D001835 333 associated lipids
Edema D004487 152 associated lipids
Esophageal Neoplasms D004938 20 associated lipids
Precancerous Conditions D011230 48 associated lipids
Prostatic Neoplasms D011471 126 associated lipids
Brain Neoplasms D001932 15 associated lipids
Per page 10 20 50 | Total 22

PubChem Associated disorders and diseases

What pathways are associated with (-)-Perillyl alcohol

Lipid pathways are not clear in current pathway databases. We organized associated pathways with (-)-Perillyl alcohol through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
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PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with (-)-Perillyl alcohol?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with (-)-Perillyl alcohol?

Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with (-)-Perillyl alcohol?

There are no associated biomedical information in the current reference collection.

What genes are associated with (-)-Perillyl alcohol?

Related references are published most in these journals:

Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with (-)-Perillyl alcohol?

Transgenic Model

Transgenic Model are used in the study 'A phase 2a study of topical perillyl alcohol cream for chemoprevention of skin cancer.' (Stratton SP et al., 2010).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with (-)-Perillyl alcohol

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Per page 10 20 50 100 | Total 165
Authors Title Published Journal PubMed Link
Ansari MA et al. Anticandidal Effect and Mechanisms of Monoterpenoid, Perillyl Alcohol against Candida albicans. 2016 PLoS ONE pmid:27627759
Chen TC et al. Perillyl Alcohol and Its Drug-Conjugated Derivatives as Potential Novel Methods of Treating Brain Metastases. 2016 Int J Mol Sci pmid:27598140
Song X et al. Temozolomide-perillyl alcohol conjugate induced reactive oxygen species accumulation contributes to its cytotoxicity against non-small cell lung cancer. 2016 Sci Rep pmid:26949038
Andrade LN et al. In Vivo Anti-Tumor Activity and Toxicological Evaluations of Perillaldehyde 8,9-Epoxide, a Derivative of Perillyl Alcohol. 2016 Int J Mol Sci pmid:26742032
Xie L et al. Therapeutic effect of TMZ-POH on human nasopharyngeal carcinoma depends on reactive oxygen species accumulation. 2016 Oncotarget pmid:26625208
Garcia DG et al. Na/K-ATPase as a target for anticancer drugs: studies with perillyl alcohol. 2015 Mol. Cancer pmid:25976744
d'Alessio PA et al. Skin repair properties of d-Limonene and perillyl alcohol in murine models. 2014 Antiinflamm Antiallergy Agents Med Chem pmid:24160248
Wróblewska A The epoxidation of limonene over the TS-1 and Ti-SBA-15 catalysts. 2014 Molecules pmid:25460313
Sarkar S et al. Chemoprevention gene therapy (CGT) of pancreatic cancer using perillyl alcohol and a novel chimeric serotype cancer terminator virus. 2014 Curr. Mol. Med. pmid:24236457
Imamura M et al. Perillyl alcohol suppresses antigen-induced immune responses in the lung. 2014 Biochem. Biophys. Res. Commun. pmid:24309112
D'Alincourt Salazar M et al. Intranasal administration of perillyl alcohol activates peripheral and bronchus-associated immune system in vivo. 2014 Arch. Immunol. Ther. Exp. (Warsz.) pmid:24257817
Nandurkar NS et al. The identification of perillyl alcohol glycosides with improved antiproliferative activity. 2014 J. Med. Chem. pmid:25121720
Hui Z et al. Synthesis and antiproliferative effects of amino-modified perillyl alcohol derivatives. 2014 Molecules pmid:24858099
