| MeSH term | MeSH ID | Detail |
|---|---|---|
| Adenocarcinoma | D000230 | 166 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Pancreatic Neoplasms | D010190 | 77 associated lipids |
| Mammary Neoplasms, Experimental | D008325 | 67 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
| Edema | D004487 | 152 associated lipids |
| Esophageal Neoplasms | D004938 | 20 associated lipids |
| Precancerous Conditions | D011230 | 48 associated lipids |
| Prostatic Neoplasms | D011471 | 126 associated lipids |
| Brain Neoplasms | D001932 | 15 associated lipids |
(-)-Perillyl alcohol
(-)-perillyl alcohol is a lipid of Prenol Lipids (PR) class. The involved functions are known as Cell Cycle Progression, Cell Cycle, Cell Proliferation, Apoptosis and Isoprenylation. (-)-perillyl alcohol often locates in Cytoplasm, Membrane and Plasma membrane. The associated genes with (-)-Perillyl alcohol are JUN gene, Candidate Disease Gene, IL24 gene, BCL2L1 gene and CFB gene. The related experimental models are Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of (-)-Perillyl alcohol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with (-)-Perillyl alcohol?
There are no associated biomedical information in the current reference collection.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with (-)-Perillyl alcohol
PubChem Associated disorders and diseases
What pathways are associated with (-)-Perillyl alcohol
Lipid pathways are not clear in current pathway databases. We organized associated pathways with (-)-Perillyl alcohol through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with (-)-Perillyl alcohol?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with (-)-Perillyl alcohol?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with (-)-Perillyl alcohol?
There are no associated biomedical information in the current reference collection.
What genes are associated with (-)-Perillyl alcohol?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with (-)-Perillyl alcohol?
Transgenic Model
Transgenic Model are used in the study 'A phase 2a study of topical perillyl alcohol cream for chemoprevention of skin cancer.' (Stratton SP et al., 2010).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with (-)-Perillyl alcohol
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Miyazawa M et al. | Sex differences in the metabolism of (+)- and (-)-limonene enantiomers to carveol and perillyl alcohol derivatives by cytochrome p450 enzymes in rat liver microsomes. | 2002 | Chem. Res. Toxicol. | pmid:11800592 |
| Clark SS et al. | Antileukemia activity of perillyl alcohol (POH): uncoupling apoptosis from G0/G1 arrest suggests that the primary effect of POH on Bcr/Abl-transformed cells is to induce growth arrest. | 2002 | Leukemia | pmid:11840288 |
| Shi W and Gould MN | Induction of cytostasis in mammary carcinoma cells treated with the anticancer agent perillyl alcohol. | 2002 | Carcinogenesis | pmid:11756234 |
| Bardon S et al. | Monoterpenes inhibit proliferation of human colon cancer cells by modulating cell cycle-related protein expression. | 2002 | Cancer Lett. | pmid:12175534 |
| Lluria-Prevatt M et al. | Effects of perillyl alcohol on melanoma in the TPras mouse model. | 2002 | Cancer Epidemiol. Biomarkers Prev. | pmid:12050099 |
| Bailey HH et al. | A phase II trial of daily perillyl alcohol in patients with advanced ovarian cancer: Eastern Cooperative Oncology Group Study E2E96. | 2002 | Gynecol. Oncol. | pmid:12051875 |