Chen TC et al. A novel temozolomide-perillyl alcohol conjugate exhibits superior activity against breast cancer cells in vitro and intracranial triple-negative tumor growth in vivo. 2014 Mol. Cancer Ther. pmid:24623736
Alonso-Gutierrez J et al. Metabolic engineering of Escherichia coli for limonene and perillyl alcohol production. 2013 Metab. Eng. pmid:23727191
Lefranc F et al. 4-Bromo-2-(piperidin-1-yl)thiazol-5-yl-phenyl methanone (12b) inhibits Na+/K(+)-ATPase and Ras oncogene activity in cancer cells. 2013 Eur J Med Chem pmid:23474907
Sundin T et al. Disruption of an hTERT-mTOR-RAPTOR protein complex by a phytochemical perillyl alcohol and rapamycin. 2013 Mol. Cell. Biochem. pmid:23283642
Koyama M et al. Perillyl alcohol causes G1 arrest through p15(INK4b) and p21(WAF1/Cip1) induction. 2013 Oncol. Rep. pmid:23233050
Sultana S et al. Perillyl alcohol as a protective modulator against rat hepatocarcinogenesis via amelioration of oxidative damage and cell proliferation. 2013 Hum Exp Toxicol pmid:23536516
Sundin T et al. eIF4E-Overexpression imparts perillyl alcohol and rapamycin-mediated regulation of telomerase reverse transcriptase. 2013 Exp. Cell Res. pmid:23747720
Silva MM et al. Influence of GSTM1 and GSTT1 polymorphisms on the survival rate of patients with malignant glioma under perillyl alcohol-based therapy. 2013 Genet. Mol. Res. pmid:23765968
DA Fonseca CO et al. Long-term outcome in patients with recurrent malignant glioma treated with Perillyl alcohol inhalation. 2013 Anticancer Res. pmid:24324108
Cornelissen S et al. Whole-cell-based CYP153A6-catalyzed (S)-limonene hydroxylation efficiency depends on host background and profits from monoterpene uptake via AlkL. 2013 Biotechnol. Bioeng. pmid:23239244
Farazuddin M et al. Anticancer efficacy of perillyl alcohol-bearing PLGA microparticles. 2012 Int J Nanomedicine pmid:22275821
Jung HJ et al. Calcium blockers decrease the bortezomib resistance in mantle cell lymphoma via manipulation of tissue transglutaminase activities. 2012 Blood pmid:22294726
Cho HY et al. Perillyl alcohol for the treatment of temozolomide-resistant gliomas. 2012 Mol. Cancer Ther. pmid:22933703
da Silveira Fd et al. Analysis of EGF+61A>G polymorphism and EGF serum levels in Brazilian glioma patients treated with perillyl alcohol-based therapy. 2012 J. Cancer Res. Clin. Oncol. pmid:22481252
Sundin T et al. The isoprenoid perillyl alcohol inhibits telomerase activity in prostate cancer cells. 2012 Biochimie pmid:22902867
Duelund L et al. Influence of the active compounds of Perilla frutescens leaves on lipid membranes. 2012 J. Nat. Prod. pmid:22272932
Bicas JL et al. Evaluation of the antioxidant and antiproliferative potential of bioflavors. 2011 Food Chem. Toxicol. pmid:21540069
Khan AQ et al. Perillyl alcohol protects against ethanol induced acute liver injury in Wistar rats by inhibiting oxidative stress, NFκ-B activation and proinflammatory cytokine production. 2011 Toxicology pmid:20923693
de Saldanha da Gama Fischer J et al. Chemo-resistant protein expression pattern of glioblastoma cells (A172) to perillyl alcohol. 2011 J. Proteome Res. pmid:20806975
da Fonseca CO et al. Efficacy of monoterpene perillyl alcohol upon survival rate of patients with recurrent glioblastoma. 2011 J. Cancer Res. Clin. Oncol. pmid:20401670
Prado R et al. Nonmelanoma skin cancer chemoprevention. 2011 Dermatol Surg pmid:21895847
Kiran I Microbial hydroxylation of S-(-)-perillyl alcohol by Fusarium heterosporium. 2011 Nat Prod Commun pmid:22312710
Cornelissen S et al. Cell physiology rather than enzyme kinetics can determine the efficiency of cytochrome P450-catalyzed C-H-oxyfunctionalization. 2011 J. Ind. Microbiol. Biotechnol. pmid:21559976
Seifert A et al. An efficient route to selective bio-oxidation catalysts: an iterative approach comprising modeling, diversification, and screening, based on CYP102A1. 2011 Chembiochem pmid:21591046
Garcia DG et al. The anticancer drug perillyl alcohol is a Na/K-ATPase inhibitor. 2010 Mol. Cell. Biochem. pmid:20689980
Stratton SP et al. A phase 2a study of topical perillyl alcohol cream for chemoprevention of skin cancer. 2010 Cancer Prev Res (Phila) pmid:20103724
Clifford JL and DiGiovanni J The promise of natural products for blocking early events in skin carcinogenesis. 2010 Cancer Prev Res (Phila) pmid:20103730
Fischer Jde S et al. Dynamic proteomic overview of glioblastoma cells (A172) exposed to perillyl alcohol. 2010 J Proteomics pmid:20083244
Yeruva L et al. Perillyl alcohol and methyl jasmonate sensitize cancer cells to cisplatin. 2010 Anticancer Drugs pmid:19820395
Chaudhary SC et al. Perillyl alcohol attenuates Ras-ERK signaling to inhibit murine skin inflammation and tumorigenesis. 2009 Chem. Biol. Interact. pmid:19161993
Da Fonseca CO et al. Correlation of tumor topography and peritumoral edema of recurrent malignant gliomas with therapeutic response to intranasal administration of perillyl alcohol. 2009 Invest New Drugs pmid:19139816
Magkouta S et al. Protective effects of mastic oil from Pistacia lentiscus variation chia against experimental growth of lewis lung carcinoma. 2009 Nutr Cancer pmid:19838938
Zhou W et al. Components of lemon essential oil attenuate dementia induced by scopolamine. 2009 Nutr Neurosci pmid:19356307
Kim D and Ortiz de Montellano PR Tricistronic overexpression of cytochrome P450cam, putidaredoxin, and putidaredoxin reductase provides a useful cell-based catalytic system. 2009 Biotechnol. Lett. pmid:19458919
da Fonseca CO et al. Ras pathway activation in gliomas: a strategic target for intranasal administration of perillyl alcohol. 2008 Jul-Aug Arch. Immunol. Ther. Exp. (Warsz.) pmid:18726148
Fischer Jde S et al. Anti-thrombin as a prognostic biomarker candidate for patients with recurrent glioblastoma multiform under treatment with perillyl alcohol. 2008 J. Exp. Ther. Oncol. pmid:19227008
Hua HY et al. High-performance liquid chromatographic and pharmacokinetic analyses of an intravenous submicron emulsion of perillyl alcohol in rats. 2008 J Pharm Biomed Anal pmid:18849133
Bailey HH et al. Phase II trial of daily oral perillyl alcohol (NSC 641066) in treatment-refractory metastatic breast cancer. 2008 Cancer Chemother. Pharmacol. pmid:17885756
da Fonseca CO et al. Preliminary results from a phase I/II study of perillyl alcohol intranasal administration in adults with recurrent malignant gliomas. 2008 Surg Neurol pmid:18295834
Bisson JF et al. Anti-inflammatory senescence actives 5203-L molecule to promote healthy aging and prolongation of lifespan. 2008 Rejuvenation Res pmid:18370605
Matos JM et al. A pilot study of perillyl alcohol in pancreatic cancer. 2008 J. Surg. Res. pmid:18498869
Stratton SP et al. Phase 1 study of topical perillyl alcohol cream for chemoprevention of skin cancer. 2008 Nutr Cancer pmid:18444166
Bhatia SP et al. Fragrance material review on p-mentha-1,8-dien-7-ol. 2008 Food Chem. Toxicol. pmid:18640209
Lebedeva IV et al. Chemoprevention by perillyl alcohol coupled with viral gene therapy reduces pancreatic cancer pathogenesis. 2008 Mol. Cancer Ther. pmid:18645014