| Teruszkin Balassiano I et al. | Effects of perillyl alcohol in glial C6 cell line in vitro and anti-metastatic activity in chorioallantoic membrane model. | 2002 | Int. J. Mol. Med. | pmid:12430008 |
| Meadows SM et al. | Phase II trial of perillyl alcohol in patients with metastatic colorectal cancer. | 2002 | Int J Gastrointest Cancer | pmid:12794248 |
| Lantry LE et al. | Chemopreventive efficacy of promising farnesyltransferase inhibitors. | 2000 | Exp. Lung Res. | pmid:11195470 |
| Wei X et al. | Perillyl alcohol inhibits TCR-mediated [Ca(2+)](i) signaling, alters cell shape and motility, and induces apoptosis in T lymphocytes. | 2000 | Cell. Immunol. | pmid:10805968 |
| Si MS and Imagawa DK | Prenylation inhibitors to treat proliferative renal disease. | 2000 | Lancet | pmid:10791545 |
| Boon PJ et al. | Cytotoxicity and biotransformation of the anticancer drug perillyl alcohol in PC12 cells and in the rat. | 2000 | Toxicol. Appl. Pharmacol. | pmid:10936079 |
| Hudes GR et al. | Phase I pharmacokinetic trial of perillyl alcohol (NSC 641066) in patients with refractory solid malignancies. | 2000 | Clin. Cancer Res. | pmid:10955786 |
| Löw-Baselli A et al. | Failure to demonstrate chemoprevention by the monoterpene perillyl alcohol during early rat hepatocarcinogenesis: a cautionary note. | 2000 | Carcinogenesis | pmid:11023545 |
| Unlu S et al. | Perillyl alcohol, an inhibitor of geranylgeranyl transferase, induces apoptosis of immortalized human vascular smooth muscle cells in vitro. | 2000 | J. Cardiovasc. Pharmacol. | pmid:10672871 |
| Ripple GH et al. | Phase I clinical and pharmacokinetic study of perillyl alcohol administered four times a day. | 2000 | Clin. Cancer Res. | pmid:10690515 |
| Crowell PL | Prevention and therapy of cancer by dietary monoterpenes. | 1999 | J. Nutr. | pmid:10082788 |
| Ariazi EA et al. | Activation of the transforming growth factor beta signaling pathway and induction of cytostasis and apoptosis in mammary carcinomas treated with the anticancer agent perillyl alcohol. | 1999 | Cancer Res. | pmid:10213501 |
| Zhang Z et al. | Gas chromatographic-mass spectrometric analysis of perillyl alcohol and metabolites in plasma. | 1999 | J. Chromatogr. B Biomed. Sci. Appl. | pmid:10379660 |
| Cerda SR et al. | Enhancement of sterol synthesis by the monoterpene perillyl alcohol is unaffected by competitive 3-hydroxy-3-methylglutaryl-CoA reductase inhibition. | 1999 | Lipids | pmid:10405975 |
| Sahin MB et al. | Perillyl alcohol selectively induces G0/G1 arrest and apoptosis in Bcr/Abl-transformed myeloid cell lines. | 1999 | Leukemia | pmid:10516760 |
| Satomi Y et al. | Induction of AP-1 activity by perillyl alcohol in breast cancer cells. | 1999 | Carcinogenesis | pmid:10506111 |
| Ripple GH and Wilding G | Drug development in prostate cancer. | 1999 | Semin. Oncol. | pmid:10597732 |
| Stayrook KR et al. | Effects of the antitumor agent perillyl alcohol on H-Ras vs. K-Ras farnesylation and signal transduction in pancreatic cells. | 1998 Mar-Apr | Anticancer Res. | pmid:9615726 |
| Bardon S et al. | Monoterpenes inhibit cell growth, cell cycle progression, and cyclin D1 gene expression in human breast cancer cell lines. | 1998 | Nutr Cancer | pmid:9824849 |
| Barthelman M et al. | Inhibitory effects of perillyl alcohol on UVB-induced murine skin cancer and AP-1 transactivation. | 1998 | Cancer Res. | pmid:9485025 |
| Belanger JT | Perillyl alcohol: applications in oncology. | 1998 | Altern Med Rev | pmid:9855569 |