Lebedeva IV et al. Mechanism of in vitro pancreatic cancer cell growth inhibition by melanoma differentiation-associated gene-7/interleukin-24 and perillyl alcohol. 2008 Cancer Res. pmid:18768668
Yamamoto Y et al. Synthesis of phosphatidylated-monoterpene alcohols catalyzed by phospholipase D and their antiproliferative effects on human cancer cells. 2008 Bioorg. Med. Chem. Lett. pmid:18556205
Yeruva L et al. Perillyl alcohol and perillic acid induced cell cycle arrest and apoptosis in non small cell lung cancer cells. 2007 Cancer Lett. pmid:17888568
Peffley DM et al. Perillyl alcohol and genistein differentially regulate PKB/Akt and 4E-BP1 phosphorylation as well as eIF4E/eIF4G interactions in human tumor cells. 2007 Arch. Biochem. Biophys. pmid:17601486
Wiseman DA et al. Cell cycle arrest by the isoprenoids perillyl alcohol, geraniol, and farnesol is mediated by p21(Cip1) and p27(Kip1) in human pancreatic adenocarcinoma cells. 2007 J. Pharmacol. Exp. Ther. pmid:17138864
Chan NL et al. Polycyclic aromatic hydrocarbon-induced CYP1B1 activity is suppressed by perillyl alcohol in MCF-7 cells. 2006 Toxicol. Appl. Pharmacol. pmid:16307765
Chung BH et al. Perillyl alcohol inhibits the expression and function of the androgen receptor in human prostate cancer cells. 2006 Cancer Lett. pmid:16029925
Clark SS Perillyl alcohol induces c-Myc-dependent apoptosis in Bcr/Abl-transformed leukemia cells. 2006 Oncology pmid:16439861
da Fonseca CO et al. Recent advances in the molecular genetics of malignant gliomas disclose targets for antitumor agent perillyl alcohol. 2006 Surg Neurol pmid:16427438
Fischer Jde S et al. Effects of perillyl alcohol and heat shock treatment in gene expression of human lung adenocarcinoma cell line A549. 2006 J. Exp. Ther. Oncol. pmid:17024970
Da Fonseca CO et al. Anaplastic oligodendroglioma responding favorably to intranasal delivery of perillyl alcohol: a case report and literature review. 2006 Surg Neurol pmid:17145324
Gómez-Contreras PC et al. In vitro induction of apoptosis in U937 cells by perillyl alcohol with sensitization by pentoxifylline: increased BCL-2 and BAX protein expression. 2006 Chemotherapy pmid:17008791
Loutrari H et al. Mastic oil from Pistacia lentiscus var. chia inhibits growth and survival of human K562 leukemia cells and attenuates angiogenesis. 2006 Nutr Cancer pmid:16965245
Gupta A et al. An HPLC method for quantitation of perillyl alcohol in a topical pharmaceutical cream formulation. 2005 J Pharm Biomed Anal pmid:15740902
Fernandes J et al. Perillyl alcohol induces apoptosis in human glioblastoma multiforme cells. 2005 Oncol. Rep. pmid:15809762
Courdavault V et al. CaaX-prenyltransferases are essential for expression of genes involvedin the early stages of monoterpenoid biosynthetic pathway in Catharanthus roseus cells. 2005 Plant Mol. Biol. pmid:15952070
Bassi AM et al. Protein and m-RNA expression of farnesyl-transferases, RhoA and RhoB in rat liver hepatocytes: action of perillyl alcohol and vitamin A in vivo. 2005 J. Biomed. Sci. pmid:15959631
Del Toro-Arreola S et al. Effect of D-limonene on immune response in BALB/c mice with lymphoma. 2005 Int. Immunopharmacol. pmid:15778119
Berchtold CM et al. Perillyl alcohol inhibits a calcium-dependent constitutive nuclear factor-kappaB pathway. 2005 Cancer Res. pmid:16166337
van Beilen JB et al. Biocatalytic production of perillyl alcohol from limonene by using a novel Mycobacterium sp. cytochrome P450 alkane hydroxylase expressed in Pseudomonas putida. 2005 Appl. Environ. Microbiol. pmid:15811996