| Ripple GH et al. | Phase I clinical trial of perillyl alcohol administered daily. | 1998 | Clin. Cancer Res. | pmid:9607573 |
| Tao L and Pereira MA | Quantification of carvone, cineole, perillaldehyde, perillyl alcohol and sobrerol by isocratic high-performance liquid chromatography. | 1998 | J Chromatogr A | pmid:9468652 |
| Ren Z et al. | Inhibition of type I and type II geranylgeranyl-protein transferases by the monoterpene perillyl alcohol in NIH3T3 cells. | 1997 | Biochem. Pharmacol. | pmid:9296357 |
| Lewis KA and Hohl RJ | Modulation of RAS expression in human malignant cells by dietary supplements. | 1997 | Nutrition | pmid:9357036 |
| Zweibel J et al. | Clinical trials referral resource. Clinical trials with perillyl alcohol. | 1997 | Oncology (Williston Park, N.Y.) | pmid:9436188 |
| Stayrook KR et al. | Induction of the apoptosis-promoting protein Bak by perillyl alcohol in pancreatic ductal adenocarcinoma relative to untransformed ductal epithelial cells. | 1997 | Carcinogenesis | pmid:9276644 |
| Fulton GJ et al. | Oral monoterpene therapy (perillyl alcohol) reduces vein graft intimal hyperplasia. | 1997 | J. Surg. Res. | pmid:9202658 |
| Reddy BS et al. | Chemoprevention of colon carcinogenesis by dietary perillyl alcohol. | 1997 | Cancer Res. | pmid:9012468 |
| Lantry LE et al. | Chemopreventive effect of perillyl alcohol on 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone induced tumorigenesis in (C3H/HeJ X A/J)F1 mouse lung. | 1997 | J. Cell. Biochem. Suppl. | pmid:9591189 |
| Karlson J et al. | Inhibition of tumor cell growth by monoterpenes in vitro: evidence of a Ras-independent mechanism of action. | 1996 | Anticancer Drugs | pmid:8826611 |
| O'Shaughnessy JA | Chemoprevention of breast cancer. | 1996 | JAMA | pmid:8614122 |
| Clinical development plan: l-perillyl alcohol. | 1996 | J. Cell. Biochem. Suppl. | pmid:9154174 | |
| Luján HD et al. | Isoprenylation of proteins in the protozoan Giardia lamblia. | 1995 | Mol. Biochem. Parasitol. | pmid:8538683 |
| Hohl RJ and Lewis K | Differential effects of monoterpenes and lovastatin on RAS processing. | 1995 | J. Biol. Chem. | pmid:7615555 |
| Gelb MH et al. | The inhibition of protein prenyltransferases by oxygenated metabolites of limonene and perillyl alcohol. | 1995 | Cancer Lett. | pmid:7767906 |
| Shi W and Gould MN | Induction of differentiation in neuro-2A cells by the monoterpene perillyl alcohol. | 1995 | Cancer Lett. | pmid:7656215 |
| Alison M | Promoting apoptosis. | 1995 | Hum Exp Toxicol | pmid:7576838 |
| Stark MJ et al. | Chemotherapy of pancreatic cancer with the monoterpene perillyl alcohol. | 1995 | Cancer Lett. | pmid:7553603 |
| Phillips LR et al. | Pharmacokinetics of active drug metabolites after oral administration of perillyl alcohol, an investigational antineoplastic agent, to the dog. | 1995 | Drug Metab. Dispos. | pmid:7587953 |
| Mills JJ et al. | Induction of apoptosis in liver tumors by the monoterpene perillyl alcohol. | 1995 | Cancer Res. | pmid:7867007 |
| Ren Z and Gould MN | Inhibition of ubiquinone and cholesterol synthesis by the monoterpene perillyl alcohol. | 1994 | Cancer Lett. | pmid:8149348 |
| Pan J et al. | [Constituents of essential oils from leaves, stems, and fruits of Perilla frutescens (L.) Britt]. | 1992 | Zhongguo Zhong Yao Za Zhi | pmid:1418538 |
| Opdyke DL | Monographs on fragrance raw materials. | 1981 | Food Cosmet Toxicol | pmid:7286874 |
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