Samaila D et al. Monoterpenes enhanced the sensitivity of head and neck cancer cells to radiation treatment in vitro. 2004 Sep-Oct Anticancer Res. pmid:15517920
Bailey HH et al. A phase I trial of perillyl alcohol administered four times daily for 14 days out of 28 days. 2004 Cancer Chemother. Pharmacol. pmid:15205914
Loutrari H et al. Perillyl alcohol is an angiogenesis inhibitor. 2004 J. Pharmacol. Exp. Ther. pmid:15210838
Gupta A and Myrdal PB Development of a perillyl alcohol topical cream formulation. 2004 Int J Pharm pmid:14706249
Stearns V et al. A pilot surrogate end point biomarker trial of perillyl alcohol in breast neoplasia. 2004 Clin. Cancer Res. pmid:15569989
Xu M et al. Perillyl alcohol-mediated inhibition of lung cancer cell line proliferation: potential mechanisms for its chemotherapeutic effects. 2004 Toxicol. Appl. Pharmacol. pmid:14998688
Yuri T et al. Perillyl alcohol inhibits human breast cancer cell growth in vitro and in vivo. 2004 Breast Cancer Res. Treat. pmid:15026623
Chen Y and Hu D Effects of POH in combination with STI571 on the proliferation and apoptosis of K562 cells. 2004 J. Huazhong Univ. Sci. Technol. Med. Sci. pmid:15165112
Kennedy S et al. Effect of antiproliferative agents on vascular function in normal and in vitro balloon-injured porcine coronary arteries. 2003 Eur. J. Pharmacol. pmid:14637181
Ahn KJ et al. Cytotoxicity of perillyl alcohol against cancer cells is potentiated by hyperthermia. 2003 Int. J. Radiat. Oncol. Biol. Phys. pmid:14529788
Clark SS et al. Anti-leukemia effect of perillyl alcohol in Bcr/Abl-transformed cells indirectly inhibits signaling through Mek in a Ras- and Raf-independent fashion. 2003 Clin. Cancer Res. pmid:14555523
Liu G et al. Phase II trial of perillyl alcohol (NSC 641066) administered daily in patients with metastatic androgen independent prostate cancer. 2003 Invest New Drugs pmid:14578686
Russell J and Ling CC Studies with cytotoxic agents suggest that apoptosis is not a major determinant of clonogenic death in neuroblastoma cells. 2003 Eur. J. Cancer pmid:14522384
Holstein SA and Hohl RJ Monoterpene regulation of Ras and Ras-related protein expression. 2003 J. Lipid Res. pmid:12671036
Rajesh D et al. Perillyl alcohol as a radio-/chemosensitizer in malignant glioma. 2003 J. Biol. Chem. pmid:12805388
Liston BW et al. Perillyl alcohol as a chemopreventive agent in N-nitrosomethylbenzylamine-induced rat esophageal tumorigenesis. 2003 Cancer Res. pmid:12750258
Azzoli CG et al. A phase I trial of perillyl alcohol in patients with advanced solid tumors. 2003 Cancer Chemother. Pharmacol. pmid:12695855
Morgan-Meadows S et al. Phase I trial of perillyl alcohol administered four times daily continuously. 2003 Cancer Chemother. Pharmacol. pmid:12904896
Rajesh D and Howard SP Perillyl alcohol mediated radiosensitization via augmentation of the Fas pathway in prostate cancer cells. 2003 Prostate pmid:12886519
Elegbede JA et al. Perillyl alcohol and perillaldehyde induced cell cycle arrest and cell death in BroTo and A549 cells cultured in vitro. 2003 Life Sci. pmid:14511768
Burke YD et al. Effects of the isoprenoids perillyl alcohol and farnesol on apoptosis biomarkers in pancreatic cancer chemoprevention. 2002 Nov-Dec Anticancer Res. pmid:12530055
Murren JR et al. Phase I study of perillyl alcohol in patients with refractory malignancies. 2002 Mar-Apr Cancer Biol. Ther. pmid:12170772
Meadows SM et al. Phase II trial of perillyl alcohol in patients with metastatic colorectal cancer. 2002 Int J Gastrointest Cancer pmid:12794248